A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin a in cells

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9797-9804

  Coffinier, Catherine ^a,e   Hudon, Sarah E ^b   Lee, Roger ^a   Farber, Emily A ^a   Nobumori, Chika ^a   Miner, Jeffrey H ^c   Andres, Douglas A ^d   Spielmann, H Peter ^d   Hrycyna, Christine A ^b   Fong, Loren G ^a   Young, Stephen G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PURDUE UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

ADVERSE SIDE EFFECTS; BIOCHEMICAL ACTIVITIES; DRUG SIDE EFFECTS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPIES; HIV PROTEASES; IN CELLS; KEY COMPONENTS; LAMIN A; LIPODYSTROPHY; METABOLIC LABELING; METABOLIC SYNDROMES; PLAUSIBLE MECHANISMS;

DIFFRACTIVE OPTICAL ELEMENTS;

DARUNAVIR; LONAFARNIB; LOPINAVIR; PRELAMIN A; PROTEIN; PROTEIN ZMPSTE24; RITONAVIR; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; METALLOPROTEINASE; NUCLEAR PROTEIN; PROTEIN PRECURSOR; PROTEINASE INHIBITOR; PYRIMIDINONE DERIVATIVE; SULFONAMIDE; ZMPSTE24 PROTEIN, HUMAN; ZMPSTE24 PROTEIN, MOUSE;

ADJUVANT THERAPY; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMICALLY INDUCED DISORDER; DIET THERAPY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPODYSTROPHY; METABOLIC SYNDROME X; METABOLISM; MOUSE MUTANT; PROTEIN PROCESSING;

ANIMALS; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HUMANS; LIPODYSTROPHY; MEMBRANE PROTEINS; METABOLIC SYNDROME X; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIMIDINONES; RITONAVIR; SULFONAMIDES;

EID: 44349132197     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709629200     Document Type: Article

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