-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669):806-811.
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
0037062951
-
RNA interference
-
Hannon GJ. RNA interference. Nature. 2002;418(6894):244-251.
-
(2002)
Nature
, vol.418
, Issue.6894
, pp. 244-251
-
-
Hannon, G.J.1
-
3
-
-
4644223259
-
Mechanisms of gene silencing by double-stranded RNA
-
Meister G, Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature. 2004;431(7006):343-349.
-
(2004)
Nature
, vol.431
, Issue.7006
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
4
-
-
3142615372
-
The RNAi revolution
-
Novina CD, Sharp PA. The RNAi revolution. Nature. 2004;430(6996): 161-164.
-
(2004)
Nature
, vol.430
, Issue.6996
, pp. 161-164
-
-
Novina, C.D.1
Sharp, P.A.2
-
5
-
-
58149242904
-
siRNA, miRNA, and shRNA: In vivo applications
-
Pushparaj PN, Aarthi JJ, Manikandan J, Kumar SD. siRNA, miRNA, and shRNA: in vivo applications. J Dent Res. 2008;87(11):992-1003.
-
(2008)
J Dent Res
, vol.87
, Issue.11
, pp. 992-1003
-
-
Pushparaj, P.N.1
Aarthi, J.J.2
Manikandan, J.3
Kumar, S.D.4
-
6
-
-
79954580272
-
Current prospects for RNA interference-based therapies
-
Davidson BL, McCray PB Jr. Current prospects for RNA interference-based therapies. Nat Rev Genet. 2011;12(5):329-340.
-
(2011)
Nat Rev Genet
, vol.12
, Issue.5
, pp. 329-340
-
-
Davidson, B.L.1
McCray Jr., P.B.2
-
7
-
-
33644768174
-
Control of translation and mRNA degradation by miRNAs and siRNAs
-
Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006;20(5):515-524.
-
(2006)
Genes Dev
, vol.20
, Issue.5
, pp. 515-524
-
-
Valencia-Sanchez, M.A.1
Liu, J.2
Hannon, G.J.3
Parker, R.4
-
8
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281-297.
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 281-297
-
-
Bartel, D.P.1
-
9
-
-
79958025810
-
Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis
-
Lund E, Sheets MD, Imboden SB, Dahlberg JE. Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis. Genes Dev. 2011;25(11):1121-1131.
-
(2011)
Genes Dev
, vol.25
, Issue.11
, pp. 1121-1131
-
-
Lund, E.1
Sheets, M.D.2
Imboden, S.B.3
Dahlberg, J.E.4
-
10
-
-
0035863097
-
RNA interference is mediated by 21-and 22-nucleotide RNAs
-
Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev. 2001;15(2):188-200.
-
(2001)
Genes Dev
, vol.15
, Issue.2
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
11
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000;101(1):25-33.
-
(2000)
Cell
, vol.101
, Issue.1
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
12
-
-
0346094457
-
Prediction of mammalian microRNA targets
-
Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115(7):787-798.
-
(2003)
Cell
, vol.115
, Issue.7
, pp. 787-798
-
-
Lewis, B.P.1
Shih, I.H.2
Jones-Rhoades, M.W.3
Bartel, D.P.4
Burge, C.B.5
-
13
-
-
37648998629
-
Getting to the root of miRNA-mediated gene silencing
-
Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell. 2008;132(1):9-14.
-
(2008)
Cell
, vol.132
, Issue.1
, pp. 9-14
-
-
Eulalio, A.1
Huntzinger, E.2
Izaurralde, E.3
-
14
-
-
77953629046
-
Regulation of mRNA translation and stability by microRNAs
-
Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351-379.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 351-379
-
-
Fabian, M.R.1
Sonenberg, N.2
Filipowicz, W.3
-
15
-
-
33744973775
-
Relief of microRNA-mediated translational repression in human cells subjected to stress
-
Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell. 2006;125(6):1111-1124.
-
(2006)
Cell
, vol.125
, Issue.6
, pp. 1111-1124
-
-
Bhattacharyya, S.N.1
Habermacher, R.2
Martine, U.3
Closs, E.I.4
Filipowicz, W.5
-
16
-
-
33750939787
-
Recent development of RNAi in drug target discovery and validation
-
Liu G, Wong-Staal F, Li QX. Recent development of RNAi in drug target discovery and validation. Drug Discov Today Technol. 2006;3(3): 293-300.
-
(2006)
Drug Discov Today Technol
, vol.3
, Issue.3
, pp. 293-300
-
-
Liu, G.1
Wong-Staal, F.2
Li, Q.X.3
-
17
-
-
0036351317
-
Analysis of gene function in somatic mammalian cells using small interfering RNAs
-
Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 2002;26(2):199-213.
-
(2002)
Methods
, vol.26
, Issue.2
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
18
-
-
84870387539
-
Development and applications of RNAi technology in drug research
-
Lina W, Chonggang Y. Development and applications of RNAi technology in drug research. Chin Bull Life Sci. 2007;19:199-213.
-
(2007)
Chin Bull Life Sci
, vol.19
, pp. 199-213
-
-
Lina, W.1
Chonggang, Y.2
-
19
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol. 2004;22(3):326-330.
-
(2004)
Nat Biotechnol
, vol.22
, Issue.3
, pp. 326-330
-
-
Reynolds, A.1
Leake, D.2
Boese, Q.3
Scaringe, S.4
Marshall, W.S.5
Khvorova, A.6
-
20
-
-
24344500241
-
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
-
Harborth J, Elbashir SM, Vandenburgh K, etal. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev. 2003;13(2):83-105.
-
(2003)
Antisense Nucleic Acid Drug Dev
, vol.13
, Issue.2
, pp. 83-105
-
-
Harborth, J.1
Elbashir, S.M.2
Vandenburgh, K.3
-
21
-
-
0842332405
-
Enzymatic production of RNAi libraries from cDNAs
-
Shirane D, Sugao K, Namiki S, Tanabe M, Iino M, Hirose K. Enzymatic production of RNAi libraries from cDNAs. Nat Genet. 2004;36(2): 190-196.
-
(2004)
Nat Genet
, vol.36
, Issue.2
, pp. 190-196
-
-
Shirane, D.1
Sugao, K.2
Namiki, S.3
Tanabe, M.4
Iino, M.5
Hirose, K.6
-
22
-
-
57449112781
-
Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats
-
Herold MJ, van den Brandt J, Seibler J, Reichardt HM. Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Proc Natl Acad Sci U S A. 2008;105(47): 18507-18512.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.47
, pp. 18507-18512
-
-
Herold, M.J.1
van den Brandt, J.2
Seibler, J.3
Reichardt, H.M.4
-
23
-
-
78650564093
-
Targeted delivery of RNAi therapeutics for cancer therapy
-
Li J, Huang L. Targeted delivery of RNAi therapeutics for cancer therapy. Nanomedicine (Lond). 2010;5(10):1483-1486.
-
(2010)
Nanomedicine (Lond)
, vol.5
, Issue.10
, pp. 1483-1486
-
-
Li, J.1
Huang, L.2
-
24
-
-
0036245743
-
Expanding small RNA interference
-
Tuschl T. Expanding small RNA interference. Nat Biotechnol. 2002; 20(5):446-448.
-
(2002)
Nat Biotechnol
, vol.20
, Issue.5
, pp. 446-448
-
-
Tuschl, T.1
-
25
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002; 296(5567):550-553.
-
(2002)
Science
, vol.296
, Issue.5567
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
26
-
-
0037452812
-
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
-
Tiscornia G, Singer O, Ikawa M, Verma IM. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A. 2003;100(4):1844-1848.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.4
, pp. 1844-1848
-
-
Tiscornia, G.1
Singer, O.2
Ikawa, M.3
Verma, I.M.4
-
27
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
-
Rubinson DA, Dillon CP, Kwiatkowski AV, etal. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003;33(3): 401-406.
-
(2003)
Nat Genet
, vol.33
, Issue.3
, pp. 401-406
-
-
Rubinson, D.A.1
Dillon, C.P.2
Kwiatkowski, A.V.3
-
28
-
-
33750824739
-
Modeling CTLA4-linked autoimmunity with RNA interference in mice
-
Chen Z, Stockton J, Mathis D, Benoist C. Modeling CTLA4-linked autoimmunity with RNA interference in mice. Proc Natl Acad Sci U S A. 2006;103(44):16400-16405.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.44
, pp. 16400-16405
-
-
Chen, Z.1
Stockton, J.2
Mathis, D.3
Benoist, C.4
-
29
-
-
0042662862
-
Establishment of conditional vectors for hairpin siRNA knockdowns
-
Matsukura S, Jones PA, Takai D. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Res. 2003;31(15):e77.
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.15
-
-
Matsukura, S.1
Jones, P.A.2
Takai, D.3
-
30
-
-
77949289074
-
Generation and characterization of a Tet-On (rtTA-M2) transgenic rat
-
Sheng Y, Lin CC, Yue J, etal. Generation and characterization of a Tet-On (rtTA-M2) transgenic rat. BMC Dev Biol. 2010;10:17.
-
(2010)
BMC Dev Biol
, vol.10
, pp. 17
-
-
Sheng, Y.1
Lin, C.C.2
Yue, J.3
-
31
-
-
34249850644
-
Reversible gene knockdown in mice using a tight, inducible shRNA expression system
-
Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F. Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res. 2007;35(7):e54.
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.7
-
-
Seibler, J.1
Kleinridders, A.2
Küter-Luks, B.3
Niehaves, S.4
Brüning, J.C.5
Schwenk, F.6
-
32
-
-
0037145513
-
A predictable ligand regulated expression strategy for stably integrated transgenes in mammalian cells in culture
-
Anastassiadis K, Kim J, Daigle N, Sprengel R, Schöler HR, Stewart AF. A predictable ligand regulated expression strategy for stably integrated transgenes in mammalian cells in culture. Gene. 2002;298(2):159-172.
-
(2002)
Gene
, vol.298
, Issue.2
, pp. 159-172
-
-
Anastassiadis, K.1
Kim, J.2
Daigle, N.3
Sprengel, R.4
Schöler, H.R.5
Stewart, A.F.6
-
33
-
-
20344377636
-
Development of 2A peptide-based strategies in the design of multicistronic vectors
-
Szymczak AL, Vignali DA. Development of 2A peptide-based strategies in the design of multicistronic vectors. Expert Opin Biol Ther. 2005;5(5):627-638.
-
(2005)
Expert Opin Biol Ther
, vol.5
, Issue.5
, pp. 627-638
-
-
Szymczak, A.L.1
Vignali, D.A.2
-
34
-
-
79959937835
-
Pharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery
-
Abdelmawla S, Guo S, Zhang L, etal. Pharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery. Mol Ther. 2011;19(7):1312-1322.
-
(2011)
Mol Ther
, vol.19
, Issue.7
, pp. 1312-1322
-
-
Abdelmawla, S.1
Guo, S.2
Zhang, L.3
-
35
-
-
22644446537
-
Nanoparticles deliver RNAi therapy
-
Woodle MC, Lu PY. Nanoparticles deliver RNAi therapy. Mater Today. 2005;8(8 Suppl 1):34-41.
-
(2005)
Mater Today
, vol.8
, Issue.8 SUPPL. 1
, pp. 34-41
-
-
Woodle, M.C.1
Lu, P.Y.2
-
36
-
-
1642362625
-
Drug delivery systems: Entering the mainstream
-
Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004;303(5665):1818-1822.
-
(2004)
Science
, vol.303
, Issue.5665
, pp. 1818-1822
-
-
Allen, T.M.1
Cullis, P.R.2
-
37
-
-
79953899274
-
SiRNA delivery with exosome nanoparticles
-
van den Boorn JG, Schlee M, Coch C, Hartmann G. SiRNA delivery with exosome nanoparticles. Nat Biotechnol. 2011;29(4):325-326.
-
(2011)
Nat Biotechnol
, vol.29
, Issue.4
, pp. 325-326
-
-
van den Boorn, J.G.1
Schlee, M.2
Coch, C.3
Hartmann, G.4
-
38
-
-
77957820261
-
RNAi and small interfering RNAs in human disease therapeutic applications
-
Lares MR, Rossi JJ, Ouellet DL. RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol. 2010; 28(11):570-579.
-
(2010)
Trends Biotechnol
, vol.28
, Issue.11
, pp. 570-579
-
-
Lares, M.R.1
Rossi, J.J.2
Ouellet, D.L.3
-
39
-
-
33750524774
-
Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro
-
Sutton D, Kim S, Shuai X, etal. Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro. Int J Nanomedicine. 2006;1(2):155-162.
-
(2006)
Int J Nanomedicine
, vol.1
, Issue.2
, pp. 155-162
-
-
Sutton, D.1
Kim, S.2
Shuai, X.3
-
40
-
-
77951159570
-
The investigation of polymer-siRNA nanoparticle for gene therapy of gastric cancer in vitro
-
Wu Y, Wang W, Chen Y, etal. The investigation of polymer-siRNA nanoparticle for gene therapy of gastric cancer in vitro. Int J Nanomedicine. 2010;5:129-136.
-
(2010)
Int J Nanomedicine
, vol.5
, pp. 129-136
-
-
Wu, Y.1
Wang, W.2
Chen, Y.3
-
41
-
-
0031745390
-
Increased expression of CD44v6mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer
-
Yamamichi K, Uehara Y, Kitamura N, Nakane Y, Hioki K. Increased expression of CD44v6mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer. Int J Cancer. 1998; 79(3):256-262.
-
(1998)
Int J Cancer
, vol.79
, Issue.3
, pp. 256-262
-
-
Yamamichi, K.1
Uehara, Y.2
Kitamura, N.3
Nakane, Y.4
Hioki, K.5
-
42
-
-
0031830395
-
Expression of CD44 variant 6 and lymphatic invasion: Importance to lymph node metastasis in gastric cancer
-
Kurozumi K, Nishida T, Nakao K, Nakahara M, Tsujimoto M. Expression of CD44 variant 6 and lymphatic invasion: importance to lymph node metastasis in gastric cancer. World J Surg. 1998;22(8):853-857.
-
(1998)
World J Surg
, vol.22
, Issue.8
, pp. 853-857
-
-
Kurozumi, K.1
Nishida, T.2
Nakao, K.3
Nakahara, M.4
Tsujimoto, M.5
-
43
-
-
0031666744
-
Development of a self-inactivating lentivirus vector
-
Miyoshi H, Blomer U, Takahashi M, Gage FH, Verma IM. Development of a self-inactivating lentivirus vector. J Virol. 1998;72(10): 8150-8157.
-
(1998)
J Virol
, vol.72
, Issue.10
, pp. 8150-8157
-
-
Miyoshi, H.1
Blomer, U.2
Takahashi, M.3
Gage, F.H.4
Verma, I.M.5
-
44
-
-
0036682975
-
Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo
-
VandenDriessche T, Thorrez L, Naldini L, etal. Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo. Blood. 2002;100(3):813-822.
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 813-822
-
-
VandenDriessche, T.1
Thorrez, L.2
Naldini, L.3
-
45
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, etal. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302(5644):415-419.
-
(2003)
Science
, vol.302
, Issue.5644
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
von Kalle, C.2
Schmidt, M.3
-
46
-
-
4644350944
-
Unlocking the potential of the human genome with RNA interference
-
Hannon GJ, Rossi JJ. Unlocking the potential of the human genome with RNA interference. Nature. 2004;431(7006):371-378.
-
(2004)
Nature
, vol.431
, Issue.7006
, pp. 371-378
-
-
Hannon, G.J.1
Rossi, J.J.2
-
47
-
-
17644383664
-
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
-
Raoul C, Abbas-Terki T, Bensadoun JC, etal. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med. 2005;11(43):423-428.
-
(2005)
Nat Med
, vol.11
, Issue.43
, pp. 423-428
-
-
Raoul, C.1
Abbas-Terki, T.2
Bensadoun, J.C.3
-
48
-
-
0021023167
-
A protease-resistant protein is a structural component of the Scrapie prion
-
McKinley MP, Bolton DC, Prusiner SB. A protease-resistant protein is a structural component of the Scrapie prion. Cell. 1983;35(1):57-62.
-
(1983)
Cell
, vol.35
, Issue.1
, pp. 57-62
-
-
McKinley, M.P.1
Bolton, D.C.2
Prusiner, S.B.3
-
49
-
-
0020490156
-
Identification of a protein that purifies with the scrapie prion
-
Bolton D, McKinley M, Prusiner S. Identification of a protein that purifies with the scrapie prion. Science. 1982;218(4579):1309-1311.
-
(1982)
Science
, vol.218
, Issue.4579
, pp. 1309-1311
-
-
Bolton, D.1
McKinley, M.2
Prusiner, S.3
-
50
-
-
0031803512
-
Role of microglia in neuronal cell death in prion disease
-
Giese A, Brown DR, Groschup MH, Feldmann C, Haist I, Kretzschmar HA. Role of microglia in neuronal cell death in prion disease. Brain Pathol. 1998;8(3):449-457.
-
(1998)
Brain Pathol
, vol.8
, Issue.3
, pp. 449-457
-
-
Giese, A.1
Brown, D.R.2
Groschup, M.H.3
Feldmann, C.4
Haist, I.5
Kretzschmar, H.A.6
-
51
-
-
0028535880
-
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene
-
Bueler H, Raeber A, Sailer A, Fischer M, Aguzzi A, Weissmann C. High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med. 1994; 1(1):19-30.
-
(1994)
Mol Med
, vol.1
, Issue.1
, pp. 19-30
-
-
Bueler, H.1
Raeber, A.2
Sailer, A.3
Fischer, M.4
Aguzzi, A.5
Weissmann, C.6
-
52
-
-
33845346122
-
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice
-
Pfeifer A, Eigenbrod S, Al-Khadra S, etal. Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice. J Clin Invest. 2006;116(12):3204-3210.
-
(2006)
J Clin Invest
, vol.116
, Issue.12
, pp. 3204-3210
-
-
Pfeifer, A.1
Eigenbrod, S.2
Al-Khadra, S.3
-
53
-
-
0242363656
-
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
-
Mallucci G, Dickinson A, Linehan J, Klöhn PC, Brandner S, Collinge J. Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis. Science. 2003;302(5646):871-874.
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 871-874
-
-
Mallucci, G.1
Dickinson, A.2
Linehan, J.3
Klöhn, P.C.4
Brandner, S.5
Collinge, J.6
-
54
-
-
50849102657
-
Prnp knockdown in transgenic mice using RNA interference
-
Gallozzi M, Chapuis J, Le Provost F, etal. Prnp knockdown in transgenic mice using RNA interference. Transgenic Res. 2008;17(5):783-791.
-
(2008)
Transgenic Res
, vol.17
, Issue.5
, pp. 783-791
-
-
Gallozzi, M.1
Chapuis, J.2
Le Provost, F.3
-
55
-
-
77956205950
-
Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures
-
Pulford B, Reim N, Bell A, etal. Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures. PLoS One. 2010;5(6):e11085.
-
(2010)
PLoS One
, vol.5
, Issue.6
-
-
Pulford, B.1
Reim, N.2
Bell, A.3
-
56
-
-
0033012398
-
Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
-
Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Ann Rev Immunol. 1999;17(1):657-700.
-
(1999)
Ann Rev Immunol
, vol.17
, Issue.1
, pp. 657-700
-
-
Berger, E.A.1
Murphy, P.M.2
Farber, J.M.3
-
58
-
-
0033842733
-
Virus and target cell evolution in human immunodeficiency virus type 1 infection
-
Mosier D. Virus and target cell evolution in human immunodeficiency virus type 1 infection. Immunol Res. 2000;21(2):253-258.
-
(2000)
Immunol Res
, vol.21
, Issue.2
, pp. 253-258
-
-
Mosier, D.1
-
59
-
-
0033659687
-
Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands
-
Simmons G, Reeves JD, Hibbitts S, etal. Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands. Immunol Rev. 2000;177(1):112-126.
-
(2000)
Immunol Rev
, vol.177
, Issue.1
, pp. 112-126
-
-
Simmons, G.1
Reeves, J.D.2
Hibbitts, S.3
-
60
-
-
2642563503
-
Human genes that limit AIDS
-
O'Brien SJ, Nelson GW. Human genes that limit AIDS. Nat Genet. 2004;36(6):565-574.
-
(2004)
Nat Genet
, vol.36
, Issue.6
, pp. 565-574
-
-
O'Brien, S.J.1
Nelson, G.W.2
-
61
-
-
0030861904
-
Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study
-
Smith MW, Dean M, Carrington M, etal. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997;277(5328):959-965.
-
(1997)
Science
, vol.277
, Issue.5328
, pp. 959-965
-
-
Smith, M.W.1
Dean, M.2
Carrington, M.3
-
62
-
-
77949885010
-
A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
-
Shimizu S, Hong P, Arumugam B, etal. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010;115(8):1534-1544.
-
(2010)
Blood
, vol.115
, Issue.8
, pp. 1534-1544
-
-
Shimizu, S.1
Hong, P.2
Arumugam, B.3
-
63
-
-
34548818764
-
Cationic lipids and polymers mediated vectors for delivery of siRNA
-
Zhang S, Zhao B, Jiang H, Wang B, Ma B. Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release. 2007;123(1):1-10.
-
(2007)
J Control Release
, vol.123
, Issue.1
, pp. 1-10
-
-
Zhang, S.1
Zhao, B.2
Jiang, H.3
Wang, B.4
Ma, B.5
-
64
-
-
36148971655
-
Delivery of siRNA from lyophilized polymeric surfaces
-
Andersen MO, Howard KA, Paludan SR, Besenbacher F, Kjems J. Delivery of siRNA from lyophilized polymeric surfaces. Biomaterials. 2008;29(4):506-512.
-
(2008)
Biomaterials
, vol.29
, Issue.4
, pp. 506-512
-
-
Andersen, M.O.1
Howard, K.A.2
Paludan, S.R.3
Besenbacher, F.4
Kjems, J.5
-
65
-
-
34447114618
-
Transvascular delivery of small interfering RNA to the central nervous system
-
Kumar P, Wu H, McBride JL, etal. Transvascular delivery of small interfering RNA to the central nervous system. Nature. 2007;448(7149): 39-43.
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 39-43
-
-
Kumar, P.1
Wu, H.2
McBride, J.L.3
-
66
-
-
16244414899
-
Rabies virus receptors
-
Lafon M. Rabies virus receptors. J Neurovirol. 2005;11(1):82-87.
-
(2005)
J Neurovirol
, vol.11
, Issue.1
, pp. 82-87
-
-
Lafon, M.1
-
67
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey DV, Lockridge JA, Shaw L, etal. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol. 2005;23(8):1002-1007.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
-
68
-
-
84857543322
-
Inorganic material coatings and their effect on cytotoxicity
-
Richards D, Ivanisevic A. Inorganic material coatings and their effect on cytotoxicity. Chem Soc Rev. 2012;41(6):2052-2060.
-
(2012)
Chem Soc Rev
, vol.41
, Issue.6
, pp. 2052-2060
-
-
Richards, D.1
Ivanisevic, A.2
-
69
-
-
80051587821
-
Gold revolution-gold nanoparticles for modern medicine and surgery
-
Rippel RA, Seifalian AM. Gold revolution-gold nanoparticles for modern medicine and surgery. J Nanosci Nanotechnol. 2011;11(5): 3740-3748.
-
(2011)
J Nanosci Nanotechnol
, vol.11
, Issue.5
, pp. 3740-3748
-
-
Rippel, R.A.1
Seifalian, A.M.2
-
70
-
-
46749122210
-
Gold nanoparticles in delivery applications
-
Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008;60(11):1307-1315.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, Issue.11
, pp. 1307-1315
-
-
Ghosh, P.1
Han, G.2
De, M.3
Kim, C.K.4
Rotello, V.M.5
-
71
-
-
77957302255
-
Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte
-
Guo S, Huang Y, Jiang Q, etal. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano. 2010;4(9):5505-5511.
-
(2010)
ACS Nano
, vol.4
, Issue.9
, pp. 5505-5511
-
-
Guo, S.1
Huang, Y.2
Jiang, Q.3
-
72
-
-
77955523390
-
Labile catalytic packaging of DNA/siRNA: Control of gold nanoparticles "out" of DNA/siRNA complexes
-
Chen AM, Taratula O, Wei D, etal. Labile catalytic packaging of DNA/siRNA: control of gold nanoparticles "out" of DNA/siRNA complexes. ACS Nano. 2010;4(7):3679-3688.
-
(2010)
ACS Nano
, vol.4
, Issue.7
, pp. 3679-3688
-
-
Chen, A.M.1
Taratula, O.2
Wei, D.3
-
73
-
-
0041923880
-
Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
-
Thomas M, Klibanov AM. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A. 2003;100(16):9138-9143.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.16
, pp. 9138-9143
-
-
Thomas, M.1
Klibanov, A.M.2
-
74
-
-
33646738061
-
Oligonucleotide-modified gold nanoparticles for intracellular gene regulation
-
Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AKR, Han MS, Mirkin CA. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science. 2006;312(5776):1027-1030.
-
(2006)
Science
, vol.312
, Issue.5776
, pp. 1027-1030
-
-
Rosi, N.L.1
Giljohann, D.A.2
Thaxton, C.S.3
Lytton-Jean, A.K.R.4
Han, M.S.5
Mirkin, C.A.6
-
75
-
-
66449127352
-
Layer-by-layer assembled gold nanoparticles for siRNA delivery
-
Elbakry A, Zaky A, Liebl R, Rachel R, Goepferich A, Breunig M. Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano Lett. 2009;9(5):2059-2064.
-
(2009)
Nano Lett
, vol.9
, Issue.5
, pp. 2059-2064
-
-
Elbakry, A.1
Zaky, A.2
Liebl, R.3
Rachel, R.4
Goepferich, A.5
Breunig, M.6
-
76
-
-
66749180499
-
Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery
-
Lee JS, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 2009;9(6):2402-2406.
-
(2009)
Nano Lett
, vol.9
, Issue.6
, pp. 2402-2406
-
-
Lee, J.S.1
Green, J.J.2
Love, K.T.3
Sunshine, J.4
Langer, R.5
Anderson, D.G.6
-
77
-
-
76749089244
-
Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery
-
Song WJ, Du JZ, Sun TM, Zhang PZ, Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small. 2010;6(2):239-246.
-
(2010)
Small
, vol.6
, Issue.2
, pp. 239-246
-
-
Song, W.J.1
Du, J.Z.2
Sun, T.M.3
Zhang, P.Z.4
Wang, J.5
-
78
-
-
84857438167
-
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
-
Zuckerman JE, Choi CHJ, Han H, Davis ME. Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane. Proc Natl Acad Sci U S A. 2012;109(8):3137-3142.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.8
, pp. 3137-3142
-
-
Zuckerman, J.E.1
Choi, C.H.J.2
Han, H.3
Davis, M.E.4
-
79
-
-
84860875427
-
Cationic lipid-coated gold nanoparticles as efficient and non-cytotoxic intracellular siRNA delivery vehicles
-
Kong W, Bae K, Jo S, Kim J, Park T. Cationic lipid-coated gold nanoparticles as efficient and non-cytotoxic intracellular siRNA delivery vehicles. Pharm Res. 2012;29(2):362-374.
-
(2012)
Pharm Res
, vol.29
, Issue.2
, pp. 362-374
-
-
Kong, W.1
Bae, K.2
Jo, S.3
Kim, J.4
Park, T.5
-
80
-
-
0038743194
-
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles
-
Sokolov K, Follen M, Aaron J, etal. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res. 2003;63(9):1999-2004.
-
(2003)
Cancer Res
, vol.63
, Issue.9
, pp. 1999-2004
-
-
Sokolov, K.1
Follen, M.2
Aaron, J.3
-
81
-
-
69249182906
-
The detection of HBV DNA with gold nanoparticle gene probes
-
Xi D, Luo X, Ning Q, Lu Q, Yao K, Liu Z. The detection of HBV DNA with gold nanoparticle gene probes. Journal of Nanjing Medical University. 2007;21(4):207-212.
-
(2007)
Journal of Nanjing Medical University
, vol.21
, Issue.4
, pp. 207-212
-
-
Xi, D.1
Luo, X.2
Ning, Q.3
Lu, Q.4
Yao, K.5
Liu, Z.6
-
82
-
-
33745455035
-
Gold nanoparticle probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples
-
Baptista PV, Koziol-Montewka M, Paluch-Oles J, Doria G, Franco R. Gold nanoparticle probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples. Clin Chem. 2006;52(7):1433-1434.
-
(2006)
Clin Chem
, vol.52
, Issue.7
, pp. 1433-1434
-
-
Baptista, P.V.1
Koziol-Montewka, M.2
Paluch-Oles, J.3
Doria, G.4
Franco, R.5
-
83
-
-
14044279957
-
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
-
Georganopoulou DG, Chang L, Nam JM, etal. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102(7): 2273-2276.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.7
, pp. 2273-2276
-
-
Georganopoulou, D.G.1
Chang, L.2
Nam, J.M.3
-
84
-
-
51949117829
-
Impedance method for detecting HIV-1 protease and screening for its inhibitors using ferrocene-peptide conjugate/Au nanoparticle/single-walled carbon nanotube modified electrode
-
Mahmoud KA, Luong JHT. Impedance method for detecting HIV-1 protease and screening for its inhibitors using ferrocene-peptide conjugate/Au nanoparticle/single-walled carbon nanotube modified electrode. Anal Chem. 2008;80(18):7056-7062.
-
(2008)
Anal Chem
, vol.80
, Issue.18
, pp. 7056-7062
-
-
Mahmoud, K.A.1
Luong, J.H.T.2
-
85
-
-
0023225629
-
A small viral RNA is required for in vitro packaging of bacteriophage phi 29 DNA
-
Guo P, Erickson S, Anderson D. A small viral RNA is required for in vitro packaging of bacteriophage phi 29 DNA. Science. 1987;236(4802): 690-694.
-
(1987)
Science
, vol.236
, Issue.4802
, pp. 690-694
-
-
Guo, P.1
Erickson, S.2
Anderson, D.3
-
86
-
-
0037036444
-
Computer modeling of three-dimensional structure of DNA-packaging RNA (pRNA) monomer, dimer, and hexamer of Phi29 DNA packaging motor
-
Hoeprich S, Guo P. Computer modeling of three-dimensional structure of DNA-packaging RNA (pRNA) monomer, dimer, and hexamer of Phi29 DNA packaging motor. J Biol Chem. 2002;277(23): 20794-20803.
-
(2002)
J Biol Chem
, vol.277
, Issue.23
, pp. 20794-20803
-
-
Hoeprich, S.1
Guo, P.2
-
87
-
-
24944565527
-
Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology
-
Khaled A, Guo S, Li F, Guo P. Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett. 2005;5(9):1797-1808.
-
(2005)
Nano Lett
, vol.5
, Issue.9
, pp. 1797-1808
-
-
Khaled, A.1
Guo, S.2
Li, F.3
Guo, P.4
-
88
-
-
0034625371
-
A dimer as a building block in assembling RNA
-
Chen C, Sheng S, Shao Z, Guo P. A dimer as a building block in assembling RNA. J Biol Chem. 2000;275(23):17510-17516.
-
(2000)
J Biol Chem
, vol.275
, Issue.23
, pp. 17510-17516
-
-
Chen, C.1
Sheng, S.2
Shao, Z.3
Guo, P.4
-
89
-
-
0028361637
-
The proximate 5' and 3' ends of the 120-base viral RNA (pRNA) are crucial for the packaging of bacteriophage Ø29 DNA
-
Zhang C, Lee CS, Guo P. The proximate 5' and 3' ends of the 120-base viral RNA (pRNA) are crucial for the packaging of bacteriophage Ø29 DNA. Virology. 1994;201(1):77-85.
-
(1994)
Virology
, vol.201
, Issue.1
, pp. 77-85
-
-
Zhang, C.1
Lee, C.S.2
Guo, P.3
-
90
-
-
0030817119
-
Boundary of pRNA functional domains and minimum pRNA sequence requirement for specific connector binding and DNA packaging of phage phi29
-
Garver K, Guo P. Boundary of pRNA functional domains and minimum pRNA sequence requirement for specific connector binding and DNA packaging of phage phi29. RNA. 1997;3(9):1068-1079.
-
(1997)
RNA.
, vol.3
, Issue.9
, pp. 1068-1079
-
-
Garver, K.1
Guo, P.2
-
91
-
-
0027992332
-
Characterization of the prohead-pRNA interaction of bacteriophage phi 29
-
Reid RJ, Bodley JW, Anderson D. Characterization of the prohead-pRNA interaction of bacteriophage phi 29. J Biol Chem. 1994;269(7): 5157-5162.
-
(1994)
J Biol Chem
, vol.269
, Issue.7
, pp. 5157-5162
-
-
Reid, R.J.1
Bodley, J.W.2
Anderson, D.3
-
92
-
-
0032981057
-
Sequence requirement for hand-in-hand interaction in formation of RNA dimers and hexamers to gear phi29 DNA translocation motor
-
Chen C, Zhang C, Guo P. Sequence requirement for hand-in-hand interaction in formation of RNA dimers and hexamers to gear phi29 DNA translocation motor. RNA. 1999;5(6):805-818.
-
(1999)
RNA.
, vol.5
, Issue.6
, pp. 805-818
-
-
Chen, C.1
Zhang, C.2
Guo, P.3
-
93
-
-
0028966682
-
Circularly permuted viral pRNA active and specific in the packaging of bacteriophage φ{symbol}29 DNA
-
Zhang C, Trottier M, Guo P. Circularly permuted viral pRNA active and specific in the packaging of bacteriophage φ{symbol}29 DNA. Virology. 1995;207(2):442-451.
-
(1995)
Virology
, vol.207
, Issue.2
, pp. 442-451
-
-
Zhang, C.1
Trottier, M.2
Guo, P.3
-
94
-
-
24944512987
-
Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA
-
Guo S, Tschammer N, Mohammed S, Guo P. Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA. Hum Gene Ther. 2005;16(9):1097-1109.
-
(2005)
Hum Gene Ther
, vol.16
, Issue.9
, pp. 1097-1109
-
-
Guo, S.1
Tschammer, N.2
Mohammed, S.3
Guo, P.4
-
95
-
-
33646356236
-
Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells
-
Guo S, Huang F, Guo P. Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells. Gene Ther. 2006;13(10):814-820.
-
(2006)
Gene Ther
, vol.13
, Issue.10
, pp. 814-820
-
-
Guo, S.1
Huang, F.2
Guo, P.3
-
96
-
-
79955115072
-
Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging
-
Liu J, Guo S, Cinier M, etal. Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging. ACS Nano. 2010;5(1):237-246.
-
(2010)
ACS Nano
, vol.5
, Issue.1
, pp. 237-246
-
-
Liu, J.1
Guo, S.2
Cinier, M.3
-
97
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CHJ, etal. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature. 2010;464(7291):1067-1070.
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.J.3
-
98
-
-
76349095131
-
RNAi-mediated CCR5silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
-
Kim SS, Peer D, Kumar P, etal. RNAi-mediated CCR5silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther. 2010;18(2):370-376.
-
(2010)
Mol Ther
, vol.18
, Issue.2
, pp. 370-376
-
-
Kim, S.S.1
Peer, D.2
Kumar, P.3
-
99
-
-
22444444974
-
Applications of RNA interference technology to drug study
-
Xinping L. Applications of RNA interference technology to drug study. Chinese Pharmacological Bulletin. 2005;21(4):400-403.
-
(2005)
Chinese Pharmacological Bulletin
, vol.21
, Issue.4
, pp. 400-403
-
-
Xinping, L.1
-
100
-
-
84871474791
-
-
TheFreeLibrary. com [homepage on the Internet], Pennsylvania: Farlex, Inc.; c 2012 [updated 2009 May 6; cited 2012 Apr 10]. Available from, Accessed Jun 25
-
TheFreeLibrary. com [homepage on the Internet]. OPKO Health Announces Update on Phase III Clinical Trial of Bevasiranib. Pennsylvania: Farlex, Inc.; c 2012 [updated 2009 May 6; cited 2012 Apr 10]. Available from: http://www.thefreelibrary.com/OPKO+Health+Announces+Update+on+Phase+III+Clinical+Trial+of.-a0195014938. Accessed Jun 25, 2012.
-
(2012)
OPKO Health Announces Update on Phase III Clinical Trial of Bevasiranib
-
-
-
102
-
-
84871515927
-
-
Tekmirapharm. com [homepage on the Internet], British Columbia: Tekmira Pharmaceuticals Corp.; c 2012 [updated 2012 May 15; cited 2012 Apr 10]. Available from, Accessed Jun 22
-
Tekmirapharm. com [homepage on the Internet]. Tekmira Provides Corporate Update and Announces First Quarter 2012 Results. British Columbia: Tekmira Pharmaceuticals Corp.; c 2012 [updated 2012 May 15; cited 2012 Apr 10]. Available from: http://investor.tekmirapharm.com/releasedetail.cfm?releaseid=673804. Accessed Jun 22, 2012.
-
(2012)
Tekmira Provides Corporate Update and Announces First Quarter 2012 Results
-
-
-
104
-
-
84871522942
-
-
Pharmaceuticals A, In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 May 30]. Available from, Accessed Jul 11
-
Pharmaceuticals A. Phase 2b Study of ALN-RSV01 in Lung Transplant Patients Infected With Respiratory Syncytial Virus (RSV). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 May 30]. Available from: http://clinicaltrials.gov/ct2/show/NCT01065935?term=Alnylam&rank=5. ClinicalTrials.gov Identifier: NCT01065935. Accessed Jul 11, 2012.
-
(2012)
Phase 2b Study of ALN-RSV01 in Lung Transplant Patients Infected With Respiratory Syncytial Virus (RSV)
-
-
-
108
-
-
84871491338
-
-
Project PC, In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2008 [updated 2008 Nov 18]. Available from, Accessed Jul 11
-
Project PC. Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2008 [updated 2008 Nov 18]. Available from: http://clinicaltrials.gov/ct2/show/NCT00716014. ClinicalTrials.gov Identifier: NCT00716014. Accessed Jul 11, 2012.
-
(2012)
Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita
-
-
-
109
-
-
84871503158
-
-
Genomeweb. com [homepage on the Internet], New York: GenomeWeb LLC.; c 2012 [updated 2009 May 28; cited 2012 Apr 11]. Available from, Accessed June 21
-
Genomeweb. com [homepage on the Internet]. Allergan Drops Development of siRNA Rx for AMD on Poor Phase II Data. New York: GenomeWeb LLC.; c 2012 [updated 2009 May 28; cited 2012 Apr 11]. Available from: http://www.genomeweb.com/rnai/allergan-drops-development-sirna-rx-amd-poor-phase-ii-data. Accessed June 21, 2012.
-
(2012)
Allergan Drops Development of siRNA Rx for AMD on Poor Phase II Data
-
-
-
110
-
-
84871506504
-
-
Quarkpharma. com [homepage on the Internet], QPI-1002, California: Quark Pharmaceuticals, Inc.; c 2007 [updated 2010 Aug 18; cited 2012 Apr 10]. Available from, Accessed Jun 15
-
Quarkpharma. com [homepage on the Internet]. QPI-1002. California: Quark Pharmaceuticals, Inc.; c 2007 [updated 2010 Aug 18; cited 2012 Apr 10]. Available from: http://www.quarkpharma.com/qbi-en/products/QPI-1002da/. Accessed Jun 15, 2012.
-
(2012)
-
-
-
111
-
-
84871522750
-
-
TheFreeLibrary. com [homepage on the Internet], Pennsylvania: Farlex, Inc.; c 2012 [updated 2011 May 11; cited 2012 Apr 10]. Available from, Accessed May 11
-
TheFreeLibrary. com [homepage on the Internet]. Santaris Pharma A/S Advances a Second Drug From Its Cardiometabolic Program, SPC4955, Inhibiting apoB, into Phase 1 Clinical Trials for the Treatment of High Cholesterol. Pennsylvania: Farlex, Inc.; c 2012 [updated 2011 May 11; cited 2012 Apr 10]. Available from: http://www.thefreelibrary.com/Santaris+Pharma+A%2fS+Advances+a+Second+Drug+From+Its+Cardiometabolic.-a0256048995. Accessed May 11, 2012.
-
(2012)
Santaris Pharma A/S Advances a Second Drug From Its Cardiometabolic Program, SPC4955, Inhibiting apoB, into Phase 1 Clinical Trials for the Treatment of High Cholesterol
-
-
-
112
-
-
84871479741
-
-
Pharmaceuticals A, In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 Apr 20]. Available from, Accessed Jul 11
-
Pharmaceuticals A. Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 Apr 20]. Available from: http://clinicaltrials.gov/ct2/show/NCT01437059?term=PCS02&rank=1. ClinicalTrials.gov Identifier: NCT01437059. Accessed Jul 11, 2012.
-
(2012)
Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)
-
-
-
114
-
-
84871490968
-
-
Tekmirapharm. com [homepage on the Internet], British Columbia: Tekmira Pharmaceuticals Corp.; c 2012 [updated 2010 Jan 7; cited 2012 Apr 10]. Available from, Accessed Jun 29
-
Tekmirapharm. com [homepage on the Internet]. Tekmira Pharmaceuticals Completes ApoB SNALP Phase 1 Clinical Trial. British Columbia: Tekmira Pharmaceuticals Corp.; c 2012 [updated 2010 Jan 7; cited 2012 Apr 10]. Available from: http://files.shareholder.com/downloads/ABEA-50QJTB/1754071349x0x425312/9b404e8f-82e2-48a8-ba61-71328539afd9/TKM_News_2010_1_7_General_Releases.pdf. Accessed Jun 29, 2012.
-
(2012)
Tekmira Pharmaceuticals Completes ApoB SNALP Phase 1 Clinical Trial
-
-
-
115
-
-
84871511510
-
-
Giiresearch. com [homepage on the Internet], Kawasaki: Global Information, Inc.; c 1997-2007 [updated 2011 Aug 12; cited 2012 Apr 11]. Available from, Accessed Jun 26
-
Giiresearch. com [homepage on the Internet]. Top Companies and Products in the RNA/DNA Therapy Products Market Forecasts: The challenge of turning technology into therapy. Kawasaki: Global Information, Inc.; c 1997-2007 [updated 2011 Aug 12; cited 2012 Apr 11]. Available from: http://www.giiresearch.com/report/kt55538-therapy-prod.html. Accessed Jun 26, 2012.
-
(2012)
Top Companies and Products in the RNA/DNA Therapy Products Market Forecasts: The challenge of turning technology into therapy
-
-
-
116
-
-
84871521655
-
-
Abnnewswire. net [homepage on the Internet], New York: ABN Newswire; c 2012 [updated 2010 Nov 1; cited 2012 Apr 11]. Available from, Accessed Jun 18
-
Abnnewswire. net [homepage on the Internet]. rHIV7-shI-TAR-CCR5RZ. New York: ABN Newswire; c 2012 [updated 2010 Nov 1; cited 2012 Apr 11]. Available from: http://www.abnnewswire.net/search.asp?cp=utf-8&lang=_c&site=press_c&client=press-search-cs&output=xml_no_dtd&proxystylesheet=press-search-cs&proxyreload=1&filter=p&getfields=*&way=abn&way=web&qu=rHIV7-shI-TAR-CCR5RZ&stype=press_c&image2.x=33&image2.y=10. Accessed Jun 18, 2012.
-
(2012)
rHIV7-shI-TAR-CCR5RZ
-
-
-
117
-
-
84871481325
-
-
Pharmaceuticals A, In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 May 23]. Available from, Accessed Jul 11
-
Pharmaceuticals A. Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated 2012 May 23]. Available from: http://clinicaltrials.gov/ct2/show/NCT01148953?term=Alnylam&rank=4. ClinicalTrials.gov Identifier: NCT01148953. Accessed Jul 11, 2012.
-
(2012)
Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis
-
-
|