Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence

Cell Death and Differentiation

Volumn 14, Issue 10, 2007, Pages 1759-1767

  Caron, M ^a,b   Auclair, M ^a,b   Donadille, B ^a,b   Bereziat V ^a,b   Guerci, B ^c   Laville, M ^d   Narbonne, H ^e   Bodemer, C ^f   Lascols, O ^a,b,g   Capeau, J ^a,b,h   Vigouroux, C ^a,b,h  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c Ctr Hospitalier Univ de Nancy   (France)

^d Centre de Recherche en Nutrition Humaine   (France)

^e TIMONE HOSPITAL   (France)

^f HÔPITAL NECKER ENFANTS MALADES   (France)

^g HÔPITAL SAINT ANTOINE   (France)

^h HÔPITAL TENON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; INDINAVIR; LAMIN A; MITOCHONDRIAL PROTEIN; NELFINAVIR; PRELAMIN A; PROTEIN FARNESYLTRANSFERASE; PROTEIN P16; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; CELL AGING; CELL PROLIFERATION; CELL SHAPE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LIPODYSTROPHY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST;

ADULT; BIOPSY; CELL AGING; CELL NUCLEUS SHAPE; CELLS, CULTURED; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; FIBROBLASTS; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; LAMIN TYPE A; LIPODYSTROPHY, FAMILIAL PARTIAL; MIDDLE AGED; MITOCHONDRIA; MUTATION; NELFINAVIR; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTEIN PRECURSORS; REACTIVE OXYGEN SPECIES;

EID: 34548713556     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402197     Document Type: Article

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