Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor

Brain

Volumn 134, Issue 7, 2011, Pages 1943-1958

  Huang, Shanshan ^a   Ling, Joseph J ^a   Yang, Su ^a   Li, Xiao Jiang ^a   Li, Shihua ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

animal models; ataxia; neurodegeneration; polyglutamine; transcription factor

Indexed keywords

BRAIN PROTEIN; CHAPERONE; GLUTAMINE; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN A5; NESTIN; NUCLEAR FACTOR Y; POLYGLUTAMINE; SPINOCEREBELLAR ATAXIA 17 PROTEIN; TATA BINDING PROTEIN; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DEGENERATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; MUTATIONAL ANALYSIS; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PURKINJE CELL;

AGE FACTORS; ANIMALS; BODY WEIGHT; BRAIN; CCAAT-BINDING FACTOR; CELL LINE, TRANSFORMED; CHROMATIN IMMUNOPRECIPITATION; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDES; TATA-BOX BINDING PROTEIN; TRANSFECTION;

EID: 79959695334     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr146     Document Type: Article

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