Ascomycin and FK506: Pharmacology and therapeutic potential as anticonvulsants and neuroprotectants

CNS Neuroscience and Therapeutics

Volumn 14, Issue 1, 2008, Pages 36-46

  Sierra Paredes, Germán ^a   Sierra Marcuño, Germán ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Anticonvulsants; Ascomycin; Calcineurin; Epilepsy; FK506; Neuroprotection

Indexed keywords

4 AMINOBUTYRIC ACID; ARGININE; ASCOMYCIN; CYCLOSPORIN A; DIZOCILPINE; IMMUNOSUPPRESSIVE AGENT; L 685818; LATRUNCULIN A; N(G) NITROARGININE METHYL ESTER; PENTETRAZOLE; PICROTOXIN; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; BINDING PROTEIN; CALCINEURIN; CALCINEURIN INHIBITOR; GLUTAMATE RECEPTOR; IMMUNOPHILIN; KAINIC ACID; PILOCARPINE; PROTEIN FKBP12; TRANSFORMING GROWTH FACTOR; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANTICONVULSANT ACTIVITY; AREA UNDER THE CURVE; BRAIN DAMAGE; BRAIN ISCHEMIA; CELL ACTIVATION; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; ENZYME INHIBITION; EPILEPTOGENESIS; HUMAN; HYPERGLYCEMIA; HYPERKALEMIA; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; NEPHROTOXICITY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PHOSPHORYLATION; RAT; REVIEW; SEIZURE; SKIN INFLAMMATION; DIABETOGENESIS; DRUG EXCRETION; DRUG PROTEIN BINDING; EPILEPTIC STATE; GABAERGIC TRANSMISSION; GASTROINTESTINAL SYMPTOM; HIPPOCAMPUS; KINDLING; MIDDLE CEREBRAL ARTERY OCCLUSION; SIDE EFFECT; ANIMAL; CHEMISTRY;

ANIMALS; ANTICONVULSANTS; HUMANS; NEUROPROTECTIVE AGENTS; TACROLIMUS;

EID: 47249120477     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2008.00036.x     Document Type: Review

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