Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in streptomyces sp. strain KCTC 11604BP

Applied and Environmental Microbiology

Volumn 78, Issue 7, 2012, Pages 2249-2255

  Mo, Sang Joon ^a   Yoo, Young Ji ^b   Ban, Yeon Hee ^b   Lee, Sung Kwon ^a   Kim, Eunji ^b   Suh, Joo Won ^a   Yoon, Yeo Joon ^b  

^a Myong Ji University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC GENE; BIOSYNTHETIC GENE CLUSTER; GENE PRODUCTS; MACROLIDES; MUTANT STRAIN; OVER-EXPRESSION; POLYKETIDES; REGULATORY GENES; REGULATORY PROTEIN; SEQUENCE ANALYSIS; STRAIN IMPROVEMENT; STREPTOMYCES SP; TRANSCRIPTION LEVEL; TRANSCRIPTIONAL REGULATOR; WILD TYPES; WILD-TYPE STRAIN;

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CLONING; ENCODING (SYMBOLS); GENES; KETONES;

TRANSCRIPTION;

BACTERIAL PROTEIN; IMMUNOSUPPRESSIVE AGENT; REPRESSOR PROTEIN; TACROLIMUS; TRANSCRIPTION FACTOR;

BACTERIUM; CLUSTER ANALYSIS; COEXISTENCE; GENE EXPRESSION; MUTATION; PROTEIN;

ARTICLE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MULTIGENE FAMILY; MUTATION; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; IMMUNOSUPPRESSIVE AGENTS; MULTIGENE FAMILY; MUTATION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOMYCES; TACROLIMUS; TRANSCRIPTION FACTORS;

STREPTOMYCES SP.;

EID: 84861163737     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.06766-11     Document Type: Article

References (39)

1. Arias P, Fernández-Moreno MA, Malpartida F. 1999. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J. Bacteriol. 181:6958-6968.
2. Bibb MJ. 2005. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8:208 -215.
3. Bierman M, et al. 1992. Plasmids cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116:43- 49.
4. Chater KF, Chandra G. 2008. The use of the rare UUA codon to define "expression space" for genes involved in secondary metabolism, development and environmental adaptation in streptomyces. J. Microbiol. 46:1-11.
5. Chen L, et al. 2008. Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl. Microbiol. Biotechnol. 80:277-286.
6. De Schrijver A, De Mot R. 1999. A subfamily of MalT-related ATPdependent regulator in the LuxR family. Microbiology 145:1287-1288.
7. Gold BG. 2000. Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opin. Invest. Drugs 9:2331-2342.
8. Goranovic D, et al. 2010. Origin of the allyl group in FK506 biosynthesis. J. Biol. Chem. 285:14292-14300.
9. He W, Lei J, Liu Y, Wang Y. 2008. The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. Arch. Microbiol. 189:501-510.
10. Henikoff S, Haughn GW, Calvo JM, Wallace JC. 1988. A large family of bacterial activator proteins. Proc. Natl. Acad. Sci. U. S. A. 85:6602- 6606.
11. Horbal L, et al. 2010. Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Appl. Microbiol. Biotechnol. 85:1069 -1079.
12. Hur YA, Choi S-S, Sherman DH, Kim ES. 2008. Identification of TcmN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. Microbiology 154:2912-2919.
13. Jeon H-G, Seo J, Lee MJ, Han K, Kim ES. 2011. Analysis and functional expression of NPP pathway-specific regulatory genes in Pseudonocardia autotrophica. J. Ind. Microbiol. Biotechnol. 38:573-579.
14. Jung WS, et al. 2008. Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae. Appl. Environ. Microbiol. 74:1972-1979.
15. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA. 2000. Practical Streptomyces genetics. John Innes Foundation, Norwich, United Kingdom.
16. Kino T, et al. 1987. FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot. (Tokyo) 40:1249 -1255.
17. Kitani S, Ikeda H, Sakamoto T, Noguchi S, Nihira T. 2009. Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. Appl. Microbiol. Biotechnol. 82:1089 -1096.
18. Kölling R, Lother H. 1985. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli. J. Bacteriol. 164: 310-315.
19. Kuscer E, et al. 2007. Role of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. J. Bacteriol. 189: 4756-4763.
20. Leskiw BK, Lawlor EJ, Fernandez-Abalos LM, Chater KF. 1991. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative Streptomyces mutants. Proc. Natl. Acad. Sci. U. S. A. 88:2461-2465.
21. MacNeil DJ, et al. 1992. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111:61- 68.
22. Martin JF, Liras P. 2010. Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr. Opin. Microbiol. 13:263-273.
23. Mo S, Ban YH, Park JW, Yoo YJ, Yoon YJ. 2009. Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor. J. Ind. Microbiol. Biotechnol. 36: 1473-1482.
24. Mo S, et al. 2011. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J. Am. Chem. Soc. 133:976 -985.
25. Motamedi H, Cai SJ, Shafiee A, Elliston KO. 1997. Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. Eur. J. Biochem. 244:74 - 80.
26. Motamedi H, et al. 1996. Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J. Bacterial. 178:5243-5248.
27. Oliynyk M, et al. 2003. Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. Mol. Microbiol. 49:1179 -1190.
28. Parsons WH, Sigal NH, Wyvratt MJ. 1993. FK506 a novel immunosuppressant. Ann. N. Y. Acad. Sci. 685:22-36.
29. Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR. 2005. Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. Appl. Environ. Microbiol. 71:4862- 4871.
30. Richet E, Raibaud O. 1989. MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator. EMBO J. 8:981-987.
31. Sambrook J, Russell DW. 2001. Molecular cloning. a laboratory manual, 3rd ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. Schmitt-John T, Engels JE. 1992. Promoter constructions for efficient secretion expression in Streptomyces lividans. Appl. Microbiol. Biotechnol. 36:493- 498.
33. Sheldon PJ, Busarow SB, Hutchinson CR. 2002. Mapping the DNAbinding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI. Mol. Microbiol. 44:449- 460.
34. Shirling EB, Gottlieb D. 1966. Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16:313-340.
35. Sierra-Paredes G, Sierra-Marcuno G. 2008. Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectabts. CNS Neurosci. Ther. 14:36-46.
36. Stratigopoulos G, Cundliffe E. 2002. Inactivation of a transcriptional repressor during empirical improvement of the tylosin producer, Streptomyces fradiae. J. Ind. Microbiol. Biotechnol. 28:219 -224.
37. Takano E. 2006. Gamma-butyrolactones: Streptomyces signaling molecules regulating antibiotic production and differentiation. Curr. Opin. Microbiol. 9:287-294.
38. Wilson DJ, Xue Y, Reynolds KA, Sherman DH. 2001. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Bacteriol. 183:3468 -3475.
39. Wu K, Chung L, Revill WP, Katz L, Reeves CD. 2000. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251:81-90.