SCOPUS 정보 검색 플랫폼

Volumn 9, Issue 7, 2014, Pages 1436-1452

Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins

(13) Yang, Chengwen a Chen, Sha b Zhou, Mi a Li, Yan a Li, Yangfeng a Zhang, Zhengxi a Liu, Zhen a Ba, Qian c Li, Jingquan c Wang, Hui c Yan, Xiaomei b Ma, Dawei a Wang, Renxiao a

a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (China)

b XIAMEN UNIVERSITY (China)

c Chinese Academy of Sciences (China)

Author keywords

antitumor agents; apoptosis; Bcl 2 family proteins; inhibitors; lead optimization; protein protein interactions

Indexed keywords

3 PHENYLTHIOPHENE 2 SULFONAMIDE; ANTINEOPLASTIC AGENT; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; YCW A 1; YCW A 10; YCW A 11; YCW A 12; YCW A 13; YCW A 2; YCW A 3; YCW A 4; YCW A 5; YCW A 6; YCW A 7; YCW A 8; YCW A 9; YCW A1; YCW A10; YCW A11; YCW A12; YCW A13; YCW A2; YCW A3; YCW A4; YCW A5; YCW A6; YCW A7; YCW A8; YCW A9; YCW B 1; YCW B 10; YCW B 2; YCW B 3; YCW B 4; YCW B 5; YCW B 6; YCW B 7; YCW B 8; YCW B 9; YCW B1; YCW B10; YCW B2; YCW B3; YCW B4; YCW B5; YCW B6; YCW B7; YCW B8; YCW B9; ABT-737; BIPHENYL DERIVATIVE; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITROPHENOL; PIPERAZINE DERIVATIVE; SULFONAMIDE; THIOPHENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CYTOTOXICITY ASSAY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION IMMUNOASSAY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HL 60 CELL LINE; HUMAN CELL CULTURE; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; TUMOR CELL; TUMOR CELL CULTURE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; MOLECULAR DOCKING; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; BIPHENYL COMPOUNDS; CASPASE 9; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; NITROPHENOLS; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES;

EID: 84903814907 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201400058 Document Type: Article

Times cited : (16)

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