Molecular pathogenesis of protein misfolding diseases: Pathological molecular environments versus quality control systems against misfolded proteins

Journal of Biochemistry

Volumn 146, Issue 6, 2009, Pages 751-756

  Naiki, Hironobu ^a,b   Nagai, Yoshitaka ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

2 microglobulin related amyloidosis; Chaperones; Polyglutamine diseases; Protein degradation system; Protein misfolding diseases

Indexed keywords

AMYLOID PROTEIN; APOLIPOPROTEIN E; BETA 2 MICROGLOBULIN; CHAPERONE; COLLAGEN TYPE 1; FATTY ACID; GELDANAMYCIN; GLYCEROL; GLYCOSAMINOGLYCAN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 105; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 84; HEPARIN; HUNTINGTIN; LIPID; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPID; MONOMER; MUTANT PROTEIN; POLYGLUTAMINE; PREALBUMIN; PROTEASOME; PROTEOGLYCAN; TANESPIMYCIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMYLOIDOSIS; AUTOPHAGY; BETA SHEET; CATALYSIS; CONFORMATIONAL TRANSITION; DEGENERATIVE DISEASE; DENTATORUBROPALLIDOLUYSIAN ATROPHY; DISEASE COURSE; DRUG TARGETING; EXTRACELLULAR SPACE; FIBER; HUMAN; HUNTINGTON CHOREA; KENNEDY DISEASE; LYSOSOME; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; PROTEIN QUALITY; PROTEIN STABILITY; QUALITY CONTROL; REGULATORY MECHANISM; SHORT SURVEY; SPINOCEREBELLAR DEGENERATION;

AMYLOIDOSIS; BETA 2-MICROGLOBULIN; HUMANS; NEURODEGENERATIVE DISEASES; PROTEOSTASIS DEFICIENCIES; QUALITY CONTROL;

EID: 71949086967     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp119     Document Type: Short Survey

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