Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program

Systems Biology in Reproductive Medicine

Volumn 58, Issue 1, 2012, Pages 3-9

  Martin, Matthew T ^a   Knudsen, Thomas B ^a   Judson, Richard S ^a   Kavlock, Robert J ^a   Dix, David J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Chemical prioritization; Predictive model; Reproductive toxicity; Tiered testing

Indexed keywords

CHEMICAL ANALYSIS; CONFERENCE PAPER; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; GENE MAPPING; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; REPRODUCTIVE TOXICITY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; COST SAVINGS; COST-BENEFIT ANALYSIS; FEMALE; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; MALE; MODELS, ANIMAL; MODELS, BIOLOGICAL; ODDS RATIO; PROGRAM EVALUATION; RATS; REPRODUCTION; RISK ASSESSMENT; TOXICITY TESTS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 84855757875     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.3109/19396368.2011.652288     Document Type: Conference Paper

References (11)

1. Collins, F.S., Gray, G.M. and Bucher, J.R. (2008) Toxicology -Transforming environmental health protection. Science 319:906-907. (Pubitemid 351263750)
2. Cronin, M.T.D. and Worth, A.P. (2008) (Q)SARs for predicting effects relating to reproductive toxicity. Qsar Comb Sci 27:91-100. (Pubitemid 351204937)
3. Dix, D.J., Houck, K.A., Martin, M.T., Richard, A.M., Setzer, R.W. and Kavlock, R.J. (2007) The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 95:5-12. (Pubitemid 44942773)
4. Gilbert, N. (2011) Data gaps threaten chemical safety law. Nature 475:150-151.
5. Judson, R., Richard, A., Dix, D.J., Houck, K., Martin, M., Kavlock, R., et al. (2009) The Toxicity Data Landscape for Environmental Chemicals. Environ Health Persp 117:685-695.
6. Judson, R.S., Houck, K.A., Kavlock, R.J., Knudsen, T.B., Martin, M.T., Mortensen, H.M., et al. (2010) In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project. Environ Health Perspect 118:485-492.
7. Kleinstreuer, N.C., Judson, R.S., Reif, D.M., Sipes, N.S., Singh, A.V., Chandler, KJ., et al. (2011) Environmental Impact on Vascular Development Predicted by High Throughput Screening. Environ Health Perspect 119:1596-1603.
8. Martin, M.T., Knudsen, T.B., Reif, D.M., Houck, K.A., Judson, R.S., Kavlock, R.J. and Dix, D.J. (2011) Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening. Biol Reprod 85:327-339.
9. Perreault, S.D., Klinefelter G.R. and Clegg E. (2008) Assessment of Male Reproductive Toxicity. Informa Healthcare, USA.
10. Scialli, A.R. (2008) The challenge of reproductive and developmental toxicology under REACH. Regul Toxicol Pharmacol 51:244-250.
11. Sipes, N.S., Martin, M.T., Reif, D.M., Kleinstreuer, N.C., Judson, R.S., Singh, A.V., et al. (2011) Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci 124:109-127.