Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Li, Ping ^a   Tian, Weixi ^a   Ma, Xiaofeng ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Alpha mangostin; Breast cancer cells; Cell apoptosis; Fatty acid synthase; Inhibitor

Indexed keywords

ALPHA MANGOSTIN; ANTINEOPLASTIC AGENT; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; FASN PROTEIN, HUMAN; FOCAL ADHESION KINASE 1; MANGOSTIN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE INHIBITOR; PTK2 PROTEIN, HUMAN; XANTHONE DERIVATIVE;

ABSORPTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER SURVIVAL; CELL COUNTING; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IN VITRO STUDY; LIPID STORAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MAMMARY GLAND; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

GARCINIA MANGOSTANA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; FATTY ACID SYNTHASE, TYPE I; FEMALE; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, HUMAN; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; XANTHONES;

EID: 84902681731     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-138     Document Type: Article

References (52)

1. Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 1989, 28:4523-4530. 10.1021/bi00437a001, 2669958.
2. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD, Pasternack GR. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci U S A 1994, 91:6379-6383. 10.1073/pnas.91.14.6379, 44205, 8022791.
3. Alò PL, Visca P, Trombetta G, Mangoni A, Lenti L, Monaco S, Botti C, Serpieri DE, Di Tondo U. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori 1999, 85:35-40.
4. Alò PL, Visca P, Framarino ML, Botti C, Monaco S, Sebastiani V, Serpieri DE, Di Tondo U. Immunohistochemical study of fatty acid synthase in ovarian neoplasms. Oncol Rep 2000, 7:1383-1391.
5. Shurbaji MS, Kalbfleisch JH, Thurmond TS. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol 1996, 27:917-921. 10.1016/S0046-8177(96)90218-X, 8816886.
6. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, Kolb HJ. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler 1986, 367:905-912. 10.1515/bchm3.1986.367.2.905, 3790257.
7. Ookhtens M, Kannan R, Lyon I, Baker N. Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol 1984, 247:R146-R153.
8. Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007, 7:763-777. 10.1038/nrc2222, 17882277.
9. Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000, 16:202-208. 10.1016/S0899-9007(99)00266-X, 10705076.
10. Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 2006, 66:5977-5980. 10.1158/0008-5472.CAN-05-4673, 16778164.
11. Flavin R, Peluso S, Nguyen PL, Loda M. Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol 2010, 6:551-562. 10.2217/fon.10.11, 3197858, 20373869.
12. Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 2008, 9:355-370. 10.3390/ijms9030355, 2635669, 19325754.
13. Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y. Preferential target is mitochondria in α-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004, 12:5799-5806. 10.1016/j.bmc.2004.08.034, 15498656.
14. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 2004, 90:161-166. 10.1016/j.jep.2003.09.048, 14698525.
15. Matsumoto K, Akao Y, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg Med Chem 2005, 13:6064-6069. 10.1016/j.bmc.2005.06.065, 16112579.
16. Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H. α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis 2012, 33:413-419. 10.1093/carcin/bgr291, 3271271, 22159229.
17. Quan X, Wang Y, Ma X, Liang Y, Tian W, Ma Q, Jiang H, Zhao Y. α-Mangostin induces apoptosis and suppresses differentiation of 3 T3-L1 cells via inhibiting fatty acid synthase. PLoS One 2012, 7:e33376. 10.1371/journal.pone.0033376, 3302861, 22428036.
18. Lu YY, Chen TS, Qu JL, Pan WL, Sun L, Wei XB. Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. J Biomed Sci 2009, 16:16. 10.1186/1423-0127-16-16, 2653522, 19272183.
19. Menendez JA, Vellon L, Colomer R, Lupu R. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. Int J Cancer 2005, 115:19-35. 10.1002/ijc.20754, 15657900.
20. Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, Fiore C, Xie W, Kung AL, Febbo PG, Subramanian A, Mucci L, Ma J, Signoretti S, Stampfer M, Hahn WC, Finn S, Loda M. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst 2009, 101:519-532. 10.1093/jnci/djp030, 2664091, 19318631.
21. Little JL, Kridel SJ. Fatty acid synthase activity in tumor cells. Subcell Biochem 2008, 49:169-194. 10.1007/978-1-4020-8831-5_7, 18751912.
22. Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 2002, 279:80-90. 10.1006/excr.2002.5600, 12213216.
23. Menendez JA, Lupu R, Colomer R. Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. Drug News Perspect 2005, 18:375-385. 10.1358/dnp.2005.18.6.927929, 16247515.
24. Puig T, Vázquez-Martín A, Relat J, Pétriz J, Menéndez JA, Porta R, Casals G, Marrero PF, Haro D, Brunet J, Colomer R. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast Cancer Res Treat 2008, 109:471-479. 10.1007/s10549-007-9678-5, 17902053.
25. Richardson RD, Smith JW. Novel antagonists of the thioesterase domain of human fatty acid synthase. Mol Cancer Ther 2007, 6:2120-2126. 10.1158/1535-7163.MCT-07-0187, 17620441.
26. Puig T, Turrado C, Benhamú B, Aguilar H, Relat J, Ortega-Gutiérrez S, Casals G, Marrero PF, Urruticoechea A, Haro D, López-Rodríguez ML, Colomer R. Novel inhibitors of fatty acid synthase with anticancer activity. Clin Cancer Res 2009, 15:7608-7615. 10.1158/1078-0432.CCR-09-0856, 20008854.
27. Hung SH, Shen KH, Wu CH, Liu CL, Shih YW. α-Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. J Agric Food Chem 2009, 57:1291-1298. 10.1021/jf8032683, 19178296.
28. Lee YB, Ko KC, Shi MD, Liao YC, Chiang TA, Wu PF, Shih YX, Shih YW. Alpha-mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. J Food Sci 2010, 75:H13-H23. 10.1111/j.1750-3841.2009.01407.x, 20492173.
29. Shih YW, Chien ST, Chen PS, Lee JH, Wu SH, Yin LT. Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells. Cell Biochem Biophys 2010, 58:31-44. 10.1007/s12013-010-9091-2, 20652762.
30. Watanapokasin R, Jarinthanan F, Nakamura Y, Sawasjirakij N, Jaratrungtawee A, Suksamrarn S. Effects of α-mangostin on apoptosis induction of human colon cancer. World J Gastroenterol 2011, 17:2086-2095. 10.3748/wjg.v17.i16.2086, 3084393, 21547127.
31. Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med 2011, 11:666-677. 10.2174/156652411797536679, 3237908, 21902651.
32. Menendez JA, Vellon L, Lupu R. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses 2005, 64:997-1001. 10.1016/j.mehy.2004.09.027, 15780499.
33. Jackowski S, Wang J, Baburina I. Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells. Biochim Biophys Acta 2000, 1483:301-315. 10.1016/S1388-1981(99)00203-6, 10666565.
34. Lacroix M, Leclercq G. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 2004, 83:249-289. 10.1023/B:BREA.0000014042.54925.cc, 14758095.
35. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006, 10:515-527. 10.1016/j.ccr.2006.10.008, 2730521, 17157791.
36. Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-κB. Int J Oncol 2004, 24:591-608.
37. Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W, Verhoeven G. Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun 2003, 302:898-903. 10.1016/S0006-291X(03)00265-1, 12646257.
38. Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 2005, 24:3574-3582. 10.1038/sj.onc.1208463, 15806173.
39. Sul HS, Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 1998, 18:331-351. 10.1146/annurev.nutr.18.1.331, 9706228.
40. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. The role of focal-adhesion kinase in cancer-a new therapeutic opportunity. Nat Rev Cancer 2005, 5:505-515. 10.1038/nrc1647, 16069815.
41. Zhao J, Guan JL. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 2009, 28:35-49. 10.1007/s10555-008-9165-4, 19169797.
42. Luo M, Guan JL. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett 2010, 289:127-139. 10.1016/j.canlet.2009.07.005, 2854647, 19643531.
43. Streuli CH, Edwards GM. Control of normal mammary epithelial phenotype by integrins. J Mammary Gland Biol Neoplasia 1998, 3:151-163. 10.1023/A:1018742822565, 10819524.
44. Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Ras-and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 2009, 119:252-266. 2631302, 19147981.
45. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100:57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
46. Boudreau N, Jones P. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 1999, 339:481-488. 10.1042/0264-6021:3390481, 1220180, 10215583.
47. Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res 2012, 72:1504-1517. 10.1158/0008-5472.CAN-11-4057, 3596828, 22266115.
48. Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin 2006, 56:37-47. 10.3322/canjclin.56.1.37, 16449185.
49. Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol 2008, 46:3227-3239. 10.1016/j.fct.2008.07.024, 18725264.
50. Chitchumroonchokchai C, Thomas-Ahner JM, Li J, Riedl KM, Nontakham J, Suksumrarn S, Clinton SK, Kinghorn AD, Failla ML. Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol Nutr Food Res 2013, 57:203-211. 10.1002/mnfr.201200539, 3886125, 23239542.
51. Choi YH, Han SY, Kim YJ, Kim YM, Chin YW. Absorption, tissue distribution, tissue metabolism and safety of α-mangostin in mangosteen extract using mouse models. Food Chem Toxicol 2014, 66:140-146.
52. Li L, Brunner I, Han AR, Hamburger M, Kinghorn AD, Frye R, Butterweck V. Pharmacokinetics of α-mangostin in rats after intravenous and oral application. Mol Nutr Food Res 2011, 55(Suppl 1):S67-S74.