Brief report: Anti-tumor necrosis factor α targets protein kinase B/c-akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis

Arthritis and Rheumatism

Volumn 65, Issue 12, 2013, Pages 3279-3284

  Wehrens, Ellen J ^a   Vastert, Sebastiaan J ^a   Mijnheer, Gerdien ^a   Meerding, Jenny ^a   Klein, Mark ^a   Wulffraat, Nico M ^a   Prakken, Berent J ^a   Van Wijk, Femke ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE B; STEROID; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ANTIRHEUMATIC AGENT; IMMUNOGLOBULIN G; PROTEIN KINASE C; TNFR-FC FUSION PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; TNFR FC FUSION PROTEIN;

ARTICLE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL FUNCTION; CELL ISOLATION; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TARGETING; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; JUVENILE RHEUMATOID ARTHRITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; SYNOVIAL FLUID; TREATMENT RESPONSE; ADOLESCENT; ANTAGONISTS AND INHIBITORS; ARTHRITIS, JUVENILE; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; SIGNAL TRANSDUCTION; DRUG ANTAGONISM; DRUG EFFECT;

ADOLESCENT; ANTIRHEUMATIC AGENTS; ARTHRITIS, JUVENILE; CELL PROLIFERATION; CHILD; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888994622     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38132     Document Type: Article

References (16)

1. Prakken B, Albani S, Martini A,. Juvenile idiopathic arthritis. Lancet 2011; 377: 2138-49.
2. Chimenti MS, Graceffa D, Perricone R,. Anti-TNFα discontinuation in rheumatoid and psoriatic arthritis: is it possible after disease remission? Autoimmun Rev 2011; 10: 636-40.
3. Tanaka T, Kishimoto T,. Immunotherapeutic implication of IL-6 blockade. Immunotherapy 2012; 4: 87-105.
4. Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004; 200: 277-85.
5. hi T-regulatory cells. Blood 2006; 108: 253-61.
6. McGovern JL, Nguyen DX, Notley CA, Mauri C, Isenberg DA, Ehrenstein MR,. Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum 2012; 64: 3129-38.
7. Nadkarni S, Mauri C, Ehrenstein MR,. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J Exp Med 2007; 204: 33-9.
8. 1 integrin+ and regulatory Foxp3+ T cells constitute two functionally distinct human CD4+ T cell subsets oppositely modulated by TNFα blockade. J Immunol 2007; 178: 201-10.
9. Wehrens EJ, Mijnheer G, Duurland CL, Klein M, Meerding J, van Loosdregt J, et al. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood 2011; 118: 3538-48.
10. Haufe S, Schepp C, Kuemmerle-Deschner J, Hansmann S, Rieber N, Tzaribachev N, et al. Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells. Arthritis Rheum 2011; 63: 3153-62.
11. Wehrens EJ, Prakken BJ, van Wijk F,. T cells out of control: impaired immune regulation in the inflamed joint. Nat Rev Rheumatol 2013; 9: 34-42.
12. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007; 13: 423-31.
13. Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 1998; 25: 1991-4.
14. Herrath J, Muller M, Amoudruz P, Janson P, Michaelsson J, Larsson PT, et al. The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function. Eur J Immunol 2011; 41: 2279-90.
15. +high regulatory T cell function. J Immunol 2002; 169: 6210-7.
16. Cheng J, Phong B, Wilson DC, Hirsch R, Kane LP,. Akt fine-tunes NF-κB-dependent gene expression during T cell activation. J Biol Chem 2011; 286: 36076-85.