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Volumn 26, Issue 18, 2012, Pages 2285-2293

Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

Author keywords

CD38; CD8 activation; cell death; human leukocyte antigen DR; immunodiscordance

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; HLA DR ANTIGEN; RALTEGRAVIR;

EID: 84870242082     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328359f20f     Document Type: Article
Times cited : (43)

References (31)
  • 3
    • 77950947891 scopus 로고    scopus 로고
    • CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
    • Massanella M, Negredo E, Pérez-Alvarez N, Puig J, Ruiz-Hernández R, Bofill M, et al. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS 2010;24:959-968.
    • (2010) AIDS , vol.24 , pp. 959-968
    • Massanella, M.1    Negredo, E.2    Pérez-Alvarez, N.3    Puig, J.4    Ruiz-Hernández, R.5    Bofill, M.6
  • 4
    • 58749087048 scopus 로고    scopus 로고
    • The absence of CD4R T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: Clinical risk, immunological gaps, and therapeutic options
    • Gazzola L, Tincati C, Bellistrí GM, Monforte A, Marchetti G. The absence of CD4R T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options. Clin Infect Dis 2009;48:328-337.
    • (2009) Clin Infect Dis , vol.48 , pp. 328-337
    • Gazzola, L.1    Tincati, C.2    Bellistrí, G.M.3    Monforte, A.4    Marchetti, G.5
  • 5
    • 79955962732 scopus 로고    scopus 로고
    • HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    • Sauce D, Larsen M, Fastenackels S, Pauchard M, Ait-Mohand H, Schneider L, et al. HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis. Blood 2011;117:5142-5151.
    • (2011) Blood , vol.117 , pp. 5142-5151
    • Sauce, D.1    Larsen, M.2    Fastenackels, S.3    Pauchard, M.4    Ait-Mohand, H.5    Schneider, L.6
  • 6
    • 77950979658 scopus 로고    scopus 로고
    • Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: Clinical implications
    • Negredo E, Massanella M, Puig J, Pérez-Alvarez N, Gallego-Escuredo JM, Villarroya J, et al. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin Infect Dis 2010;50:1300-1308.
    • (2010) Clin Infect Dis , vol.50 , pp. 1300-1308
    • Negredo, E.1    Massanella, M.2    Puig, J.3    Pérez-Alvarez, N.4    Gallego-Escuredo, J.M.5    Villarroya, J.6
  • 7
    • 80052882129 scopus 로고    scopus 로고
    • Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    • Lederman MM, Calabrese L, Funderburg NT, Clagett B, Medvik K, Bonilla H, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis 2011;204:1217-1226.
    • (2011) J Infect Dis , vol.204 , pp. 1217-1226
    • Lederman, M.M.1    Calabrese, L.2    Funderburg, N.T.3    Clagett, B.4    Medvik, K.5    Bonilla, H.6
  • 8
    • 79954536349 scopus 로고    scopus 로고
    • Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy
    • Merlini E, Bai F, Bellistrí GM, Tincati C, d'Arminio Monforte A, Marchetti G. Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapy. PLoS One 2011;6:e18580.
    • (2011) PLoS One , vol.6
    • Merlini, E.1    Bai, F.2    Bellistrí, G.M.3    Tincati, C.4    D'Arminio Monforte, A.5    Marchetti, G.6
  • 9
    • 79956196632 scopus 로고    scopus 로고
    • Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death
    • Boulware DR, Hullsiek KH, Puronen CE, Rupert A, Baker JV, French MA, et al. Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis 2011;203:1637-1646.
    • (2011) J Infect Dis , vol.203 , pp. 1637-1646
    • Boulware, D.R.1    Hullsiek, K.H.2    Puronen, C.E.3    Rupert, A.4    Baker, J.V.5    French, M.A.6
  • 10
    • 79751470489 scopus 로고    scopus 로고
    • T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women
    • Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, et al. T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis 2011;203:452-463.
    • (2011) J Infect Dis , vol.203 , pp. 452-463
    • Kaplan, R.C.1    Sinclair, E.2    Landay, A.L.3    Lurain, N.4    Sharrett, A.R.5    Gange, S.J.6
  • 11
    • 79955028940 scopus 로고    scopus 로고
    • Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4R T cell recovery on antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, Epling L, Teague J, Jacobson MA, et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4R T cell recovery on antiretroviral therapy. J Infect Dis 2011;203:1474-1483.
    • (2011) J Infect Dis , vol.203 , pp. 1474-1483
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3    Epling, L.4    Teague, J.5    Jacobson, M.A.6
  • 12
    • 80053203528 scopus 로고    scopus 로고
    • Hydroxychloroquine drastically reduces immune activation in HIV-infected, ART-treated, immunological nonresponders
    • Piconi S, Parisotto S, Rizzardini G, Passerini S, Terzi R, Argenteri B, et al. Hydroxychloroquine drastically reduces immune activation in HIV-infected, ART-treated, immunological nonresponders. Blood 2011;118:3263-3272.
    • (2011) Blood , vol.118 , pp. 3263-3272
    • Piconi, S.1    Parisotto, S.2    Rizzardini, G.3    Passerini, S.4    Terzi, R.5    Argenteri, B.6
  • 13
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, Zheng L, Bosch RJ, Chan ES, Margolis DM, Read S, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med 2010;7:e1000321.
    • (2010) PLoS Med , vol.7
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3    Chan, E.S.4    Margolis, D.M.5    Read, S.6
  • 14
    • 79953000877 scopus 로고    scopus 로고
    • A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4R T cell response
    • Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, et al. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4R T cell response. J Infect Dis 2011;203:960-968.
    • (2011) J Infect Dis , vol.203 , pp. 960-968
    • Hatano, H.1    Hayes, T.L.2    Dahl, V.3    Sinclair, E.4    Lee, T.H.5    Hoh, R.6
  • 15
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
    • Buzón MJ, Massanella M, Llibre JM, Esteve A, Dahl V, Puertas MC, et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat Med 2010;16:460-465.
    • (2010) Nat Med , vol.16 , pp. 460-465
    • Buzón, M.J.1    Massanella, M.2    Llibre, J.M.3    Esteve, A.4    Dahl, V.5    Puertas, M.C.6
  • 16
    • 84860345691 scopus 로고    scopus 로고
    • Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: A randomized 48-week study
    • Llibre JM, Buzón MJ, Massanella M, Esteve A, Dahl V, Puertas MC, et al. Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study. Antivir Ther 2012;17:355-364.
    • (2012) Antivir Ther , vol.17 , pp. 355-364
    • Llibre, J.M.1    Buzón, M.J.2    Massanella, M.3    Esteve, A.4    Dahl, V.5    Puertas, M.C.6
  • 17
    • 4143148495 scopus 로고    scopus 로고
    • Immunological and virological study of enfuvirtide-treated HIV-positive patients
    • DOI 10.1097/01.aids.0000131350.22032.b5
    • Barretina J, Blanco J, Bonjoch A, Llano A, Clotet B, Esté JA. Immunological and virological study of enfuvirtide-treated HIV-positive patients. AIDS 2004;18:1673-1682. (Pubitemid 39095784)
    • (2004) AIDS , vol.18 , Issue.12 , pp. 1673-1682
    • Barretina, J.1    Blanco, J.2    Bonjoch, A.3    Llano, A.4    Clotet, B.5    Este, J.A.6
  • 18
    • 4744354507 scopus 로고    scopus 로고
    • R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism
    • DOI 10.1189/jlb.0204100
    • Blanco J, Barretina J, Clotet B, Esté JA. R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism. J Leukoc Biol 2004;76:804-811. (Pubitemid 39313716)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.4 , pp. 804-811
    • Blanco, J.1    Barretina, J.2    Clotet, B.3    Este, J.A.4
  • 20
    • 80054739868 scopus 로고    scopus 로고
    • Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIVinfected patients with suboptimal CD4R T-cell response: A randomized controlled trial
    • Byakwaga H, Kelly M, Purcell DF, French MA, Amin J, Lewin SR, et al. Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIVinfected patients with suboptimal CD4R T-cell response: a randomized controlled trial. J Infect Dis 2011;204:1532-1540.
    • (2011) J Infect Dis , vol.204 , pp. 1532-1540
    • Byakwaga, H.1    Kelly, M.2    Purcell, D.F.3    French, M.A.4    Amin, J.5    Lewin, S.R.6
  • 21
    • 79957617692 scopus 로고    scopus 로고
    • Immune reconstitution under antiretroviral therapy: The new challenge in HIV-1 infection
    • Corbeau P, Reynes J. Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection. Blood 2011;117:5582-5590.
    • (2011) Blood , vol.117 , pp. 5582-5590
    • Corbeau, P.1    Reynes, J.2
  • 22
    • 84855176017 scopus 로고    scopus 로고
    • Mechanisms involved in CD4 gains in HIVinfected patients switched to raltegravir
    • Garrido C, Rallón N, Soriano V, Lopez M, Zahonero N, de Mendoza C, et al. Mechanisms involved in CD4 gains in HIVinfected patients switched to raltegravir. AIDS 2012;26:551-557.
    • (2012) AIDS , vol.26 , pp. 551-557
    • Garrido, C.1    Rallón, N.2    Soriano, V.3    Lopez, M.4    Zahonero, N.5    De Mendoza, C.6
  • 23
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIVpositive adults on suppressive antiretroviral therapy
    • Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIVpositive adults on suppressive antiretroviral therapy. AIDS 2010;24:2451-2460.
    • (2010) AIDS , vol.24 , pp. 2451-2460
    • Yukl, S.A.1    Shergill, A.K.2    McQuaid, K.3    Gianella, S.4    Lampiris, H.5    Hare, C.B.6
  • 24
  • 25
    • 0027965585 scopus 로고
    • CD8R lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLADRR CD38-CD8R cells is associated with subsequent stable CD4R cell levels. The Multicenter AIDS Cohort Study Group
    • Giorgi JV, Ho HN, Hirji K, Chou CC, Hultin LE, O'Rourke S, et al. CD8R lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLADRR CD38-CD8R cells is associated with subsequent stable CD4R cell levels. The Multicenter AIDS Cohort Study Group. J Infect Dis 1994;170:775-781.
    • (1994) J Infect Dis , vol.170 , pp. 775-781
    • Giorgi, J.V.1    Ho, H.N.2    Hirji, K.3    Chou, C.C.4    Hultin, L.E.5    O'Rourke, S.6
  • 26
    • 8944259909 scopus 로고    scopus 로고
    • Increased numbers of primed activated CD8RCD38R CD45RORT cells predict the decline of CD4RT cells in HIV-1-infected patients
    • Bofill M, Mocroft A, Lipman M, Medina E, Borthwick NJ, Sabin CA, et al. Increased numbers of primed activated CD8RCD38R CD45RORT cells predict the decline of CD4RT cells in HIV-1-infected patients. AIDS 1996;10:827-834.
    • (1996) AIDS , vol.10 , pp. 827-834
    • Bofill, M.1    Mocroft, A.2    Lipman, M.3    Medina, E.4    Borthwick, N.J.5    Sabin, C.A.6
  • 27
    • 33745444576 scopus 로고    scopus 로고
    • Interferon-α differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection
    • DOI 10.1097/01.aids.0000233571.51899.ab, PII 0000203020060626000004
    • Rodriguez B, Lederman MM, Jiang W, Bazdar DA, Gàrate K, Harding CV, et al. Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection. AIDS 2006;20:1379-1389. (Pubitemid 43948244)
    • (2006) AIDS , vol.20 , Issue.10 , pp. 1379-1389
    • Rodriguez, B.1    Lederman, M.M.2    Jiang, W.3    Bazdar, D.A.4    Garate, K.5    Harding, C.V.6    Sieg, S.F.7
  • 28
    • 77952913414 scopus 로고    scopus 로고
    • Changes in T-cell subsets in HIV-HCV-coinfected patients during pegylated interferon-alpha2a plus ribavirin treatment
    • Massanella M, Tural C, Papagno L, Garcia E, Jou A, Bofill M, et al. Changes in T-cell subsets in HIV-HCV-coinfected patients during pegylated interferon-alpha2a plus ribavirin treatment. Antivir Ther 2010;15:333-342.
    • (2010) Antivir Ther , vol.15 , pp. 333-342
    • Massanella, M.1    Tural, C.2    Papagno, L.3    Garcia, E.4    Jou, A.5    Bofill, M.6
  • 30
    • 79957912712 scopus 로고    scopus 로고
    • Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque
    • Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger S, Martinez R, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest 2011;121:2391-2400.
    • (2011) J Clin Invest , vol.121 , pp. 2391-2400
    • Rotger, M.1    Dalmau, J.2    Rauch, A.3    McLaren, P.4    Bosinger, S.5    Martinez, R.6
  • 31
    • 55949116720 scopus 로고    scopus 로고
    • Phenotype and function of human T lymphocyte subsets: Consensus and issues
    • Appay V, van Lier RA, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008;73:975-983.
    • (2008) Cytometry A , vol.73 , pp. 975-983
    • Appay, V.1    Van Lier, R.A.2    Sallusto, F.3    Roederer, M.4


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