Conformational restriction by repulsion between adjacent substituents on a cyclopropane ring: Design and enantioselective synthesis of 1-phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as potent NMDA receptor antagonists

Journal of Organic Chemistry

Volumn 61, Issue 3, 1996, Pages 915-923

  Shuto, Satoshi ^a   Ono, Shizuka ^a   Hase, Yukako ^a   Kamiyama, Noriko ^a   Takada, Hironao ^b   Yamasihita, Kanako ^b   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; MILNACIPRAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 0030040736     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9518056     Document Type: Article

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50. The author has deposited atomic coordinates for this structure with the Cambridge Crystallographic Data Centre. The coordinates can be obtained, on request, from the Director, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, UK.