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Volumn 28, Issue 2, 2014, Pages 229-246

Update on research and clinical translation on specific clinical areas: From bench to bedside: How insight in immune pathogenesis can lead to precision medicine of severe juvenile idiopathic arthritis

Author keywords

Bench to bedside; JIA; Personalized medicine; Translational research

Indexed keywords

INFLAMMASOME; INTERLEUKIN 18;

EID: 84903318634     PISSN: 15216942     EISSN: 15321770     Source Type: Journal    
DOI: 10.1016/j.berh.2014.05.002     Document Type: Review
Times cited : (19)

References (139)
  • 1
    • 0026609159 scopus 로고
    • Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. Double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and the Cooperative Children's Study Group
    • E.H. Giannini, E.J. Brewer, and N. Kuzmina et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and the Cooperative Children's Study Group N Engl J Med 326 16 1992 Apr 16 1043 1049
    • (1992) N Engl J Med , vol.326 , Issue.16 , pp. 1043-1049
    • Giannini, E.H.1    Brewer, E.J.2    Kuzmina, N.3
  • 2
    • 0018842573 scopus 로고
    • Gold therapy in the management of juvenile rheumatoid arthritis
    • E.J. Brewer Jr., E.H. Giannini, and E. Barkley Gold therapy in the management of juvenile rheumatoid arthritis Arthritis Rheum 23 4 1980 Apr 404 411
    • (1980) Arthritis Rheum , vol.23 , Issue.4 , pp. 404-411
    • Brewer, Jr.E.J.1    Giannini, E.H.2    Barkley, E.3
  • 3
    • 0019431985 scopus 로고
    • Pharmacotherapy of juvenile rheumatoid arthritis
    • C.B. Lindsley Pharmacotherapy of juvenile rheumatoid arthritis Pediatr Clin North Am 28 1 1981 Feb 161 177
    • (1981) Pediatr Clin North Am , vol.28 , Issue.1 , pp. 161-177
    • Lindsley, C.B.1
  • 4
    • 0022573025 scopus 로고
    • Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. Double-blind placebo-controlled trial
    • E.J. Brewer, E.H. Giannini, and N. Kuzmina et al. Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind placebo-controlled trial N Engl J Med 314 20 1986 May 15 1269 1276
    • (1986) N Engl J Med , vol.314 , Issue.20 , pp. 1269-1276
    • Brewer, E.J.1    Giannini, E.H.2    Kuzmina, N.3
  • 5
    • 77749277178 scopus 로고    scopus 로고
    • Methotrexate-how does it really work?
    • E.S. Chan, and B.N. Cronstein Methotrexate-how does it really work? Nat Rev Rheumatol 6 3 2010 Mar 175 178
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.3 , pp. 175-178
    • Chan, E.S.1    Cronstein, B.N.2
  • 6
    • 0027528798 scopus 로고
    • Anticytokine strategies in the treatment of the systemic inflammatory response syndrome
    • C.A. Dinarello, J.A. Gelfand, and S.M. Wolff Anticytokine strategies in the treatment of the systemic inflammatory response syndrome J Am Med Assoc 269 14 1993 Apr 14 1829 1835
    • (1993) J Am Med Assoc , vol.269 , Issue.14 , pp. 1829-1835
    • Dinarello, C.A.1    Gelfand, J.A.2    Wolff, S.M.3
  • 7
    • 0038461042 scopus 로고    scopus 로고
    • Visual loss in uveitis of childhood
    • J. de Boer, N. Wulffraat, and A. Rothova Visual loss in uveitis of childhood Br J Ophthalmol 87 7 2003 Jul 879 884
    • (2003) Br J Ophthalmol , vol.87 , Issue.7 , pp. 879-884
    • De Boer, J.1    Wulffraat, N.2    Rothova, A.3
  • 8
    • 84866862867 scopus 로고    scopus 로고
    • Systemic juvenile idiopathic arthritis
    • A. Martini Systemic juvenile idiopathic arthritis Autoimmun Rev 12 1 2012 Nov 56 59
    • (2012) Autoimmun Rev , vol.12 , Issue.1 , pp. 56-59
    • Martini, A.1
  • 9
    • 79959963298 scopus 로고    scopus 로고
    • Pathogenesis of systemic juvenile idiopathic arthritis: Some answers, more questions
    • E.D. Mellins, C. Macaubas, and A.A. Grom Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions Nat Rev Rheumatol 7 7 2011 Jul 416 426
    • (2011) Nat Rev Rheumatol , vol.7 , Issue.7 , pp. 416-426
    • Mellins, E.D.1    Macaubas, C.2    Grom, A.A.3
  • 10
    • 0033512202 scopus 로고    scopus 로고
    • Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5'-flanking region of the TNF alpha gene and HLA genes
    • Y. Date, N. Seki, and S. Kamizono et al. Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5'-flanking region of the TNF alpha gene and HLA genes Arthritis Rheum 42 12 1999 Dec 2577 2582
    • (1999) Arthritis Rheum , vol.42 , Issue.12 , pp. 2577-2582
    • Date, Y.1    Seki, N.2    Kamizono, S.3
  • 11
    • 0038708312 scopus 로고    scopus 로고
    • Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis
    • F. De Benedetti, C. Meazza, and M. Vivarelli et al. Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 48 5 2003 May 1398 1407
    • (2003) Arthritis Rheum , vol.48 , Issue.5 , pp. 1398-1407
    • De Benedetti, F.1    Meazza, C.2    Vivarelli, M.3
  • 12
    • 0034742201 scopus 로고    scopus 로고
    • A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    • R.P. Donn, E. Shelley, and W.E. Ollier et al. A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis Arthritis Rheum 44 8 2001 Aug 1782 1785
    • (2001) Arthritis Rheum , vol.44 , Issue.8 , pp. 1782-1785
    • Donn, R.P.1    Shelley, E.2    Ollier, W.E.3
  • 13
    • 34547216848 scopus 로고    scopus 로고
    • Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
    • M.S. Fife, A. Gutierrez, and E.M. Ogilvie et al. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis Arthritis Res Ther 8 5 2006 R148
    • (2006) Arthritis Res Ther , vol.8 , Issue.5 , pp. 148
    • Fife, M.S.1    Gutierrez, A.2    Ogilvie, E.M.3
  • 14
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    • D. Fishman, G. Faulds, and R. Jeffery et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis J Clin Invest 102 7 1998 Oct 1 1369 1376
    • (1998) J Clin Invest , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffery, R.3
  • 15
    • 79952652977 scopus 로고    scopus 로고
    • IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA)
    • J.C. Moller, D. Paul, and G. Ganser et al. IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA) Clin Exp Rheumatol 28 6 2010 Nov 912 918
    • (2010) Clin Exp Rheumatol , vol.28 , Issue.6 , pp. 912-918
    • Moller, J.C.1    Paul, D.2    Ganser, G.3
  • 16
    • 0242579549 scopus 로고    scopus 로고
    • The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: A multicenter study using simplex and multiplex juvenile idiopathic arthritis families
    • E.M. Ogilvie, M.S. Fife, and S.D. Thompson et al. The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families Arthritis Rheum 48 11 2003 Nov 3202 3206
    • (2003) Arthritis Rheum , vol.48 , Issue.11 , pp. 3202-3206
    • Ogilvie, E.M.1    Fife, M.S.2    Thompson, S.D.3
  • 17
    • 84867656904 scopus 로고    scopus 로고
    • Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA)
    • E. Omoyinmi, P. Forabosco, and R. Hamaoui et al. Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA) PLoS One 7 10 2012 e47673
    • (2012) PLoS One , vol.7 , Issue.10 , pp. 47673
    • Omoyinmi, E.1    Forabosco, P.2    Hamaoui, R.3
  • 18
    • 67650066800 scopus 로고    scopus 로고
    • Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    • M.G. Barnes, A.A. Grom, and S.D. Thompson et al. Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis Arthritis Rheum 60 7 2009 Jul 2102 2112
    • (2009) Arthritis Rheum , vol.60 , Issue.7 , pp. 2102-2112
    • Barnes, M.G.1    Grom, A.A.2    Thompson, S.D.3
  • 19
    • 36049020585 scopus 로고    scopus 로고
    • Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    • N. Fall, M. Barnes, and S. Thornton et al. Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome Arthritis Rheum 56 11 2007 Nov 3793 3804
    • (2007) Arthritis Rheum , vol.56 , Issue.11 , pp. 3793-3804
    • Fall, N.1    Barnes, M.2    Thornton, S.3
  • 20
    • 79958276203 scopus 로고    scopus 로고
    • Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: Implications for pathogenesis
    • C.H. Hinze, N. Fall, and S. Thornton et al. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis Arthritis Res Ther 12 3 2010 R123
    • (2010) Arthritis Res Ther , vol.12 , Issue.3 , pp. 123
    • Hinze, C.H.1    Fall, N.2    Thornton, S.3
  • 21
    • 34447523762 scopus 로고    scopus 로고
    • Specific gene expression profiles in systemic juvenile idiopathic arthritis
    • E.M. Ogilvie, A. Khan, and M. Hubank et al. Specific gene expression profiles in systemic juvenile idiopathic arthritis Arthritis Rheum 56 6 2007 Jun 1954 1965
    • (2007) Arthritis Rheum , vol.56 , Issue.6 , pp. 1954-1965
    • Ogilvie, E.M.1    Khan, A.2    Hubank, M.3
  • 22
    • 5444222071 scopus 로고    scopus 로고
    • A common pathway in periodic fever syndromes
    • M.F. McDermott A common pathway in periodic fever syndromes Trends Immunol 25 9 2004 Sep 457 460
    • (2004) Trends Immunol , vol.25 , Issue.9 , pp. 457-460
    • McDermott, M.F.1
  • 23
    • 61749104104 scopus 로고    scopus 로고
    • The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    • M. Frosch, M. Ahlmann, and T. Vogl et al. The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 60 3 2009 Mar 883 891
    • (2009) Arthritis Rheum , vol.60 , Issue.3 , pp. 883-891
    • Frosch, M.1    Ahlmann, M.2    Vogl, T.3
  • 24
    • 43949116263 scopus 로고    scopus 로고
    • The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    • M. Gattorno, A. Piccini, and D. Lasiglie et al. The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis Arthritis Rheum 58 5 2008 May 1505 1515
    • (2008) Arthritis Rheum , vol.58 , Issue.5 , pp. 1505-1515
    • Gattorno, M.1    Piccini, A.2    Lasiglie, D.3
  • 25
    • 18644385243 scopus 로고    scopus 로고
    • Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    • V. Pascual, F. Allantaz, and E. Arce et al. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade J Exp Med 201 9 2005 May 2 1479 1486
    • (2005) J Exp Med , vol.201 , Issue.9 , pp. 1479-1486
    • Pascual, V.1    Allantaz, F.2    Arce, E.3
  • 26
    • 34548436508 scopus 로고    scopus 로고
    • Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    • F. Allantaz, D. Chaussabel, and D. Stichweh et al. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade J Exp Med 204 9 2007 Sep 3 2131 2144
    • (2007) J Exp Med , vol.204 , Issue.9 , pp. 2131-2144
    • Allantaz, F.1    Chaussabel, D.2    Stichweh, D.3
  • 27
    • 47249152715 scopus 로고    scopus 로고
    • How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    • V. Pascual, F. Allantaz, and P. Patel et al. How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets Immunol Rev 223 2008 Jun 39 59
    • (2008) Immunol Rev , vol.223 , pp. 39-59
    • Pascual, V.1    Allantaz, F.2    Patel, P.3
  • 28
    • 73449117152 scopus 로고    scopus 로고
    • Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states
    • C. Macaubas, K. Nguyen, and C. Deshpande et al. Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states Clin Immunol 134 2 2010 Feb 206 216
    • (2010) Clin Immunol , vol.134 , Issue.2 , pp. 206-216
    • Macaubas, C.1    Nguyen, K.2    Deshpande, C.3
  • 29
    • 1542283765 scopus 로고    scopus 로고
    • Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
    • A.A. Grom Natural killer cell dysfunction: a common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? Arthritis Rheum 50 3 2004 Mar 689 698
    • (2004) Arthritis Rheum , vol.50 , Issue.3 , pp. 689-698
    • Grom, A.A.1
  • 30
    • 21744452702 scopus 로고    scopus 로고
    • Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • J. Villanueva, S. Lee, and E.H. Giannini et al. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome Arthritis Res Ther 7 1 2005 R30 R37
    • (2005) Arthritis Res Ther , vol.7 , Issue.1
    • Villanueva, J.1    Lee, S.2    Giannini, E.H.3
  • 31
    • 0037293064 scopus 로고    scopus 로고
    • Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
    • N.M. Wulffraat, G.T. Rijkers, and E. Elst et al. Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation Rheumatology (Oxford) 42 2 2003 Feb 375 379
    • (2003) Rheumatology (Oxford) , vol.42 , Issue.2 , pp. 375-379
    • Wulffraat, N.M.1    Rijkers, G.T.2    Elst, E.3
  • 32
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease (*)
    • S.L. Masters, A. Simon, and I. Aksentijevich et al. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*) Annu Rev Immunol 27 2009 621 668
    • (2009) Annu Rev Immunol , vol.27 , pp. 621-668
    • Masters, S.L.1    Simon, A.2    Aksentijevich, I.3
  • 33
    • 73249139175 scopus 로고    scopus 로고
    • Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
    • M. Guma, L. Ronacher, and R. Liu-Bryan et al. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation Arthritis Rheum 60 12 2009 Dec 3642 3650
    • (2009) Arthritis Rheum , vol.60 , Issue.12 , pp. 3642-3650
    • Guma, M.1    Ronacher, L.2    Liu-Bryan, R.3
  • 34
    • 0030015099 scopus 로고    scopus 로고
    • Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
    • M. Cazzola, L. Ponchio, and B.F. De et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis Blood 87 11 1996 Jun 1 4824 4830
    • (1996) Blood , vol.87 , Issue.11 , pp. 4824-4830
    • Cazzola, M.1    Ponchio, L.2    De, B.F.3
  • 35
    • 0026014522 scopus 로고
    • Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis
    • F. De Benedetti, M. Massa, and P. Robbioni et al. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis Arthritis Rheum 34 9 1991 Sep 1158 1163
    • (1991) Arthritis Rheum , vol.34 , Issue.9 , pp. 1158-1163
    • De Benedetti, F.1    Massa, M.2    Robbioni, P.3
  • 36
    • 0028345082 scopus 로고
    • Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis
    • F. De Benedetti, M. Massa, and P. Pignatti et al. Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis J Clin Invest 93 5 1994 May 2114 2119
    • (1994) J Clin Invest , vol.93 , Issue.5 , pp. 2114-2119
    • De Benedetti, F.1    Massa, M.2    Pignatti, P.3
  • 37
    • 17944375020 scopus 로고    scopus 로고
    • Effect of IL-6 on IGF binding protein-3: A study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritis
    • F. De Benedetti, C. Meazza, and M. Oliveri et al. Effect of IL-6 on IGF binding protein-3: a study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritis Endocrinology 142 11 2001 Nov 4818 4826
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4818-4826
    • De Benedetti, F.1    Meazza, C.2    Oliveri, M.3
  • 38
    • 84871321221 scopus 로고    scopus 로고
    • Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis
    • F. De Benedetti, H.I. Brunner, and N. Ruperto et al. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis N Engl J Med 367 25 2012 Dec 20 2385 2395
    • (2012) N Engl J Med , vol.367 , Issue.25 , pp. 2385-2395
    • De Benedetti, F.1    Brunner, H.I.2    Ruperto, N.3
  • 39
    • 31544451391 scopus 로고    scopus 로고
    • Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: Proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement
    • P. Woo, N. Wilkinson, and A.M. Prieur et al. Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement Arthritis Res Ther 7 6 2005 R1281 R1288
    • (2005) Arthritis Res Ther , vol.7 , Issue.6
    • Woo, P.1    Wilkinson, N.2    Prieur, A.M.3
  • 40
    • 2342575674 scopus 로고    scopus 로고
    • Effective application of anti-IL-6-monoclonal antibody for children with systemic-onset juvenile idiopathic arthritis
    • S. Yokota Effective application of anti-IL-6-monoclonal antibody for children with systemic-onset juvenile idiopathic arthritis Nihon Rinsho Meneki Gakkai Kaishi 27 1 2004 Feb 22 27
    • (2004) Nihon Rinsho Meneki Gakkai Kaishi , vol.27 , Issue.1 , pp. 22-27
    • Yokota, S.1
  • 41
    • 20144362101 scopus 로고    scopus 로고
    • Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis
    • S. Yokota, T. Miyamae, and T. Imagawa et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis Arthritis Rheum 52 3 2005 Mar 818 825
    • (2005) Arthritis Rheum , vol.52 , Issue.3 , pp. 818-825
    • Yokota, S.1    Miyamae, T.2    Imagawa, T.3
  • 42
    • 40749152243 scopus 로고    scopus 로고
    • Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: A randomised, double-blind, placebo-controlled, withdrawal phase III trial
    • S. Yokota, T. Imagawa, and M. Mori et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial Lancet 371 9617 2008 Mar 22 998 1006
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 998-1006
    • Yokota, S.1    Imagawa, T.2    Mori, M.3
  • 43
    • 0032607876 scopus 로고    scopus 로고
    • IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
    • C.A. Dinarello IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family J Allergy Clin Immunol 103 1 Pt 1 1999 Jan 11 24
    • (1999) J Allergy Clin Immunol , vol.103 , Issue.1 PART 1 , pp. 11-24
    • Dinarello, C.A.1
  • 44
    • 0034268386 scopus 로고    scopus 로고
    • Interleukin-18, a proinflammatory cytokine
    • C.A. Dinarello Interleukin-18, a proinflammatory cytokine Eur Cytokine Netw 11 3 2000 Sep 483 486
    • (2000) Eur Cytokine Netw , vol.11 , Issue.3 , pp. 483-486
    • Dinarello, C.A.1
  • 45
    • 33847336449 scopus 로고    scopus 로고
    • Interleukin-18 and the pathogenesis of inflammatory diseases
    • C.A. Dinarello Interleukin-18 and the pathogenesis of inflammatory diseases Semin Nephrol 27 1 2007 Jan 98 114
    • (2007) Semin Nephrol , vol.27 , Issue.1 , pp. 98-114
    • Dinarello, C.A.1
  • 46
    • 0031749136 scopus 로고    scopus 로고
    • Overview of interleukin-18: More than an interferon-gamma inducing factor
    • C.A. Dinarello, D. Novick, and A.J. Puren et al. Overview of interleukin-18: more than an interferon-gamma inducing factor J Leukoc Biol 63 6 1998 Jun 658 664
    • (1998) J Leukoc Biol , vol.63 , Issue.6 , pp. 658-664
    • Dinarello, C.A.1    Novick, D.2    Puren, A.J.3
  • 47
    • 0035451438 scopus 로고    scopus 로고
    • A role for IL-18 in neutrophil activation
    • B.P. Leung, S. Culshaw, and J.A. Gracie et al. A role for IL-18 in neutrophil activation J Immunol 167 5 2001 Sep 1 2879 2886
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2879-2886
    • Leung, B.P.1    Culshaw, S.2    Gracie, J.A.3
  • 48
    • 34248147607 scopus 로고    scopus 로고
    • Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: A cross-sectional study
    • W. de Jager, E.P. Hoppenreijs, and N.M. Wulffraat et al. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study Ann Rheum Dis 66 5 2007 May 589 598
    • (2007) Ann Rheum Dis , vol.66 , Issue.5 , pp. 589-598
    • De Jager, W.1    Hoppenreijs, E.P.2    Wulffraat, N.M.3
  • 49
    • 34447123133 scopus 로고    scopus 로고
    • Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis
    • M. Jelusic, I.K. Lukic, and L. Tambic-Bukovac et al. Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis Clin Rheumatol 26 8 2007 Aug 1332 1334
    • (2007) Clin Rheumatol , vol.26 , Issue.8 , pp. 1332-1334
    • Jelusic, M.1    Lukic, I.K.2    Tambic-Bukovac, L.3
  • 50
    • 34247350845 scopus 로고    scopus 로고
    • Interleukin 18 as a marker of disease activity and severity in patients with juvenile idiopathic arthritis
    • A.P. Lotito, A. Campa, and C.A. Silva et al. Interleukin 18 as a marker of disease activity and severity in patients with juvenile idiopathic arthritis J Rheumatol 34 4 2007 Apr 823 830
    • (2007) J Rheumatol , vol.34 , Issue.4 , pp. 823-830
    • Lotito, A.P.1    Campa, A.2    Silva, C.A.3
  • 51
    • 0036746084 scopus 로고    scopus 로고
    • Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: Comment on the article by Kawashima et al
    • N. Maeno, S. Takei, and Y. Nomura et al. Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al Arthritis Rheum 46 9 2002 Sep 2539 2541
    • (2002) Arthritis Rheum , vol.46 , Issue.9 , pp. 2539-2541
    • Maeno, N.1    Takei, S.2    Nomura, Y.3
  • 52
    • 2642527912 scopus 로고    scopus 로고
    • Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome
    • N. Maeno, S. Takei, and H. Imanaka et al. Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome Arthritis Rheum 50 6 2004 Jun 1935 1938
    • (2004) Arthritis Rheum , vol.50 , Issue.6 , pp. 1935-1938
    • Maeno, N.1    Takei, S.2    Imanaka, H.3
  • 53
    • 84873184774 scopus 로고    scopus 로고
    • Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles
    • M. Shimizu, Y. Nakagishi, and A. Yachie Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles Cytokine 61 2 2013 345 348
    • (2013) Cytokine , vol.61 , Issue.2 , pp. 345-348
    • Shimizu, M.1    Nakagishi, Y.2    Yachie, A.3
  • 54
    • 84898640609 scopus 로고    scopus 로고
    • Effectiveness of first line use of recombinant IL-1RA treatment in steroid naive systemic juvenile idiopathic arthritis: Results of a prospective cohort study
    • S.J. Vastert, W. de Jager, and B.J. Noordman et al. Effectiveness of first line use of recombinant IL-1RA treatment in steroid naive systemic juvenile idiopathic arthritis: results of a prospective cohort study Arthritis Rheum 66 4 2014 1034 1043
    • (2014) Arthritis Rheum , vol.66 , Issue.4 , pp. 1034-1043
    • Vastert, S.J.1    De Jager, W.2    Noordman, B.J.3
  • 56
    • 0034235247 scopus 로고    scopus 로고
    • Interleukin 18: A pleiotropic participant in chronic inflammation
    • I.B. McInnes, J.A. Gracie, and B.P. Leung et al. Interleukin 18: a pleiotropic participant in chronic inflammation Immunol Today 21 7 2000 Jul 312 315
    • (2000) Immunol Today , vol.21 , Issue.7 , pp. 312-315
    • McInnes, I.B.1    Gracie, J.A.2    Leung, B.P.3
  • 57
    • 0037338925 scopus 로고    scopus 로고
    • Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • A.A. Grom, J. Villanueva, and S. Lee et al. Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome J Pediatr 142 3 2003 Mar 292 296
    • (2003) J Pediatr , vol.142 , Issue.3 , pp. 292-296
    • Grom, A.A.1    Villanueva, J.2    Lee, S.3
  • 58
    • 69449093422 scopus 로고    scopus 로고
    • Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis
    • W. de Jager, S.J. Vastert, and J.M. Beekman et al. Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 60 9 2009 Sep 2782 2793
    • (2009) Arthritis Rheum , vol.60 , Issue.9 , pp. 2782-2793
    • De Jager, W.1    Vastert, S.J.2    Beekman, J.M.3
  • 59
    • 0030370451 scopus 로고    scopus 로고
    • Macrophage activation syndrome in systemic juvenile rheumatoid arthritis
    • A.A. Grom, and M. Passo Macrophage activation syndrome in systemic juvenile rheumatoid arthritis J Pediatr 129 5 1996 Nov 630 632
    • (1996) J Pediatr , vol.129 , Issue.5 , pp. 630-632
    • Grom, A.A.1    Passo, M.2
  • 60
    • 0036707740 scopus 로고    scopus 로고
    • Macrophage activation syndrome
    • A. Ravelli Macrophage activation syndrome Curr Opin Rheumatol 14 5 2002 Sep 548 552
    • (2002) Curr Opin Rheumatol , vol.14 , Issue.5 , pp. 548-552
    • Ravelli, A.1
  • 61
    • 84861685616 scopus 로고    scopus 로고
    • Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: Diagnosis, genetics, pathophysiology and treatment
    • A. Ravelli, A.A. Grom, and E.M. Behrens et al. Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment Genes Immun 13 4 2012 Jun 289 298
    • (2012) Genes Immun , vol.13 , Issue.4 , pp. 289-298
    • Ravelli, A.1    Grom, A.A.2    Behrens, E.M.3
  • 62
    • 84855932987 scopus 로고    scopus 로고
    • Familial and acquired hemophagocytic lymphohistiocytosis
    • G.E. Janka Familial and acquired hemophagocytic lymphohistiocytosis Annu Rev Med 63 2012 233 246
    • (2012) Annu Rev Med , vol.63 , pp. 233-246
    • Janka, G.E.1
  • 63
    • 79959370461 scopus 로고    scopus 로고
    • Juvenile idiopathic arthritis
    • B. Prakken, S. Albani, and A. Martini Juvenile idiopathic arthritis Lancet 377 9783 2011 Jun 18 2138 2149
    • (2011) Lancet , vol.377 , Issue.9783 , pp. 2138-2149
    • Prakken, B.1    Albani, S.2    Martini, A.3
  • 64
    • 34248666067 scopus 로고    scopus 로고
    • Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    • E.M. Behrens, T. Beukelman, and M. Paessler et al. Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis J Rheumatol 34 5 2007 May 1133 1138
    • (2007) J Rheumatol , vol.34 , Issue.5 , pp. 1133-1138
    • Behrens, E.M.1    Beukelman, T.2    Paessler, M.3
  • 65
    • 33847068680 scopus 로고    scopus 로고
    • First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome
    • D. Rigante, E. Capoluongo, and B. Bertoni et al. First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome Arthritis Rheum 56 2 2007 Feb 658 661
    • (2007) Arthritis Rheum , vol.56 , Issue.2 , pp. 658-661
    • Rigante, D.1    Capoluongo, E.2    Bertoni, B.3
  • 66
    • 49749127387 scopus 로고    scopus 로고
    • Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    • K. Zhang, J. Biroschak, and D.N. Glass et al. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms Arthritis Rheum 58 9 2008 Sep 2892 2896
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2892-2896
    • Zhang, K.1    Biroschak, J.2    Glass, D.N.3
  • 67
    • 77649267675 scopus 로고    scopus 로고
    • Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis
    • C.A. Nold-Petry, T. Lehrnbecher, and A. Jarisch et al. Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis PLoS One 5 1 2010 e8663
    • (2010) PLoS One , vol.5 , Issue.1 , pp. 8663
    • Nold-Petry, C.A.1    Lehrnbecher, T.2    Jarisch, A.3
  • 68
    • 0032855445 scopus 로고    scopus 로고
    • Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: A novel marker of disease activity
    • H. Takada, S. Ohga, and Y. Mizuno et al. Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: a novel marker of disease activity Br J Haematol 106 1 1999 Jul 182 189
    • (1999) Br J Haematol , vol.106 , Issue.1 , pp. 182-189
    • Takada, H.1    Ohga, S.2    Mizuno, Y.3
  • 69
    • 0034926839 scopus 로고    scopus 로고
    • Interleukin-18 in hemophagocytic lymphohistiocytosis
    • H. Takada, A. Nomura, and S. Ohga et al. Interleukin-18 in hemophagocytic lymphohistiocytosis Leuk Lymphoma 42 1-2 2001 Jun 21 28
    • (2001) Leuk Lymphoma , vol.42 , Issue.12 , pp. 21-28
    • Takada, H.1    Nomura, A.2    Ohga, S.3
  • 70
    • 79953323633 scopus 로고    scopus 로고
    • A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
    • P. Quartier, F. Allantaz, and R. Cimaz et al. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial) Ann Rheum Dis 70 5 2011 May 747 754
    • (2011) Ann Rheum Dis , vol.70 , Issue.5 , pp. 747-754
    • Quartier, P.1    Allantaz, F.2    Cimaz, R.3
  • 71
    • 79551654446 scopus 로고    scopus 로고
    • Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter series
    • P.A. Nigrovic, M. Mannion, and F.H. Prince et al. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series Arthritis Rheum 63 2 2011 Feb 545 555
    • (2011) Arthritis Rheum , vol.63 , Issue.2 , pp. 545-555
    • Nigrovic, P.A.1    Mannion, M.2    Prince, F.H.3
  • 72
    • 39549109506 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset still disease: Preliminary experience in France
    • T. Lequerre, P. Quartier, and D. Rosellini et al. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset still disease: preliminary experience in France Ann Rheum Dis 67 3 2008 Mar 302 308
    • (2008) Ann Rheum Dis , vol.67 , Issue.3 , pp. 302-308
    • Lequerre, T.1    Quartier, P.2    Rosellini, D.3
  • 73
    • 69449106110 scopus 로고    scopus 로고
    • IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    • L. Guo, G. Wei, and J. Zhu et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells Proc Natl Acad Sci U S A 106 32 2009 Aug 11 13463 13468
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.32 , pp. 13463-13468
    • Guo, L.1    Wei, G.2    Zhu, J.3
  • 74
    • 0032743708 scopus 로고    scopus 로고
    • A proinflammatory role for IL-18 in rheumatoid arthritis
    • J.A. Gracie, R.J. Forsey, and W.L. Chan et al. A proinflammatory role for IL-18 in rheumatoid arthritis J Clin Invest 104 10 1999 Nov 1393 1401
    • (1999) J Clin Invest , vol.104 , Issue.10 , pp. 1393-1401
    • Gracie, J.A.1    Forsey, R.J.2    Chan, W.L.3
  • 75
    • 0034659770 scopus 로고    scopus 로고
    • Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
    • B.P. Leung, I.B. McInnes, and E. Esfandiari et al. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis J Immunol 164 12 2000 Jun 15 6495 6502
    • (2000) J Immunol , vol.164 , Issue.12 , pp. 6495-6502
    • Leung, B.P.1    McInnes, I.B.2    Esfandiari, E.3
  • 76
    • 0035173776 scopus 로고    scopus 로고
    • Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    • X.Q. Wei, B.P. Leung, and H.M. Arthur et al. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18 J Immunol 166 1 2001 Jan 1 517 521
    • (2001) J Immunol , vol.166 , Issue.1 , pp. 517-521
    • Wei, X.Q.1    Leung, B.P.2    Arthur, H.M.3
  • 77
    • 40549138745 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    • K. Nistala, H. Moncrieffe, and K.R. Newton et al. Interleukin-17- producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers Arthritis Rheum 58 3 2008 Mar 875 887
    • (2008) Arthritis Rheum , vol.58 , Issue.3 , pp. 875-887
    • Nistala, K.1    Moncrieffe, H.2    Newton, K.R.3
  • 78
    • 65849467800 scopus 로고    scopus 로고
    • Th17 and regulatory T cells: Rebalancing pro- and anti-inflammatory forces in autoimmune arthritis
    • K. Nistala, and L.R. Wedderburn Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis Rheumatology (Oxford) 48 6 2009 Jun 602 606
    • (2009) Rheumatology (Oxford) , vol.48 , Issue.6 , pp. 602-606
    • Nistala, K.1    Wedderburn, L.R.2
  • 79
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • H.J. Koenen, R.L. Smeets, and P.M. Vink et al. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells Blood 112 6 2008 Sep 15 2340 2352
    • (2008) Blood , vol.112 , Issue.6 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3
  • 80
    • 84860919270 scopus 로고    scopus 로고
    • The toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis
    • D. Holzinger, M. Frosch, and A. Kastrup et al. The toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis Ann Rheum Dis 71 6 2012 Jun 974 980
    • (2012) Ann Rheum Dis , vol.71 , Issue.6 , pp. 974-980
    • Holzinger, D.1    Frosch, M.2    Kastrup, A.3
  • 81
    • 0018184099 scopus 로고
    • Light- and electron-microscopic findings of juvenile rheumatoid arthritis synovium: Comparison with normal juvenile synovium
    • C.R. Wynne-Roberts, C.H. Anderson, and A.M. Turano et al. Light- and electron-microscopic findings of juvenile rheumatoid arthritis synovium: comparison with normal juvenile synovium Semin Arthritis Rheum 7 4 1978 May 287 302
    • (1978) Semin Arthritis Rheum , vol.7 , Issue.4 , pp. 287-302
    • Wynne-Roberts, C.R.1    Anderson, C.H.2    Turano, A.M.3
  • 82
    • 0032898003 scopus 로고    scopus 로고
    • Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood
    • L.R. Wedderburn, M.K. Maini, and A. Patel et al. Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood Int Immunol 11 4 1999 Apr 535 543
    • (1999) Int Immunol , vol.11 , Issue.4 , pp. 535-543
    • Wedderburn, L.R.1    Maini, M.K.2    Patel, A.3
  • 83
    • 0027472870 scopus 로고
    • Synovial fluid cells in juvenile arthritis: Evidence of selective T cell migration to inflamed tissue
    • E.D. Silverman, B. Isacovics, and D. Petsche et al. Synovial fluid cells in juvenile arthritis: evidence of selective T cell migration to inflamed tissue Clin Exp Immunol 91 1 1993 Jan 90 95
    • (1993) Clin Exp Immunol , vol.91 , Issue.1 , pp. 90-95
    • Silverman, E.D.1    Isacovics, B.2    Petsche, D.3
  • 84
    • 0030457099 scopus 로고    scopus 로고
    • Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis
    • K.J. Murray, L. Luyrink, and A.A. Grom et al. Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis J Rheumatol 23 12 1996 Dec 2116 2124
    • (1996) J Rheumatol , vol.23 , Issue.12 , pp. 2116-2124
    • Murray, K.J.1    Luyrink, L.2    Grom, A.A.3
  • 85
    • 0017460557 scopus 로고
    • Pathologic aspects of juvenile chronic polyarthritis
    • E.G. Bywaters Pathologic aspects of juvenile chronic polyarthritis Arthritis Rheum 20 2 Suppl. 1977 Mar 271 276
    • (1977) Arthritis Rheum , vol.20 , Issue.2 SUPPL. , pp. 271-276
    • Bywaters, E.G.1
  • 86
    • 84871768044 scopus 로고    scopus 로고
    • T cells out of control-impaired immune regulation in the inflamed joint
    • E.J. Wehrens, B.J. Prakken, and W.F. van T cells out of control-impaired immune regulation in the inflamed joint Nat Rev Rheumatol 9 1 2012 Sep 18 34 42
    • (2012) Nat Rev Rheumatol , vol.9 , Issue.1 , pp. 34-42
    • Wehrens, E.J.1    Prakken, B.J.2    Van, W.F.3
  • 87
    • 70349245581 scopus 로고    scopus 로고
    • Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis
    • B. Olivito, G. Simonini, and S. Ciullini et al. Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis J Rheumatol 36 9 2009 Sep 2017 2024
    • (2009) J Rheumatol , vol.36 , Issue.9 , pp. 2017-2024
    • Olivito, B.1    Simonini, G.2    Ciullini, S.3
  • 88
    • 79961117793 scopus 로고    scopus 로고
    • Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis
    • L. Cosmi, R. Cimaz, and L. Maggi et al. Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis Arthritis Rheum 63 8 2011 Aug 2504 2515
    • (2011) Arthritis Rheum , vol.63 , Issue.8 , pp. 2504-2515
    • Cosmi, L.1    Cimaz, R.2    Maggi, L.3
  • 89
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • S. Sakaguchi, N. Sakaguchi, and M. Asano et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 3 1995 Aug 1 1151 1164
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 90
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • S. Sakaguchi, M. Ono, and R. Setoguchi et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease Immunol Rev 212 2006 Aug 8 27
    • (2006) Immunol Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3
  • 91
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • I. de Kleer, L.R. Wedderburn, and L.S. Taams et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis J Immunol 172 10 2004 May 15 6435 6443
    • (2004) J Immunol , vol.172 , Issue.10 , pp. 6435-6443
    • De Kleer, I.1    Wedderburn, L.R.2    Taams, L.S.3
  • 92
    • 0038681274 scopus 로고    scopus 로고
    • The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10
    • I. de Kleer, S.M. Kamphuis, and G.T. Rijkers et al. The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10 Arthritis Rheum 48 7 2003 Jul 2001 2010
    • (2003) Arthritis Rheum , vol.48 , Issue.7 , pp. 2001-2010
    • De Kleer, I.1    Kamphuis, S.M.2    Rijkers, G.T.3
  • 93
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • J. van Loosdregt, Y. Vercoulen, and T. Guichelaar et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization Blood 115 5 2010 Feb 4 965 974
    • (2010) Blood , vol.115 , Issue.5 , pp. 965-974
    • Van Loosdregt, J.1    Vercoulen, Y.2    Guichelaar, T.3
  • 94
    • 84882692382 scopus 로고    scopus 로고
    • Canonical Wnt signaling negatively modulates regulatory T cell function
    • J. van Loosdregt, V. Fleskens, and M.M. Tiemessen et al. Canonical Wnt signaling negatively modulates regulatory T cell function Immunity 39 2 2013 Aug 22 298 310
    • (2013) Immunity , vol.39 , Issue.2 , pp. 298-310
    • Van Loosdregt, J.1    Fleskens, V.2    Tiemessen, M.M.3
  • 95
    • 84882592280 scopus 로고    scopus 로고
    • Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity
    • J. van Loosdregt, V. Fleskens, and J. Fu et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity Immunity 39 2 2013 Aug 22 259 271
    • (2013) Immunity , vol.39 , Issue.2 , pp. 259-271
    • Van Loosdregt, J.1    Fleskens, V.2    Fu, J.3
  • 96
    • 79957483535 scopus 로고    scopus 로고
    • 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: Initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features
    • T. Beukelman, N.M. Patkar, and K.G. Saag et al. 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features Arthritis Care Res (Hoboken) 63 4 2011 Apr 465 482
    • (2011) Arthritis Care Res (Hoboken) , vol.63 , Issue.4 , pp. 465-482
    • Beukelman, T.1    Patkar, N.M.2    Saag, K.G.3
  • 97
    • 84856555944 scopus 로고    scopus 로고
    • Evidence and consensus based GKJR guidelines for the treatment of juvenile idiopathic arthritis
    • G. Dueckers, N. Guellac, and M. Arbogast et al. Evidence and consensus based GKJR guidelines for the treatment of juvenile idiopathic arthritis Clin Immunol 142 2 2012 Feb 176 193
    • (2012) Clin Immunol , vol.142 , Issue.2 , pp. 176-193
    • Dueckers, G.1    Guellac, N.2    Arbogast, M.3
  • 98
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells
    • L. Genestier, R. Paillot, and S. Fournel et al. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells J Clin Invest 102 2 1998 Jul 15 322 328
    • (1998) J Clin Invest , vol.102 , Issue.2 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3
  • 99
    • 78650528837 scopus 로고    scopus 로고
    • How does methotrexate suppress inflammation?
    • B. Cronstein How does methotrexate suppress inflammation? Clin Exp Rheumatol 28 5 Suppl. 61 2010 Sep S21 S23
    • (2010) Clin Exp Rheumatol , vol.28 , Issue.5 SUPPL. 61
    • Cronstein, B.1
  • 100
    • 0027139914 scopus 로고
    • The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
    • B.N. Cronstein, D. Naime, and E. Ostad The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation J Clin Invest 92 6 1993 Dec 2675 2682
    • (1993) J Clin Invest , vol.92 , Issue.6 , pp. 2675-2682
    • Cronstein, B.N.1    Naime, D.2    Ostad, E.3
  • 101
    • 84960580218 scopus 로고
    • The antirheumatic agents sulphasalazine and methotrexate share an anti-inflammatory mechanism
    • B.N. Cronstein The antirheumatic agents sulphasalazine and methotrexate share an anti-inflammatory mechanism Br J Rheumatol 34 Suppl. 2 1995 Nov 30 32
    • (1995) Br J Rheumatol , vol.34 , Issue.SUPPL. 2 , pp. 30-32
    • Cronstein, B.N.1
  • 102
    • 0034933712 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
    • M. Cutolo, A. Sulli, and C. Pizzorni et al. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis Ann Rheum Dis 60 8 2001 Aug 729 735
    • (2001) Ann Rheum Dis , vol.60 , Issue.8 , pp. 729-735
    • Cutolo, M.1    Sulli, A.2    Pizzorni, C.3
  • 103
    • 0037207972 scopus 로고    scopus 로고
    • Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
    • M.C. Montesinos, A. Desai, and D. Delano et al. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68 Arthritis Rheum 48 1 2003 Jan 240 247
    • (2003) Arthritis Rheum , vol.48 , Issue.1 , pp. 240-247
    • Montesinos, M.C.1    Desai, A.2    Delano, D.3
  • 104
    • 34248524004 scopus 로고    scopus 로고
    • The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: Findings in a study of ecto-5'-nucleotidase gene-deficient mice
    • M.C. Montesinos, M. Takedachi, and L.F. Thompson et al. The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice Arthritis Rheum 56 5 2007 May 1440 1445
    • (2007) Arthritis Rheum , vol.56 , Issue.5 , pp. 1440-1445
    • Montesinos, M.C.1    Takedachi, M.2    Thompson, L.F.3
  • 105
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • G. Borsellino, M. Kleinewietfeld, and M.D. Di et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression Blood 110 4 2007 Aug 15 1225 1232
    • (2007) Blood , vol.110 , Issue.4 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    Di, M.D.3
  • 106
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • S. Deaglio, K.M. Dwyer, and W. Gao et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression J Exp Med 204 6 2007 Jun 11 1257 1265
    • (2007) J Exp Med , vol.204 , Issue.6 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 107
    • 33947647317 scopus 로고    scopus 로고
    • CD39 and control of cellular immune responses
    • K.M. Dwyer, S. Deaglio, and W. Gao et al. CD39 and control of cellular immune responses Purinergic Signal 3 1-2 2007 Mar 171 180
    • (2007) Purinergic Signal , vol.3 , Issue.12 , pp. 171-180
    • Dwyer, K.M.1    Deaglio, S.2    Gao, W.3
  • 108
    • 73349127157 scopus 로고    scopus 로고
    • CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis
    • J.M. Fletcher, R. Lonergan, and L. Costelloe et al. CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis J Immunol 183 11 2009 Dec 1 7602 7610
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7602-7610
    • Fletcher, J.M.1    Lonergan, R.2    Costelloe, L.3
  • 109
    • 77956218918 scopus 로고    scopus 로고
    • High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population
    • H. Moncrieffe, K. Nistala, and Y. Kamhieh et al. High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population J Immunol 185 1 2010 Jul 1 134 143
    • (2010) J Immunol , vol.185 , Issue.1 , pp. 134-143
    • Moncrieffe, H.1    Nistala, K.2    Kamhieh, Y.3
  • 110
    • 83055163766 scopus 로고    scopus 로고
    • Factors associated with treatment response to etanercept in juvenile idiopathic arthritis
    • M.H. Otten, F.H. Prince, and W. Armbrust et al. Factors associated with treatment response to etanercept in juvenile idiopathic arthritis J Am Med Assoc 306 21 2011 Dec 7 2340 2347
    • (2011) J Am Med Assoc , vol.306 , Issue.21 , pp. 2340-2347
    • Otten, M.H.1    Prince, F.H.2    Armbrust, W.3
  • 111
    • 0024314554 scopus 로고
    • Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
    • F.M. Brennan, D. Chantry, and A. Jackson et al. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis Lancet 2 8657 1989 Jul 29 244 247
    • (1989) Lancet , vol.2 , Issue.8657 , pp. 244-247
    • Brennan, F.M.1    Chantry, D.2    Jackson, A.3
  • 112
    • 1542376173 scopus 로고    scopus 로고
    • The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis
    • M. Feldmann, F.M. Brennan, and R.O. Williams et al. The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis Best Pract Res Clin Rheumatol 18 1 2004 Feb 59 80
    • (2004) Best Pract Res Clin Rheumatol , vol.18 , Issue.1 , pp. 59-80
    • Feldmann, M.1    Brennan, F.M.2    Williams, R.O.3
  • 113
    • 0034673697 scopus 로고    scopus 로고
    • Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group
    • D.J. Lovell, E.H. Giannini, and A. Reiff et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group N Engl J Med 342 11 2000 Mar 16 763 769
    • (2000) N Engl J Med , vol.342 , Issue.11 , pp. 763-769
    • Lovell, D.J.1    Giannini, E.H.2    Reiff, A.3
  • 114
    • 49949115223 scopus 로고    scopus 로고
    • Adalimumab with or without methotrexate in juvenile rheumatoid arthritis
    • D.J. Lovell, N. Ruperto, and S. Goodman et al. Adalimumab with or without methotrexate in juvenile rheumatoid arthritis N Engl J Med 359 8 2008 Aug 21 810 820
    • (2008) N Engl J Med , vol.359 , Issue.8 , pp. 810-820
    • Lovell, D.J.1    Ruperto, N.2    Goodman, S.3
  • 115
    • 34848884299 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis
    • N. Ruperto, D.J. Lovell, and R. Cuttica et al. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis Arthritis Rheum 56 9 2007 Sep 3096 3106
    • (2007) Arthritis Rheum , vol.56 , Issue.9 , pp. 3096-3106
    • Ruperto, N.1    Lovell, D.J.2    Cuttica, R.3
  • 116
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    • S. Nadkarni, C. Mauri, and M.R. Ehrenstein Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta J Exp Med 204 1 2007 Jan 22 33 39
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 117
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • M.R. Ehrenstein, J.G. Evans, and A. Singh et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy J Exp Med 200 3 2004 Aug 2 277 285
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3
  • 118
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    • X. Valencia, G. Stephens, and R. Goldbach-Mansky et al. TNF downmodulates the function of human CD4+CD25hi T-regulatory cells Blood 108 1 2006 Jul 1 253 261
    • (2006) Blood , vol.108 , Issue.1 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3
  • 119
    • 79958108824 scopus 로고    scopus 로고
    • Advances in rheumatology: New targeted therapeutics
    • P.P. Tak, and J.R. Kalden Advances in rheumatology: new targeted therapeutics Arthritis Res Ther 13 Suppl. 1 2011 S5
    • (2011) Arthritis Res Ther , vol.13 , Issue.SUPPL. 1 , pp. 5
    • Tak, P.P.1    Kalden, J.R.2
  • 120
    • 84888994622 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor alpha targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis
    • E.J. Wehrens, S.J. Vastert, and G. Mijnheer et al. Anti-tumor necrosis factor alpha targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis Arthritis Rheum 65 12 2013 Dec 3279 3284
    • (2013) Arthritis Rheum , vol.65 , Issue.12 , pp. 3279-3284
    • Wehrens, E.J.1    Vastert, S.J.2    Mijnheer, G.3
  • 121
    • 4344705888 scopus 로고    scopus 로고
    • Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: Analysis of clinical effects, mortality, and transplant related morbidity
    • I. de Kleer, D.M. Brinkman, and A. Ferster et al. Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity Ann Rheum Dis 63 10 2004 Oct 1318 1326
    • (2004) Ann Rheum Dis , vol.63 , Issue.10 , pp. 1318-1326
    • De Kleer, I.1    Brinkman, D.M.2    Ferster, A.3
  • 122
    • 0032992520 scopus 로고    scopus 로고
    • Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis
    • N. Wulffraat, A. van Royen, and M. Bierings et al. Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis Lancet 353 9152 1999 Feb 13 550 553
    • (1999) Lancet , vol.353 , Issue.9152 , pp. 550-553
    • Wulffraat, N.1    Van Royen, A.2    Bierings, M.3
  • 123
    • 34547458668 scopus 로고    scopus 로고
    • Autologous stem cell transplantation in children with severe progressive systemic or polyarticular juvenile idiopathic arthritis: Long-term follow-up of a prospective clinical trial
    • D.M. Brinkman, I. de Kleer, and R. Ten Cate et al. Autologous stem cell transplantation in children with severe progressive systemic or polyarticular juvenile idiopathic arthritis: long-term follow-up of a prospective clinical trial Arthritis Rheum 56 7 2007 Jul 2410 2421
    • (2007) Arthritis Rheum , vol.56 , Issue.7 , pp. 2410-2421
    • Brinkman, D.M.1    De Kleer, I.2    Ten Cate, R.3
  • 124
    • 79551673231 scopus 로고    scopus 로고
    • Restoration of the immune balance by autologous bone marrow transplantation in juvenile idiopathic arthritis
    • E. Delemarre, S. Roord, and N. Wulffraat et al. Restoration of the immune balance by autologous bone marrow transplantation in juvenile idiopathic arthritis Curr Stem Cell Res Ther 6 1 2011 Mar 3 9
    • (2011) Curr Stem Cell Res Ther , vol.6 , Issue.1 , pp. 3-9
    • Delemarre, E.1    Roord, S.2    Wulffraat, N.3
  • 125
    • 84896296738 scopus 로고    scopus 로고
    • Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the teff cell compartment
    • E.M. Delemarre, S.T. Roord, and T. van den Broek et al. Brief report: autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the teff cell compartment Arthritis Rheumatol 66 2 2014 Feb 350 356
    • (2014) Arthritis Rheumatol , vol.66 , Issue.2 , pp. 350-356
    • Delemarre, E.M.1    Roord, S.T.2    Van Den Broek, T.3
  • 126
    • 65549165389 scopus 로고    scopus 로고
    • In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses
    • H.G. Evans, N.J. Gullick, and S. Kelly et al. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses Proc Natl Acad Sci U S A 106 15 2009 Apr 14 6232 6237
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.15 , pp. 6232-6237
    • Evans, H.G.1    Gullick, N.J.2    Kelly, S.3
  • 127
    • 34047169354 scopus 로고    scopus 로고
    • Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue
    • M. Gattorno, L. Chicha, and A. Gregorio et al. Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue Rheumatology (Oxford) 46 4 2007 Apr 657 665
    • (2007) Rheumatology (Oxford) , vol.46 , Issue.4 , pp. 657-665
    • Gattorno, M.1    Chicha, L.2    Gregorio, A.3
  • 128
    • 33947168299 scopus 로고    scopus 로고
    • Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    • J.M. van Amelsfort, J.A. van Roon, and M. Noordegraaf et al. Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis Arthritis Rheum 56 3 2007 Mar 732 742
    • (2007) Arthritis Rheum , vol.56 , Issue.3 , pp. 732-742
    • Van Amelsfort, J.M.1    Van Roon, J.A.2    Noordegraaf, M.3
  • 129
    • 77957032994 scopus 로고    scopus 로고
    • Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
    • K. Nistala, S. Adams, and H. Cambrook et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment Proc Natl Acad Sci U S A 107 33 2010 Aug 17 14751 14756
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.33 , pp. 14751-14756
    • Nistala, K.1    Adams, S.2    Cambrook, H.3
  • 130
    • 85027937949 scopus 로고    scopus 로고
    • TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis
    • E. Zonneveld-Huijssoon, F. van Wjik, and S. Roord et al. TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis Ann Rheum Dis 71 10 2012 Oct 1706 1715
    • (2012) Ann Rheum Dis , vol.71 , Issue.10 , pp. 1706-1715
    • Zonneveld-Huijssoon, E.1    Van Wjik, F.2    Roord, S.3
  • 131
    • 82755182665 scopus 로고    scopus 로고
    • Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide
    • E. Zonneveld-Huijssoon, S.T. Roord, and W. de Jager et al. Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide Ann Rheum Dis 70 12 2011 Dec 2199 2206
    • (2011) Ann Rheum Dis , vol.70 , Issue.12 , pp. 2199-2206
    • Zonneveld-Huijssoon, E.1    Roord, S.T.2    De Jager, W.3
  • 132
    • 84881479557 scopus 로고    scopus 로고
    • Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus erythematosus: An international multicentre PRINTO study
    • P.M. Miettunen, A. Pistorio, and E. Palmisani et al. Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus erythematosus: an international multicentre PRINTO study Ann Rheum Dis 72 9 2013 1503 1509
    • (2013) Ann Rheum Dis , vol.72 , Issue.9 , pp. 1503-1509
    • Miettunen, P.M.1    Pistorio, A.2    Palmisani, E.3
  • 133
    • 84857697133 scopus 로고    scopus 로고
    • Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: A randomized trial
    • M.F. Bakker, J.W. Jacobs, and P.M. Welsing et al. Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial Ann Intern Med 156 5 2012 Mar 6 329 339
    • (2012) Ann Intern Med , vol.156 , Issue.5 , pp. 329-339
    • Bakker, M.F.1    Jacobs, J.W.2    Welsing, P.M.3
  • 134
    • 0036225386 scopus 로고    scopus 로고
    • Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis
    • T. Mottonen, P. Hannonen, and M. Korpela et al. Delay to institution of therapy and induction of remission using single-drug or combination-disease- modifying antirheumatic drug therapy in early rheumatoid arthritis Arthritis Rheum 46 4 2002 Apr 894 898
    • (2002) Arthritis Rheum , vol.46 , Issue.4 , pp. 894-898
    • Mottonen, T.1    Hannonen, P.2    Korpela, M.3
  • 135
    • 84870278198 scopus 로고    scopus 로고
    • Long-term results of the FIN-RACo trial; Treatment with a combination of traditional disease-modifying anti-rheumatic drugs is an excellent option in early rheumatoid arthritis
    • V. Rantalaiho, K. Puolakka, and M. Korpela et al. Long-term results of the FIN-RACo trial; treatment with a combination of traditional disease-modifying anti-rheumatic drugs is an excellent option in early rheumatoid arthritis Clin Exp Rheumatol 30 4 Suppl. 73 2012 Jul S27 S31
    • (2012) Clin Exp Rheumatol , vol.30 , Issue.4 SUPPL. 73
    • Rantalaiho, V.1    Puolakka, K.2    Korpela, M.3
  • 136
    • 84861815507 scopus 로고    scopus 로고
    • Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis
    • C.A. Wallace, E.H. Giannini, and S.J. Spalding et al. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis Arthritis Rheum 64 6 2012 Jun 2012 2021
    • (2012) Arthritis Rheum , vol.64 , Issue.6 , pp. 2012-2021
    • Wallace, C.A.1    Giannini, E.H.2    Spalding, S.J.3
  • 137
    • 80051470174 scopus 로고    scopus 로고
    • Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): A multicentre randomised open-label clinical trial
    • P. Tynjala, P. Vahasalo, and M. Tarkiainen et al. Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial Ann Rheum Dis 70 9 2011 Sep 1605 1612
    • (2011) Ann Rheum Dis , vol.70 , Issue.9 , pp. 1605-1612
    • Tynjala, P.1    Vahasalo, P.2    Tarkiainen, M.3
  • 138
    • 77950512831 scopus 로고    scopus 로고
    • Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: A randomized clinical trial
    • D. Foell, N. Wulffraat, and L.R. Wedderburn et al. Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial J Am Med Assoc 303 13 2010 Apr 7 1266 1273
    • (2010) J Am Med Assoc , vol.303 , Issue.13 , pp. 1266-1273
    • Foell, D.1    Wulffraat, N.2    Wedderburn, L.R.3
  • 139
    • 84878610261 scopus 로고    scopus 로고
    • What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?
    • J.F. Swart, S. de Roock, and N.M. Wulffraat What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis? Arthritis Res Ther 15 3 2013 May 24 213
    • (2013) Arthritis Res Ther , vol.15 , Issue.3 , pp. 213
    • Swart, J.F.1    De Roock, S.2    Wulffraat, N.M.3


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