Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

PLoS Biology

Volumn 11, Issue 4, 2013, Pages

  Suzuki, Ryo ^a,b   Ferris, Heather A ^a   Chee, Melissa J ^a   Maratos Flier, Eleftheria ^a   Kahn, C Ronald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; SCAP PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; COGNITION; CONTROLLED STUDY; ENERGY EXPENDITURE; FACILITATION; FEEDING BEHAVIOR; GENE DELETION; GLIOSIS; HAPLOINSUFFICIENCY; HIPPOCAMPUS; INSULIN DEPENDENT DIABETES MELLITUS; LONG TERM POTENTIATION; MICROCEPHALY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PERINATAL MORTALITY; RECOGNITION; SCAP GENE; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS;

ANIMALS; BRAIN; CHOLESTEROL; COGNITION; DIABETES MELLITUS, EXPERIMENTAL; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE DELETION; HAPLOINSUFFICIENCY; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, G-PROTEIN-COUPLED; RECOGNITION (PSYCHOLOGY); SYNAPSES; SYNAPTIC TRANSMISSION;

MUS;

EID: 84876967280     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001532     Document Type: Article

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