Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems

Applied and Environmental Microbiology

Volumn 78, Issue 15, 2012, Pages 5093-5103

  Chen, Dandan ^a,b   Zhang, Qi ^b   Zhang, Qinglin ^b   Cen, Peilin ^a   Xu, Zhinan ^a   Liu, Wen ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; CARRIER PROTEINS; CLINICAL APPLICATION; GENETIC MANIPULATIONS; MACROCYCLICS; METHOXY GROUP; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE; POLYKETIDES; RECOMBINATION SYSTEM; SIDE-CHAINS; SITE-SPECIFIC RECOMBINATION; TRANSCRIPTIONAL ANALYSIS;

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; ENZYME ACTIVITY; GENES; GLUCOSE; SCAFFOLDS (BIOLOGY);

KETONES;

ACYL CARRIER PROTEIN; ALLYL COMPOUND; IMMUNOSUPPRESSIVE AGENT; POLYKETIDE; PRIMER DNA; TACROLIMUS;

BACTERIUM; BIOENGINEERING; ENZYME ACTIVITY; GENETIC ANALYSIS; GLUCOSE; PROTEIN; RECOMBINATION; SECONDARY METABOLITE;

ARTICLE; BIOSYNTHESIS; BIOTECHNOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DNA SEQUENCE; ESCHERICHIA COLI; GENE DUPLICATION; GENETIC RECOMBINATION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES;

ACYL CARRIER PROTEIN; ALLYL COMPOUNDS; BASE SEQUENCE; BIOSYNTHETIC PATHWAYS; BIOTECHNOLOGY; DNA PRIMERS; ESCHERICHIA COLI; GENE DUPLICATION; IMMUNOSUPPRESSIVE AGENTS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; POLYKETIDES; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; TACROLIMUS;

STREPTOMYCES TSUKUBAENSIS;

EID: 84866179988     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00450-12     Document Type: Article

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