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Volumn 9, Issue 4, 2014, Pages 371-378

Emerging clinical issues related to management of multiorgan comorbidities and polypharmacy

Author keywords

aging biomarkers; anti inflammatory immune modulatory drugs; benefit risk ratio; comorbidities; HIV management

Indexed keywords

ACETYLSALICYLIC ACID; ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE ANTIBODY; HERBACEOUS AGENT; HISTONE DEACETYLASE INHIBITOR; HYDROXYCHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOMODULATING AGENT; INTEGRASE INHIBITOR; INTERLEUKIN 6 ANTIBODY; LEFLUNOMIDE; MESSENGER RNA; METHOTREXATE; MITOCHONDRIAL DNA; NON PRESCRIPTION DRUG; PREBIOTIC AGENT; PROBIOTIC AGENT; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RESVERATROL; RNA DIRECTED DNA POLYMERASE INHIBITOR; SEVELAMER; UNINDEXED DRUG; VACCINE; VALGANCICLOVIR; VITAMIN D;

EID: 84902299892     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000068     Document Type: Review
Times cited : (11)

References (72)
  • 1
    • 84875655420 scopus 로고    scopus 로고
    • Management of human immunodeficiency virus infection in advanced age
    • Greene M, Justice AC, Lampiris HW, Valcour V. Management of human immunodeficiency virus infection in advanced age. JAMA 2013; 309:1397-1405.
    • (2013) JAMA , vol.309 , pp. 1397-1405
    • Greene, M.1    Justice, A.C.2    Lampiris, H.W.3    Valcour, V.4
  • 3
    • 84892173855 scopus 로고    scopus 로고
    • Cause-specific mortality among HIVinfected individuals, by CD4 cell count at HAART initiation, compared with HIV-uninfected individuals
    • Wada N, Jacobson LP, Cohen M, et al. Cause-specific mortality among HIVinfected individuals, by CD4 cell count at HAART initiation, compared with HIV-uninfected individuals. AIDS 2014; 28:257-265.
    • (2014) AIDS , vol.28 , pp. 257-265
    • Wada, N.1    Jacobson, L.P.2    Cohen, M.3
  • 4
    • 84863838413 scopus 로고    scopus 로고
    • Lessons learned from the first wave of aging with HIV
    • Justice AC, Braithwaite RS. Lessons learned from the first wave of aging with HIV. AIDS 2012; 26 (Suppl 1):S11-S18.
    • (2012) AIDS , vol.26 , Issue.SUPPL. 1
    • Justice, A.C.1    Braithwaite, R.S.2
  • 5
    • 84886790685 scopus 로고    scopus 로고
    • The end of AIDS: HIV infection as a chronic disease
    • Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet 2013; 382:1525-1533.
    • (2013) Lancet , vol.382 , pp. 1525-1533
    • Deeks, S.G.1    Lewin, S.R.2    Havlir, D.V.3
  • 6
    • 84882450447 scopus 로고    scopus 로고
    • Omics technologies and the study of human ageing
    • Valdes AM, Glass D, Spector TD. Omics technologies and the study of human ageing. Nat Rev Genet 2013; 14:601-607.
    • (2013) Nat Rev Genet , vol.14 , pp. 601-607
    • Valdes, A.M.1    Glass, D.2    Spector, T.D.3
  • 7
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120:437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 8
    • 34548713556 scopus 로고    scopus 로고
    • Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
    • Caron M, Auclair M, Donadille B, et al. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell Death Differ 2007; 14:1759-1767.
    • (2007) Cell Death Differ , vol.14 , pp. 1759-1767
    • Caron, M.1    Auclair, M.2    Donadille, B.3
  • 9
    • 77953023624 scopus 로고    scopus 로고
    • Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging
    • Ragnauth CD, Warren DT, Liu Y, et al. Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation 2010; 121:2200-2210.
    • (2010) Circulation , vol.121 , pp. 2200-2210
    • Ragnauth, C.D.1    Warren, D.T.2    Liu, Y.3
  • 10
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16:238-246.
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 12
    • 84864276304 scopus 로고    scopus 로고
    • HIV and aging: State of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group
    • High KP, Brennan-Ing M, Clifford DB, et al. HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. J Acquir Immune Defic Syndr 2012; 60 (Suppl 1):S1-S18.
    • (2012) J Acquir Immune Defic Syndr , vol.60 , Issue.SUPPL. 1
    • High, K.P.1    Brennan-Ing, M.2    Clifford, D.B.3
  • 13
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5:e203.
    • (2008) PLoS Med , vol.5
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3
  • 14
    • 79952335046 scopus 로고    scopus 로고
    • Plasma levels of soluble CD14 independently predict mortality in HIV infection
    • Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203: 780-790.
    • (2011) J Infect Dis , vol.203 , pp. 780-790
    • Sandler, N.G.1    Wand, H.2    Roque, A.3
  • 15
    • 84861232560 scopus 로고    scopus 로고
    • Summary report from the Human Immunodeficiency Virus and Aging Consensus Project: Treatment strategies for clinicians managing older individuals with the human immunodeficiency virus
    • Project GfHaAC. Summary report from the Human Immunodeficiency Virus and Aging Consensus Project: treatment strategies for clinicians managing older individuals with the human immunodeficiency virus. J Am Geriatr Soc 2012; 60:974-979.
    • (2012) J Am Geriatr Soc , vol.60 , pp. 974-979
    • Gfhaac, P.1
  • 16
    • 84888862917 scopus 로고    scopus 로고
    • The CD4:CD8 ratio is associated with markers of age-associated disease in virally suppressed HIVinfected patients with immunological recovery
    • Serrano-Villar S, Moreno S, Fuentes-Ferrer M, et al. The CD4:CD8 ratio is associated with markers of age-associated disease in virally suppressed HIVinfected patients with immunological recovery. HIV Med 2014; 15:40-49.
    • (2014) HIV Med , vol.15 , pp. 40-49
    • Serrano-Villar, S.1    Moreno, S.2    Fuentes-Ferrer, M.3
  • 17
    • 84864469250 scopus 로고    scopus 로고
    • HIV replication and immune status are independent predictors of the risk of myocardial infarction in HIV-infected individuals
    • Lang S, Mary-Krause M, Simon A, et al. HIV replication and immune status are independent predictors of the risk of myocardial infarction in HIV-infected individuals. Clin Infect Dis 2012; 55:600-607.
    • (2012) Clin Infect Dis , vol.55 , pp. 600-607
    • Lang, S.1    Mary-Krause, M.2    Simon, A.3
  • 18
    • 70649103959 scopus 로고    scopus 로고
    • Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDHANRS CO4): A prospective cohort study
    • Guiguet M, Boue F, Cadranel J, et al. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDHANRS CO4): a prospective cohort study. Lancet Oncol 2009; 10:1152-1159.
    • (2009) Lancet Oncol , vol.10 , pp. 1152-1159
    • Guiguet, M.1    Boue, F.2    Cadranel, J.3
  • 19
    • 84858340818 scopus 로고    scopus 로고
    • A new frailty syndrome: Central obesity and frailty in older adults with the human immunodeficiency virus
    • Shah K, Hilton TN, Myers L, et al. A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus. J Am Geriatr Soc 2012; 60:545-549.
    • (2012) J Am Geriatr Soc , vol.60 , pp. 545-549
    • Shah, K.1    Hilton, T.N.2    Myers, L.3
  • 20
    • 0034492351 scopus 로고    scopus 로고
    • Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy
    • Mynarcik DC, McNurlan MA, Steigbigel RT, et al. Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy. J Acquir Immune Defic Syndr 2000; 25:312-321.
    • (2000) J Acquir Immune Defic Syndr , vol.25 , pp. 312-321
    • Mynarcik, D.C.1    McNurlan, M.A.2    Steigbigel, R.T.3
  • 21
    • 0042869786 scopus 로고    scopus 로고
    • Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy
    • Vigouroux C, Maachi M, Nguyen TH, et al. Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy. AIDS 2003; 17:1503-1511.
    • (2003) AIDS , vol.17 , pp. 1503-1511
    • Vigouroux, C.1    Maachi, M.2    Nguyen, T.H.3
  • 22
    • 84856158153 scopus 로고    scopus 로고
    • Immune deficiency could be an early risk factor for altered insulin sensitivity in antiretroviral-naive HIV-1-infected patients: The ANRS COPANA cohort
    • Boufassa F, Goujard C, Viard JP, et al. Immune deficiency could be an early risk factor for altered insulin sensitivity in antiretroviral-naive HIV-1-infected patients: the ANRS COPANA cohort. Antivir Ther 2012; 17:91-100.
    • (2012) Antivir Ther , vol.17 , pp. 91-100
    • Boufassa, F.1    Goujard, C.2    Viard, J.P.3
  • 23
    • 84896743037 scopus 로고    scopus 로고
    • Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men
    • Althoff KN, Jacobson LP, Cranston RD, et al. Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men. J Gerontol A Biol Sci Med Sci 2014; 69:189-198.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 189-198
    • Althoff, K.N.1    Jacobson, L.P.2    Cranston, R.D.3
  • 24
    • 84880237729 scopus 로고    scopus 로고
    • Increased ocular lens density in HIVinfected individuals with low nadir CD4 counts in South Africa: Evidence of accelerated aging
    • Pathai S, Lawn SD, Weiss HA, et al. Increased ocular lens density in HIVinfected individuals with low nadir CD4 counts in South Africa: evidence of accelerated aging. J Acquir Immune Defic Syndr 2013; 63:307-314.
    • (2013) J Acquir Immune Defic Syndr , vol.63 , pp. 307-314
    • Pathai, S.1    Lawn, S.D.2    Weiss, H.A.3
  • 25
    • 84874533741 scopus 로고    scopus 로고
    • Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: A case-control study
    • Pathai S, Lawn SD, Shiels PG, et al. Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study. PLoS One 2013; 8:e57422.
    • (2013) PLoS One , vol.8
    • Pathai, S.1    Lawn, S.D.2    Shiels, P.G.3
  • 26
    • 79960930133 scopus 로고    scopus 로고
    • Mitochondrial aging is accelerated by antiretroviral therapy through the clonal expansion of mtDNA mutations
    • Payne BA, Wilson IJ, Hateley CA, et al. Mitochondrial aging is accelerated by antiretroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet 2011; 43:806-810.
    • (2011) Nat Genet , vol.43 , pp. 806-810
    • Payne, B.A.1    Wilson, I.J.2    Hateley, C.A.3
  • 27
    • 84896986281 scopus 로고    scopus 로고
    • In vivo mitochondrial function in hiv-infected persons treated with contemporary anti-retroviral therapy: A magnetic resonance spectroscopy study
    • Payne BA, Hollingsworth KG, Baxter J, et al. In vivo mitochondrial function in hiv-infected persons treated with contemporary anti-retroviral therapy: a magnetic resonance spectroscopy study. PLoS One 2014; 9:e84678.
    • (2014) PLoS One , vol.9
    • Payne, B.A.1    Hollingsworth, K.G.2    Baxter, J.3
  • 28
    • 84875082255 scopus 로고    scopus 로고
    • Markers of oxidant stress that are clinically relevant in aging and age-related disease
    • Jacob KD, Noren Hooten N, Trzeciak AR, Evans MK. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev 2013; 134:139-157.
    • (2013) Mech Ageing Dev , vol.134 , pp. 139-157
    • Jacob, K.D.1    Noren Hooten, N.2    Trzeciak, A.R.3    Evans, M.K.4
  • 29
    • 70350457524 scopus 로고    scopus 로고
    • Human immunodeficiency virus in an aging population, a complication of success
    • Kirk JB, Goetz MB. Human immunodeficiency virus in an aging population, a complication of success. J Am Geriatr Soc 2009; 57:2129-2138.
    • (2009) J Am Geriatr Soc , vol.57 , pp. 2129-2138
    • Kirk, J.B.1    Goetz, M.B.2
  • 30
    • 84902277983 scopus 로고    scopus 로고
    • Soluble markers of inflammation & coagulation, but not T-cell activation, predict non-AIDS-defining events during suppressive antiretroviral therapy (ART)
    • Atlanta USA, abstract 790
    • Tenorio AR, Zheng Y, Bosch RJ, et al. Soluble markers of inflammation & coagulation, but not T-cell activation, predict non-AIDS-defining events during suppressive antiretroviral therapy (ART). Conference on Retroviruses and Opportunistic Infections (CROI) 2013, Atlanta USA, abstract 790.
    • (2013) Conference on Retroviruses and Opportunistic Infections (CROI)
    • Tenorio, A.R.1    Zheng, Y.2    Bosch, R.J.3
  • 31
    • 84880540665 scopus 로고    scopus 로고
    • Dysbiosis of the gut microbiota is associated with hiv disease progression and tryptophan catabolism
    • Vujkovic-Cvijin I, Dunham RM, Iwai S, et al. Dysbiosis of the gut microbiota is associated with hiv disease progression and tryptophan catabolism. Sci Transl Med 2013; 5:193ra191.
    • (2013) Sci Transl Med , vol.5
    • Vujkovic-Cvijin, I.1    Dunham, R.M.2    Iwai, S.3
  • 32
    • 84891605485 scopus 로고    scopus 로고
    • Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction
    • Pedersen KK, Pedersen M, Troseid M, et al. Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction. J Acquir Immune Defic Syndr 2013; 64:425-433.
    • (2013) J Acquir Immune Defic Syndr , vol.64 , pp. 425-433
    • Pedersen, K.K.1    Pedersen, M.2    Troseid, M.3
  • 33
    • 84874746841 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: A potential factor contributing to HIV-associated accelerated aging
    • Leeansyah E, Cameron PU, Solomon A, et al. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. J Infect Dis 2013; 207:1157-1165.
    • (2013) J Infect Dis , vol.207 , pp. 1157-1165
    • Leeansyah, E.1    Cameron, P.U.2    Solomon, A.3
  • 34
    • 84898917478 scopus 로고    scopus 로고
    • Association between short leukocyte telomere length and HIV infection in a cohort study; No evidence of a relationship with antiretroviral therapy
    • Zanet DL, Thorne A, Singer J, et al. Association between short leukocyte telomere length and HIV infection in a cohort study; no evidence of a relationship with antiretroviral therapy. Clin Infect Dis 2014; 58:1322-1332.
    • (2014) Clin Infect Dis , vol.58 , pp. 1322-1332
    • Zanet, D.L.1    Thorne, A.2    Singer, J.3
  • 35
    • 67651180787 scopus 로고    scopus 로고
    • Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
    • Liu Y, Sanoff HK, Cho H, et al. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009; 8:439-448.
    • (2009) Aging Cell , vol.8 , pp. 439-448
    • Liu, Y.1    Sanoff, H.K.2    Cho, H.3
  • 36
    • 84866441992 scopus 로고    scopus 로고
    • Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy
    • Nelson JA, Krishnamurthy J, Menezes P, et al. Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. Aging Cell 2012; 11:916-918.
    • (2012) Aging Cell , vol.11 , pp. 916-918
    • Nelson, J.A.1    Krishnamurthy, J.2    Menezes, P.3
  • 37
    • 44349132197 scopus 로고    scopus 로고
    • A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells
    • Coffinier C, Hudon SE, Lee R, et al. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem 2008; 283:9797-9804.
    • (2008) J Biol Chem , vol.283 , pp. 9797-9804
    • Coffinier, C.1    Hudon, S.E.2    Lee, R.3
  • 38
    • 78650414373 scopus 로고    scopus 로고
    • Premature senescence of vascular cells is induced by HIV protease inhibitors: Implication of prelamin A and reversion by statin
    • Lefevre C, Auclair M, Boccara F, et al. Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin. Arterioscler Thromb Vasc Biol 2010; 30:2611-2620.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2611-2620
    • Lefevre, C.1    Auclair, M.2    Boccara, F.3
  • 39
    • 84861076398 scopus 로고    scopus 로고
    • Cardiovascular risk estimation in 2012: Lessons learned and applicability to the HIV population
    • D'Agostino RB Sr. Cardiovascular risk estimation in 2012: lessons learned and applicability to the HIV population. J Infect Dis 2012; 205 (Suppl 3): S362-S367.
    • (2012) J Infect Dis , vol.205 , Issue.SUPPL. 3
    • D'Agostino, R.B.S.R.1
  • 40
    • 84891682256 scopus 로고    scopus 로고
    • Direct comparison of eight national FRAX(R) tools for fracture prediction and treatment qualification in Canadian women
    • Leslie WD, Brennan SL, Lix LM, et al. Direct comparison of eight national FRAX(R) tools for fracture prediction and treatment qualification in Canadian women. Arch Osteoporos 2013; 8:145.
    • (2013) Arch Osteoporos , vol.8 , pp. 145
    • Leslie, W.D.1    Brennan, S.L.2    Lix, L.M.3
  • 42
    • 84902251019 scopus 로고    scopus 로고
    • A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study
    • Peters BS, Perry M, Wierzbicki AS, et al. A cross-sectional randomised study of fracture risk in people with HIV infection in the probono 1 study. PLoS One 2013; 8:e78048.
    • (2013) PLoS One , vol.8
    • Peters, B.S.1    Perry, M.2    Wierzbicki, A.S.3
  • 43
    • 84858132523 scopus 로고    scopus 로고
    • Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?
    • Justice AC, Freiberg MS, Tracy R, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis 2012; 54:984-994.
    • (2012) Clin Infect Dis , vol.54 , pp. 984-994
    • Justice, A.C.1    Freiberg, M.S.2    Tracy, R.3
  • 44
    • 84875640119 scopus 로고    scopus 로고
    • Physiologic frailty and fragility fracture in HIV-infected male veterans
    • Womack JA, Goulet JL, Gibert C, et al. Physiologic frailty and fragility fracture in HIV-infected male veterans. Clin Infect Dis 2013; 56:1498-1504.
    • (2013) Clin Infect Dis , vol.56 , pp. 1498-1504
    • Womack, J.A.1    Goulet, J.L.2    Gibert, C.3
  • 45
    • 84893774157 scopus 로고    scopus 로고
    • The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment
    • Marquine MJ, Umlauf A, Rooney AS, et al. The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment. J Acquir Immune Defic Syndr 2014; 65:190-197.
    • (2014) J Acquir Immune Defic Syndr , vol.65 , pp. 190-197
    • Marquine, M.J.1    Umlauf, A.2    Rooney, A.S.3
  • 46
    • 84883012175 scopus 로고    scopus 로고
    • Association of the veterans aging cohort study index with exercise capacity in HIV-infected adults
    • Oursler KK, Tate JP, Gill TM, et al. Association of the veterans aging cohort study index with exercise capacity in HIV-infected adults. AIDS Res Hum Retroviruses 2013; 29:1218-1223.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 1218-1223
    • Oursler, K.K.1    Tate, J.P.2    Gill, T.M.3
  • 47
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis 2011; 53:1120-1126.
    • (2011) Clin Infect Dis , vol.53 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3
  • 48
    • 84890021241 scopus 로고    scopus 로고
    • HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation
    • Agarwal N, Iyer D, Patel SG, et al. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med 2013; 5:213ra164.
    • (2013) Sci Transl Med , vol.5
    • Agarwal, N.1    Iyer, D.2    Patel, S.G.3
  • 49
    • 84884147970 scopus 로고    scopus 로고
    • Host-pathogen interaction in HIV infection
    • Chowdhury A, Silvestri G. Host-pathogen interaction in HIV infection. Curr Opin Immunol 2013; 25:463-469.
    • (2013) Curr Opin Immunol , vol.25 , pp. 463-469
    • Chowdhury, A.1    Silvestri, G.2
  • 50
    • 84880826437 scopus 로고    scopus 로고
    • The next therapeutic challenge in HIV: Polypharmacy
    • Edelman EJ, Gordon KS, Glover J, et al. The next therapeutic challenge in HIV: polypharmacy. Drugs Aging 2013; 30:613-628.
    • (2013) Drugs Aging , vol.30 , pp. 613-628
    • Edelman, E.J.1    Gordon, K.S.2    Glover, J.3
  • 51
    • 80755136930 scopus 로고    scopus 로고
    • Morbidity and aging in HIV-infected persons: The Swiss HIV cohort study
    • Hasse B, Ledergerber B, Furrer H, et al. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2011; 53:1130-1139.
    • (2011) Clin Infect Dis , vol.53 , pp. 1130-1139
    • Hasse, B.1    Ledergerber, B.2    Furrer, H.3
  • 52
    • 84879387839 scopus 로고    scopus 로고
    • Polypharmacy in the HIV-infected older adult population
    • Gleason LJ, Luque AE, Shah K. Polypharmacy in the HIV-infected older adult population. Clin Interv Aging 2013; 8:749-763.
    • (2013) Clin Interv Aging , vol.8 , pp. 749-763
    • Gleason, L.J.1    Luque, A.E.2    Shah, K.3
  • 53
  • 54
    • 84885753789 scopus 로고    scopus 로고
    • Systemic effects of inflammation on health during chronic HIV infection
    • Deeks SG, Tracy R, Douek DC. Systemic effects of inflammation on health during chronic HIV infection. Immunity 2013; 39:633-645.
    • (2013) Immunity , vol.39 , pp. 633-645
    • Deeks, S.G.1    Tracy, R.2    Douek, D.C.3
  • 55
    • 84879096060 scopus 로고    scopus 로고
    • Persistent immune activation in chronic HIV infection: Do any interventions work?
    • Rajasuriar R, Khoury G, Kamarulzaman A, et al. Persistent immune activation in chronic HIV infection: do any interventions work? AIDS 2013; 27:1199-1208.
    • (2013) AIDS , vol.27 , pp. 1199-1208
    • Rajasuriar, R.1    Khoury, G.2    Kamarulzaman, A.3
  • 56
    • 84874739728 scopus 로고    scopus 로고
    • Statin therapy and mortality in HIV-infected individuals; A Danish nationwide population-based cohort study
    • Rasmussen LD, Kronborg G, Larsen CS, et al. Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study. PLoS One 2013; 8:e52828.
    • (2013) PLoS One , vol.8
    • Rasmussen, L.D.1    Kronborg, G.2    Larsen, C.S.3
  • 57
    • 84877252239 scopus 로고    scopus 로고
    • Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death
    • Overton ET, Kitch D, Benson CA, et al. Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death. Clin Infect Dis 2013; 56:1471-1479.
    • (2013) Clin Infect Dis , vol.56 , pp. 1471-1479
    • Overton, E.T.1    Kitch, D.2    Benson, C.A.3
  • 58
    • 79960202601 scopus 로고    scopus 로고
    • Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients
    • Moore RD, Bartlett JG, Gallant JE. Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients. PLoS One 2011; 6:e21843.
    • (2011) PLoS One , vol.6
    • Moore, R.D.1    Bartlett, J.G.2    Gallant, J.E.3
  • 59
    • 80053203528 scopus 로고    scopus 로고
    • Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders
    • Piconi S, Parisotto S, Rizzardini G, et al. Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders. Blood 2011; 118:3263-3272.
    • (2011) Blood , vol.118 , pp. 3263-3272
    • Piconi, S.1    Parisotto, S.2    Rizzardini, G.3
  • 60
    • 84864149976 scopus 로고    scopus 로고
    • Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: A randomized controlled trial
    • Paton NI, Goodall RL, Dunn DT, et al. Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial. JAMA 2012; 308:353-361.
    • (2012) JAMA , vol.308 , pp. 353-361
    • Paton, N.I.1    Goodall, R.L.2    Dunn, D.T.3
  • 61
    • 84869028426 scopus 로고    scopus 로고
    • Underutilization of aspirin for primary prevention of cardiovascular disease among HIV-infected patients
    • Burkholder GA, Tamhane AR, Salinas JL, et al. Underutilization of aspirin for primary prevention of cardiovascular disease among HIV-infected patients. Clin Infect Dis 2012; 55:1550-1557.
    • (2012) Clin Infect Dis , vol.55 , pp. 1550-1557
    • Burkholder, G.A.1    Tamhane, A.R.2    Salinas, J.L.3
  • 62
    • 77951605056 scopus 로고    scopus 로고
    • Don't use aspirin for primary prevention of cardiovascular disease
    • Barnett H, Burrill P, Iheanacho I. Don't use aspirin for primary prevention of cardiovascular disease. BMJ 2010; 340:c1805.
    • (2010) BMJ , vol.340
    • Barnett, H.1    Burrill, P.2    Iheanacho, I.3
  • 63
    • 84904037791 scopus 로고    scopus 로고
    • Switch to raltegravir decreases soluble CD14 in virologically suppressed overweight women: The Women, Integrase and Fat Accumulation Trial
    • doi 10. 1111. [Epub ahead of print]
    • Lake J, McComsey G, Hulgan T, et al. Switch to raltegravir decreases soluble CD14 in virologically suppressed overweight women: the Women, Integrase and Fat Accumulation Trial. HIV Med 2014; doi: 10. 1111. [Epub ahead of print]
    • (2014) HIV Med
    • Lake, J.1    McComsey, G.2    Hulgan, T.3
  • 64
    • 84870242082 scopus 로고    scopus 로고
    • Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery
    • Massanella M, Negredo E, Puig J, et al. Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery. AIDS 2012; 26:2285-2293.
    • (2012) AIDS , vol.26 , pp. 2285-2293
    • Massanella, M.1    Negredo, E.2    Puig, J.3
  • 65
    • 84880421532 scopus 로고    scopus 로고
    • The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4T-cell recovery: A randomized trial
    • Hunt PW, Shulman NS, Hayes TL, et al. The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4T-cell recovery: a randomized trial. Blood 2013; 121:4635-4646.
    • (2013) Blood , vol.121 , pp. 4635-4646
    • Hunt, P.W.1    Shulman, N.S.2    Hayes, T.L.3
  • 66
    • 79751492933 scopus 로고    scopus 로고
    • Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection
    • Yonkers NL, Sieg S, Rodriguez B, Anthony DD. Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection. J Infect Dis 2011; 203:635-645.
    • (2011) J Infect Dis , vol.203 , pp. 635-645
    • Yonkers, N.L.1    Sieg, S.2    Rodriguez, B.3    Anthony, D.D.4
  • 67
    • 84863724325 scopus 로고    scopus 로고
    • T cell responses in hepatitis C: The good, the bad and the unconventional
    • Klenerman P, Thimme R. T cell responses in hepatitis C: the good, the bad and the unconventional. Gut 2012; 61:1226-1234.
    • (2012) Gut , vol.61 , pp. 1226-1234
    • Klenerman, P.1    Thimme, R.2
  • 68
    • 79953285141 scopus 로고    scopus 로고
    • Increasing burden of liver disease in patients with HIV infection
    • Joshi D, O'Grady J, Dieterich D, et al. Increasing burden of liver disease in patients with HIV infection. Lancet 2011; 377:1198-1209.
    • (2011) Lancet , vol.377 , pp. 1198-1209
    • Joshi, D.1    O'Grady, J.2    Dieterich, D.3
  • 70
    • 84880378679 scopus 로고    scopus 로고
    • Resveratrol in mammals: Effects on aging biomarkers, age-related diseases, and life span
    • Marchal J, Pifferi F, Aujard F. Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span. Ann N Y Acad Sci 2013; 1290:67-73.
    • (2013) Ann N y Acad Sci , vol.1290 , pp. 67-73
    • Marchal, J.1    Pifferi, F.2    Aujard, F.3
  • 71
    • 84899968223 scopus 로고    scopus 로고
    • Skeletal muscle mitochondria in the elderly: Effects of physical fitness and exercise training
    • Epub ahead of print
    • Broskey NT, Greggio C, Boss A, et al. Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. J Clin Endocrinol Metab 2014; jc20133983. [Epub ahead of print]
    • (2014) J Clin Endocrinol Metab
    • Broskey, N.T.1    Greggio, C.2    Boss, A.3
  • 72
    • 84884284220 scopus 로고    scopus 로고
    • Does social isolation predict hospitalization and mortality among HIV and uninfected older veterans
    • Greysen SR, Horwitz LI, Covinsky KE, et al. Does social isolation predict hospitalization and mortality among HIV and uninfected older veterans? J Am Geriatr Soc 2013; 61:1456-1463.
    • (2013) J Am Geriatr Soc , vol.61 , pp. 1456-1463
    • Greysen, S.R.1    Horwitz, L.I.2    Covinsky, K.E.3


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