메뉴 건너뛰기




Volumn 501, Issue 7467, 2013, Pages 416-420

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; UBIQUITIN;

EID: 84884416517     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12452     Document Type: Article
Times cited : (179)

References (34)
  • 1
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: From initiation to recovery or adaptation
    • Bartek, J. & Lukas, J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opin. Cell Biol. 19, 238-245 (2007)
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 2
    • 0033679966 scopus 로고    scopus 로고
    • A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C
    • Gartner, A., Milstein, S., Ahmed, S., Hodgkin, J. & Hengartner, M. O. A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans. Mol. Cell 5, 435-443 (2000)
    • (2000) Elegans. Mol. Cell , vol.5 , pp. 435-443
    • Gartner, A.1    Milstein, S.2    Ahmed, S.3    Hodgkin, J.4    Hengartner, M.O.5
  • 3
    • 0023780523 scopus 로고
    • Radiation effects on life span in Caenorhabditis elegans
    • Johnson, T. E. & Hartman, P. S. Radiation effects on life span in Caenorhabditis elegans. J. Gerontol. 43, B137-B141 (1988)
    • (1988) J. Gerontol. , vol.43
    • Johnson, T.E.1    Hartman, P.S.2
  • 4
    • 77953193047 scopus 로고    scopus 로고
    • Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development
    • Lans, H. et al. Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development. PLoS Genet. 6, e1000941 (2010)
    • (2010) PLoS Genet. , vol.6
    • Lans, H.1
  • 5
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu, A. L., Murphy, C. T. & Kenyon, C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145 (2003)
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 6
    • 29244440434 scopus 로고    scopus 로고
    • Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans
    • Garcia-Muse, T. & Boulton, S. J. Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J. 24, 4345-4355 (2005)
    • (2005) EMBO J. , vol.24 , pp. 4345-4355
    • Garcia-Muse, T.1    Boulton, S.J.2
  • 7
    • 66149140649 scopus 로고    scopus 로고
    • Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development
    • Moser, S. C. et al. Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development. PLoS Genet. 5, e1000451 (2009)
    • (2009) PLoS Genet. , vol.5
    • Moser, S.C.1
  • 8
    • 0041695475 scopus 로고    scopus 로고
    • Synaptonemal complex assembly in C elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination
    • Colaiácovo, M. P. et al. Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination. Dev. Cell 5, 463-474 (2003)
    • (2003) Dev. Cell , vol.5 , pp. 463-474
    • Colaiácovo, M.P.1
  • 9
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin, K., Hsin, H., Libina, N. & Kenyon, C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nature Genet. 28, 139-145 (2001)
    • (2001) Nature Genet. , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 10
    • 77956821042 scopus 로고    scopus 로고
    • The somatic reproductive tissues of C elegans promote longevity through steroid hormone signaling
    • Yamawaki, T. M. et al. The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol. 8, e1000468 (2010)
    • (2010) PLoS Biol. , vol.8
    • Yamawaki, T.M.1
  • 11
    • 80052332372 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling
    • Rutkowski, R. et al. Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling. PLoS Genet. 7, e1002238 (2011)
    • (2011) PLoS Genet. , vol.7
    • Rutkowski, R.1
  • 12
    • 79958181684 scopus 로고    scopus 로고
    • Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage
    • Karpac, J., Younger, A. & Jasper, H. Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 20, 841-854 (2011)
    • (2011) Dev. Cell , vol.20 , pp. 841-854
    • Karpac, J.1    Younger, A.2    Jasper, H.3
  • 14
    • 48549085585 scopus 로고    scopus 로고
    • Transcriptional profiling in C elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family
    • Greiss, S., Schumacher, B., Grandien, K., Rothblatt, J. & Gartner, A. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics 9, 334 (2008)
    • (2008) BMC Genomics , vol.9 , pp. 334
    • Greiss, S.1    Schumacher, B.2    Grandien, K.3    Rothblatt, J.4    Gartner, A.5
  • 15
    • 45849133385 scopus 로고    scopus 로고
    • Transcriptional responses to pathogens in Caenorhabditis elegans
    • Shivers, R. P., Youngman, M. J.&Kim, D. H. Transcriptional responses to pathogens in Caenorhabditis elegans. Curr. Opin. Microbiol. 11, 251-256 (2008)
    • (2008) Curr. Opin. Microbiol. , vol.11 , pp. 251-256
    • Shivers, R.P.1    Youngman, M.J.2    Kim, D.H.3
  • 16
    • 3342973834 scopus 로고    scopus 로고
    • The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C
    • Nicholas, H. R. & Hodgkin, J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr. Biol. 14, 1256-1261 (2004)
    • (2004) Elegans. Curr. Biol. , vol.14 , pp. 1256-1261
    • Nicholas, H.R.1    Hodgkin, J.2
  • 17
    • 33746727711 scopus 로고    scopus 로고
    • Putative pathogen recognitionmolecules, and antimicrobial genes are induced by infection of C elegans with M nematophilum
    • O'Rourke, D., Baban, D., Demidova, M., Mott, R. & Hodgkin, J. Genomic clusters, putative pathogen recognitionmolecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. GenomeRes. 16, 1005-1016 (2006)
    • (2006) GenomeRes. , vol.16 , pp. 1005-1016
    • O'Rourke, D.1    Baban, D.2    Demidova, M.3    Mott, R.4    Clusters Genomic, H.J.5
  • 18
    • 33751382748 scopus 로고    scopus 로고
    • P38 MAPK regulates expression of immune response genes and contributes to longevity in C elegans
    • Troemel, E. R. et al. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2, e183 (2006)
    • (2006) PLoS Genet. , vol.2
    • Troemel, E.R.1
  • 19
    • 72949096858 scopus 로고    scopus 로고
    • Evolution of host innate defence: Insights from Caenorhabditis elegans and primitive invertebrates
    • Irazoqui, J. E., Urbach, J. M. & Ausubel, F. M. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nature Rev. Immunol. 10, 47-58 (2010)
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 47-58
    • Irazoqui, J.E.1    Urbach, J.M.2    Ausubel, F.M.3
  • 20
    • 33646171878 scopus 로고    scopus 로고
    • Concerted evolution of two novel protein families in Caenorhabditis species
    • Thomas, J. H. Concerted evolution of two novel protein families in Caenorhabditis species. Genetics 172, 2269-2281 (2006)
    • (2006) Genetics , vol.172 , pp. 2269-2281
    • Thomas, J.H.1
  • 21
    • 77952376722 scopus 로고    scopus 로고
    • Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    • Shivers, R. P. et al. Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 6, e1000892 (2010)
    • (2010) PLoS Genet. , vol.6
    • Shivers, R.P.1
  • 22
    • 72649094825 scopus 로고    scopus 로고
    • Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C elegans
    • Shivers, R. P., Kooistra, T., Chu, S. W., Pagano, D. J. & Kim, D. H. Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans. Cell Host Microbe 6, 321-330 (2009)
    • (2009) Cell Host Microbe , vol.6 , pp. 321-330
    • Shivers, R.P.1    Kooistra, T.2    Chu, S.W.3    Pagano, D.J.4    Kim, D.H.5
  • 23
    • 79955366725 scopus 로고    scopus 로고
    • A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans
    • Segref, A., Torres, S. & Hoppe, T. A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans. Genetics 187, 1235-1240 (2011)
    • (2011) Genetics , vol.187 , pp. 1235-1240
    • Segref, A.1    Torres, S.2    Hoppe, T.3
  • 24
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • Muruve, D. A. et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452, 103-107 (2008)
    • (2008) Nature , vol.452 , pp. 103-107
    • Muruve, D.A.1
  • 25
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser, S., Orsulic, S., Brown, E. J. & Raulet, D. H. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436, 1186-1190 (2005)
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 26
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • erratum 11, 973-979 2009
    • Rodier, F. et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nature Cell Biol. 11, 973-979 (2009); erratum 11, 973-979 (2009)
    • (2009) Nature Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1
  • 27
    • 84885861342 scopus 로고    scopus 로고
    • Wound healing of intestinal epithelial cells
    • Iizuka, M. & Konno, S. Wound healing of intestinal epithelial cells. World J. Gastroenterol. 11, 1272 (2009)
    • (2009) World J. Gastroenterol. , vol.11 , pp. 1272
    • Iizuka, M.1    Konno, S.2
  • 28
    • 78650409670 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense skin injury and promote wound healing through type i interferons
    • Gregorio, J. et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J. Exp. Med. 207, 2921-2930 (2010)
    • (2010) J. Exp. Med. , vol.207 , pp. 2921-2930
    • Gregorio, J.1
  • 29
    • 77649135472 scopus 로고    scopus 로고
    • An essential role for XBP-1 in host protectionagainst immune activationin C elegans
    • Richardson, C. E., Kooistra, T. & Kim, D. H. An essential role for XBP-1 in host protectionagainst immune activationinC. elegans.Nature 463,1092-1095(2010
    • (2010) Nature , vol.463 , pp. 1092-1095
    • Richardson, C.E.1    Kooistra, T.2    Kim, D.H.3
  • 30
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974)
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 31
    • 0037178731 scopus 로고    scopus 로고
    • A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    • Kim, D. H. et al. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297, 623-626 (2002)
    • (2002) Science , vol.297 , pp. 623-626
    • Kim, D.H.1
  • 32
    • 80053345905 scopus 로고    scopus 로고
    • SignalP 4.0: Discriminating signal peptides fromtransmembrane regions
    • Petersen, T. N., Brunak, S., von Heijne, G. & Nielsen, H. SignalP 4.0: discriminating signal peptides fromtransmembrane regions. NatureMethods 8, 785-786 (2011)
    • (2011) NatureMethods , vol.8 , pp. 785-786
    • Petersen, T.N.1    Brunak, S.2    Von Heijne, G.3    Nielsen, H.4
  • 33
    • 34547560275 scopus 로고    scopus 로고
    • WoLF PSORT: Protein localization predictor
    • Horton, P. et al. WoLF PSORT: protein localization predictor. Nucleic Acids Res. 35, W585-W587 (2007)
    • (2007) Nucleic Acids Res. , vol.35
    • Horton, P.1
  • 34
    • 0030898710 scopus 로고    scopus 로고
    • Proteasome inhibition leads to a heatshock response, induction of endoplasmic reticulum chaperones, and thermotolerance
    • Bush, K. T., Goldberg, A. L. & Nigam, S. K. Proteasome inhibition leads to a heatshock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J. Biol. Chem. 272, 9086-9092 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 9086-9092
    • Bush, K.T.1    Goldberg, A.L.2    Nigam, S.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.