메뉴 건너뛰기




Volumn 138, Issue 2-3, 2007, Pages 126-132

Metabolism of glucagon-like peptide-2 in pigs: Role of dipeptidyl peptidase IV

Author keywords

DPP IV; GLP 2; MCR; Valine pyrrolidide

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; GLUCAGON LIKE PEPTIDE 2; GLUCAGON LIKE PEPTIDE 2 [3-33]; UNCLASSIFIED DRUG; VALINE PYRROLIDIDE;

EID: 33846032686     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2006.08.012     Document Type: Article
Times cited : (25)

References (31)
  • 1
    • 0037198482 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats
    • Hartmann B., Thulesen J., Hare K.J., Kissow H., Orskov C., Poulsen S.S., and Holst J.J. Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats. Regul Pept 105 (2002) 173-179
    • (2002) Regul Pept , vol.105 , pp. 173-179
    • Hartmann, B.1    Thulesen, J.2    Hare, K.J.3    Kissow, H.4    Orskov, C.5    Poulsen, S.S.6    Holst, J.J.7
  • 2
    • 0029795016 scopus 로고    scopus 로고
    • Induction of intestinal epithelial proliferation by glucagon-like peptide 2
    • Drucker D.J., Erlich P., Asa S.L., and Brubaker P.L. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A 93 (1996) 7911-7916
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7911-7916
    • Drucker, D.J.1    Erlich, P.2    Asa, S.L.3    Brubaker, P.L.4
  • 4
    • 0242409214 scopus 로고    scopus 로고
    • Clinical significance of GLP-2 in short-bowel syndrome
    • Jeppesen P.B. Clinical significance of GLP-2 in short-bowel syndrome. J Nutr 133 (2003) 3721-3724
    • (2003) J Nutr , vol.133 , pp. 3721-3724
    • Jeppesen, P.B.1
  • 5
    • 0030901415 scopus 로고    scopus 로고
    • Enteroglucagon
    • Holst J.J. Enteroglucagon. Annu Rev Physiol 59 (1997) 257-271
    • (1997) Annu Rev Physiol , vol.59 , pp. 257-271
    • Holst, J.J.1
  • 6
    • 0036869408 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
    • Holst J.J. Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 18 (2002) 430-441
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 430-441
    • Holst, J.J.1
  • 7
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • Deacon C.F., Pridal L., Klarskov L., Olesen M., and Holst J.J. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 271 (1996) E458-E464
    • (1996) Am J Physiol , vol.271
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 8
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • Deacon C.F., Hughes T.E., and Holst J.J. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes 47 (1998) 764-769
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 9
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R., Gallwitz B., and Schmidt W.E. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 214 (1993) 829-835
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 11
    • 0033680541 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice
    • Hartmann B., Thulesen J., Kissow H., Thulesen S., Orskov C., Ropke C., Poulsen S.S., and Holst J.J. Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice. Endocrinology 141 (2000) 4013-4020
    • (2000) Endocrinology , vol.141 , pp. 4013-4020
    • Hartmann, B.1    Thulesen, J.2    Kissow, H.3    Thulesen, S.4    Orskov, C.5    Ropke, C.6    Poulsen, S.S.7    Holst, J.J.8
  • 12
    • 0030782159 scopus 로고    scopus 로고
    • Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2
    • Brubaker P.L., Crivici A., Izzo A., Ehrlich P., Tsai C.H., and Drucker D.J. Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology 138 (1997) 4837-4843
    • (1997) Endocrinology , vol.138 , pp. 4837-4843
    • Brubaker, P.L.1    Crivici, A.2    Izzo, A.3    Ehrlich, P.4    Tsai, C.H.5    Drucker, D.J.6
  • 13
    • 0033028489 scopus 로고    scopus 로고
    • Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans
    • Xiao Q., Boushey R.P., Drucker D.J., and Brubaker P.L. Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans. Gastroenterology 117 (1999) 99-105
    • (1999) Gastroenterology , vol.117 , pp. 99-105
    • Xiao, Q.1    Boushey, R.P.2    Drucker, D.J.3    Brubaker, P.L.4
  • 18
    • 0033970249 scopus 로고    scopus 로고
    • Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats
    • Tavares W., Drucker D.J., and Brubaker P.L. Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats. Am J Physiol Endocrinol Metab 278 (2000) E134-E139
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Tavares, W.1    Drucker, D.J.2    Brubaker, P.L.3
  • 19
    • 0035403058 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
    • Deacon C.F., Danielsen P., Klarskov L., Olesen M., and Holst J.J. Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 50 (2001) 1588-1597
    • (2001) Diabetes , vol.50 , pp. 1588-1597
    • Deacon, C.F.1    Danielsen, P.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 21
    • 0031693473 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs
    • Wojdemann M., Wettergren A., Hartmann B., and Holst J.J. Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs. Scand J Gastroenterol 33 (1998) 828-832
    • (1998) Scand J Gastroenterol , vol.33 , pp. 828-832
    • Wojdemann, M.1    Wettergren, A.2    Hartmann, B.3    Holst, J.J.4
  • 22
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85 (1999) 9-24
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 23
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon C.F., Johnsen A.H., and Holst J.J. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80 (1995) 952-957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 24
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon C.F., Nauck M.A., Toft-Nielsen M., Pridal L., Willms B., and Holst J.J. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44 (1995) 1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 25
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T., Agerso H., Krarup T., and Holst J.J. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88 (2003) 220-224
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 26
    • 0037114464 scopus 로고    scopus 로고
    • A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro
    • Lambeir A.M., Proost P., Scharpe S., and De M.I. A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro. Biochem Pharmacol 64 (2002) 1753-1756
    • (2002) Biochem Pharmacol , vol.64 , pp. 1753-1756
    • Lambeir, A.M.1    Proost, P.2    Scharpe, S.3    De, M.I.4
  • 27
    • 0018352691 scopus 로고
    • Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase). II. Blood vessels
    • Lojda Z. Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase). II. Blood vessels. Histochemistry 59 (1979) 153-166
    • (1979) Histochemistry , vol.59 , pp. 153-166
    • Lojda, Z.1
  • 28
    • 33644819643 scopus 로고    scopus 로고
    • Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs
    • Simonsen L., Holst J.J., and Deacon C.F. Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. Diabetologia 49 (2006) 706-712
    • (2006) Diabetologia , vol.49 , pp. 706-712
    • Simonsen, L.1    Holst, J.J.2    Deacon, C.F.3
  • 29
    • 0842346386 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum
    • Hansen L., Hartmann B., Mineo H., and Holst J.J. Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum. Regul Pept 118 (2004) 11-18
    • (2004) Regul Pept , vol.118 , pp. 11-18
    • Hansen, L.1    Hartmann, B.2    Mineo, H.3    Holst, J.J.4
  • 30
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • Toft-Nielsen M.B., Madsbad S., and Holst J.J. Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 22 (1999) 1137-1143
    • (1999) Diabetes Care , vol.22 , pp. 1137-1143
    • Toft-Nielsen, M.B.1    Madsbad, S.2    Holst, J.J.3
  • 31
    • 0036188070 scopus 로고    scopus 로고
    • Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
    • Deacon C.F., Wamberg S., Bie P., Hughes T.E., and Holst J.J. Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs. J Endocrinol 172 (2002) 355-362
    • (2002) J Endocrinol , vol.172 , pp. 355-362
    • Deacon, C.F.1    Wamberg, S.2    Bie, P.3    Hughes, T.E.4    Holst, J.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.