Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy

Human Molecular Genetics

Volumn 23, Issue 13, 2014, Pages 3552-3565

  Tohnai, Genki ^a   Adachi, Hiroaki ^a   Katsuno, Masahisa ^a   Doi, Hideki ^a   Matsumoto, Shinjiro ^a   Kondo, Naohide ^a   Miyazaki, Yu ^a   Iida, Madoka ^a   Nakatsuji, Hideaki ^a   Qiang, Qiang ^a   Ding, Ying ^a   Watanabe, Hirohisa ^a   Yamamoto, Masahiko ^b   Ohtsuka, Kenzo ^c   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c CHUBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CHAPERONE; HEAT SHOCK COGNATE PROTEIN 70; NUCLEAR FACTOR; NUCLEAR FACTOR YA; PAEONIFLORIN; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; AR PROTEIN, HUMAN; GLUCOSIDE; TERPENE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; HUMAN TISSUE; KENNEDY DISEASE; MALE; MOTONEURON; MOUSE; NONHUMAN; PAEONIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPINAL MUSCULAR ATROPHY; THERAPY EFFECT; UPREGULATION; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; IMMUNOHISTOCHEMISTRY; PHYSIOLOGY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; CELL SURVIVAL; GLUCOSIDES; IMMUNOHISTOCHEMISTRY; MICE; MONOTERPENES; MUSCULAR ATROPHY, SPINAL; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN;

EID: 84902354701     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu066     Document Type: Article

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