Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Dengler, Michael A ^a   Staiger, Annette M ^a   Gutekunst, Matthias ^a   Hofmann, Ute ^a   Doszczak, Malgorzata ^b   Scheurich, Peter ^b   Schwab, Matthias ^a,c   Aulitzky, Walter E ^d   van der Kuip, Heiko ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d ROBERT BOSCH HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BCR ABL PROTEIN; BETAMETHASONE; BIM PROTEIN; CORTICOSTEROID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMATINIB; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISOLONE; PROTEIN BCL XL; PROTEIN ELF2ALPHA; PROTEIN KINASE B; PROTEIN RIP1; RAS PROTEIN; STAT PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GLUCOCORTICOID; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

AEROBIC GLYCOLYSIS; ALTERNATIVE RNA SPLICING; AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; CELL SWELLING; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GLUTAMINOLYSIS; GLYCOLYSIS; LYMPHOCYTE; NONHUMAN; ONCOGENIC STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS; UPREGULATION; ANIMAL; APOPTOSIS; CELL CULTURE; CELL CYCLE; CELL TRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENETICS; MASS FRAGMENTOGRAPHY; METABOLISM; METABOLOMICS; MOUSE; NECROSIS; PATHOLOGY; PRE B LYMPHOCYTE; WESTERN BLOTTING;

MAMMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; FUSION PROTEINS, BCR-ABL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOCORTICOIDS; GLYCOLYSIS; METABOLOMICS; MICE; NECROSIS; PIPERAZINES; PRECURSOR CELLS, B-LYMPHOID; PYRIMIDINES; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 80052956828     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025139     Document Type: Article

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