Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 15-30

  Friberg, Anders ^a   Vigil, Dominico ^a   Zhao, Bin ^a   Daniels, R Nathan ^a   Burke, Jason P ^a   Garcia Barrantes, Pedro M ^a   Camper, Demarco ^a   Chauder, Brian A ^a   Lee, Taekyu ^a   Olejniczak, Edward T ^a   Fesik, Stephen W ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (NAPHTHALEN 1 YL)ETHYL]BENZOFURAN 2 CARBOXYLIC ACID; 3 [3 (2 TOLYLOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (4 CHLORO 3 ETHYLPHENOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (4 CHLORO 3 METHYLPHENOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPYL]BENZO[B] THIOPHENE 2 CARBOXYLIC ACID; 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPYL]BENZOFURAN 2 CARBOXYLIC ACID; 3 [3 (4 CHLOROPHENOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (4 TOLYLOXY)PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 (NAPHTHALEN 1 YL)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 3 [3 (NAPHTHALEN 1 YL)PROPYL]BENZOFURAN 2 CARBOXYLIC ACID; 3 [3 (NAPHTHALEN 1 YLOXY)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 3 [3 (NAPHTHALEN 1 YLOXY)PROPYL]BENZOFURAN 2 CARBOXYLIC ACID; 3 [3 (O TOLYLOXY)PROPYL] 1H INDOLE 2 CARBOXYIC ACID; 3 [3 [(1,1' BIPHENYL) 3 YLOXY]PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 [2 (TRIFLUOROMETHYL)PHENOXY]PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 [3 (TRIFLUOROMETHYL)PHENOXY]PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 3 [3 [5 TRIFLUOROMETHYL)PHENOXY]PROPYL] 1H INDOLE 2 CARBOXYLIC ACID; 4 CHLORO 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 5 CHLRO 3 [3 (NAPHTHALEN 1 YLOXY)PROPYL]BENZOFURAN 2 CARBOXYLIC ACID; 6 CHLORO 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 6 CHLORO 3 [3 (NAPHTHALEN 1 YLOXY)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 7 CHLORO 3 [3 (4 CHLORO 3,5 DIMETHYLPHENOXY)PROPY]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; 7 CHLORO 3 [3 (NAPHTHALEN 1 YLOXY)PROPYL]BENZO[B]THIOPHENE 2 CARBOXYLIC ACID; ANTILEUKEMIC AGENT; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BCL-X PROTEIN; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; INDOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872301920     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301448p     Document Type: Article

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