IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA)

Clinical and Experimental Rheumatology

Volumn 28, Issue 6, 2010, Pages 912-918

  Moller J C ^a   Paul, D ^a   Ganser, G ^b   Range, U ^c   Gahr, M ^a   Kelsch, R ^d   Rosen Wolff, A ^a   Hedrich, C M ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b Abt Kinder und Jugendrheumatologie   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Cytokine; Il 10; Inflammation; Polymorphism; SNP; Still's disease; Systemic onset jia

Indexed keywords

GENOMIC DNA; INTERLEUKIN 10;

ALLELE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; CASE CONTROL STUDY; CHILD; CLINICAL TRIAL; GENETICS; HETEROZYGOTE; HOMOZYGOTE; MULTICENTER STUDY;

ADOLESCENT; ALLELES; ARTHRITIS, JUVENILE RHEUMATOID; CASE-CONTROL STUDIES; CHILD; HAPLOTYPES; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INTERLEUKIN-10; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 79952652977     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. FIFE MS, GUTIERREZ A, OGILVIE EM et al:. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res Ther 2006; 8: R148.
2. Ostlie IL, Aasland A, JOHANSSON I, FLATO B, MÖLLER A: A longitudinal followup study of physical and psychosocial health in young adults with chronic childhood arthritis. Clin Exp Rheumatol 2009; 27: 1039-46.
3. Minden K, Niewerth M, Listing J et al:. The economic burden of juvenile idiopathic arthritis-results from the German paediatric rheumatologic database. Clin Exp Rheumatol 2009; 27: 863-9.
4. th ed. Saunders, 2005.
5. Horneff G, Burgos-Vargas R: Juvenile idiopathic arthritis. Subgroup characteristics and comparisons between rheumatoid arthri-tis-like subgroups and ankylosing spondylitis-like subgroups. Clin Exp Rheumatol 2009; 27 (Suppl. 55): S131-8.
6. BORCHERS AT, SELMI C, CHEEMA G et al. Juvenile idiopathic arthritis. Autoimmun Rev 2006; 5: 279-98.
7. Fishman D, Faulds G, Jeffery R et al.: The effect of novel polymorphisms in the interIeukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-76.
8. Donn R, Alourh Z, De Benedetti F et al:. British Paediatric Rheumatology Study Group. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum 2002; 46: 2402-9.
9. Hedrich CM, Bream JH: Cell type-specific regulation of IL-10 expression in inflammation and disease. Immunol Res 2010; 47: 185-206.
10. Gibson AW, Edberg JC, Wu J et al.: Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-W production and enhance the risk of systemic lupus erythematosus. J Immunol 2001; 166: 3915-22.
11. MÖRMANN M, RIETH H, HUA TD et al:. Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used. Genes Immun 2004; 5: 246-55.
12. Salhi A, Rodrigues V JR, Santoro F et al.: Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol 2008; 180: 6139-48.
13. Oleksyk TK, Shrestha S, Truelove AL et al.:. Extended IL-10 haplotypes and their association with HIV progression to AIDS. Genes Immun 2009; 10: 309-22.
14. Fumagalli M, Pozzoli U, Cagliani R et al.: Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J Exp Med 2009; 206: 1395-408.
15. Reuss E, Fimmers R, Kruger A et al.: Differential regulation of interleukin-10 production by genetic and environmental factors - a twin study. Genes Immun 2002; 3: 407-13.
16. Ranatunga D, Hedrich CM, Wang F et al.: A human IL-10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. Proc Natl Acad Sci USA 2009; 106: 17123-8.
17. Crawley E, Kon S, Woo P: Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. Rheumatology (Oxford) 2001; 40: 574-8.
18. DE BENEDETTI F, PlGNATTI P, MASSA M et al.: Circulating levels of interleukin 1 beta and of interleukin 1 receptor antagonist in systemic juvenile chronic arthritis. Clin Exp Rheumatol 1995; 13: 779-84.
19. De Benedetti F, Massa M, Pignatti P et al.: Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. J Rheumatol 1995; 22: 1581-5.
20. De Benedetti F, Robbioni P, Massa M et al.: Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis. Clin Exp Rheumatol 1992; 10: 493-8.
21. Mourão AF, Caetano-Lopes J, Costa P et al.: Tumor necrosis factor-alpha -308 genotypes influence inflammatory activity and TNF-alpha serum concentrations in children with juvenile idiopathic arthritis. J Rheumatol 2009; 36: 837-42.
22. Ou LS, See LC, Wu CJ et al.: Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis. Clin Rheumatol 2002; 21: 52-6.
23. Mangge H, GALLISTLS, SCHAUENSTEIN K: Long-term follow-up of cytokines and soluble cytokine receptors in peripheral blood of patients with juvenile rheumatoid arthritis. J Interferon Cytokine Res 1999; 19: 1005-10.
24. Mtiraoui N, Ezzidi I, Kacem M et al.: Predictive value of interleukin-10 promoter genotypes and haplotypes in determining the susceptibility to nephropathy in type 2 diabetes patients. Diabetes Metab Res Rev 2009; 25: 57-63.
25. Farouk S, Salih MA, Musa AM et al.: Interleukin 10 gene polymorphisms and development of post Kala-Azar dermal leishmaniasis in a selected Sudanese population. Public Health Genomics 2010; 13: 362-7.
26. Donn RP, Barrett JH, Farhan A et al:. Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. Arthritis Rheum 2001; 44: 802-10.
27. OLEKSYK TK, ZHAO K, DE LA VEGA FM, GILBERT DA, O'BRIEN SJ, SMITH MW: Identifying selected regions from heterozygosity and divergence using a light-coverage genomic dataset from two human populations. PLoS One 2008; 3: e1712.
28. SHIN HD, WINKLER C, STEPHENS JC et al:. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL-10. Proc Natl Acad Sei USA 2000; 97: 14467-72.
29. Norkina O, Dolganiuc A, Shapiro T et al.: Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J Leukoc Biol 2007; 82: 752-62.
30. WILSON JN, ROCKETT K, KEATING B et al:. A hallmark of balancing selection is present at the promoter region of interleukin 10. Genes Immun 2006; 7: 680-3.
31. Franke A, Balschun T, Karlsen Th et al:. Sequence variants in IL-10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008; 40: 1319-23.
32. Jones EA, Flavell RA: Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster. J Immunol 2005; 175: 7437-46.