Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy

Clinical Infectious Diseases

Volumn 58, Issue 9, 2014, Pages 1322-1332

  Zanet, De Anna L ^a   Thorne, Anona ^b   Singer, Joel ^b   Maan, Evelyn J ^a   Sattha, Beheroze ^a   Le Campion, Armelle ^d   Soudeyns, Hugo ^d   Pick, Neora ^a   Murray, Melanie ^a   Money, Deborah M ^c   Côté, Hélène C F ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^c Department of Obstetrics and Gynecology ^*  (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

accelerated aging; HIV; leukocyte telomere length; smoking; telomere shortening

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; C REACTIVE PROTEIN; VIRUS RNA; BIOLOGICAL MARKER;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD SAMPLING; CELL AGING; CELLULAR PARAMETERS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG USE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCOME; LEUKOCYTE; LEUKOCYTE TELOMERE LENGTH; LOWEST INCOME GROUP; MAJOR CLINICAL STUDY; PARENTAL AGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RACE DIFFERENCE; SMOKING; TELOMERE; TELOMERE SHORTENING; VIRUS LOAD; CHEMISTRY; COMPLICATION; GENETICS; HIV INFECTIONS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; REGRESSION ANALYSIS; TELOMERE HOMEOSTASIS;

ADULT; AGED; ANTI-HIV AGENTS; BIOLOGICAL MARKERS; CELL AGING; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; REGRESSION ANALYSIS; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84898917478     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciu051     Document Type: Article

References (40)

1. Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis 2011; 53:1120-6
2. Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 2009; 338:a3172
3. Boccara F, Lang S, Meuleman C, et al. HIV and coronary heart disease: Time for a better understanding. J Am Coll Cardiol 2013; 61:511-23
4. Blackburn EH. Telomeres. Trends Biochem Sci 1991; 16:378-81
5. Choudhary B, Karande AA, Raghavan SC. Telomere and telomerase in stem cells: Relevance in ageing and disease. Front Biosci (Schol Ed) 2012; 4:16-30
6. Oeseburg H, de Boer RA, van Gilst WH, van der Harst P. Telomere biology in healthy aging and disease. Pflugers Arch 2010; 459:259-68
7. Pace GW, Leaf CD. The role of oxidative stress in HIV disease. Free Radic Biol Med 1995; 19:523-8
8. Franzese O, Adamo R, Pollicita M, et al. Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4(+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1). J Med Virol 2007; 79:639-46
9. Reynoso R, Minces L, Salomon H, Quarleri J. HIV-1 infection downregulates nuclear telomerase activity on lymphoblastoic cells without affecting the enzymatic components at the transcriptional level. AIDS Res Hum Retrov 2006; 22:425-9
10. Hotchkiss G, Pehrson PO, Larsson S, Ahrlund-Richter L, Britton S. Telomere loss in peripheral blood mononuclear cells may be moderately accelerated during highly active antiretroviral therapy (HAART). J Acquir Immune Defic Syndr 1999; 22:445-52
11. Murakami J, Nagai N, Shigemasa K, Ohama K. Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines. Eur J Cancer 1999; 35: 1027-34
12. Hukezalie KR, Thumati NR, Cote HC, Wong JM. In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs. PLoS One 2012; 7:e47505
13. Leeansyah E, Cameron PU, Solomon A, et al. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: A potential factor contributing to HIV-Associated accelerated aging. J Infect Dis 2013; 207:1157-65
14. Caron M, Auclairt M, Vissian A, Vigouroux C, Capeau J. Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues. Antivir Ther 2008; 13:27-38
15. Kline ER, Sutliff RL. The roles of HIV-1 proteins and antiretroviral drug therapy in HIV-1-Associated endothelial dysfunction. J Investig Med 2008; 56:752-69
16. Rickabaugh TM, Kilpatrick RD, Hultin LE, et al. The dual impact of HIV-1 infection and aging on naive CD4 T-cells: Additive and distinct patterns of impairment. PLoS One 2011; 6:e16459
17. Pommier JP, Gauthier L, Livartowski J, et al. Immunosenescence in HIV pathogenesis. Virology 1997; 231:148-54
18. Effros RB, Allsopp R, Chiu CP, et al. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996; 10:F17-22
19. Pathai S, Lawn SD, Gilbert CE, et al. Accelerated biological aging in HIV-infected individuals in South Africa: A case-control study. AIDS 2013; 27:2375-84
20. Zanet DL, Saberi S, Oliveira L, Sattha B, Gadawski I, Cote HC. Blood and dried blood spot telomere length measurement by qPCR: Assay considerations. PLoS One 2013; 8:e57787
21. Liu X, Takahashi H, Harada Y, et al. 3′-Azido-2′,3′- dideoxynucleoside 5′-Triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells. Nucleic Acids Res 2007; 35:7140-9
22. Ballon G, Ometto L, Righetti E, et al. Human immunodeficiency virus type 1 modulates telomerase activity in peripheral blood lymphocytes. J Infect Dis 2001; 183:417-24
23. Comandini A, Naro C, Adamo R, et al. Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4 (+) T lymphocytes. Mol Immunol 2013; 54:181-92
24. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 2003; 23:842-6
25. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 2007; 165:14-21
26. Weischer M, Bojesen SE, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Nordestgaard BG. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol 2012; 32:822-9
27. Gibellini D, Borderi M, Clo A, et al. HIV-related mechanisms in atherosclerosis and cardiovascular diseases. J Cardiovasc Med (Hagerstown) 2013; 14:780-90
28. Zanni MV, Abbara S, Lo J, et al. Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men. AIDS 2013; 27:1263-72
29. Aviv A. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res 2012; 730:68-74
30. Zanni MV, Grinspoon SK. HIV-specific immune dysregulation and atherosclerosis. Curr HIV/AIDS Rep 2012; 9:200-5
31. Cohen S, Janicki-Deverts D, Turner RB, et al. Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA 2013; 309:699-705
32. Hsue PY, Hunt PW, Schnell A, et al. Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-Associated atherosclerosis. AIDS 2009; 23:1059-67
33. Kitay-Cohen Y, Goldberg-Bittman L, Hadary R, Fejgin MD, Amiel A. Telomere length in hepatitis C. Cancer Genet Cytogenet 2008; 187:34-8
34. Reynoso R, Laufer N, Bolcic F, Quarleri J. Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients. Virus Res 2010; 147:284-7
35. O'Donnell CJ, Demissie S, Kimura M, et al. Leukocyte telomere length and carotid artery intimal medial thickness: The Framingham Heart Study. Arterioscler Thromb Vasc Biol 2008; 28:1165-71
36. Helleberg M, Afzal S, Kronborg G, et al. Mortality attributable to smoking among HIV-1-infected individuals: A nationwide, population-based cohort study. Clin Infect Dis 2013; 56:727-34
37. Moller P, Mayer S, Mattfeldt T, Muller K,Wiegand P, Bruderlein S. Sexrelated differences in length and erosion dynamics of human telomeres favor females. Aging 2009; 1:733-9
38. Cherkas LF, Aviv A, Valdes AM, et al. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell 2006; 5:361-5
39. van de Berg PJ, Griffiths SJ, Yong SL, et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 2010; 184:3417-23
40. Effros RB. Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress. Exp Gerontol 2011; 46: 135-40.