Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 3 46-3, 2002, Pages

  Perseghin, Gianluca ^a,c   Scifo, Paola ^a   Danna, Massimo ^a   Battezzati, Alberto ^a   Benedini, Stefano ^a   Meneghini, Elena ^b   Maschio, Alessandro Del ^a   Luzi, Livio ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Amino Acids and Stable Isotopes Laboratory   (Italy)

Author keywords

Insulin resistance; Intramyocellular lipid content; Leptin; Lipid oxidation; Nuclear magnetic resonance spectroscopy; Tumor necrosis factor

Indexed keywords

LIPID;

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY EXPENDITURE; FEMALE; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; LIPID STORAGE; MALE; OBESITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WEIGHT GAIN;

EID: 0036710284     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00127.2002     Document Type: Article

References (59)

1. Baecke JAH, Burema J, and Frijters JER. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 36: 936-942, 1982.
2. Battezzati A, Simonson DC, Luzi L, and Matthews DE. Glucagon increases glutamine uptake without affecting glutamine release in humans. Metabolism 47: 713-723, 1998.
3. Bergman RN, Finegood DT, and Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev 6: 45-86, 1985.
4. Binnert C, Koistinen HA, Martin G, Andreelli F, Ebeling P, Koivisto VA, Laville M, Auwerx J, and Vidal H. Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans. Am J Physiol Endocrinol Metab 279: E1072-E1079, 2000.
5. 13C] palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects. Diabetes 51: 784-789, 2002.
6. Blaak EE, Wagenmakers AJM, Glatz JFC, Wolffenbuttel BHR, Kemerink GJ, Langerberg CJM, Heidendal GAK, and Saris WHM. Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. Am J Physiol Endocrinol Metab 279: E146-E154, 2000.
7. Blaak EE, Wolffenbuttel BH, Saris WH, Pelsers MM, and Wagenmakers AJ. Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects. J Clin Endocrinol Metab 86: 1638-1644, 2001.
8. 1H-MR-spectroscopy. Magn Reson Med 37: 484-493, 1997.
9. Coldberg SR, Simoneau JA, Thaete FL, and Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95: 1846-1853, 1995.
10. DeFronzo RA, Tobin JD, and Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 6: 214-223, 1979.
11. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, and Shulman GI. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103: 253-259, 1999.
12. Dvorak RV, DeNino WF, Ades PA, and Poehlam ET. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes 48: 2210-2214, 1999.
13. Elia M. Organ and tissue contribution to metabolic rate. In: Energy Metabolism: Tissue Determinants and Cellular Corollaries, edited by Kinney JM and Tucker HN. New York: Raven, 1992, p. 61-79.
14. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55: 628-634, 1983.
15. Frias JP, Macaraeg GB, Ofrecio J, Yu JG, Olefsky JM, and Kruszynska YT. Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women. Diabetes 50: 1344-1350, 2001.
16. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, and Reitman ML. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105: 271-278, 2000.
17. Goodpaster BH, He J, Watkins S, and Kelley DE. Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86: 5755-5761, 2001.
18. Hawk PD. Kjeldhal method. In: Practical Physiological Chemistry (12th ed.). Toronto: Blakiston, 1947, p. 814-822.
19. Hevener AL, Wong JC, Janez A, and Olefsky J. Estrogen protects against free fatty acid-induced insulin resistance (Abstract A307). Diabetes 50, Suppl 2: 1227, 2001.
20. Hotamisligil GS, Arner P, Atkinson RL, and Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46: 451-455, 1997.
21. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, and Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 95: 2409-2415, 1995.
22. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, and Häring HU. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48: 1113-1119, 1999.
23. Kahn BB and Flier JS. Obesity and insulin resistance. J Clin Invest 106: 473-478, 2000.
24. Kelley DE, Goodpaster B, Wing RR, and Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. Am J Physiol Endocrinol Metab 277: E1130-E1141, 1999.
25. Kelley DE and Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance. A reexamination. Diabetes 49: 677-683, 2000.
26. Kim JK, Gavrilova O, Chen Y, Reitman ML, and Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 275: 8456-8460, 2000.
27. Kim JY, Hickner RC, Cortright RL, Dohm GL, and Houmard JA. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279: E1039-E1044, 2000.
28. 1H NMR spectroscopy study. Diabetologia 42: 113-116, 1999.
29. Ley CJ, Lees B, and Stevenson JC. Sex- and menopause-associated changes in body-fat distribution. Am J Clin Nutr 55: 950-954, 1992.
30. 2max. Am J Physiol Endocrinol Metab 279: E601- E607, 2000.
31. Luzi L, Dozio N, Battezzati A, Perseghin G, Sarugeri E, Terruzzi I, and Spotti D. Anomalous leucine metabolism in total lipoatrophic diabetes: a possible mechanism of muscle mass hypertrophy. Acta Diabetologica 29: 86-93, 1992.
32. McGarry JD. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770, 1992.
33. Montague CT and O'Rahilly S. The perils of portliness. Causes and consequences of visceral adiposity. Diabetes 49: 883-888, 2000.
34. Montague CT, Prins JB, Sanders L, Digby JE, and O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression. Implications for the control of regional fat distribution. Diabetes 46: 342-347, 1997.
35. Monti LD, Sandoli EP, Phan VC, Piatti PM, Costa S, Secchi A, and Pozza G. A sensitive and reliable method for assaying true human insulin without interaction with human proinsulin-like molecules. Acta Diabetol 32: 57-63, 1995.
36. Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, and Coleman RA. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363, 1997.
37. Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS, and Attie AD. The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci USA 97: 11371-11376, 2000.
38. Perseghin G, Ghosh S, Gerow K, and Shulman GI. Metabolic defects in lean nondiabetic offspring of NIDDM parents. A cross-sectional study. Diabetes 46: 1001-1009, 1997.
39. Perseghin G, Meneghini E, Scifo P, Pagliato E, Mignogna G, Tambussi G, Del Maschio A, Lazzarin A, and Luzi L. Intramyocellular triglyceride content is increased in HIV-1 patients with peripheral lipodystrophy (Abstract A71). Diabetes 49, Suppl 1: 289, 2000.
40. Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, Rothman DL, and Shulman GI. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335: 1357-1362, 1996.
41. 13C NMR spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48: 1600-1606, 1999.
42. Perseghin G, Scifo P, Pagliato E, Battezzatl A, Soldini L, Benedini S, Testolin G, Del Maschio A, and Luzi L. Gender factors affect fatty acids-induced insulin resistance in nonobese humans: Effects of oral steroidal contraception. J Clin Endocrinol Metab 86: 3188-3196, 2001.
43. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, and Shulman GI. Mechanism of free fatty acid induced insulin resistance in humans. J Clin Invest 97: 2859-2866, 1996.
44. Ruderman NB, Chisholm D, Pi-Sunyer X, and Schneider SH. The metabolically obese, normal-weight individual revisited. Diabetes 47: 699-713, 1998.
45. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, and Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue. Magn Reson Med 29: 158-167, 1993.
46. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, and Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94: 4637-4641, 1997.
47. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 106: 171-176, 2000.
48. Simoneau JA, Colberg SR, Thaete FL, and Kelley DE. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 9: 273-278, 1995.
49. Steele R. Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82: 420-431, 1959.
50. Stein DT, Dobbins R, Szczepaniak L, Malloy C, and McGarry JD. Skeletal muscle triglyceride stores are increased in insulin resistance (Abstract). Diabetes 46, Suppl 1: 23A, 1997.
51. Stein DT, Szczepaniak L, Dobbins R, and McGarry JD. Increasing intramyocellular triglyceride stores are associated with impaired glucose tolerance and NIDDM (Abstract). Diabetes 48, Suppl 1: 287A, 1999.
52. Svendsen OL, Hassager C, Bergmann I, and Christiansen C. Measurement of abdominal and intra-abdominal fat in post-menopausal women by DEXA and anthropometry: Comparison with computed tomography. Int J Obes 17: 45-51, 1993.
53. 1H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab 276: E977-E989, 1999.
54. Tappy L, Owen OE, and Boden G. Effect of hyperinsulinemia on urea pool size and substrate oxidation rates. Diabetes 37: 1212-1216, 1988.
55. Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44: 863-870, 1995.
56. Unger RH, Zhou YT, and Orci L. Regulation of fatty acid homeostasis in cells: Novel role of leptin. Proc Natl Acad Sci USA 96: 2327-2332, 1999.
57. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol (Lond) 109: 1-9, 1949.
58. Willett WC, Dietz WH, and Colditz GA. Guidelines for healthy weight. N Engl J Med 341: 427-434, 1999.
59. Zhou YT, Wang ZW, Higa M, Newgard CB, and Unger RH. Reversing adipocyte differentiation: Implications for treatment of obesity. Proc Natl Acad Sci USA 96: 2391-2395, 1999.