Duodenal luminal chemosensing; acid, ATP, and nutrients

Current Pharmaceutical Design

Volumn 20, Issue 16, 2014, Pages 2760-2765

  Akiba, Yasutada ^a   Kaunitz, Jonathan D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

G protein coupled receptors and gut hormone release; Luminal nutrient

Indexed keywords

ACID; ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; BILE ACID; FATTY ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 43; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 2; INCRETIN; RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

APPETITE; ARTICLE; DEFENSE MECHANISM; DIGESTION; DIGESTIVE SYSTEM INJURY; DUODENUM; DUODENUM MUCOSA; ENTEROENDOCRINE CELL; FUNCTIONAL DISEASE; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL SECRETION; HORMONE RELEASE; HUMAN; METABOLIC DISORDER; METABOLISM; NUTRIENT; PH; PRIORITY JOURNAL; SATIETY; ANIMAL; CHEMORECEPTOR CELL; EATING; INTESTINE MUCOSA; PHYSIOLOGY; SECRETION (PROCESS); STOMACH ACID;

ADENOSINE TRIPHOSPHATE; ANIMALS; CHEMORECEPTOR CELLS; DUODENUM; EATING; GASTRIC ACID; HUMANS; INTESTINAL MUCOSA; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84903720814     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990565     Document Type: Article

References (65)

1. Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol 1902; 28: 325-53.
2. Reimann F, Habib AM, Tolhurst G, et al. Glucose sensing in L cells: a primary cell study. Cell Metab 2008; 8: 532-9.
3. Liou AP, Lu X, Sei Y, et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. Gastroenterology 2011; 140: 903-12.
4. Akiba Y, Kaunitz JD. Duodenal chemosensing: Master control for epigastric sensation? J Gastroenterol Hepatol 2011; 26: 6-7.
5. Rune SJ, Viskum K. Duodenal pH values in normal controls and in patients with duodenal ulcer. Gut 1969; 10: 569-71.
6. Rune SJ, Henriksen FW. Carbon dioxide tensions in the proximal part of the canine gastrointestinal tract. Gastroenterology 1969; 56: 758-62.
7. Mizumori M, Meyerowitz J, Takeuchi T, et al. Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol 2006; 573: 827-842.
8. Akiba Y, Ghayouri S, Takeuchi T, et al. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology 2006; 131: 142-52.
9. Akiba Y, Nakamura M, Nagata H, Kaunitz JD, Ishii H. Acidsensing pathways in rat gastrointestinal mucosa. J Gastroenterol 2002; 37: 133-8.
10. Kaunitz JD, Akiba Y. Acid-sensing protective mechanisms of duodenum. J Physiol Pharmacol. 2003; 54: 19-26.
11. Gamble JL, Ross SG. The factors in the dehydration following pyloric obstruction. J Clin Invest 1925; 1: 403-23.
12. Rune SJ. The metabolic alkalosis following aspiration of gastric acid secretion. Scand.J. Clin. Lab Invest 1965; 17: 305-10.
13. Sasaki Y, Aihara E, Ohashi Y, et al. Stimulation by sparkling water of gastroduodenal HCO3-secretion in rats. Med Sci Monit 2009; 15: BR349-BR356.
14. Sjöblom M, Singh AK, Zheng W, et al. Duodenal acidity "sensing" but not epithelial HCO3-supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci USA 2009; 106: 13094-9.
15. Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24.
16. Tominaga M, Caterina MJ, Malmberg AB, et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998; 21: 531-43.
17. Holzer P. Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2007; 292: G699-G705.
18. Akiba Y, Mizumori M, Kuo M, et al. CO2 chemosensing in rat oesophagus. Gut 2008; 57: 1654-64.
19. Holzer P, Livingston EH, Guth PH. Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology 1991; 101: 416-23.
20. Akiba Y, Guth PH, Engel E, Nastaskin I, Kaunitz JD. Acid-sensing pathways of rat duodenum. Am J Physiol Gastrointest Liver Physiol 1999; 277: G268-G274.
21. Aihara E, Hayashi M, Sasaki Y, Kobata A, Takeuchi K. Mechanisms underlying capsaicin-stimulated secretion in the stomach: comparison with mucosal acidification. J Pharmacol Exp Ther 2005; 315: 423-32.
22. Garcia-Anoveros J, Nagata K. TRPA1. Handb Exp Pharmacol 2007: 347-62.
23. Kaji I, Karaki S, Kuwahara A. Effects of luminal thymol on epithelial transport in human and rat colon. Am J Physiol Gastrointest Liver Physiol 2011; 300: G1132-G1143.
24. Akiba Y, Kaunitz JD. Capsiate, a non-pungent capsinoid, enhances mucosal defenses via activation of TRPV1 and TRPA1 in rat duodenum. Gastroenterology 2011; 140: S32.
25. Nozawa K, Kawabata-Shoda E, Doihara H, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci USA 2009; 106: 3408-13.
26. Doihara H, Nozawa K, Kawabata-Shoda E, et al. TRPA1 agonists delay gastric emptying in rats through serotonergic pathways. Naunyn Schmiedebergs Arch Pharmacol 2009; 380: 353-7.
27. Ono K, Tsukamoto-Yasui M, Hara-Kimura Y, et al. Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. J Appl. Physiol 2011; 110: 789-98.
28. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012; 95: 845-50.
29. Akiba Y, Mizumori M, Guth PH, Engel E, Kaunitz JD. Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol 2007; 293: G1223-G1233.
30. Mizumori M, Ham M, Guth PH, et al. Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol 2009; 587: 3651-63.
31. Ham M, Mizumori M, Watanabe C, et al. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther 2010; 335: 607-13.
32. Kaunitz JD, Akiba Y. Purinergic regulation of duodenal surface pH and ATP concentration: implications for mucosal defence, lipid uptake and cystic fibrosis. Acta Physiol (Oxf) 2011; 201: 109-16.
33. Higashiyama M, Akiba Y, Rudenkyy S, et al. Dual oxidase: a novel antimicrobial duodenal defense mechanism. Gastroenterology 2012; 142: S489.
34. Sato M, Yamashita S, Ogawa H. Potentiation of gustatory response to monosodium glutamate in rat chorda tympani fibers by addition of 5'-ribonucleotides. Jpn J Physiol 1970; 20: 444-64.
35. Nelson G, Chandrashekar J, Hoon MA, et al. An amino-acid taste receptor. Nature 2002; 416: 199-202.
36. Zhao GQ, Zhang Y, Hoon MA, et al. The receptors for mammalian sweet and umami taste. Cell 2003; 115: 255-66.
37. Chaudhari N, Landin AM, Roper SD. A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 2000; 3: 113-9.
38. Toyono T, Seta Y, Kataoka S, et al. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res 2003; 313: 29-35.
39. Akiba Y, Watanabe C, Mizumori M, Kaunitz JD. Luminal Lglutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 2009; 297: G781-G791.
40. Wang JH, Inoue T, Higashiyama M, et al. Umami receptor activation increases duodenal bicarbonate secretion via glucagonlike peptide-2 release in rats. J Pharmacol Exp Ther 2011; 339: 464-73.
41. Hansen L, Hare KJ, Hartmann B, et al. Metabolism of glucagonlike peptide-2 in pigs: role of dipeptidyl peptidase IV. Regul Pept 2007; 138: 126-32.
42. Inoue T, Wang JH, Higashiyama M, et al. Dipeptidyl peptidase IV inhibition potentiates amino acid-and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol 2012; 303: G810-G816.
43. Kawamata Y, Fujii R, Hosoya M, et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003; 278: 9435-40.
44. Katsuma S, Hirasawa A, Tsujimoto G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 2005; 329: 386-90.
45. Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10: 167-77.
46. Andersson S. Inhibitory effects of hydrochloric acid in the duodenum on gastrin-stimulated gastric secretion in Heidenhain pouch dogs. Acta Physiol Scand 1960; 50: 105-12.
47. Raybould HE. Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosa. Am J Physiol Gastrointest Liver Physiol 1999; 277: G751-G755.
48. Samuel BS, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci USA 2008; 105: 16767-72.
49. Hirasawa A, Tsumaya K, Awaji T, et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005; 11: 90-4.
50. Inoue T, Akiba Y, Higashiyama M, et al. Luminal fatty acids differentially stimulate duodenal HCO3-secretion in rats. Gastroenterology 2012; 142: S202.
51. +-glucose cotransporter 1. Proc Natl Acad Sci USA 2007; 104: 15075-80.
52. Rozengurt E. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol 2006; 291: G171-G177.
53. Mace OJ, Affleck J, Patel N, Kellett GL. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 2007; 582: 379-92.
54. Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calciumsensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 2005; 289: G664-G669.
55. Bronner F. Recent developments in intestinal calcium absorption. Nutr Rev 2009; 67: 109-13.
56. Barley NF, Howard A, O'Callaghan D, Legon S, Walters JR. Epithelial calcium transporter expression in human duodenum. Am J Physiol Gastrointest Liver Physiol 2001; 280: G285-G290.
57. Balesaria S, Sangha S, Walters JR. Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol 2009; 297: G1193-G1197.
58. Akiba Y, Kaunitz JD. Luminal chemosensing and upper gastrointestinal mucosal defenses. Am J Clin Nutr 2009; 90: 826S-831S.
59. van Boxel OS, Ter Linde JJ, Siersema PD, Smout AJ. Role of chemical stimulation of the duodenum in dyspeptic symptom generation. Am J Gastroenterol 2010; 105: 803-11.
60. Tanimura T, Adachi K, Furuta K, et al. Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper gastrointestinal symptoms. J Gastroenterol Hepatol 2011; 26: 98-103.
61. Ugleholdt R, Zhu X, Deacon CF, et al. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology 2004; 145: 1349-55.
62. Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol 2011; 300: G795-G802.
63. Kindel TL, Yoder SM, Seeley RJ, D'Alessio DA, Tso P. Duodenaljejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg 2009; 13: 1762-72.
64. Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med 2012; 366: 1567-76.
65. Curet-Scott MJ, Meller JL, Shermeta DW. Transduodenal feedings: a superior route of enteral nutrition. J Pediatr Surg 1987; 22: 516-8.