Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

Bioresource Technology

Volumn 101, Issue 12, 2010, Pages 4549-4553

  Shin, Hyun Yong ^a   Lee, Jin Young ^a   Jung, You Ree ^a   Kim, Seung Wook ^a  

^a Korea University   (South Korea)

Author keywords

Acremonium chrysogenum; Glycerol; Isopenicillin N synthase; Morphological characteristics; Transporter

Indexed keywords

ACREMONIUM; ACREMONIUM CHRYSOGENUM; CELL DIFFERENTIATION; CELL MORPHOLOGY; CEPHALOSPORIN C; EARLY-EXPONENTIAL PHASE; HYPHAL FRAGMENTS; ISOPENICILLIN N SYNTHASE; MORPHOLOGICAL CHARACTERISTIC; SYNTHASES; UP-REGULATION;

TRANSCRIPTION;

GLYCEROL;

CEPHALOSPORIN C; GLYCEROL; ISOPENICILLIN N SYNTHETASE;

ANTIBIOTICS; CELL ORGANELLE; FORMATION MECHANISM; FUNGUS; MORPHOLOGY; SPORE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIUM CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CEPHALOSPORIUM ACREMONIUM; FUNGUS HYPHAE; GENETIC TRANSCRIPTION; NONHUMAN; ORGANISMS BY CARBON SOURCE; PRIORITY JOURNAL; UPREGULATION;

ACREMONIUM; CARBON; CEPHALOSPORINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GLUCOSE; GLYCEROL; HYDROGEN-ION CONCENTRATION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ACREMONIUM CHRYSOGENUM;

EID: 77649338443     PISSN: 09608524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biortech.2010.01.095     Document Type: Article

References (33)

1. Bader F.G., Boekeloo M.K., Graham H.E., and Cagle J.W. Sterilization of oils: data to support the use of a continuous point-of-use sterilizer. Biotechnol. Bioeng. 26 (1984) 848-856
2. Behmer C.j., and Demain A.L. Further studies on carbon catabolite regulation of β-lactam antibiotic synthesis in Cephalosporium acremonium. Curr. Microbiol. 8 (1983) 107-114
3. Brakhage A.A., Sprote P., Al-Abdallah Q., Gehrke A., Plattner H., and Tuncher A. Regulation of penicillin biosynthesis in filamentous fungi. Adv. Biochem. Eng. Biotechnol. 88 (2004) 45-90
4. Chen K.C., Lin Y.H., Wu J.Y., and Hwang S.C.J. Enhancement of clavulanic acid production in Streptomyces clavuligerus with orthine feeding. Enzyme Microb. Technol. 32 (2003) 152-156
5. Christensen B., Thykaer J., and Nielsen J. Metabolic characterization of high- and low-yielding strains of Penicillium chrysogenum. Appl. Microbiol. Biotechnol. 54 (2000) 212-217
6. Galan M.I., Bonet J., Sire R., Reneaume J.M., and Plesu A.E. From residual to useful oil: revalorization of glycerine from the biodiesel synthesis. Bioresour. Technol. 100 (2009) 3775-3778
7. Hu W.S., Brana A.F., and Demain A.L. Carbon source regulation of cephem antibiotic production by resting cell of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors. Enzyme Microb. Technol. 6 (1984) 155-160
8. Jekosch K., and Kuck U. Loss of glucose repression in an Acremonium chrysogenum beta-lactam producer strain and its restoration by multiple copies of the cre1 gene. Appl. Microbiol. Biotechnol. 54 (2000) 556-563
9. Kamp M., Driessen A.J., and Konings W.N. Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi. Anton. Van Leeuw. 75 (1999) 41-78
10. Kim J.C., Lim J.S., Kim J.M., Kim C., and Kim S.W. Relationship between morphology and viscosity of the main culture broth of Cephalosporium acremonium M25. Korea-Aust. Rheol. J. 17 (2005) 15-20
11. Kim J.C., Kang S.W., Lim J.S., Song Y.S., and Kim S.W. Stimulation of cephalosporin C production by Acremonium chrysogenum M35 with fatty acid. J. Microbiol. Biotechnol. 16 (2006) 1120-1124
12. Keweloh H., Diefenbach R., and Rehm H.J. Increase of phenol tolerance of Escherichia coli by alterations of the fatty acid composition of the membrane lipids. Arch. Microbiol. 157 (1991) 49-53
13. Kosalkova K., Marcos A.T., and Martin J.F. A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum. J. Ind. Microbiol. Biotechnol. 27 (2001) 252-258
14. Lee M.S., Lim J.S., Kim C.H., Oh K.K., Yang D.R., and Kim S.W. Enhancement of cephalosporin C production by cultivation of Cephalosporium acremonium M25 using a mixture of inocula. Lett. Appl. Microbiol. 32 (2001) 402-406
15. Liepins J., Kuorelahti S., Penttila M., and Richard P. Enzymes for the NADPH-dependent reduction of dihydroxyacetone and d-glyceraldehyde and l-glyceraldehyde in the mould Hypocrea jecorina. FEBS J. 273 (2006) 4229-4235
16. Litzka O., Then Bergh K., Van den Brulle J., Steidl S., and Brakhage A.A. Transcriptional control of expression of fungal beta-lactam biosynthesis genes. Anton. Van Leeuw. 75 (1999) 95-105
17. Liu G., Casqueiro J., Banuelos O., Cardoza R.E., Gutierrez S., and Martin J.F. Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes. J. Bacteriol. 183 (2001) 1765-1772
18. Lotfy W.A. The utilization of beet molasses as a novel carbon source for cephalosporin C production by Acremonium chrysogenum: optimization of process parameters through statistical experimental designs. Bioresour. Technol. 98 (2007) 3491-3498
19. Martin J.F., and Demain A.L. Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum. Trends Biotechnol. 20 (2002) 502-507
20. Martin J.F., Casqueiro J., and Liras P. Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication. Curr. Opin. Microbiol. 8 (2005) 282-293
21. Mehta R.J., Speth J.L., and Nash C.H. Lysine stimulation of cephalosporin C synthesis. Eur. J. Appl. Microbiol. Biotechnol. 8 (1979) 177-182
22. Nijland J.G., Kovalchuk A., Berg M.A., Bovenberg R.A.L., and Driessen A.J.M. Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillin chrysogenum. Fungal Genet. Biol. 45 (2008) 1415-1421
23. Papacharilaou E., and Pisano M.A. Changes in the lipid composition of Paecilomyces persicinus P-10 M1 during growth and cephalosporin C production. Appl. Environ. Microbiol. 48 (1984) 1084-1087
24. Peters D. Raw materials. Adv. Biochem. Eng. Biotechnol. 105 (2007) 1-30
25. Queener S.W., and Ellis L.F. Differentiation of mutants of Cephalosporium acremonium in complex medium: the formation of unicellular arthrospores and their germination. Can. J. Microbiol. 21 (1975) 1981-1996
26. Revin V.V., Kasatkin S.A., Cherkasova G.N., Nikolaev V.T., Iamashkina N.S., Chabushkina M.N., Popova O.A., and Belianina V.F. Effect of the quality of fat substrate on the dynamics of fatty acid utilization during biosynthesis of cephalosporin C. Antibiot. Khimioter. 36 (1991) 5-8
27. Sambrook J., and Russell D.W. Molecular Cloning. A Laboratory Manual. third ed. (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
28. Saudagar P.S., and Singhal R.S. Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus. Bioresour. Technol. 98 (2007) 2010-2017
29. Schmitt E.K., Bunse A., Janus D., Hoff B., Friedlin E., Kurnsteiner H., and Kuck U. Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum. Eukaryotic Cell 3 (2004) 121-134
30. Schmitt E.K., Hoff B., and Kuck U. AcFKH1, a novel member of the fork head family, associates with the RFX transcription factor CPCR1 in the cephalosporin C-producing fungus Acremonium chrysogenum. Gene 342 (2004) 269-281
31. Ullan R.V., Liu G., Casqueiro J., Gutierrez S., Banuelos O., and Martin J.F. The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production. Mol. Genet. Genomics 267 (2002) 673-683
32. Usher J.J., Hughes D.W., Lewis M.A., and Chiang S.J. Determination of the rate-limiting step(s) in the biosynthetic pathways leading to penicillin and cephalosporin. J. Ind. Microbiol. 10 (1992) 157-163
33. Velasco J., Gutierrez S., Fernandez F.J., Marcos A.T., Arenos C., and Martin J.F. Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum. J. Bacteriol. 176 (1994) 985-991