메뉴 건너뛰기




Volumn 115, Issue 1, 2014, Pages 69-76

In vitro and modelling approaches to risk assessment from the U.S. environmental protection agency ToxCast programme

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CARCINOGEN; CYTOCHROME P450; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; XENOBIOTIC AGENT;

EID: 84902120685     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12239     Document Type: Article
Times cited : (123)

References (53)
  • 3
    • 84863886918 scopus 로고    scopus 로고
    • Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management
    • Kavlock R, Chandler K, Houck K, Hunter S, Judson R, Kleinstreuer N et al. Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management. Chem Res Toxicol 2012;25:1287-302.
    • (2012) Chem Res Toxicol , vol.25 , pp. 1287-1302
    • Kavlock, R.1    Chandler, K.2    Houck, K.3    Hunter, S.4    Judson, R.5    Kleinstreuer, N.6
  • 5
    • 84880294804 scopus 로고    scopus 로고
    • Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells
    • Rotroff DM, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT et al. Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells. Chem Res Toxicol 2013;26:1097-107.
    • (2013) Chem Res Toxicol , vol.26 , pp. 1097-1107
    • Rotroff, D.M.1    Dix, D.J.2    Houck, K.A.3    Kavlock, R.J.4    Knudsen, T.B.5    Martin, M.T.6
  • 7
    • 84863298868 scopus 로고    scopus 로고
    • Aggregating data for computational toxicology applications: the U.S. environmental protection agency (EPA) aggregated computational toxicology resource (ACToR) system
    • Judson RS, Martin MT, Egeghy P, Gangwal S, Reif DM, Kothiya P et al. Aggregating data for computational toxicology applications: the U.S. environmental protection agency (EPA) aggregated computational toxicology resource (ACToR) system. Int J Mol Sci 2012;13:1805-31.
    • (2012) Int J Mol Sci , vol.13 , pp. 1805-1831
    • Judson, R.S.1    Martin, M.T.2    Egeghy, P.3    Gangwal, S.4    Reif, D.M.5    Kothiya, P.6
  • 9
    • 67650729693 scopus 로고    scopus 로고
    • Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    • Knudsen TB, Martin MT, Kavlock RJ, Judson RJ, Dix DJ, Singh AV. Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB. Reprod Toxicol 2009;28:209-19.
    • (2009) Reprod Toxicol , vol.28 , pp. 209-219
    • Knudsen, T.B.1    Martin, M.T.2    Kavlock, R.J.3    Judson, R.J.4    Dix, D.J.5    Singh, A.V.6
  • 10
  • 11
    • 67649233774 scopus 로고    scopus 로고
    • Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database
    • Martin MT, Mendez E, Corum DG, Judson RS, Kavlock RJ, Rotroff DM et al. Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database. Toxicol Sci 2009;110:181-90.
    • (2009) Toxicol Sci , vol.110 , pp. 181-190
    • Martin, M.T.1    Mendez, E.2    Corum, D.G.3    Judson, R.S.4    Kavlock, R.J.5    Rotroff, D.M.6
  • 13
    • 79958158241 scopus 로고    scopus 로고
    • Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    • Chandler KJ, Barrier M, Jeffay S, Nichols HP, Kleinstreuer NC, Singh AV et al. Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS ONE 2011;6:e18540.
    • (2011) PLoS ONE , vol.6
    • Chandler, K.J.1    Barrier, M.2    Jeffay, S.3    Nichols, H.P.4    Kleinstreuer, N.C.5    Singh, A.V.6
  • 14
    • 72149104630 scopus 로고    scopus 로고
    • Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    • Houck KA, Dix DJ, Judson RS, Kavlock RJ, Yang J, Berg EL. Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems. J Biomol Screen 2009;14:1054-66.
    • (2009) J Biomol Screen , vol.14 , pp. 1054-1066
    • Houck, K.A.1    Dix, D.J.2    Judson, R.S.3    Kavlock, R.J.4    Yang, J.5    Berg, E.L.6
  • 15
    • 79961042769 scopus 로고    scopus 로고
    • Chemical genomics profiling of environmental chemical modulation of human nuclear receptors
    • Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA et al. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect 2011;119:1142-8.
    • (2011) Environ Health Perspect , vol.119 , pp. 1142-1148
    • Huang, R.1    Xia, M.2    Cho, M.H.3    Sakamuru, S.4    Shinn, P.5    Houck, K.A.6
  • 16
    • 70349512691 scopus 로고    scopus 로고
    • Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals
    • Knight AW, Little S, Houck K, Dix D, Judson R, Richard A et al. Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals. Regul Toxicol Pharmacol 2009;55:188-99.
    • (2009) Regul Toxicol Pharmacol , vol.55 , pp. 188-199
    • Knight, A.W.1    Little, S.2    Houck, K.3    Dix, D.4    Judson, R.5    Richard, A.6
  • 18
    • 77949413202 scopus 로고    scopus 로고
    • Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program
    • Martin MT, Dix DJ, Judson RS, Kavlock RJ, Reif DM, Richard AM et al. Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol 2010;23:578-90.
    • (2010) Chem Res Toxicol , vol.23 , pp. 578-590
    • Martin, M.T.1    Dix, D.J.2    Judson, R.S.3    Kavlock, R.J.4    Reif, D.M.5    Richard, A.M.6
  • 19
    • 77953983411 scopus 로고    scopus 로고
    • Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
    • Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA et al. Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. J Toxicol Environ Health B Crit Rev 2010;13:329-46.
    • (2010) J Toxicol Environ Health B Crit Rev , vol.13 , pp. 329-346
    • Rotroff, D.M.1    Beam, A.L.2    Dix, D.J.3    Farmer, A.4    Freeman, K.M.5    Houck, K.A.6
  • 22
    • 84902105110 scopus 로고    scopus 로고
    • Modelling in vitro cell-based assays experiments: cell population dynamics
    • Jordan F, Jorgensen SE, eds). Elsevier, Amsterdam
    • Zaldívar Comenges JM, Wambaugh J, Judson R. Modelling in vitro cell-based assays experiments: cell population dynamics. In: Jordan F, Jorgensen SE, (eds). Models of the Ecological Hierarchy. Elsevier, Amsterdam, 2012; 92.
    • (2012) Models of the Ecological Hierarchy , pp. 92
    • Zaldívar Comenges, J.M.1    Wambaugh, J.2    Judson, R.3
  • 23
    • 84858442380 scopus 로고    scopus 로고
    • Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos
    • Cowden J, Padnos B, Hunter D, MacPhail R, Jensen K, Padilla S. Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos. Reprod Toxicol 2012;33:165-73.
    • (2012) Reprod Toxicol , vol.33 , pp. 165-173
    • Cowden, J.1    Padnos, B.2    Hunter, D.3    MacPhail, R.4    Jensen, K.5    Padilla, S.6
  • 25
    • 84902105111 scopus 로고    scopus 로고
    • U.S. EPA. FIFRA SAP Meeting Held January 29-31, 2013 on the scientific issues associated with "prioritizing the universe of endocrine disruptor screening program (EDSP) chemicals using computational toxicology tools" 2013 (last accessed on 28 October 2013).
    • U.S. EPA. FIFRA SAP Meeting Held January 29-31, 2013 on the scientific issues associated with "prioritizing the universe of endocrine disruptor screening program (EDSP) chemicals using computational toxicology tools". http://ntp.niehs.nih.gov/NTP/About_NTP/SACATM/2013/September/SAPMtgRpt_Jan2013_508BE.pdf. 2013 (last accessed on 28 October 2013).
  • 28
    • 80053516123 scopus 로고    scopus 로고
    • Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    • Sipes NS, Martin MT, Reif DM, Kleinstreuer NC, Judson RS, Singh AV et al. Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci 2011;124:109-27.
    • (2011) Toxicol Sci , vol.124 , pp. 109-127
    • Sipes, N.S.1    Martin, M.T.2    Reif, D.M.3    Kleinstreuer, N.C.4    Judson, R.S.5    Singh, A.V.6
  • 29
    • 84855757875 scopus 로고    scopus 로고
    • Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program
    • Martin MT, Knudsen TB, Judson RS, Kavlock RJ, Dix DJ. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program. Syst Biol Reprod Med 2012;58:3-9.
    • (2012) Syst Biol Reprod Med , vol.58 , pp. 3-9
    • Martin, M.T.1    Knudsen, T.B.2    Judson, R.S.3    Kavlock, R.J.4    Dix, D.J.5
  • 31
    • 84875279062 scopus 로고    scopus 로고
    • Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays
    • Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS et al. Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci 2013;132:327-46.
    • (2013) Toxicol Sci , vol.132 , pp. 327-346
    • Wetmore, B.A.1    Wambaugh, J.F.2    Ferguson, S.S.3    Li, L.4    Clewell, H.J.5    Judson, R.S.6
  • 32
    • 84555187264 scopus 로고    scopus 로고
    • Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
    • Wetmore BA, Wambaugh JF, Ferguson SS, Sochaski MA, Rotroff DM, Freeman K et al. Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. Toxicol Sci 2012;125:157-74.
    • (2012) Toxicol Sci , vol.125 , pp. 157-174
    • Wetmore, B.A.1    Wambaugh, J.F.2    Ferguson, S.S.3    Sochaski, M.A.4    Rotroff, D.M.5    Freeman, K.6
  • 34
  • 36
    • 84872386643 scopus 로고    scopus 로고
    • In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
    • Kleinstreuer NC, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT et al. In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis. Toxicol Sci 2013;131:40-55.
    • (2013) Toxicol Sci , vol.131 , pp. 40-55
    • Kleinstreuer, N.C.1    Dix, D.J.2    Houck, K.A.3    Kavlock, R.J.4    Knudsen, T.B.5    Martin, M.T.6
  • 37
    • 44849090379 scopus 로고    scopus 로고
    • A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model
    • Judson R, Elloumi F, Setzer RW, Li Z, Shah I. A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model. BMC Bioinformatics 2008;9:241.
    • (2008) BMC Bioinformatics , vol.9 , pp. 241
    • Judson, R.1    Elloumi, F.2    Setzer, R.W.3    Li, Z.4    Shah, I.5
  • 38
    • 84856241088 scopus 로고    scopus 로고
    • Disruption of embryonic vascular development in predictive toxicology
    • Knudsen TB, Kleinstreuer NC. Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C Embryo Today 2011;93:312-23.
    • (2011) Birth Defects Res C Embryo Today , vol.93 , pp. 312-323
    • Knudsen, T.B.1    Kleinstreuer, N.C.2
  • 39
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 41
    • 84887916009 scopus 로고    scopus 로고
    • Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework
    • Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I et al. Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework. Toxicol Sci 2013;136:4-18.
    • (2013) Toxicol Sci , vol.136 , pp. 4-18
    • Thomas, R.S.1    Philbert, M.A.2    Auerbach, S.S.3    Wetmore, B.A.4    Devito, M.J.5    Cote, I.6
  • 43
    • 84865380803 scopus 로고    scopus 로고
    • A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening
    • Thomas RS, Black MB, Li L, Healy E, Chu TM, Bao W et al. A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening. Toxicol Sci 2012;128:398-417.
    • (2012) Toxicol Sci , vol.128 , pp. 398-417
    • Thomas, R.S.1    Black, M.B.2    Li, L.3    Healy, E.4    Chu, T.M.5    Bao, W.6
  • 44
    • 84884582909 scopus 로고    scopus 로고
    • Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity?
    • Benigni R. Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2013;31:201-12.
    • (2013) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev , vol.31 , pp. 201-212
    • Benigni, R.1
  • 47
    • 28144457622 scopus 로고    scopus 로고
    • Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data
    • Seed J, Carney EW, Corley RA, Crofton KM, DeSesso JM, Foster PM et al. Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit Rev Toxicol 2005;35:664-72.
    • (2005) Crit Rev Toxicol , vol.35 , pp. 664-672
    • Seed, J.1    Carney, E.W.2    Corley, R.A.3    Crofton, K.M.4    DeSesso, J.M.5    Foster, P.M.6
  • 50
    • 81255159025 scopus 로고    scopus 로고
    • Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics
    • Kleinstreuer NC, Smith AM, West PR, Conard KR, Fontaine BR, Weir-Hauptman AM et al. Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 2011;257:111-21.
    • (2011) Toxicol Appl Pharmacol , vol.257 , pp. 111-121
    • Kleinstreuer, N.C.1    Smith, A.M.2    West, P.R.3    Conard, K.R.4    Fontaine, B.R.5    Weir-Hauptman, A.M.6
  • 53
    • 77954612559 scopus 로고    scopus 로고
    • Simulating microdosimetry in a virtual hepatic lobule
    • Wambaugh J, Shah I. Simulating microdosimetry in a virtual hepatic lobule. PLoS Comput Biol 2010;6:e1000756.
    • (2010) PLoS Comput Biol , vol.6
    • Wambaugh, J.1    Shah, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.