Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK

Cancer Letters

Volumn 351, Issue 1, 2014, Pages 41-49

  Kim, Ha Na ^a   Kim, Do Hee ^a   Kim, Eun Hee ^a,f   Lee, Mee Hyun ^a,g   Kundu, Joydeb Kumar ^b   Na, Hye Kyung ^c   Cha, Young Nam ^d   Surh, Young Joon ^a,e  

^a Seoul National University   (South Korea)

^b Keimyung University   (South Korea)

^c Sungshin Women's University   (South Korea)

^d Inha University School of Medicine   (South Korea)

^e Seoul National University   (South Korea)

^f CHA University   (South Korea)

^g The Catholic University of Korea   (South Korea)

Author keywords

Chemoprevention; Cyclooxygenase 2; IkappaB kinase; NF B activating kinase; Sulforaphane

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEAR FACTOR KAPPA B ACTIVATING KINASE; PHORBOL ESTER; PHOSPHOTRANSFERASE; SULFORAPHANE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST EPITHELIUM; CANCER PREVENTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CHEMOPREVENTION; CYCLOOXYGENASE-2; IKAPPAB KINASE; NF-ΚB-ACTIVATING KINASE; SULFORAPHANE;

ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; CELL LINE; CYCLOOXYGENASE 2; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION; HUMANS; I-KAPPA B KINASE; ISOTHIOCYANATES; MAMMARY GLANDS, HUMAN; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; TETRADECANOYLPHORBOL ACETATE;

EID: 84903698145     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.03.037     Document Type: Article

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