Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies

Journal of Industrial Microbiology and Biotechnology

Volumn 41, Issue 7, 2014, Pages 1131-1143

  Du, Wenjie ^a   Huang, Di ^b   Xia, Menglei ^a   Wen, Jianping ^a,c,d   Huang, Ming ^e  

^a TIANJIN UNIVERSITY   (China)

^b NANKAI UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d SynBio Research Platform   (China)

^e DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Dynamic fed batch strategies; FK506 (tacrolimus); Gene expression; Genome shuffling; Polyketide macrolide; Precursors resistances; Streptomyces tsukubaensis

Indexed keywords

DISODIUM MALONATE; DISODIUM METHYLMALONATE; IMMUNOSUPPRESSIVE AGENT; MALONIC ACID DERIVATIVE; TACROLIMUS; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; CULTURE MEDIUM; FED BATCH CULTURE; FED BATCH FERMENTATION; GENE EXPRESSION ASSAY; GENETIC ENGINEERING; GENOME SHUFFLING; NONHUMAN; PROCESS OPTIMIZATION; REPRODUCIBILITY; STREPTOMYCES TSUKUBAENSIS; TRANSCRIPTION REGULATION; WILD TYPE; BACTERIAL GENOME; BATCH CELL CULTURE; BIOREACTOR; DNA SHUFFLING; FERMENTATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GENOMIC INSTABILITY; HIGH THROUGHPUT SCREENING; ISOLATION AND PURIFICATION; METABOLISM; STREPTOMYCES;

BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; DNA SHUFFLING; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; GENOMIC INSTABILITY; HIGH-THROUGHPUT SCREENING ASSAYS; IMMUNOSUPPRESSIVE AGENTS; MALONATES; METABOLIC NETWORKS AND PATHWAYS; STREPTOMYCES; TACROLIMUS; TRANSCRIPTION, GENETIC;

EID: 84902676517     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-014-1450-3     Document Type: Article

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