Corneal Endothelial Cells Provide Evidence of Accelerated Cellular Senescence Associated with HIV Infection: A Case-Control Study

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Pathai, Sophia ^a,b   Lawn, Stephen D ^a,b   Shiels, Paul G ^c   Weiss, Helen A ^a   Cook, Colin ^d   Wood, Robin ^b   Gilbert, Clare E ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIRETROVIRUS AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; CELL AGING; CELL DENSITY; CELL SENESCENCE; CELL SHAPE; CELL SIZE; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DISEASE MARKER; DNA DAMAGE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; ONSET AGE; PROTEIN EXPRESSION; SENESCENCE; VIRUS LOAD;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL AGING; CELL COUNT; CELL SHAPE; CELL SIZE; ENDOTHELIAL CELLS; ENDOTHELIUM, CORNEAL; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS;

EID: 84874533741     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057422     Document Type: Article

References (49)

1. Deeks SG, (2009) Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med 17: 118-123.
2. Lohse N, Hansen AB, Pedersen G, Kronborg G, Gerstoft J, et al. (2007) Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann Intern Med 146: 87-95.
3. Joyce NC, Zhu CC, Harris DL, (2009) Relationship among oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Investigative Ophthalmology & Visual Science 50: 2116-2122.
4. Campisi J, (2011) Cellular senescence: putting the paradoxes in perspective. Current Opinion in Genetics & Development 21: 107-112.
5. Joyce NC, (2012) Proliferative capacity of corneal endothelial cells. Experimental Eye Research 95: 16-23.
6. Bourne WM, McLaren JW, (2004) Clinical responses of the corneal endothelium. Experimental Eye Research 78: 561-572.
7. Amann J, Holley GP, Lee SB, Edelhauser HF, (2003) Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am J Ophthalmol 135: 584-590.
8. Laing RA, Sanstrom MM, Berrospi AR, Leibowitz HM, (1976) Changes in the corneal endothelium as a function of age. Exp Eye Res 22: 587-594.
9. Sanchis-Gimeno JA, Lleo-Perez A, Alonso L, Rahhal MS, Martinez Soriano F, (2005) Corneal endothelial cell density decreases with age in emmetropic eyes. Histol Histopathol 20: 423-427.
10. Wilson RS, Roper-Hall MJ, (1982) Effect of age on the endothelial cell count in the normal eye. Br J Ophthalmol 66: 513-515.
11. Bourne WM, Nelson LR, Hodge DO, (1997) Central corneal endothelial cell changes over a ten-year period. Investigative Ophthalmology & Visual Science 38: 779-782.
12. Yee RW, Matsuda M, Schultz RO, Edelhauser HF, (1985) Changes in the normal corneal endothelial cellular pattern as a function of age. Curr Eye Res 4: 671-678.
13. Cheng H, Jacobs PM, McPherson K, Noble MJ, (1985) Precision of cell density estimates and endothelial cell loss with age. Arch Ophthalmol 103: 1478-1481.
14. Wang Y, Zang X, Wang Y, Chen P, (2012) High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea. Mol Vis 18: 803-815.
15. Zhu C, Joyce NC, (2004) Proliferative Response of Corneal Endothelial Cells from Young and Older Donors. Investigative Ophthalmology & Visual Science 45: 1743-1751.
16. McGlynn LM, Stevenson K, Lamb K, Zino S, Brown M, et al. (2009) Cellular senescence in pretransplant renal biopsies predicts postoperative organ function. Aging Cell 8: 45-51.
17. Koppelstaetter C, Schratzberger G, Perco P, Hofer J, Mark W, et al. (2008) Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell 7: 491-497.
18. Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC, (2009) A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. Proc Natl Acad Sci U S A 106: 16562-16567.
19. Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, et al. (2009) Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8: 439-448.
20. Carrero JJ, Stenvinkel P, Fellström B, Qureshi AR, Lamb K, et al. (2008) Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. J Intern Med 263: 302-312.
21. Rasmussen LD, Engsig FN, Christensen H, Gerstoft J, Kronborg G, et al. (2011) Risk of cerebrovascular events in persons with and without HIV: a Danish nationwide population-based cohort study. AIDS 25: 1637-1646.
22. Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, et al. (2011) Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population. Clinical Infectious Diseases 53: 1120-1126.
23. Phillips AN, Neaton J, Lundgren JD, (2008) The role of HIV in serious diseases other than AIDS. AIDS 22: 2409-2418.
24. Capeau J, (2011) Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses. CLIN INFECT DIS 53: 1127-1129.
25. Pathai S, Gilbert C, Weiss HA, Cook C, Wood R, et al. (2012) Frailty in HIV-infected adults in South Africa. J Acquir Immune Defic Syndr. 62: 43-51.
26. Pathai S, Weiss HA, Lawn SD, Peto T, L.M D'Costa, et al. (2012) Retinal arterioles narrow with increasing duration of anti-retroviral therapy in HIV infection: a novel estimator of vascular risk in HIV? PLoS ONE 7: e51405.
27. Lawn SD, Myer L, Bekker LG, Wood R, (2006) Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control. AIDS 20: 1605-1612.
28. Lawn SD, Myer L, Orrell C, Bekker LG, Wood R, (2005) Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design. AIDS 19: 2141-2148.
29. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
30. Sheerin AN, Smith SK, Jennert-Burston K, Brook AJ, Allen MC, et al. (2012) Characterization of cellular senescence mechanisms in human corneal endothelial cells. Aging Cell 11: 234-240.
31. Higuchi A, Ito K, Dogru M, Kitamura M, Mitani F, et al. (2011) Corneal damage and lacrimal gland dysfunction in a smoking rat model. Free Radical Biology and Medicine 51: 2210-2216.
32. Mccarey BE, Edelhauser HF, Lynn MJ, (2008) Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea 27: 1-16.
33. Schultz RO, Matsuda M, Yee RW, Edelhauser HF, Schultz KJ, (1984) Corneal endothelial changes in type I and type II diabetes mellitus. Am J Ophthalmol 98: 401-410.
34. Bergmanson JP, (1992) Histopathological analysis of corneal endothelial polymegethism. Cornea 11: 133-142.
35. Campisi J, d'Adda di Fagagna F, (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740.
36. Deeks SG, (2011) HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 62: 141-155.
37. Song Z, Wang Y, Xie L, Zang X, Yin H, (2008) Expression of senescence-related genes in human corneal endothelial cells. Mol Vis 14: 161-170.
38. Xiao X, Wang Y, Gong H, Chen P, Xie L, (2009) Molecular evidence of senescence in corneal endothelial cells of senescence-accelerated mice. Mol Vis 15: 747-761.
39. Newton R, Ziegler J, Beral V, Mbidde E, Carpenter L, et al. (2001) A case-control study of human immunodeficiency virus infection and cancer in adults and children residing in Kampala, Uganda. Int J Cancer 92: 622-627.
40. Waddell K, Kwehangana J, Johnston WT, Lucas S, Newton R (2010) A case-control study of ocular surface squamous neoplasia (OSSN) in Uganda. Int J Cancer 127 427-432.
41. Fisher M, Cooper V, (2012) HIV and ageing: premature ageing or premature conclusions? Curr Opin Infect Dis 25: 1-3.
42. Martin J, Volberding P, (2010) HIV and premature aging: A field still in its infancy. Ann Intern Med 153: 477-479.
43. Ohguro N, Matsuda M, Fukuda M, (1999) Corneal endothelial changes in patients with chronic renal failure. Am J Ophthalmol 128: 234-236.
44. Larsson LI, Bourne WM, Pach JM, Brubaker RF, (1996) Structure and function of the corneal endothelium in diabetes mellitus type I and type II. Arch Ophthalmol 114: 9-14.
45. Lee JS, Oum BS, Choi HY, Lee JE, Cho BM, (2006) Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye (Lond) 20: 315-318.
46. Pathanapitoon K, Riemens A, Kongyai N, Sirirungsi W, Leechanachai P, et al. (2011) Intraocular and plasma HIV-1 RNA loads and HIV uveitis. AIDS (London, England) 25: 81-86.
47. Otiti-Sengeri J, Meenken C, van den Horn GJ, Kempen JH, (2008) Ocular immune reconstitution inflammatory syndromes. Curr Opin HIV AIDS 3: 432-437.
48. Pathai S, Gilbert C, Weiss HA, McNally M, Lawn SD, (2011) Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South Africa. Trop Med Int Health 16: 356-359.
49. Deeks SG, Phillips AN, (2009) HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 338: a3172.