Two transcriptional regulators GlnR and GlnRII are involved in regulation of nitrogen metabolism in Streptomyces coelicolor A3(2)

Molecular Microbiology

Volumn 46, Issue 2, 2002, Pages 331-347

  Fink, D ^a   Weissschuh N ^a   Reuther, J ^a   Wohlleben, W ^a   Engels, Anke ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BACTERIAL PROTEIN; DNA BINDING PROTEIN; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; ISOENZYME; MUTANT PROTEIN; NUCLEOTIDYLTRANSFERASE; PROTEIN GLNR; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CELL DIFFERENTIATION; CULTURE MEDIUM; ENZYME ACTIVITY; EUKARYOTE; GENE EXPRESSION REGULATION; GENE MAPPING; GENETIC CODE; GENETIC TRANSCRIPTION; MOLECULAR RECOGNITION; MORPHOLOGY; NITROGEN METABOLISM; NONHUMAN; NUCLEASE PROTECTION ASSAY; OPERON; PHENOTYPE; PRIORITY JOURNAL; PROKARYOTE; PROMOTER REGION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STREPTOMYCES COELICOLOR; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GLUTAMATE-AMMONIA LIGASE; MOLECULAR SEQUENCE DATA; NITROGEN; OPERATOR REGIONS (GENETICS); PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; STREPTOMYCES; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA; STREPTOMYCES; STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

EID: 18744383916     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.03150.x     Document Type: Article

References (70)

1. Altenbuchner, J., Viell, P., and Pelltier, I. (1992) Positive selection vectors based on palindromic DNA sequences. Methods Enzymol 216: 457-466.
2. Aoyama, T., and Oka, A. (1990) A common mechanism of transcriptional activation by the three positive regulators, VirG, PhoB and OmpR. FEBS Lett 263: 1-4.
3. Behrmann, I., Hillemann, D., Pühler, A., Strauch, E., and Wohlleben, W. (1990) Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine. J Bacteriol 172: 5326-5334.
4. Bierman, M., Logan, R., O'Brien, K., Seno, E.T., Rao, R.N., and Schoner, B.E. (1992) Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116: 43-49.
5. Birck, C., Mourey, L., Gouet, P., Fabry, B., Schumacher, J., Rousseau, P., and Samama, J.P. (1999) Conformational changes induced by phosphorylation of the FixJ receiver domain. Structure 7: 1505-1515.
6. Brown, J.R., Masuchi, Y., Robb, F.T., and Doolittle, W.F. (1994) Evolutionary relationships of bacterial and archaeal glutamine synthetase genes. J Mol Evol 38: 566-576.
7. de Bruijn, F., Rossbach, S., Schneider, M., Ratete, P., Messmer, S., Szeto, W., et al. (1989) Rhizobium meliloti 1020 has three differentially regulated loci involved in glutamine biosynthesis none of which is essential for symbiotic nitrogen fixation. J Bacteriol 171: 1673-1682.
8. Bullock, W.O., Fernandez, J.M., and Short, J.M. (1987) XL1-Blue, a high efficiency plasmid transforming recA Escherichia coli strain with beta galactosidase selection. Biotechniques 5: 376-378.
9. Buratowski, S., and Chodosh, L.A. (1996) Mobility shift DNA-binding assay using gel electrophoresis. In Current Protocols in Molecular Biology. Ausabel, F. et al. (eds). New York: John Wiley and Sons, 12.2.1-12.2.11.
10. Carlson, T.A., Martin, G.B., and Chelm, B.K. (1987) Differential transcription of the two glutamine synthetase genes of Bradyrhizobium japonicum. J Bacteriol 169: 5861-5866.
11. Chater, K.F., and Losick, R. (1996) The mycelial-life style of Streptomyces coelicolor A3(2) and its relatives. In Bacteria as Multicellular Organisms. Shapiro, J.H., and Dworkin, M. (eds). New York: Oxford University Press, pp. 93-114.
12. Darrow, R.A., and Knotts, R.R. (1977) Two forms of glutamine synthetase in free-living root-nodule bacteria. Biochem Biophys Res Commun 78: 554-559.
13. Delgado, J., Forst, S., Harlocker, S., and Inouye, M. (1993) Identification of a phosphorylation site and functional analysis of conserved aspartic acid residues of OmpR, a transcriptional activator of ompF and ompC in Escherichia coli. Mol Microbiol 10: 1037-1047.
14. Edmunds, J., Noridge, N., and Benson, D. (1987) The actinorhizal root nodule symbiont Frankia sp. strain Cpi1 has two glutamine synthetases. Proc Natl Acad Sci USA 84: 6126-6150.
15. Evans, C.G.T., Herbet, D., and Tempest, D.W. (1970) The continuous culture of microorganisms. 2. Construction of a chemostat. In Methods in Microbiology, Vol. 2. Norris, J.R., and Ribbons, D.W. (eds). London: Academic Press, pp. 277-327.
16. Feng, J., Goss, T.J., Bender, R.A., and Ninfa, A.J. (1995) Activation of transcription initiation from the nac promoter of Klebsiella aerogenes. J Bacteriol 177: 5523-5534.
17. Fink, D., Falke, D., Wohlleben, W., and Engels, A. (1999) Nitrogen metabolism in Streptomyces coelicolor A3(2): Modification of glutamine synthetase I by an adenylyltransferase. Microbiology 145: 2313-2322.
18. Fisher, S.H. (1999) Regulation of nitrogen metabolism in Bacillus subtilis: Vive la différence! Mol Microbiol 32: 223-232.
19. Fisher, S.H., and Wray, L.V., Jr (1989) Regulation of glutamine synthetase in Streptomyces coelicolor. J Bacteriol 171: 2378-2383.
20. Flett, F., Mersinias, V., and Smith, C.P. (1997) High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol Lett 155: 223-229.
21. Harlocker, S.L., Bergstrom, L., and Inouye, M. (1995) Tandem binding of six OmpR proteins to the ompF upstream regulatory sequence of Escherichia coli. J Biol Chem 270: 26849-26856.
22. Hesketh, A., Fink, D., Gust, B., Rexer, H.-U., Scheel, B., Chater, K., et al. (2002) The GlnD and GlnK homologues of Streptomyces coelicolor A3(2) are functionally dissimilar to their nitrogen regulatory system counterparts from enteric bacteria. Mol Microbiol 46: 319-330.
23. Hillemann, D., Dammann, T., Hillemann, A., and Wohlleben, W. (1993) Genetic and biochemical characterization of the two glutamine synthetases GSI and GSII of the phosphinothricyl-alanyl-alanine producer, Streptomyces viridochromogenes Tü94. J Gen Microbiol 139: 1773-1783.
24. Hodgson, D.A. (2000) Primary metabolism and its control in streptomycetes: A most unusual group of bacteria. In Advances in Microbial Physiology, Vol. 42. Poole, R.K. (ed). London: Academic Press, pp. 47-238.
25. Itou, H., and Tanaka, I. (2001) The OmpR-family of proteins: Insight into the tertiary structure and functions of two component regulator proteins. J Biochem 129: 343-350.
26. Karandiker, A., Sharples, G.P., and Hobbs, G. (1997) Differentiation of Streptomyces coelicolor A3(2) under nitrate limited conditions. Microbiology 143: 3581-3590.
27. Kelemen, G.H., Brown, G.L., Kormanec, J., Potková, L., Chater, K.F., and Buttner, M.J. (1996) The position of the sigma factor genes, whiG and sigF, in the hierarchy controlling the development in spore chains in the aerial hyphae of Streptomyces coelicolor A3(2). Mol Microbiol 21: 593-603.
28. Kieser, T., Bibb, M.J., Buttner, M., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces Genetics. Norwich: The John Innes Foundation.
29. Kondo, H., Nakagawa, A., Nishihira, J., Nishimura, Y., Mizuno, T., and Tanaka, I. (1997) Escherichia coli positive regulator OmpR has a large loop structure at the putative RNA polymerase interaction site. Nature Struct Biol 4: 28-31.
30. Kumada, Y., Anzai, H., Takano, E., Murakami, T., Hara, O., Itoh, R., et al. (1988) The bialaphos resistance gene (bar) plays a role in both self-defense and bialaphos biosynthesis in Streptomyces hygroscopicus. J Antibiot 41: 1838-1845.
31. Kumada, Y., Takano, E., Nagaoka, K., and Thompson, C.J. (1990) Streptomyces hygroscopicus has two glutamine synthetase genes. J Bacteriol 172: 5343-5351.
32. Kustu, S., Hirschmann, J., Burton, D., Jelesko, J., and Meeks, J.C. (1984) Covalent modification of bacterial glutamine synthetase: Physiological significance. Mol Gen Genet 197: 309-317.
33. MacNeil, D.J., Gewain, K.M., Ruby, C.L., Dezeny, G., Gibbons, P.H., and MacNeil, T. (1992) Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111: 61-68.
34. Magasanik, B. (1996) Regulation of nitrogen utilization. In Escherichia coli and Salmonella: Cellular and Molecular Biology. Neidhardt, F.C., Curtiss, I.R., Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., et al. (eds). Washington, DC: American Society for Microbiology Press, pp. 1344-1356.
35. Martinez-Hackert, E., and Stock, A.M. (1997) Structural relationships in the OmpR family of winged-helix transcription factors. J Mol Biol 269: 301-312.
36. Merrick, M.J., and Edwards, R.A. (1995) Nitrogen control in bacteria. Microbiol Rev 59: 604-622.
37. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
38. Mizuno, T., and Mizushima, S. (1990) Signal transduction and gene regulation through the phosphorylation of two regulatory components: The molecular basis for the osmotic regulation of the porin genes. Mol Microbiol 4: 1077-1082.
39. Mizuno, T., and Tanaka, I. (1997) Structure of the DNA-binding domain of the OmpR family of response regulators. Mol Microbiol 24: 665-670.
40. Muth, G., Nußbaumer, B., Wohlleben, W., and Pühler, A. (1989) A vector system with temperature-sensitive replication for gene disruption and mutational cloning in streptomycetes. Mol Gen Genet 219: 341-348.
41. Nguyen, K.T., Nguyen, L.T., and Behal, V. (1994) What type of glutamine synthetase is important for Streptomyces coelicolor A3(2) under nitrogen-limited growth conditions? Biotech Lett 16: 1027-1030.
42. Oh, S.-H., and Chater, K. (1997) Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3(2): Possible relevance to other organisms. J Bacteriol 179: 122-127.
43. Okanishi, M., Suzuki, K., and Umezawa, H. (1974) Formation and reversion of streptomycetes protoplasts: Cultural condition and morphological study. J Gen Microbiol 80: 389-400.
44. Pratt, L.A., and Silhavy, T.J. (1995) Identification of base pairs important for OmpR-DNA interaction. Mol Microbiol 17: 565-573.
45. Reitzer, L.J. (1996) Sources of nitrogen and their utilization. In Escherichia coli and Salmonella: Cellular and Molecular Biology. Neidhardt, F.C., Curtiss, I.R., Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., et al. (eds). Washington, DC: American Society for Microbiology Press, pp. 380-390.
46. Rossbach, S., Schell, J., and De Bruijn, F.J. (1987) The ntrC gene of Agrobacterium tumefaciens C58 controls glutamine synthetase (GSII) activity, growth on nitrate and chromosomal but not Ti-encoded arginine catabolism pathways. Mol Gen Genet 209: 419-426.
47. Sanders, D.A., Gillece-Castro, B.L., Stock, A.M., Burlingame, A.L., and Koshland, D.E., Jr (1989) Identification of the site of phosphorylation of the chemotaxis response regulator CheY. J Biol Chem 264: 21770-21778.
48. Schwartz, D., Alijah, R., Nußbaumer, B., Pelzer, S., and Wohlleben, W. (1996) The peptide synthetase gene phsA from Streptomyces viridochromogenes is not juxtaposed with other genes involved in nonribosomal biosynthesis of peptides. Appl Environ Microbiol 62: 570-577.
49. Shiau, S.P., Schneider, B.L., Gu, W., and Reitzer, L.J. (1992) Role of nitrogen regulator I (NtrC), the transcriptional activator of glnA. Enteric bacteria, in reducing expression of glnA during nitrogen-limited growth. J Bacteriol 174: 179-185.
50. Spinosa, M., Riccio, A., Mandrich, L., Manco, G., Lamberti, A., Iaccarino, M., et al. (2000) Inhibition of glutamine synthetase II expression by the product of the gstl gene. Mol Microbiol 37: 443-452.
51. Strauch, E., Wohlleben, W., and Pühler, A. (1988) Cloning of a phosphinotricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Streptomyces lividans and Escherichia coli. Gene 63: 65-74.
52. Sun, J., Kelemen, G.H., Fernandoz-Abalos, J.M., and Bibb, M.J. (1999) Green fluorescent protein as a reporter for spatial and temporal gene expression in Streptomyces coelicolor A3(2). Microbiology 145: 2221-2227.
53. Thompson, C.J., Ward, J.M., and Hopwood, D.A. (1980) DNA cloning in Streptomyces: Resistance genes from antibiotic-producing species. Nature 286: 525-527.
54. Thompson, J.D., Higgins, D.G., and Gibson, T.J. (1994) Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 11: 4673-4680.
55. Torriani, A. (1990) From cell membrane to nucleotides: The phosphate regulon in Escherichia coli. Bioessays 12: 371-376.
56. Vara, J., Lewandowska-Skarbek, M., Wang, Y.-G., Donadio, S., and Hutchinson, C.R. (1989) Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J Bacteriol 171: 5872-5881.
57. Vieira, J., and Messing, J. (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19: 259-268.
58. Voelker, F., and Altaba, S. (2001) Nitrogen source governs the patterns of growth and pristinamycin production in Streptomyces pristinaespiralis. Microbiology 147: 2447-2459.
59. Volff, J.N., Eichenseer, C., Viell, P., Piendl, W., and Altenbuchner, J. (1996) Nucleotide sequence and role in DNA amplification of the direct repeats composing the amplifiable element AUD1 of Streptomyces lividans 66. Mol Microbiol 21: 1037-1047.
60. Volz, K., and Matsumara, P. (1991) Crystal structure of Escherichia coli CheY refined at 1.7 angstrom resolution. J Biol Chem 266: 15511-15519.
61. Weißschuh, N., Fink, D., Vierling, S., Bibb, M., Wohlleben, W., and Engels, A. (2000) Transcriptional analysis of the glutamine synthetase II and two upstream genes in Streptomyces coelicolor A3(2). Mol Gen Genet 264: 461-469.
62. Welch, M., Chinardet, N., Mourey, L., Brick, C., and Samama, J.P. (1998) Structure of the CheY-binding domain of histidine kinase CheA in complex with CheY. Nature Struct Biol 5: 25-29.
63. Wietzorrek, A., and Bibb, M. (1997) A novel family of proteins that regulate antibiotic production in Streptomyces appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 25: 1177-1184.
64. Winans, S.C. (1991) An Agrobacterium two-component regulatory system for the detection of chemicals released from plant wounds. Mol Microbiol 5: 2345-2350.
65. Wohlleben, W., and Muth, G. (1993) Streptomyces plasmid vectors. In Plasmids. Hardy, K.G. (ed.). Oxford: IRL Press at Oxford University Press, pp. 147-175.
66. Wray, L.V., and Fisher, S.H. (1988) Cloning and nucleotide sequence of the Streptomyces coelicolor gene encoding glutamine synthetase. Gene 71: 247-255.
67. Wray, L.V., and Fisher, S.H. (1991) Identification and cloning of the glnR locus, which is required for transcription of the glnA gene in Streptomyces coelicolor. J Bacteriol 173: 7351-7360.
68. Wray, L.V., and Fisher, S.H. (1993) The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators. Gene 130: 145-150.
69. Wray, L.V., Zalieckas, J.M., and Fisher, S.H. (2001) Bacillus subtilis glutamine synthetase controls gene expression through a protein-protein interaction with transcription factor TnrA. Cell 107: 427-435.
70. Yanisch-Perron, C., Vieira, J., and Messing, J. (1985) Improved M13 phage cloning vectors and host strains. Nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103-119.