Gold nanoparticles for nucleic acid delivery

Molecular Therapy

Volumn 22, Issue 6, 2014, Pages 1075-1083

  Ding, Ya ^a,b   Jiang, Ziwen ^a   Saha, Krishnendu ^a   Kim, Chang Soo ^a   Kim, Sung Tae ^a   Landis, Ryan F ^a   Rotello, Vincent M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; GOLD NANOPARTICLE; MICRORNA; NUCLEIC ACID; SMALL INTERFERING RNA; GOLD; METAL NANOPARTICLE; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA;

ARTICLE; BIOCOMPATIBILITY; COVALENT BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; GENE TARGETING; NONHUMAN; RNA INTERFERENCE; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENE THERAPY; HUMAN; 3' UNTRANSLATED REGION; BINDING AFFINITY; CELL TRANSPORT; CONJUGATE; DRUG HALF LIFE; GENE DELIVERY SYSTEM; GENE SILENCING; PLASMA HALF LIFE; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW;

DRUG DELIVERY SYSTEMS; GENETIC THERAPY; GOLD; HUMANS; METAL NANOPARTICLES; MODELS, MOLECULAR; NUCLEIC ACIDS;

EID: 84902179753     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2014.30     Document Type: Review

References (95)

1. Anderson, WF (1992). Human gene therapy. Science 256: 808-813.
2. Mulligan, RC (1993). The basic science of gene therapy. Science 260: 926-932.
3. Bonadio, J, Smiley, E, Patil, P and Goldstein, S (1999). Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 5: 753-759. (Pubitemid 29318608)
4. Zhao, N, Fogg, JM, Zechiedrich, L and Zu, Y (2011). Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells. Gene Ther 18: 220-224.
5. Hamilton, AJ and Baulcombe, DC (1999). A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286: 950-952.
6. Sokolova, V and Epple, M (2008). Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed Engl 47: 1382-1395.
7. Walther, W and Stein, U (2000). Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 60: 249-271.
8. Kay, MA, Glorioso, JC and Naldini, L (2001). Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 7: 33-40. (Pubitemid 32095639)
9. Takahashi, Y, Nishikawa, M and Takakura, Y (2009). Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAibased gene therapy. Adv Drug Deliv Rev 61: 760-766.
10. Semple, SC, Akinc, A, Chen, J, Sandhu, AP, Mui, BL, Cho, CK et al. (2010). Rational design of cationic lipids for siRNA delivery. Nat Biotechnol 28: 172-176.
11. Wu, J, Yamanouchi, D, Liu, B, Chu, CC (2012). Biodegradable arginine-based poly(ether ester amide)s as a non-viral DNA delivery vector and their structure- function study. J Mater Chem 22: 18983-18991.
12. Yamanouchi, D, Wu, J, Lazar, AN, Kent, KC, Chu, CC and Liu, B (2008). Biodegradable arginine-based poly(ester-amide)s as non-viral gene delivery reagents. Biomaterials 29: 3269-3277.
13. Dufès, C, Uchegbu, IF and Schätzlein, AG (2005). Dendrimers in gene delivery. Adv Drug Deliv Rev 57: 2177-2202. (Pubitemid 41759392)
14. Kichler, A, Zauner, W, Ogris, M and Wagner, E (1998). Influence of the DNA complexation medium on the transfection efficiency of lipospermine/DNA particles. Gene Ther 5: 855-860.
15. Dalby, B, Cates, S, Harris, A, Ohki, EC, Tilkins, ML, Price, PJ et al. (2004). Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and highthroughput applications. Methods 33: 95-103. (Pubitemid 38569654)
16. Pantarotto, D, Singh, R, McCarthy, D, Erhardt, M, Briand, JP, Prato, M et al. (2004). Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl 43: 5242-5246. (Pubitemid 39382552)
17. Kam, NW, Liu, Z and Dai, H (2005). Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc 127: 12492-12493. (Pubitemid 41292159)
18. Biju, V, Anas, A, Akita, H, Shibu, ES, Itoh, T, Harashima, H et al. (2012). FRET from quantum dots to photodecompose undesired acceptors and report the condensation and decondensation of plasmid DNA. ACS Nano 6: 3776-3788.
19. Chen, AA, Derfus, AM, Khetani, SR and Bhatia, SN (2005). Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res 33: e190. (Pubitemid 43125090)
20. Kievit, FM, Veiseh, O, Bhattarai, N, Fang, C, Gunn, JW, Lee, D et al. (2009). PEIPEG-Chitosan Copolymer Coated Iron OxiDe N.anoparticles for Safe Gene Delivery: synthesis, complexation, and transfection. Adv Funct Mater 19: 2244-2251.
21. Arsianti, M, Lim, M, Marquis, CP and Amal, R (2010). Assembly of polyethyleniminebased magnetic iron oxide vectors: insights into gene delivery. Langmuir 26: 7314-7326.
22. Ghosh, P, Han, G, De, M, Kim, CK and Rotello, VM (2008). Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60: 1307-1315.
23. Boisselier, E and Astruc, D (2009). Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38: 1759-1782.
24. Rana, S, Bajaj, A, Mout, R and Rotello, VM (2012). Monolayer coated gold nanoparticles for delivery applications. Adv Drug Deliv Rev 64: 200-216.
25. Jewell, CM, Jung, JM, Atukorale, PU, Carney, RP, Stellacci, F and Irvine, DJ (2011). Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. Angew Chem Int Ed Engl 50: 12312-12315.
26. Kim, ST, Saha, K, Kim, C and Rotello, VM (2013). The role of surface functionality in determining nanoparticle cytotoxicity. Acc Chem Res 46: 681-691.
27. Gindy, ME and Prud'homme, RK (2009). Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv 6: 865-878.
28. Panyala, NR, Pena-Mendez, EM, Josef, H (2009). Gold and nano-gold in medicine: overview, toxicology and perspectives. J Appl Biomed 7: 75-91.
29. Park, K, Lee, S, Kang, E, Kim, K, Choi, K and Kwon, IC (2009). New generation of multifunctional nanoparticles for cancer imaging and therapy. Adv Funct Mater 19: 1553-1566.
30. Beaux, MF 2nd, McIlroy, DN and Gustin, KE (2008). Utilization of solid nanomaterials for drug delivery. Expert Opin Drug Deliv 5: 725-735.
31. Roca, M and Haes, AJ (2008). Probing cells with noble metal nanoparticle aggregates. Nanomedicine (Lond) 3: 555-565.
32. Sanvicens, N and Marco, MP (2008). Multifunctional nanoparticles- properties and prospects for their use in human medicine. Trends Biotechnol 26: 425-433.
33. Bhattacharya, R and Mukherjee, P (2008). Biological properties of "naked" metal nanoparticles. Adv Drug Deliv Rev 60: 1289-1306.
34. Xu, ZP, Zeng, QH, Lu, GQ and Yu, AB (2006). Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng Sci 61: 1027-1040. (Pubitemid 41650188)
35. Daniel, MC and Astruc, D (2004). Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104: 293-346.
36. Shenhar, R and Rotello, VM (2003). Nanoparticles: scaffolds and building blocks. Acc Chem Res 36: 549-561.
37. Sun, Y and Xia, Y (2002). Shape-controlled synthesis of gold and silver nanoparticles. Science 298: 2176-2179. (Pubitemid 35471239)
38. Brust, M, Walker, M, Bethell, D, Schiffrin, DJ and Whyman, R (1994). Synthesis of thiol-derivatized gold nanoparticles in a 2-phase liquid-liquid system. J Chem Soc, Chem Commun 7: 801-802.
39. Bowman, MC, Ballard, TE, Ackerson, CJ, Feldheim, DL, Margolis, DM and Melander, C (2008). Inhibition of HIV fusion with multivalent gold nanoparticles. J Am Chem Soc 130: 6896-6897. (Pubitemid 351770109)
40. Ryan, JA, Overton, KW, Speight, ME, Oldenburg, CN, Loo, L, Robarge, W et al. (2007). Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates. Anal Chem 79: 9150-9159. (Pubitemid 350231728)
41. Chompoosor, A, Saha, K, Ghosh, PS, Macarthy, DJ, Miranda, OR, Zhu, ZJ et al. (2010). The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small 6: 2246-2249.
42. Zhu, ZJ, Carboni, R, Quercio, MJ Jr, Yan, B, Miranda, OR, Anderton, DL et al. (2010). Surface properties dictate uptake, distribution, excretion, and toxicity of nanoparticles in fish. Small 6: 2261-2265.
43. De Jong, WH, Hagens, WI, Krystek, P, Burger, MC, Sips, AJ and Geertsma, RE (2008). Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29: 1912-1919.
44. Sonavane, G, Tomoda, K and Makino, K (2008). Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids Surf B Biointerfaces 66: 274-280.
45. Wang, B, He, X, Zhang, Z, Zhao, Y and Feng, W (2013). Metabolism of nanomaterials in vivo: blood circulation and organ clearance. Acc Chem Res 46: 761-769.
46. Longmire, M, Choyke, PL and Kobayashi, H (2008). Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine (Lond) 3: 703-717.
47. Zhu, M, Perrett, S and Nie, G (2013). Understanding the particokinetics of engineered nanomaterials for safe and effective therapeutic applications. Small 9: 1619-1634.
48. Pakiari, AH and Jamshidi, Z (2010). Nature and strength of M-S bonds (m = Au, Ag, and Cu) in binary alloy gold clusters. J Phys Chem A 114: 9212-9221.
49. Mirkin, CA, Letsinger, RL, Mucic, RC and Storhoff, JJ (1996). A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382: 607-609. (Pubitemid 26268949)
50. Rosi, NL, Giljohann, DA, Thaxton, CS, Lytton-Jean, AK, Han, MS and Mirkin, CA (2006). Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 312: 1027-1030.
51. Ghildiyal, M and Zamore, PD (2009). Small silencing RNAs: an expanding universe. Nat Rev Genet 10: 94-108.
52. Giljohann, DA, Seferos, DS, Prigodich, AE, Patel, PC and Mirkin, CA (2009). Gene regulation with polyvalent siRNA-nanoparticle conjugates. J Am Chem Soc 131: 2072-2073.
53. Lytton-Jean, AK, Langer, R and Anderson, DG (2011). Five years of siRNA delivery: spotlight on gold nanoparticles. Small 7: 1932-1937.
54. Seferos, DS, Prigodich, AE, Giljohann, DA, Patel, PC and Mirkin, CA (2009). Polyvalent DNA nanoparticle conjugates stabilize nucleic acids. Nano Lett 9: 308-311.
55. Giljohann, DA, Seferos, DS, Daniel, WL, Massich, MD, Patel, PC and Mirkin, CA (2010). Gold nanoparticles for biology and medicine. Angew Chem Int Ed Engl 49: 3280-3294.
56. Patel, PC, Giljohann, DA, Daniel, WL, Zheng, D, Prigodich, AE and Mirkin, CA (2010). Scavenger receptors mediate cellular uptake of polyvalent oligonucleotidefunctionalized gold nanoparticles. Bioconjug Chem 21: 2250-2256.
57. Giljohann, DA, Seferos, DS, Patel, PC, Millstone, JE, Rosi, NL and Mirkin, CA (2007). Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Lett 7: 3818-3821.
58. Jin, R, Wu, G, Li, Z, Mirkin, CA and Schatz, GC (2003). What controls the melting properties of DNA-linked gold nanoparticle assemblies? J Am Chem Soc 125: 1643-1654. (Pubitemid 36206246)
59. Choi, CH, Hao, L, Narayan, SP, Auyeung, E and Mirkin, CA (2013). Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc Natl Acad Sci U S A 110: 7625-7630.
60. Zhang, K, Hao, L, Hurst, SJ and Mirkin, CA (2012). Antibody-linked spherical nucleic acids for cellular targeting. J Am Chem Soc 134: 16488-16491.
61. Hao, L, Patel, PC, Alhasan, AH, Giljohann, DA and Mirkin, CA (2011). Nucleic acidgold nanoparticle conjugates as mimics of microRNA. Small 7: 3158-3162.
62. Chen, J and Xie, J (2012). Progress on RNAi-based molecular medicines. Int J Nanomedicine 7: 3971-3980.
63. Oishi, M, Nakaogami, J, Ishii, T and Nagasaki, Y (2006). Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing. Chem Lett 35: 1046-1047. (Pubitemid 44859908)
64. Prausnitz, MR, Mitragotri, S and Langer, R (2004). Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3: 115-124. (Pubitemid 38239773)
65. Prausnitz, MR and Langer, R (2008). Transdermal drug delivery. Nat Biotechnol 26: 1261-1268.
66. Zheng, D, Giljohann, DA, Chen, DL, Massich, MD, Wang, XQ, Iordanov, H et al. (2012). Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Proc Natl Acad Sci U S A 109: 11975-11980.
67. Nel, AE, Mädler, L, Velegol, D, Xia, T, Hoek, EM, Somasundaran, P et al. (2009). Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8: 543-557.
68. Lévy, R, Shaheen, U, Cesbron, Y and Sée, V (2010). Gold nanoparticles delivery in mammalian live cells: a critical review. Nano Rev 1: 4889.
69. Gilleron, J, Querbes, W, Zeigerer, A, Borodovsky, A, Marsico, G, Schubert, U et al. (2013). Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape. Nat Biotechnol 31: 638-646.
70. Massich, MD, Giljohann, DA, Seferos, DS, Ludlow, LE, Horvath, CM and Mirkin, CA (2009). Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates. Mol Pharm 6: 1934-1940.
71. McIntosh, CM, Esposito, EA 3rd, Boal, AK, Simard, JM, Martin, CT and Rotello, VM (2001). Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. J Am Chem Soc 123: 7626-7629. (Pubitemid 32899398)
72. Sandhu, KK, McIntosh, CM, Simard, JM, Smith, SW and Rotello, VM (2002). Gold nanoparticle-mediated transfection of mammalian cells. Bioconjug Chem 13: 3-6. (Pubitemid 34119628)
73. Han, G, Martin, CT and Rotello, VM (2006). Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des 67: 78-82. (Pubitemid 43881390)
74. Goodman, CM, Chari, NS, Han, G, Hong, R, Ghosh, P and Rotello, VM (2006). DNAbinding by functionalized gold nanoparticles: mechanism and structural requirements. Chem Biol Drug Des 67: 297-304.
75. Thomas, M and Klibanov, AM (2003). Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 100: 9138-9143. (Pubitemid 37033896)
76. You, CC, De, M, Han, G and Rotello, VM (2005). Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles. J Am Chem Soc 127: 12873-12881. (Pubitemid 41339171)
77. You, CC, Agasti, SS and Rotello, VM (2008). Isomeric control of protein recognition with amino acid-and dipeptide-functionalized gold nanoparticles. Chemistry 14: 143-150.
78. Ghosh, PS, Han, G, Erdogan, B, Rosado, O, Krovi, SA and Rotello, VM (2007). Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chem Biol Drug Des 70: 13-18. (Pubitemid 47057424)
79. Ghosh, PS, Kim, CK, Han, G, Forbes, NS and Rotello, VM (2008). Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano 2: 2213-2218.
80. Kim, ST, Chompoosor, A, Yeh, YC, Agasti, SS, Solfiell, DJ and Rotello, VM (2012). Dendronized gold nanoparticles for siRNA delivery. Small 8: 3253-3256.
81. Yang, S and May, S (2008). Release of cationic polymer-DNA complexes from the endosome: a theoretical investigation of the proton sponge hypothesis. J Chem Phys 129: 185105.
82. Behr, J (1997). The proton sponge: a trick to enter cells the viruses did not exploit. Chimia 51: 34-36. (Pubitemid 127033737)
83. Chou, LY, Ming, K and Chan, WC (2011). Strategies for the intracellular delivery of nanoparticles. Chem Soc Rev 40: 233-245.
84. Benjaminsen, RV, Mattebjerg, MA, Henriksen, JR, Moghimi, SM and Andresen, TL (2013). The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH. Mol Ther 21: 149-157.
85. Elbakry, A, Zaky, A, Liebl, R, Rachel, R, Goepferich, A and Breunig, M (2009). Layer-bylayer assembled gold nanoparticles for siRNA delivery. Nano Lett 9: 2059-2064.
86. Guo, S, Huang, Y, Jiang, Q, Sun, Y, Deng, L, Liang, Z et al. (2010). Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano 4: 5505-5511.
87. Anderson, ME (1998). Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111-112: 1-14. (Pubitemid 28271929)
88. Hong, R, Han, G, Fernández, JM, Kim, BJ, Forbes, NS and Rotello, VM (2006). Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc 128: 1078-1079. (Pubitemid 43190611)
89. Han, G, You, CC, Kim, BJ, Turingan, RS, Forbes, NS, Martin, CT et al. (2006). Lightregulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl 45: 3165-3169. (Pubitemid 44099044)
90. Weissleder, R (2001). A clearer vision for in vivo imaging. Nat Biotechnol 19: 316-317.
91. Pissuwan, D, Niidome, T and Cortie, MB (2011). The forthcoming applications of gold nanoparticles in drug and gene delivery systems. J Control Release 149: 65-71.
92. Chen, CC, Lin, YP, Wang, CW, Tzeng, HC, Wu, CH, Chen, YC et al. (2006). DNA-gold nanorod conjugates for remote control of localized gene expression by near infrared irradiation. J Am Chem Soc 128: 3709-3715.
93. Wijaya, A, Schaffer, SB, Pallares, IG and Hamad-Schifferli, K (2009). Selective release of multiple DNA oligonucleotides from gold nanorods. ACS Nano 3: 80-86.
94. Chithrani, BD, Ghazani, AA and Chan, WC (2006). Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6: 662-668.
95. Chen, J and Irudayaraj, J (2009). Quantitative investigation of compartmentalized dynamics of ErbB2 targeting gold nanorods in live cells by single molecule spectroscopy. ACS Nano 3: 4071-4079.