-
1
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, Morimoto RI (2009) Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A 106: 14914-14919.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
2
-
-
77956795163
-
Widespread protein aggregation as an inherent part of aging in C. elegans
-
David DC, Ollikainen N, Trinidad JC, Cary MP, Burlingame AL, et al. (2010) Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol 8: e1000450.
-
(2010)
PLoS Biol
, vol.8
-
-
David, D.C.1
Ollikainen, N.2
Trinidad, J.C.3
Cary, M.P.4
Burlingame, A.L.5
-
4
-
-
79961023008
-
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
-
Liu G, Rogers J, Murphy CT, Rongo C (2011) EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J 30: 2990-3003.
-
(2011)
EMBO J
, vol.30
, pp. 2990-3003
-
-
Liu, G.1
Rogers, J.2
Murphy, C.T.3
Rongo, C.4
-
5
-
-
0033609291
-
Signals from the reproductive system regulate the lifespan of C. elegans
-
DOI 10.1038/20694
-
Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399: 362-366. (Pubitemid 29318134)
-
(1999)
Nature
, vol.399
, Issue.6734
, pp. 362-366
-
-
Hsin, H.1
Kenyon, C.2
-
6
-
-
77956821042
-
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling
-
Yamawaki TM, Berman JR, Suchanek-Kavipurapu M, McCormick M, Gaglia MM, et al. (2010) The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol 8.
-
(2010)
PLoS Biol
, vol.8
-
-
Yamawaki, T.M.1
Berman, J.R.2
Suchanek-Kavipurapu, M.3
McCormick, M.4
Gaglia, M.M.5
-
7
-
-
34247563364
-
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
-
DOI 10.1073/pnas.0700847104
-
Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, et al. (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A 104: 5014-5019. (Pubitemid 47186168)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.12
, pp. 5014-5019
-
-
Gerisch, B.1
Rottiers, V.2
Li, D.3
Motola, D.L.4
Cummins, C.L.5
Lehrach, H.6
Mangelsdorf, D.J.7
Antebi, A.8
-
8
-
-
84858341125
-
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals
-
McCormick M, Chen K, Ramaswamy P, Kenyon C (2012) New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell 11: 192-202.
-
(2012)
Aging Cell
, vol.11
, pp. 192-202
-
-
McCormick, M.1
Chen, K.2
Ramaswamy, P.3
Kenyon, C.4
-
9
-
-
84859991779
-
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity
-
Wollam J, Magner DB, Magomedova L, Rass E, Shen Y, et al. (2012) A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol 10: e1001305.
-
(2012)
PLoS Biol
, vol.10
-
-
Wollam, J.1
Magner, D.B.2
Magomedova, L.3
Rass, E.4
Shen, Y.5
-
10
-
-
33644772542
-
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
-
DOI 10.1016/j.cell.2006.01.039, PII S0092867406002376
-
Berman JR, Kenyon C (2006) Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124: 1055-1068. (Pubitemid 43344243)
-
(2006)
Cell
, vol.124
, Issue.5
, pp. 1055-1068
-
-
Berman, J.R.1
Kenyon, C.2
-
11
-
-
70349668985
-
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans
-
Ghazi A, Henis-Korenblit S, Kenyon C (2009) A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet 5: e1000639.
-
(2009)
PLoS Genet
, vol.5
-
-
Ghazi, A.1
Henis-Korenblit, S.2
Kenyon, C.3
-
12
-
-
55849101681
-
Fat metabolism links germline stem cells and longevity in C. elegans
-
Wang MC, O'Rourke EJ, Ruvkun G (2008) Fat metabolism links germline stem cells and longevity in C. elegans. Science 322: 957-960.
-
(2008)
Science
, vol.322
, pp. 957-960
-
-
Wang, M.C.1
O'Rourke, E.J.2
Ruvkun, G.3
-
13
-
-
79953683136
-
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans
-
Goudeau J, Bellemin S, Toselli-Mollereau E, Shamalnasab M, Chen Y, et al. (2011) Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol 9: e1000599.
-
(2011)
PLoS Biol
, vol.9
-
-
Goudeau, J.1
Bellemin, S.2
Toselli-Mollereau, E.3
Shamalnasab, M.4
Chen, Y.5
-
14
-
-
84883767608
-
Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood
-
Shemesh N, Shai N, Ben-Zvi A (2013) Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood. Aging Cell 12: 814-822.
-
(2013)
Aging Cell
, vol.12
, pp. 814-822
-
-
Shemesh, N.1
Shai, N.2
Ben-Zvi, A.3
-
15
-
-
33645472504
-
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
-
Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1: 119-128.
-
(2005)
PLoS Genet
, vol.1
, pp. 119-128
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
16
-
-
80053312481
-
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
-
Lapierre LR, Gelino S, Melendez A, Hansen M (2011) Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol 21: 1507-1514.
-
(2011)
Curr Biol
, vol.21
, pp. 1507-1514
-
-
Lapierre, L.R.1
Gelino, S.2
Melendez, A.3
Hansen, M.4
-
17
-
-
84879029746
-
Regulation of longevity by the reproductive system
-
Antebi A (2012) Regulation of longevity by the reproductive system. Exp Gerontol 48(7): 596-602.
-
(2012)
Exp Gerontol
, vol.48
, Issue.7
, pp. 596-602
-
-
Antebi, A.1
-
18
-
-
84866182143
-
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
-
Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, et al. (2012) RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 489: 263-268.
-
(2012)
Nature
, vol.489
, pp. 263-268
-
-
Vilchez, D.1
Morantte, I.2
Liu, Z.3
Douglas, P.M.4
Merkwirth, C.5
-
19
-
-
0037127026
-
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
-
DOI 10.1126/science.1065768
-
Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C (2002) Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295: 502-505. (Pubitemid 34101641)
-
(2002)
Science
, vol.295
, Issue.5554
, pp. 502-505
-
-
Arantes-Oliveira, N.1
Apfeld, J.2
Dillin, A.3
Kenyon, C.4
-
20
-
-
0015366448
-
5-Fluoro-29-deoxyuridylate: Covalent complex with thymidylate synthetase
-
Santi DV, McHenry CS (1972) 5-Fluoro-29-deoxyuridylate: covalent complex with thymidylate synthetase. Proc Natl Acad Sci U S A 69: 1855-1857.
-
(1972)
Proc Natl Acad Sci U S A
, vol.69
, pp. 1855-1857
-
-
Santi, D.V.1
McHenry, C.S.2
-
21
-
-
0018346542
-
Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine
-
Mitchell DH, Stiles JW, Santelli J, Sanadi DR (1979) Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine. J Gerontol 34: 28-36. (Pubitemid 9101693)
-
(1979)
Journals of Gerontology
, vol.34
, Issue.1
, pp. 28-36
-
-
Mitchell, D.H.1
Stiles, J.W.2
Santelli, J.3
Rao, S.D.4
-
22
-
-
33947417262
-
Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans
-
DOI 10.1111/j.1474-9726.2007.00273.x
-
Golden TR, Beckman KB, Lee AH, Dudek N, Hubbard A, et al. (2007) Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging Cell 6: 179-188. (Pubitemid 46455062)
-
(2007)
Aging Cell
, vol.6
, Issue.2
, pp. 179-188
-
-
Golden, T.R.1
Beckman, K.B.2
Lee, A.H.J.3
Dudek, N.4
Hubbard, A.5
Samper, E.6
Melov, S.7
-
23
-
-
0018080011
-
Sterilization and growth inhibition of Caenorhabditis elegans by 5-fluorodeoxyuridine
-
Hosono R (1978) Sterilization and growth inhibition of Caenorhabditis elegans by 5-fluorodeoxyuridine. Exp Gerontol 13: 369-374.
-
(1978)
Exp Gerontol
, vol.13
, pp. 369-374
-
-
Hosono, R.1
-
24
-
-
0018894725
-
A simple method for maintaining large, aging populations of Caenorhabditis elegans
-
DOI 10.1016/0047-6374(80)90090-1
-
Gandhi S, Santelli J, Mitchell DH, Stiles JW, Sanadi DR (1980) A simple method for maintaining large, aging populations of Caenorhabditis elegans. Mech Ageing Dev 12: 137-150. (Pubitemid 10113067)
-
(1980)
Mechanisms of Ageing and Development
, vol.12
, Issue.2
, pp. 137-150
-
-
Gandhi, S.1
Santelli, J.2
Mitchell, D.H.3
-
25
-
-
80053386830
-
FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1
-
Van Raamsdonk JM, Hekimi S (2011) FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. Mech Ageing Dev 132: 519-521.
-
(2011)
Mech Ageing Dev
, vol.132
, pp. 519-521
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
26
-
-
77953082493
-
The use of FUdR can cause prolonged longevity in mutant nematodes
-
Aitlhadj L, Sturzenbaum SR (2010) The use of FUdR can cause prolonged longevity in mutant nematodes. Mech Ageing Dev 131: 364-365.
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 364-365
-
-
Aitlhadj, L.1
Sturzenbaum, S.R.2
-
27
-
-
84856231279
-
Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans
-
Davies SK, Leroi AM, Bundy JG (2012) Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans. Mech Ageing Dev 133: 46-49.
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 46-49
-
-
Davies, S.K.1
Leroi, A.M.2
Bundy, J.G.3
-
28
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
-
Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, et al. (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112. (Pubitemid 34831435)
-
(2002)
Genetics
, vol.161
, Issue.3
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.-L.2
Fraser, A.G.3
Kamath, R.S.4
Abringet, J.5
Kenyon, C.6
-
29
-
-
79954571967
-
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
-
Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ (2011) Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 472: 226-229.
-
(2011)
Nature
, vol.472
, pp. 226-229
-
-
Alavez, S.1
Vantipalli, M.C.2
Zucker, D.J.3
Klang, I.M.4
Lithgow, G.J.5
-
30
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
DOI 10.1126/science.1124514
-
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI (2006) Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311: 1471-1474. (Pubitemid 43376703)
-
(2006)
Science
, vol.311
, Issue.5766
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
31
-
-
84878873702
-
Regulation of organismal proteostasis by transcellular chaperone signaling
-
van Oosten-Hawle P, Porter RS, Morimoto RI (2013) Regulation of organismal proteostasis by transcellular chaperone signaling. Cell 153: 1366-1378.
-
(2013)
Cell
, vol.153
, pp. 1366-1378
-
-
Van Oosten-Hawle, P.1
Porter, R.S.2
Morimoto, R.I.3
-
32
-
-
0016358187
-
Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegans
-
Epstein HF, Thomson JN (1974) Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegans. Nature 250: 579-580.
-
(1974)
Nature
, vol.250
, pp. 579-580
-
-
Epstein, H.F.1
Thomson, J.N.2
-
33
-
-
34250020179
-
Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients
-
DOI 10.1523/JNEUROSCI.1032-07.2007
-
Clark DA, Gabel CV, Gabel H, Samuel AD (2007) Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients. J Neurosci 27: 6083-6090. (Pubitemid 46890022)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.23
, pp. 6083-6090
-
-
Clark, D.A.1
Gabel, C.V.2
Gabel, H.3
Samuel, A.D.T.4
-
34
-
-
34548645020
-
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination
-
DOI 10.1111/j.1474-9726.2007.00327.x
-
Crawford D, Libina N, Kenyon C (2007) Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell 6: 715-721. (Pubitemid 47400053)
-
(2007)
Aging Cell
, vol.6
, Issue.5
, pp. 715-721
-
-
Crawford, D.1
Libina, N.2
Kenyon, C.3
-
35
-
-
84884416517
-
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance
-
Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, et al. (2013) DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501(7467): 416-420.
-
(2013)
Nature
, vol.501
, Issue.7467
, pp. 416-420
-
-
Ermolaeva, M.A.1
Segref, A.2
Dakhovnik, A.3
Ou, H.L.4
Schneider, J.I.5
-
36
-
-
33744828285
-
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans
-
DOI 10.1126/science.1124981
-
Olsen A, Vantipalli MC, Lithgow GJ (2006) Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science 312: 1381-1385. (Pubitemid 43839550)
-
(2006)
Science
, vol.312
, Issue.5778
, pp. 1381-1385
-
-
Olsen, A.1
Vantipalli, M.C.2
Lithgow, G.J.3
-
37
-
-
80052137410
-
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins
-
Prahlad V, Morimoto RI (2011) Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc Natl Acad Sci U S A 108: 14204-14209.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14204-14209
-
-
Prahlad, V.1
Morimoto, R.I.2
-
38
-
-
84856326577
-
Regulation of cellular protein quality control networks in a multicellular organism
-
Bar-Lavan Y, Kosolapov L, Frumkin A, Ben-Zvi A (2012) Regulation of cellular protein quality control networks in a multicellular organism. FEBS J 279: 526-531.
-
(2012)
FEBS J
, vol.279
, pp. 526-531
-
-
Bar-Lavan, Y.1
Kosolapov, L.2
Frumkin, A.3
Ben-Zvi, A.4
-
39
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux J, Wolff S, Dillin A (2011) The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144: 79-91.
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
40
-
-
77953247518
-
Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
-
Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, et al. (2010) Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell 9: 126-134.
-
(2010)
Aging Cell
, vol.9
, pp. 126-134
-
-
Cohen, E.1
Du, D.2
Joyce, D.3
Kapernick, E.A.4
Volovik, Y.5
-
41
-
-
0023655202
-
Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
-
Yoshioka A, Tanaka S, Hiraoka O, Koyama Y, Hirota Y, et al. (1987) Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem 262: 8235-8241.
-
(1987)
J Biol Chem
, vol.262
, pp. 8235-8241
-
-
Yoshioka, A.1
Tanaka, S.2
Hiraoka, O.3
Koyama, Y.4
Hirota, Y.5
-
42
-
-
76749108400
-
Cell-nonautonomous regulation of C. elegans germ cell death by kri-1
-
Ito S, Greiss S, Gartner A, Derry WB (2010) Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Curr Biol 20: 333-338.
-
(2010)
Curr Biol
, vol.20
, pp. 333-338
-
-
Ito, S.1
Greiss, S.2
Gartner, A.3
Derry, W.B.4
-
43
-
-
84884685638
-
A shift to organismal stress resistance in programmed cell death mutants
-
Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, et al. (2013) A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet 9: e1003714.
-
(2013)
PLoS Genet
, vol.9
-
-
Judy, M.E.1
Nakamura, A.2
Huang, A.3
Grant, H.4
McCurdy, H.5
-
44
-
-
84870993730
-
Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans
-
Vermezovic J, Stergiou L, Hengartner MO, d'Adda di Fagagna F (2012) Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans. Cell Death Differ 19: 1847-1855.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1847-1855
-
-
Vermezovic, J.1
Stergiou, L.2
Hengartner, M.O.3
D'Adda Di Fagagna, F.4
-
45
-
-
79956311279
-
The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans
-
Haldimann P, Muriset M, Vigh L, Goloubinoff P (2011) The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286: 18784-18794.
-
(2011)
J Biol Chem
, vol.286
, pp. 18784-18794
-
-
Haldimann, P.1
Muriset, M.2
Vigh, L.3
Goloubinoff, P.4
-
46
-
-
84874271499
-
omega-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
-
O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G (2013) omega-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev 27: 429-440.
-
(2013)
Genes Dev
, vol.27
, pp. 429-440
-
-
O'Rourke, E.J.1
Kuballa, P.2
Xavier, R.3
Ruvkun, G.4
-
47
-
-
0032706619
-
Direct observation of stress response in Caenorhabditis elegans using a reporter transgene
-
Link CD, Cypser JR, Johnson CJ, Johnson TE (1999) Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell Stress Chaperones 4: 235-242.
-
(1999)
Cell Stress Chaperones
, vol.4
, pp. 235-242
-
-
Link, C.D.1
Cypser, J.R.2
Johnson, C.J.3
Johnson, T.E.4
-
48
-
-
0020825822
-
Differential localization of two myosins within nematode thick filaments
-
Miller DM 3rd, Ortiz I, Berliner GC, Epstein HF (1983) Differential localization of two myosins within nematode thick filaments. Cell 34: 477-490.
-
(1983)
Cell
, vol.34
, pp. 477-490
-
-
Miller III, D.M.1
Ortiz, I.2
Berliner, G.C.3
Epstein, H.F.4
|