Body and liver fat mass rather than muscle mitochondrial function determine glucose metabolism in women with a history of gestational diabetes mellitus

Diabetes Care

Volumn 34, Issue 2, 2011, Pages 430-436

  Prikoszovich, Thomas ^a   Winzer, Christine ^a   Schmid, Albrecht Ingo ^a,b   Szendroedi, Julia ^b,c   Chmelik, Marek ^a,b   Pacini, Giovanni ^d   Krššák, Martin ^a   Moser, Ewald ^a   Funahashi, Tohru ^e   Waldhäusl, Werner ^a   Kautzky Willer, Alexandra ^a   Roden, Michael ^a,b,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Karl Landsteiner Institute of Endocrinology and Metabolism   (Austria)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d CNR   (Italy)

^e OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN;

ADULT; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DELIVERY; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID STORAGE; MUSCLE MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL GLUCOSE TOLERANCE TEST; PHYSICAL ACTIVITY; PREGNANCY DIABETES MELLITUS;

ADENOSINE TRIPHOSPHATASES; ADIPONECTIN; ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; DIABETES, GESTATIONAL; ENERGY METABOLISM; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MAGNETIC RESONANCE IMAGING; MITOCHONDRIA; MUSCLE, SKELETAL; PREGNANCY; RISK FACTORS;

EID: 79951703890     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-1002     Document Type: Article

References (25)

1. Szendroedi J, RodenM. Ectopic lipids and organ function. Curr Opin Lipidol 2009; 20:50-56
2. Trujillo ME, Scherer PE. Adipose tissue-derived factors: impact on health and disease. Endocr Rev 2006;27:762-778 (Pubitemid 44936059)
3. Thamer C, Machann J, Bachmann O, et al. Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab 2003;88: 1785-1791 (Pubitemid 36623405)
4. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004;350:664-671 (Pubitemid 38364625)
5. Szendroedi J, Schmid AI, Chmelik M, et al. Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLoS Med 2007;4:e154
6. Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, et al. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetesmellitus and BMI-matched control subjects. Diabetologia 2007;50: 113-120 (Pubitemid 46035859)
7. Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 2002;25:1862-1868
8. Kautzky-Willer A, Krssak M, Winzer C, et al. Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes. Diabetes 2003;52: 244-251 (Pubitemid 36173175)
9. Tiikkainen M, Tamminen M, Häkkinen AM, et al. Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res 2002;10:859-867 (Pubitemid 135688898)
10. Winzer C, Wagner O, Festa A, et al. Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus. Diabetes Care 2004;27:1721-1727 (Pubitemid 38857450)
11. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 2006;55: 1430-1435 (Pubitemid 44195383)
12. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001;24:539-548 (Pubitemid 32198427)
13. Mari A, Pacini G, Brazzale AR, Ahrén B. Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test. Diabetologia 2005; 48:748-751 (Pubitemid 40591231)
14. Utzschneider KM, Prigeon RL, Tong J, et al. Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies. Diabetologia 2007;50:2516-2525 (Pubitemid 350060640)
15. Pacini G, Tonolo G, Sambataro M, et al. Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT. Am J Physiol 1998;274:E592-E599
16. Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhäusl W, Roden M. Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 2006;55:136-140 (Pubitemid 43343308)
17. Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005; 54:8-14 (Pubitemid 40105089)
18. Petersen KF, Dufour S, Savage DB, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 2007;104:12587-12594 (Pubitemid 47255198)
19. 1H NMR spectroscopy study. Diabetologia 1999;42:113-116
20. Buchanan TA, Xiang AH, Peters RK, et al. Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. Diabetes 2000;49:782-788 (Pubitemid 30339994)
21. Rubinstein E, Lavine JE, Schwimmer JB. Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:380-385
22. Szendroedi J, Chmelik M, Schmid AI, et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 2009;50:1079-1086
23. Civitarese AE, Ukropcova B, Carling S, et al. Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab 2006;4:75-87 (Pubitemid 43942255)
24. Buchanan TA, Xiang AH, Peters RK, et al. Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes 2002;51:2796-2803 (Pubitemid 34970933)
25. Xiang AH, Peters RK, Kjos SL, et al. Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes. Diabetes 2006;55:517-522 (Pubitemid 43343284)