Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor

Open Biology

Volumn 2, Issue JANUARY, 2012, Pages

  Metcalfe, Clive ^a   Cresswell, Peter ^b   Barclay, A Neil ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD132; Cytokine receptor; Disulfides; IL 2; Membrane proteins; Redox

Indexed keywords

CYTOKINE RECEPTOR; DISULFIDE; IL2 PROTEIN, HUMAN; IL2RG PROTEIN, HUMAN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR GAMMA; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL; ARTICLE; CD132; CHEMICALLY INDUCED DISORDER; CHO CELL; COMMON VARIABLE IMMUNODEFICIENCY; CRICETULUS; DRUG EFFECT; GENETIC DISORDER; GENETICS; HAMSTER; HUMAN; IL-2; IMMUNOLOGY; INFLAMMATION; MISSENSE MUTATION; MOUSE; PATHOLOGY; RAT; REDOX; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

CD132; CYTOKINE RECEPTOR; DISULFIDES; IL-2; MEMBRANE PROTEINS; REDOX;

AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; COMMON VARIABLE IMMUNODEFICIENCY; CRICETINAE; CRICETULUS; DISULFIDES; GENETIC DISEASES, INBORN; HUMANS; INFLAMMATION; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; INTERLEUKIN-2; LIPOPOLYSACCHARIDES; MICE; MUTATION, MISSENSE; RATS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84864226064     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.110036     Document Type: Article

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