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Volumn 11, Issue 6, 2014, Pages 365-376

Evolution of androgen receptor targeted therapy for advanced prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ABIRATERONE ACETATE; ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; ASP 9521; AZD 3514; BICALUTAMIDE; BUSERELIN; CYPROTERONE; DEGARELIX; DIETHYLSTILBESTROL; ENZALUTAMIDE; EZN 4176; FLUTAMIDE; GALETERONE; GOSERELIN; KETOCONAZOLE; LEUPRORELIN; NAFARELIN ACETATE; NILUTAMIDE; ODM 201; ORTERONEL; PLACEBO; PREDNISONE; TRIPTORELIN; UNCLASSIFIED DRUG; VT 464;

EID: 84902116487     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2014.72     Document Type: Review
Times cited : (159)

References (173)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal, A. et al. Global cancer statistics. CA Cancer J. Clin. 61, 69-90 (2011).
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 69-90
    • Jemal, A.1
  • 2
    • 0001189211 scopus 로고
    • Studies on prostate cancer II. The effects of castration on advanced carcinoma of the prostate
    • Huggins, C., Stephens, R. E. & Hodges, C. V. Studies on prostate cancer II. The effects of castration on advanced carcinoma of the prostate. Arch. Surg. 43, 209-223 (1941).
    • (1941) Arch. Surg. , vol.43 , pp. 209-223
    • Huggins, C.1    Stephens, R.E.2    Hodges, C.V.3
  • 3
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono, J. S. et al. Abiraterone and increased survival in metastatic prostate cancer. N. Engl. J. Med. 364, 1995-2005 (2001).
    • (2001) N. Engl. J. Med. , vol.364 , pp. 1995-2005
    • De Bono, J.S.1
  • 4
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • Ryan, C. J. et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N. Engl. J. Med. 368, 138-148 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 138-148
    • Ryan, C.J.1
  • 5
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher, H. I. et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N. Engl. J. Med. 367, 1187-1197 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1187-1197
    • Scher, H.I.1
  • 6
    • 84879912756 scopus 로고    scopus 로고
    • Improved survival in a cohort of trial participants with metastatic castration-resistant prostate cancer demonstrates the need for updated prognostic nomograms
    • Omlin, A. et al. Improved survival in a cohort of trial participants with metastatic castration-resistant prostate cancer demonstrates the need for updated prognostic nomograms. Eur. Urol. 64, 300-306 (2013).
    • (2013) Eur. Urol. , vol.64 , pp. 300-306
    • Omlin, A.1
  • 8
    • 0034989719 scopus 로고    scopus 로고
    • Prostate cancer: A brief history and the discovery of hormonal ablation treatment
    • Lytton, B. Prostate cancer: a brief history and the discovery of hormonal ablation treatment. J. Urol. 165, 1859-1862 (2001).
    • (2001) J. Urol. , vol.165 , pp. 1859-1862
    • Lytton, B.1
  • 9
    • 0023929785 scopus 로고
    • Molecular cloning of human and rat complementary DNA encoding androgen receptors
    • Chang, C. S., Kokontis, J. & Liao. S. T. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240, 324-326 (1988).
    • (1988) Science , vol.240 , pp. 324-326
    • Chang, C.S.1    Kokontis, J.2    Liao, S.T.3
  • 10
    • 84908206676 scopus 로고    scopus 로고
    • Nobelprize.org [online]
    • The Nobel Prize in Physiology or Medicine 1966. Nobelprize.org [online], http://www.nobelprize.org/nobel-prizes/medicine/laureates/1966/(2014).
    • (2014) The Nobel Prize in Physiology or Medicine 1966
  • 11
    • 0014088849 scopus 로고
    • Treatment and survival of patients with cancer of the prostate
    • Veterans Administration Cooperative Urological Research Group
    • Veterans Administration Cooperative Urological Research Group. Treatment and survival of patients with cancer of the prostate. Surg. Gynecol. Obstet. 124, 1011-1017 (1967).
    • (1967) Surg. Gynecol. Obstet. , vol.124 , pp. 1011-1017
  • 12
    • 0015156571 scopus 로고
    • Hypothalamic FSH and LH-regulating hormone: Structure, physiology and clinical studies
    • Schally, A. V., Kastin, A. J. & Arimura, A. Hypothalamic FSH and LH-regulating hormone: structure, physiology and clinical studies. Fertil. Steril. 22, 703-721 (1971).
    • (1971) Fertil. Steril. , vol.22 , pp. 703-721
    • Schally, A.V.1    Kastin, A.J.2    Arimura, A.3
  • 13
    • 0033809968 scopus 로고    scopus 로고
    • Peptide analogs in the therapy of prostate cancer
    • Schally, A. V. et al. Peptide analogs in the therapy of prostate cancer. Prostate 45, 158-166 (2000).
    • (2000) Prostate , vol.45 , pp. 158-166
    • Schally, A.V.1
  • 14
    • 0018422475 scopus 로고
    • Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamicpituitary-gonadal axis in immature female rats
    • Vilchez-Martinez, J. A., Pedroza, E., Arimura, A. & Schally, A. V. Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamicpituitary-gonadal axis in immature female rats. Fertil. Steril. 31, 677-682 (1979).
    • (1979) Fertil. Steril. , vol.31 , pp. 677-682
    • Vilchez-Martinez, J.A.1    Pedroza, E.2    Arimura, A.3    Schally, A.V.4
  • 15
    • 0017858354 scopus 로고
    • Pituitary gonadotropin inhibition by a highly active analog of luteinizing hormone-releasing hormone
    • Sandow, J., Von Rechenberg, W., Jerzabek, G. & Stoll, W. Pituitary gonadotropin inhibition by a highly active analog of luteinizing hormone-releasing hormone. Fertil. Steril. 30, 205-209 (1978).
    • (1978) Fertil. Steril. , vol.30 , pp. 205-209
    • Sandow, J.1    Von Rechenberg, W.2    Jerzabek, G.3    Stoll, W.4
  • 16
    • 84908206676 scopus 로고    scopus 로고
    • Nobelprize.org [online]
    • The Nobel Prize in Physiology or Medicine 1977. Nobelprize.org [online], http://www.nobelprize.org/nobel-prizes/medicine/laureates/1977/(2014).
    • (2014) The Nobel Prize in Physiology or Medicine 1977
  • 17
    • 0034603826 scopus 로고    scopus 로고
    • Single-therapy androgen suppression in men with advanced prostate cancer: A systematic review and meta-analysis
    • Seidenfeld, J. et al. Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. Ann. Intern. Med. 132, 566-577 (2000).
    • (2000) Ann. Intern. Med. , vol.132 , pp. 566-577
    • Seidenfeld, J.1
  • 18
    • 0023726635 scopus 로고
    • Hormone therapy for prostate cancer: Results of the Veterans Administration Cooperative Urological Research Group studies
    • Byar, D. P. & Corle, D. K. Hormone therapy for prostate cancer: results of the Veterans Administration Cooperative Urological Research Group studies. NCI Monogr. 7, 165-170 (1988).
    • (1988) NCI Monogr. , vol.7 , pp. 165-170
    • Byar, D.P.1    Corle, D.K.2
  • 19
    • 0021721387 scopus 로고
    • Leuprolide versus diethylstilbestrol for metastatic prostate cancer
    • The Leuprolide Study Group
    • The Leuprolide Study Group. Leuprolide versus diethylstilbestrol for metastatic prostate cancer. N. Engl. J. Med. 311, 1281-1286 (1984).
    • (1984) N. Engl. J. Med. , vol.311 , pp. 1281-1286
  • 20
    • 44649169622 scopus 로고    scopus 로고
    • Testosterone surge: Rationale for gonadotropin releasing hormone blockers?
    • Van Poppel, H. & Nilsson, S. Testosterone surge: rationale for gonadotropin releasing hormone blockers? Urology 71, 1001-1006 (2008).
    • (2008) Urology , vol.71 , pp. 1001-1006
    • Van Poppel, H.1    Nilsson, S.2
  • 21
    • 33847129303 scopus 로고    scopus 로고
    • Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist
    • Princivalle, M. et al. Rapid suppression of plasma testosterone levels and tumor growth in the Dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J. Pharmacol. Exp. Ther. 320, 1113-1118 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , pp. 1113-1118
    • Princivalle, M.1
  • 22
    • 53249121469 scopus 로고    scopus 로고
    • A 1-year, open label, randomized phase II dose finding study of degarelix for the treatment of prostate cancer in North America
    • Gittelman, M. et al. A 1-year, open label, randomized phase II dose finding study of degarelix for the treatment of prostate cancer in North America. J. Urol. 180, 1986-1992 (2008).
    • (2008) J. Urol. , vol.180 , pp. 1986-1992
    • Gittelman, M.1
  • 23
    • 56649116179 scopus 로고    scopus 로고
    • The efficacy and safety of degarelix: A 12-month, comparative, randomized, open-label, parallel group phase III study in patients with prostate cancer
    • Klotz, L. et al. The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel group phase III study in patients with prostate cancer. BJU Int. 102, 1531-1538 (2008).
    • (2008) BJU Int. , vol.102 , pp. 1531-1538
    • Klotz, L.1
  • 24
    • 50849110501 scopus 로고    scopus 로고
    • Degarelix: A novel gonadotropin-releasing hormone (GnRH) receptor blocker-results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer
    • Van Poppel, H. et al. Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker-results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer. Eur. Urol. 54, 805-813 (2008).
    • (2008) Eur. Urol. , vol.54 , pp. 805-813
    • Van Poppel, H.1
  • 25
    • 0014424444 scopus 로고
    • Selective retention of dihydrotestosterone by prostatic nuclei
    • Anderson, K. M. & Liao, S. Selective retention of dihydrotestosterone by prostatic nuclei. Nature 219, 277-279 (1968).
    • (1968) Nature , vol.219 , pp. 277-279
    • Anderson, K.M.1    Liao, S.2
  • 26
    • 0014430280 scopus 로고
    • The intranuclear binding of testosterone and 5-α-androstan-17- β-ol-3-one by rat prostate
    • Bruchovsky, N. & Wilson, J. D. The intranuclear binding of testosterone and 5-α-androstan-17-β-ol-3-one by rat prostate. J. Biol. Chem. 243, 5953-5960 (1968).
    • (1968) J. Biol. Chem. , vol.243 , pp. 5953-5960
    • Bruchovsky, N.1    Wilson, J.D.2
  • 27
    • 0014639879 scopus 로고
    • A soluble androgen receptor in the cytoplasm of rat prostate
    • Mainwaring, W. I. A soluble androgen receptor in the cytoplasm of rat prostate. J. Endocrinol. 45, 531-541 (1969).
    • (1969) J. Endocrinol. , vol.45 , pp. 531-541
    • Mainwaring, W.I.1
  • 29
    • 0022446072 scopus 로고
    • Comparison of diethylstilbestrol, cyproterone acetate and medroxyprogesterone acetate in the treatment of advanced prostatic cancer: Final analysis of a randomized phase III trial of the European Organization for Research on Treatment of Cancer Urological Group
    • Pavone-Macaluso, M. et al. Comparison of diethylstilbestrol, cyproterone acetate and medroxyprogesterone acetate in the treatment of advanced prostatic cancer: final analysis of a randomized phase III trial of the European Organization for Research on Treatment of Cancer Urological Group. J. Urol. 136, 624-631 (1986).
    • (1986) J. Urol. , vol.136 , pp. 624-631
    • Pavone-Macaluso, M.1
  • 30
    • 0016365709 scopus 로고
    • Action of a nonsteroidal antiandrogen, flutamide, on the receptor binding and nuclear retention of 5α-dihydrotestosterone in rat ventral prostate
    • Liao, S., Howell, D. K. & Chang, T. M. Action of a nonsteroidal antiandrogen, flutamide, on the receptor binding and nuclear retention of 5α-dihydrotestosterone in rat ventral prostate. Endocrinology 94, 1205-1209 (1974).
    • (1974) Endocrinology , vol.94 , pp. 1205-1209
    • Liao, S.1    Howell, D.K.2    Chang, T.M.3
  • 31
    • 84902105865 scopus 로고    scopus 로고
    • US Food and Drug Administration Flutamide (Eulexin) Label and
    • US Food and Drug Administration. Flutamide (Eulexin) Label and Approval History [online], http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index. cfm?fuseaction=Search.Label-ApprovalHistory#apphist (2014).
    • (2014)
  • 32
    • 0020354138 scopus 로고
    • New hormonal therapy in prostatic carcinoma: Combined treatment with an LHRH agonist and an antiandrogen
    • Labrie, F. et al. New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen. Clin. Invest. Med. 5, 267-275 (1982).
    • (1982) Clin. Invest. Med. , vol.5 , pp. 267-275
    • Labrie, F.1
  • 33
    • 0020462799 scopus 로고
    • Combined long-term treatment with an LHRH agonist and a pure antiandrogen blocks androgenic influence in the rat
    • Lefebvre, F. A. et al. Combined long-term treatment with an LHRH agonist and a pure antiandrogen blocks androgenic influence in the rat. Prostate 3, 569-578 (1982).
    • (1982) Prostate , vol.3 , pp. 569-578
    • Lefebvre, F.A.1
  • 34
    • 84921430358 scopus 로고    scopus 로고
    • Maximal androgenblockade for advanced prostate cancer
    • Art. No: CD001526. http://dx.doi.10.1002/14651858.CD001526
    • Schmitt, B., Bennett, C., Seidenfeld, J., Samson, D. & Wilt, T. Maximal androgenblockade for advanced prostate cancer. Cochrane Database Systematic Reviews. Issue 2. Art. No: CD001526. http://dx.doi.10.1002/14651858. CD001526 (2000).
    • (2000) Cochrane Database Systematic Reviews , Issue.2
    • Schmitt, B.1    Bennett, C.2    Seidenfeld, J.3    Samson, D.4    Wilt, T.5
  • 35
    • 68149098902 scopus 로고    scopus 로고
    • Combined androgen blockade with bicalutamide for advanced prostate cancer long-term follow-up of a phase 3, double-blind, randomized study for survival
    • Akaza, H. et al. Combined androgen blockade with bicalutamide for advanced prostate cancer long-term follow-up of a phase 3, double-blind, randomized study for survival. Cancer 115, 3437-3445 (2009).
    • (2009) Cancer , vol.115 , pp. 3437-3445
    • Akaza, H.1
  • 36
    • 0042130389 scopus 로고    scopus 로고
    • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663
    • Taplin, M. E. et al. Androgen receptor mutations in androgen-independent prostate cancer: cancer and Leukemia Group B Study 9663. J. Clin. Oncol. 21, 2673-2678 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2673-2678
    • Taplin, M.E.1
  • 37
    • 79959282824 scopus 로고    scopus 로고
    • Translating scientific advancement into clinical benefit for castration-resistant prostate cancer patients
    • Attard, G. & de Bono, J. S. Translating scientific advancement into clinical benefit for castration-resistant prostate cancer patients. Clin. Cancer Res. 17, 3867-3875 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3867-3875
    • Attard, G.1    De Bono, J.S.2
  • 38
    • 84873801216 scopus 로고    scopus 로고
    • The changing natural history of metastatic prostate cancer
    • Alva, A. & Hussain, M. The changing natural history of metastatic prostate cancer. Cancer J. 19, 19-24 (2013).
    • (2013) Cancer J. , vol.19 , pp. 19-24
    • Alva, A.1    Hussain, M.2
  • 39
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone for advanced prostate cancer
    • Tannock, I. F. et al. Docetaxel plus prednisone or mitoxantrone for advanced prostate cancer. N. Engl. J. Med. 351, 1502-1512 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1502-1512
    • Tannock, I.F.1
  • 40
    • 77956684050 scopus 로고    scopus 로고
    • Regulation of androgen action
    • Roy, A. K. et al. Regulation of androgen action. Vit. Horm. 55, 309-352 (1998).
    • (1998) Vit. Horm. , vol.55 , pp. 309-352
    • Roy, A.K.1
  • 41
    • 0035680408 scopus 로고    scopus 로고
    • Androgen receptor: Structural domains and functional dynamics after ligand-receptor interaction
    • Roy, A. K. et al. Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Ann. NY Acad. Sci. 949, 44-57 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.949 , pp. 44-57
    • Roy, A.K.1
  • 42
    • 20444403792 scopus 로고    scopus 로고
    • The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor
    • Edwards, J. & Bartlett, J. M. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor. BJU Int. 95, 1320-1326 (2005).
    • (2005) BJU Int. , vol.95 , pp. 1320-1326
    • Edwards, J.1    Bartlett, J.M.2
  • 43
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • Heinlein, C. A. & Chang, C. Androgen receptor in prostate cancer. Endocr. Rev. 25, 276-308 (2004).
    • (2004) Endocr. Rev. , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 44
    • 0034464787 scopus 로고    scopus 로고
    • Androgen induction of cyclin-dependent kinase inhibitor p21 gene: Role of androgen receptor and transcription factor Sp1 complex
    • Lu, S., Jenster, G. & Epner, D. E. Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex. Mol. Endocrinol. 14, 753-760 (2000).
    • (2000) Mol. Endocrinol. , vol.14 , pp. 753-760
    • Lu, S.1    Jenster, G.2    Epner, D.E.3
  • 45
    • 33747880070 scopus 로고    scopus 로고
    • Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and posttranscriptional increases in cyclin D proteins
    • Xu, Y., Chen, S. Y., Ross, K. N. & Balk, S. P. Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and posttranscriptional increases in cyclin D proteins. Cancer Res. 66, 7783-7792 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7783-7792
    • Xu, Y.1    Chen, S.Y.2    Ross, K.N.3    Balk, S.P.4
  • 46
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen independent prostate cancer
    • Wang, Q. et al. Androgen receptor regulates a distinct transcription program in androgen independent prostate cancer. Cell 138, 245-256 (2009).
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1
  • 47
    • 33749870551 scopus 로고    scopus 로고
    • TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions
    • Cerveira, N. et al. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia 8, 826-832 (2006).
    • (2006) Neoplasia , vol.8 , pp. 826-832
    • Cerveira, N.1
  • 48
    • 33645750799 scopus 로고    scopus 로고
    • TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    • Tomlins, S. A. et al. Chinnaiyan, A. M. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res. 66, 3396-3400 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 3396-3400
    • Tomlins, S.A.1    Chinnaiyan, A.2
  • 49
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu, J. et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 17, 443-454 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1
  • 50
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005).
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1
  • 51
    • 66749100105 scopus 로고    scopus 로고
    • Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    • King, J. C. et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat. Genet. 41, 524-526 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 524-526
    • King, J.C.1
  • 52
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver, B. S. et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat. Genet. 41, 619-624 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 619-624
    • Carver, B.S.1
  • 53
    • 84882285291 scopus 로고    scopus 로고
    • ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
    • Chen, Y. et al. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat. Med. 19, 1023-1029 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1023-1029
    • Chen, Y.1
  • 54
    • 39049150843 scopus 로고    scopus 로고
    • Role of the TMPRSS2-ERG gene fusion in prostate cancer
    • Tomlins, S. A. et al. Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia 10, 177-188 (2008).
    • (2008) Neoplasia , vol.10 , pp. 177-188
    • Tomlins, S.A.1
  • 55
    • 80053071543 scopus 로고    scopus 로고
    • Androgen receptor rediscovered: The new biology and targeting the androgen receptor therapeutically
    • Ryan, C. J. & Tindall, D. J. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J. Clin. Oncol. 29, 3651-3658 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3651-3658
    • Ryan, C.J.1    Tindall, D.J.2
  • 56
    • 79953320228 scopus 로고    scopus 로고
    • New strategies in metastatic prostate cancer: Targeting the androgen receptor signaling pathway
    • Attard, G., Richards, J. & de Bono, J. S. New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway. Clin. Cancer Res. 17, 1649-1657 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1649-1657
    • Attard, G.1    Richards, J.2    De Bono, J.S.3
  • 57
    • 11144322812 scopus 로고    scopus 로고
    • Adrenal androgens and intracrinology
    • Labrie, F. Adrenal androgens and intracrinology. Semin. Reprod. Med. 22, 299-309 (2004).
    • (2004) Semin. Reprod. Med. , vol.22 , pp. 299-309
    • Labrie, F.1
  • 58
    • 0842311632 scopus 로고    scopus 로고
    • The androgen axis in recurrent prostate cancer
    • Mohler, J. L. et al. The androgen axis in recurrent prostate cancer. Clin. Cancer Res. 10, 440-448 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 440-448
    • Mohler, J.L.1
  • 59
    • 27644452640 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    • Titus, M. A., Schell, M. J., Lih, F. B., Tomer, K. B. & Mohler, J. L. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin. Cancer Res. 11, 4653-4657 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4653-4657
    • Titus, M.A.1    Schell, M.J.2    Lih, F.B.3    Tomer, K.B.4    Mohler, J.L.5
  • 60
    • 33749550602 scopus 로고    scopus 로고
    • Persistent intraprostatic androgen concentrations after medical castration in healthy men
    • Page, S. T. et al. Persistent intraprostatic androgen concentrations after medical castration in healthy men. J. Clin. Endocrinol. Metab. 91, 3850-3856 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 3850-3856
    • Page, S.T.1
  • 61
    • 84879134376 scopus 로고    scopus 로고
    • Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer
    • Ferraldeschi, R., Sharifi, N., Auchus, R. J. & Attard, G. Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer. Clin. Cancer Res. 19, 3353-3359 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3353-3359
    • Ferraldeschi, R.1    Sharifi, N.2    Auchus, R.J.3    Attard, G.4
  • 62
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen, C. D. et al. Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 10, 33-39 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 33-39
    • Chen, C.D.1
  • 63
    • 0042978480 scopus 로고    scopus 로고
    • Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer
    • Edwards, J., Krishna, N. S., Grigor, K. M. & Bartlett, J. M. Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer. Br. J. Cancer 89, 552-556 (2003).
    • (2003) Br. J. Cancer , vol.89 , pp. 552-556
    • Edwards, J.1    Krishna, N.S.2    Grigor, K.M.3    Bartlett, J.M.4
  • 64
    • 1542574202 scopus 로고    scopus 로고
    • Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
    • Holzbeierlein, J. et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am. J. Pathol. 164, 217-227 (2004).
    • (2004) Am. J. Pathol. , vol.164 , pp. 217-227
    • Holzbeierlein, J.1
  • 65
    • 80053567168 scopus 로고    scopus 로고
    • The changing therapeutic landscape of castration-resistant prostate cancer
    • Yap, T. A., Zivi, A., Omlin, A. & de Bono, J. S. The changing therapeutic landscape of castration-resistant prostate cancer. Nat. Rev. Clin. Oncol. 8, 597-610 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 597-610
    • Yap, T.A.1    Zivi, A.2    Omlin, A.3    De Bono, J.S.4
  • 66
    • 1842457650 scopus 로고    scopus 로고
    • Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583)
    • Small, E. J. et al. Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). J. Clin. Oncol. 22, 1025-1033 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1025-1033
    • Small, E.J.1
  • 67
    • 52049115874 scopus 로고    scopus 로고
    • Antiandrogen withdrawal in castrate-refractory prostate cancer: A Southwest Oncology Group trial (SWOG 9426)
    • Sartor, A. O. et al. Antiandrogen withdrawal in castrate-refractory prostate cancer: a Southwest Oncology Group trial (SWOG 9426). Cancer 112, 2393-2400 (2008).
    • (2008) Cancer , vol.112 , pp. 2393-2400
    • Sartor, A.O.1
  • 68
    • 0029084601 scopus 로고
    • The anti-androgen withdrawal syndrome. Experience in a large cohort of unselected patients with advanced prostate cancer
    • Small, E. J. & Srinivas, S. The anti-androgen withdrawal syndrome. Experience in a large cohort of unselected patients with advanced prostate cancer. Cancer 76, 1428-1434 (1995).
    • (1995) Cancer , vol.76 , pp. 1428-1434
    • Small, E.J.1    Srinivas, S.2
  • 69
    • 79951825699 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting the achilles' heel of androgen receptor activity
    • Sadar, M. D. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res. 71, 1208-1213 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1208-1213
    • Sadar, M.D.1
  • 70
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu, R. et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 69, 16-22 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 16-22
    • Hu, R.1
  • 71
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun, S. et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J. Clin. Invest. 120, 2715-2730 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2715-2730
    • Sun, S.1
  • 72
    • 0028904382 scopus 로고
    • Identification of two transcription activation units in the N.-terminal domain of the human androgen receptor
    • Jenster, G. et al. Identification of two transcription activation units in the N.-terminal domain of the human androgen receptor. J. Biol. Chem. 270, 7341-7346 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 7341-7346
    • Jenster, G.1
  • 73
    • 80053566273 scopus 로고    scopus 로고
    • RAS pathways in prostate cancer-mediators of hormone resistance?
    • Whitaker, H. C. & Neal, D. E. RAS pathways in prostate cancer-mediators of hormone resistance? Curr. Cancer Drug Targets 10, 834-839 (2010).
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 834-839
    • Whitaker, H.C.1    Neal, D.E.2
  • 74
    • 33748927940 scopus 로고    scopus 로고
    • Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    • Wu, J. D. et al. Interaction of IGF signaling and the androgen receptor in prostate cancer progression. J. Cell Biochem. 99, 392-401 (2006).
    • (2006) J. Cell Biochem. , vol.99 , pp. 392-401
    • Wu, J.D.1
  • 75
    • 0034671668 scopus 로고    scopus 로고
    • HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway
    • Wen, Y. et al. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res. 60, 6841-6845 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6841-6845
    • Wen, Y.1
  • 76
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormone independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • Craft, N., Shostak, Y., Carey, M. & Sawyers, C. L. A mechanism for hormone independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med. 5, 280-285 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3    Sawyers, C.L.4
  • 77
    • 0034614108 scopus 로고    scopus 로고
    • Her-2-neu expression and progression toward androgen independence in human prostate cancer
    • Signoretti, S. et al. Her-2-neu expression and progression toward androgen independence in human prostate cancer. J. Natl Cancer Inst. 92, 1918-1925 (2000).
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1918-1925
    • Signoretti, S.1
  • 78
    • 33746661499 scopus 로고    scopus 로고
    • Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells
    • Yuan, X. et al. Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am. J. Pathol. 169, 682-696 (2006).
    • (2006) Am. J. Pathol. , vol.169 , pp. 682-696
    • Yuan, X.1
  • 79
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver, B. S. et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19, 575-586 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1
  • 80
    • 78651458656 scopus 로고    scopus 로고
    • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
    • Chandarlapaty, S. et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 19, 58-71 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 58-71
    • Chandarlapaty, S.1
  • 81
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • Mulholland, D. J. et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19, 792-804 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1
  • 82
    • 28544432178 scopus 로고    scopus 로고
    • Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer
    • Attard, G., Belldegrun, A. S. & de Bono, J. S. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 96, 1241-1246 (2005).
    • (2005) BJU Int. , vol.96 , pp. 1241-1246
    • Attard, G.1    Belldegrun, A.S.2    De Bono, J.S.3
  • 83
    • 0020577565 scopus 로고
    • A novel and rapid treatment for advanced prostatic cancer
    • Trachtenberg, J., Halpern, N. & Pont, A. Ketoconazole: a novel and rapid treatment for advanced prostatic cancer. J. Urol. 130, 152-153 (1983).
    • (1983) J. Urol. , vol.130 , pp. 152-153
    • Trachtenberg, J.1    Halpern, N.2    Ketoconazole, P.A.3
  • 84
    • 0020531983 scopus 로고
    • Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes
    • Loose, D. S., Kan, P. B., Hirst, M. A., Marcus, R. A. & Feldman, D. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J. Clin. Invest. 71, 1495-1499 (1983).
    • (1983) J. Clin. Invest. , vol.71 , pp. 1495-1499
    • Loose, D.S.1    Kan, P.B.2    Hirst, M.A.3    Marcus, R.A.4    Feldman, D.5
  • 85
    • 0029058770 scopus 로고
    • Novel steroidal inhibitors of human cytochrome P45017 alpha(17 alpha-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer
    • Potter, G. A., Barrie, S. E., Jarman, M. & Rowlands, M. G. Novel steroidal inhibitors of human cytochrome P45017 alpha(17 alpha-hydroxylase-C17, 20-lyase): potential agents for the treatment of prostatic cancer. J. Med. Chem. 38, 2463-2471 (1995).
    • (1995) J. Med. Chem. , vol.38 , pp. 2463-2471
    • Potter, G.A.1    Barrie, S.E.2    Jarman, M.3    Rowlands, M.G.4
  • 86
    • 0024267273 scopus 로고
    • Selective inhibition of cholesterol side-chain cleavage by potential pro-drug forms of aminoglutethimide
    • Jarman, M., Barrie, S. E., Leung, C. S. & Rowlands, M. G. Selective inhibition of cholesterol side-chain cleavage by potential pro-drug forms of aminoglutethimide. Anticancer Drug Des. 3, 185-190 (1988).
    • (1988) Anticancer Drug Des. , vol.3 , pp. 185-190
    • Jarman, M.1    Barrie, S.E.2    Leung, C.S.3    Rowlands, M.G.4
  • 87
    • 53749090666 scopus 로고    scopus 로고
    • Phase i clinical trial of selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • Attard, G. et al. Phase I clinical trial of selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J. Clin. Oncol. 26, 4563-4571 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4563-4571
    • Attard, G.1
  • 88
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castrastion-resistant prostate cancer
    • Danila, D. C. et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castrastion-resistant prostate cancer. J. Clin. Oncol. 28, 1496-1501 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1496-1501
    • Danila, D.C.1
  • 89
    • 77951518711 scopus 로고    scopus 로고
    • Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
    • Reid, A. H. et al. Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J. Clin. Oncol. 28, 1489-1495 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1489-1495
    • Reid, A.H.1
  • 90
    • 77951523950 scopus 로고    scopus 로고
    • Phase i clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
    • Ryan, C. J. et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J. Clin. Oncol. 28, 1481-1488 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1481-1488
    • Ryan, C.J.1
  • 91
    • 84856774377 scopus 로고    scopus 로고
    • Clinical and biochemical consequences of cyp17a1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer
    • Attard, G. et al. Clinical and biochemical consequences of cyp17a1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. J. Clin. Endocrinol. Metab. 97, 507-516 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 507-516
    • Attard, G.1
  • 92
    • 84866948935 scopus 로고    scopus 로고
    • Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: Final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
    • Fizazi, K. et al. Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 13, 983-992 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 983-992
    • Fizazi, K.1
  • 93
    • 84902072628 scopus 로고    scopus 로고
    • Tumor responses after steroid switch of prednisolone (P) to dexamethasone (D) in castration-resistant prostate cancer (CRPC) patients (pts) on abiraterone acetate (AA) [abstract]
    • Lorente, D. et al. Tumor responses after steroid switch of prednisolone (P) to dexamethasone (D) in castration-resistant prostate cancer (CRPC) patients (pts) on abiraterone acetate (AA) [abstract]. Eur. J. Cancer 49 (Suppl. 2), a2918 (2013).
    • (2013) Eur. J. Cancer , vol.49 , Issue.SUPPL. 2
    • Lorente, D.1
  • 94
    • 84895453094 scopus 로고    scopus 로고
    • Steroid receptors aplenty in prostate cancer
    • Sharifi, N. Steroid receptors aplenty in prostate cancer. N. Engl. J. Med. 370, 970-971 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 970-971
    • Sharifi, N.1
  • 95
    • 78649523986 scopus 로고    scopus 로고
    • Safety pharmacokinetics and efficacy of TAK-700 in castration-resistant metastatic prostate cancer: A phase I/II open-label study [abstract]
    • Dreicer, R. et al. Safety, pharmacokinetics, and efficacy of TAK-700 in castration-resistant, metastatic prostate cancer: A phase I/II, open-label study [abstract]. J. Clin. Oncol. 28 (Suppl. 15), a3084 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15
    • Dreicer, R.1
  • 96
    • 84860870765 scopus 로고    scopus 로고
    • Safety efficacy and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): Updated data from a phase I/II study [abstract]
    • Agus, D. B. et al. Safety, efficacy, and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study [abstract]. J. Clin. Oncol. 30 (Suppl. 5), a98 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL. 5
    • Agus, D.B.1
  • 97
    • 84873298103 scopus 로고    scopus 로고
    • Safety and activity of the investigational agent orteronel (ortl) without prednisone in men with non-metastatic castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA): Updated results of a phase II study [abstract]
    • George, D. J. C. P. et al. Safety and activity of the investigational agent orteronel (ortl) without prednisone in men with non-metastatic castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA): updated results of a phase II study [abstract]. J. Clin. Oncol. 30 (Suppl.), a4549 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • George, D.J.C.P.1
  • 98
    • 84878167537 scopus 로고    scopus 로고
    • A phase I/II study of safety and efficacy of orteronel (TAK-700) an oral investigational nonsteroidal 1720-lyase inhibitor with docetaxel and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC): Updated phase II results [abstract]
    • Petrylak, D. et al. A phase I/II study of safety and efficacy of orteronel (TAK-700), an oral, investigational, nonsteroidal 17,20-lyase inhibitor, with docetaxel and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC): Updated phase II results [abstract]. J. Clin. Oncol. 31 (Suppl. 6), a59 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL. 6
    • Petrylak, D.1
  • 99
    • 84899879256 scopus 로고    scopus 로고
    • Safety, efficacy, and health-related quality of life (HRQoL) of the investigational single agent orteronel (ortl) in nonmetastatic castration-resistant prostate cancer (nmCRPC)
    • Hussain, M. et al. Safety, efficacy, and health-related quality of life (HRQoL) of the investigational single agent orteronel (ortl) in nonmetastatic castration-resistant prostate cancer (nmCRPC). J. Clin. Oncol. 31 (Suppl.), a5076 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Hussain, M.1
  • 100
    • 84902105866 scopus 로고    scopus 로고
    • Takeda Newsroom July-September 2013. Takeda Pharmaceutical Company Limited [online]
    • Takeda Newsroom July-September 2013. Takeda Pharmaceutical Company Limited [online], http://www.takeda.com/news/2013/20130726-5894.html (2013).
    • (2013)
  • 101
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01193244 (2014).
    • (2014) US National Library of Medicine
  • 102
    • 20944449560 scopus 로고    scopus 로고
    • Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
    • Handratta, V. D. et al. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J. Med. Chem. 48, 2972-2984 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 2972-2984
    • Handratta, V.D.1
  • 103
    • 53349101498 scopus 로고    scopus 로고
    • Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole- 1-yl)androsta-5,16-diene in prostate cancer
    • Vasaitis, T. et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol. Cancer Ther. 7, 2348-2357 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2348-2357
    • Vasaitis, T.1
  • 104
    • 54049128964 scopus 로고    scopus 로고
    • 17 alpha-Hydroxylase/17,20 lyase inhibitor VN/124-121 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
    • Bruno, R. D., Gover, T. D., Burger, A. M., Brodie, A. M. & Njar, V. C. 17 alpha-Hydroxylase/17,20 lyase inhibitor VN/124-121 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Mol. Cancer Ther. 7, 2828-2836 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2828-2836
    • Bruno, R.D.1    Gover, T.D.2    Burger, A.M.3    Brodie, A.M.4    Njar, V.C.5
  • 105
    • 38349186341 scopus 로고    scopus 로고
    • Synergistic effect of a novel anti-androgen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro
    • Schayowitz, A., Sabnis, G., Njar, V. C., Brodie, A. M. Synergistic effect of a novel anti-androgen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro. Mol. Cancer Ther. 7, 121-132 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 121-132
    • Schayowitz, A.1    Sabnis, G.2    Njar, V.C.3    Brodie, A.M.4
  • 106
    • 84907430249 scopus 로고    scopus 로고
    • ARMOR1: Safety of galeterone (TOK-001) in a phase 1 clinical trial in chemotherapy naive patients with castration resistant prostate cancer (CRPC) [abstract]
    • Taplin, M. E. C. F. et al. ARMOR1: safety of galeterone (TOK-001) in a phase 1 clinical trial in chemotherapy naive patients with castration resistant prostate cancer (CRPC) [abstract]. Cancer Res. 72 (Suppl. 8), CT-07 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.SUPPL. 8
    • Taplin, M.E.C.F.1
  • 107
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01709734 (2014).
    • (2014) US National Library of Medicine
  • 108
    • 84864592379 scopus 로고    scopus 로고
    • VT-464: A novel selective inhibitor of P450c17(CYP17)-1720 lyase for castration-refractory prostate cancer (CRPC) [abstract]
    • Eisner, J. R. et al. VT-464: A novel, selective inhibitor of P450c17(CYP17)-17,20 lyase for castration-refractory prostate cancer (CRPC) [abstract]. J. Clin. Oncol. 30 (Suppl. 5), a198 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL. 5
    • Eisner, J.R.1
  • 109
    • 84900471705 scopus 로고    scopus 로고
    • Activity of oral VT-464 a selective CYP17-lyase inhibitor in the LNCaP prostate cancer xenograft [abstract]
    • Figg, W. D. et al. Activity of oral VT-464, a selective CYP17-lyase inhibitor, in the LNCaP prostate cancer xenograft [abstract]. J. Clin. Oncol. 30 (Suppl. 5), a4671 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL. 5
    • Figg, W.D.1
  • 110
    • 84902079996 scopus 로고    scopus 로고
    • ClinicalTrialsRegister.eu [online]
    • EU Clinical Trials Register. ClinicalTrialsRegister.eu [online], https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-004103-20 (2014).
    • (2014) EU Clinical Trials Register
  • 111
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen independent prostate cancer
    • Stanbrough, M. et al. Increased expression of genes converting adrenal androgens to testosterone in androgen independent prostate cancer. Cancer Res. 66, 2815-2825 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 2815-2825
    • Stanbrough, M.1
  • 112
    • 33645987281 scopus 로고    scopus 로고
    • Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma
    • Fung, K. M. et al. Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr. Relat. Cancer 13, 169-180 (2006).
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 169-180
    • Fung, K.M.1
  • 113
    • 0031023049 scopus 로고    scopus 로고
    • The key role of 17 β-hydroxysteroid dehydrogenases in sex steroid biology
    • Labrie, F. et al. The key role of 17 β-hydroxysteroid dehydrogenases in sex steroid biology. Steroids 62, 148-158 (1997).
    • (1997) Steroids , vol.62 , pp. 148-158
    • Labrie, F.1
  • 114
    • 0030784509 scopus 로고    scopus 로고
    • Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: Demonstration of bifunctional 3α/17β-HSD activity and cellular distribution
    • Lin, H. K. et al. Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution. Mol. Endocrinol. 11, 1971-1984 (1997).
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1971-1984
    • Lin, H.K.1
  • 115
    • 85019171303 scopus 로고    scopus 로고
    • ASP9521, a novel, selective, orally bioavailable AKR1C3 (type 5,17β-hydroxysteroid dehydrogenase) inhibitor: In vitro and in vivo characterization [abstract]
    • Kikuchi, A. et al. ASP9521, a novel, selective, orally bioavailable AKR1C3 (type 5,17β-hydroxysteroid dehydrogenase) inhibitor: In vitro and in vivo characterization [abstract]. J. Clin. Oncol. 31 (Suppl.), a5046 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Kikuchi, A.1
  • 116
    • 84902105868 scopus 로고    scopus 로고
    • Safety tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC): Multi-centre phase I/II study [abstract]
    • Loriot, Y. et al. Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC): Multi-centre phase I/II study [abstract]. Eur. J. Cancer 49 (Suppl. 3), LBA22 (2013).
    • (2013) Eur. J. Cancer , vol.49 , Issue.SUPPL. 3
    • Loriot, Y.1
  • 117
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in the metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery, R. B. et al. Maintenance of intratumoral androgens in the metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 68, 4447-4454 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1
  • 118
    • 70349395222 scopus 로고    scopus 로고
    • Antiandrogens and androgen depleting therapies in prostate cancer: Novel agents for an established target
    • Chen, Y., Clegg, N. J. & Scher, H. I. Antiandrogens and androgen depleting therapies in prostate cancer: novel agents for an established target. Lancet Oncol. 10, 981-991 (2009).
    • (2009) Lancet Oncol. , vol.10 , pp. 981-991
    • Chen, Y.1    Clegg, N.J.2    Scher, H.I.3
  • 119
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive castration resistant prostate cancer: Directed therapies targeting the androgen receptor signaling axis
    • Scher, H. I. & Sawyers, C. Biology of progressive castration resistant prostate cancer: directed therapies targeting the androgen receptor signaling axis. J. Clin. Oncol. 23, 8253-8261 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.2
  • 120
    • 84873025061 scopus 로고    scopus 로고
    • Abiraterone and novel antiandrogens: Overcoming castration resistance in prostate cancer
    • Ferraldeschi, R., Pezaro, C., Karavasilis, V. & de Bono, J. Abiraterone and novel antiandrogens: overcoming castration resistance in prostate cancer. Annu. Rev. Med. 64, 1-13 (2012).
    • (2012) Annu. Rev. Med. , vol.64 , pp. 1-13
    • Ferraldeschi, R.1    Pezaro, C.2    Karavasilis, V.3    De Bono, J.4
  • 121
    • 77950574393 scopus 로고    scopus 로고
    • Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration resistant prostate cancer
    • Jung, M. E. et al. Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration resistant prostate cancer. J. Med. Chem. 53, 2779-2796 (2010).
    • (2010) J. Med. Chem. , vol.53 , pp. 2779-2796
    • Jung, M.E.1
  • 122
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran, C. et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324, 787-790 (2009).
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1
  • 123
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
    • Scher, H. I. et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 375, 1437-1446 (2010).
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1
  • 124
    • 0005248386 scopus 로고    scopus 로고
    • Enzulatamide (Xtandi Capsules) [online]
    • US Food and Drug Administration. Enzulatamide (Xtandi Capsules) [online], http://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm317997.htm (2012).
    • (2012) US Food and Drug Administration
  • 125
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01212991 (2014).
    • (2014) US National Library of Medicine
  • 126
    • 84902105869 scopus 로고    scopus 로고
    • Medivation [online]
    • Medivation. Medivation Investor Relations [online], http://investors. medivation.com/releasedetail.cfm?ReleaseID=798880 (2013).
    • (2013) Medivation Investor Relations
  • 127
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online] http://clinicaltrials.gov/show/NCT01565928 (2014).
    • (2014) US National Library of Medicine
  • 128
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01650194 (2014).
    • (2014) US National Library of Medicine
  • 129
    • 84863230424 scopus 로고    scopus 로고
    • ARN-509: A novel antiandrogen for prostate cancer treatment
    • Clegg, N. J. et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 72, 1494-1503 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 1494-1503
    • Clegg, N.J.1
  • 130
    • 84891538656 scopus 로고    scopus 로고
    • Phase i study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer
    • Rathkopf, D. E. et al. Phase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer. J. Clin Oncol. 31, 3525-3530 (2013).
    • (2013) J. Clin Oncol. , vol.31 , pp. 3525-3530
    • Rathkopf, D.E.1
  • 131
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01171898 (2014).
    • (2014) US National Library of Medicine
  • 132
    • 84870868470 scopus 로고    scopus 로고
    • A phase II study of the androgen signaling inhibitor ARN-509 in patients with castration resistant prostate cancer (CRPC) [abstract]
    • Rathkopf, D. E. et al. A phase II study of the androgen signaling inhibitor ARN-509 in patients with castration resistant prostate cancer (CRPC) [abstract]. J. Clin. Oncol. 30 (Suppl.), TPS4697 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.SUPPL.
    • Rathkopf, D.E.1
  • 133
    • 84873847379 scopus 로고    scopus 로고
    • ARN-509 in men with high-risk non-metastatic castration-resistant prostate cancer [abstract]
    • a920P
    • Smith, M. R. et al. ARN-509 in men with high-risk non-metastatic castration-resistant prostate cancer [abstract]. Ann. Oncol. 23 (Suppl. 9), ix303, a920P (2012).
    • (2012) Ann. Oncol. , vol.23 , Issue.SUPPL. 9 , pp. 9303
    • Smith, M.R.1
  • 134
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01946204 (2014).
    • (2014) US National Library of Medicine
  • 135
    • 79951825699 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting the achilles' heel of androgen receptor activity
    • Sadar, M. D. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res. 71, 1208-1213 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1208-1213
    • Sadar, M.D.1
  • 136
    • 77953280591 scopus 로고    scopus 로고
    • Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
    • Andersen, R. J. et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535-546 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 535-546
    • Andersen, R.J.1
  • 137
    • 84884504514 scopus 로고    scopus 로고
    • AZD3514: A small molecule that modulates androgen receptor signaling and function in vitro and in vivo
    • Loddick, S. A. et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol. Cancer Ther. 9, 1715-1727 (2013).
    • (2013) Mol. Cancer Ther. , vol.9 , pp. 1715-1727
    • Loddick, S.A.1
  • 138
    • 84897932032 scopus 로고    scopus 로고
    • A first-in-human study of the oral selective androgen receptor down-regulating drug (SARD) AZD3514 in patients with castration-resistant prostate cancer (CRPC) [abstract]
    • Omlin, A. G. et al. A first-in-human study of the oral selective androgen receptor down-regulating drug (SARD) AZD3514 in patients with castration-resistant prostate cancer (CRPC) [abstract]. J. Clin. Oncol. 31 (Suppl.), a4511 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Omlin, A.G.1
  • 139
    • 20344371233 scopus 로고    scopus 로고
    • Antisense therapy for cancer
    • Gleave, M. E. & Monia, B. P. Antisense therapy for cancer. Nat. Rev. Cancer 5, 468-479 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 468-479
    • Gleave, M.E.1    Monia, B.P.2
  • 140
    • 83355163334 scopus 로고    scopus 로고
    • Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer
    • Zhang, Y. et al. Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer. Mol. Cancer Ther. 10, 2309-2319 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 2309-2319
    • Zhang, Y.1
  • 141
    • 84887841103 scopus 로고    scopus 로고
    • First-in-human phase i study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)
    • Bianchini, D. et al. First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC). Br. J. Cancer 109, 2579-2586 (2013).
    • (2013) Br. J. Cancer , vol.109 , pp. 2579-2586
    • Bianchini, D.1
  • 142
    • 84873839629 scopus 로고    scopus 로고
    • ARADES trial: A first-in-man open-label phase I/II safety pharmacokinetic and proof-of-concept study of ODM-201 in patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC) [abstract]
    • LBA25-PR
    • Massard, C. et al. ARADES trial: A first-in-man, open-label, phase I/II safety, pharmacokinetic, and proof-of-concept study of ODM-201 in patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC) [abstract]. Ann. Oncol. 23 (Suppl. 9), 9-16, LBA25-PR (2012).
    • (2012) Ann. Oncol. , vol.23 , Issue.SUPPL. 9 , pp. 9-16
    • Massard, C.1
  • 143
    • 84902085380 scopus 로고    scopus 로고
    • An open-label phase I/II safety pharmacokinetic and proof-of concept study of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (CRPC) [abstract]
    • Fizazi, K. et al. An open-label, phase I/II safety, pharmacokinetic, and proof-of concept study of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (CRPC) [abstract]. Eur. J. Cancer 49 (Suppl. 2), a2853 (2013).
    • (2013) Eur. J. Cancer , vol.49 , Issue.SUPPL. 2
    • Fizazi, K.1
  • 144
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online] http://clinicaltrials.gov/show/NCT01317641 (2014).
    • (2014) US National Library of Medicine
  • 145
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online] http://clinicaltrials.gov/show/NCT01429064 (2014).
    • (2014) US National Library of Medicine
  • 146
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online] http://clinicaltrials.gov/show/NCT01784757 (2014).
    • (2014) US National Library of Medicine
  • 147
    • 84866909021 scopus 로고    scopus 로고
    • Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: Clinical evidence for cross-resistance?
    • Mezynski, J. et al. Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: clinical evidence for cross-resistance? Ann. Oncol. 11, 2943-2947 (2012).
    • (2012) Ann. Oncol. , vol.11 , pp. 2943-2947
    • Mezynski, J.1
  • 148
    • 84891633214 scopus 로고    scopus 로고
    • Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone
    • Bianchini, D. et al. Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone. Eur. J. Cancer 50, 78-84 (2014).
    • (2014) Eur. J. Cancer , vol.50 , pp. 78-84
    • Bianchini, D.1
  • 149
    • 84888852048 scopus 로고    scopus 로고
    • Enzalutamide in castration-resistant prostate cancer patients progressing after docetaxel and abiraterone
    • Schrader, A. J. et al. Enzalutamide in castration-resistant prostate cancer patients progressing after docetaxel and abiraterone. Eur. J. Cancer 65, 30-36 (2014).
    • (2014) Eur. J. Cancer , vol.65 , pp. 30-36
    • Schrader, A.J.1
  • 150
    • 84882789820 scopus 로고    scopus 로고
    • Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100)
    • Loriot, Y. et al. Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100). Ann. Oncol. 24, 1807-1812 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 1807-1812
    • Loriot, Y.1
  • 151
    • 84882799782 scopus 로고    scopus 로고
    • Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide
    • Noonan, K. L. et al. Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide. Ann. Oncol. 24, 1802-1807 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 1802-1807
    • Noonan, K.L.1
  • 152
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li, Y. et al. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res. 73, 483-489 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 483-489
    • Li, Y.1
  • 153
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver, B. S. et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19, 575-586 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1
  • 154
    • 84874918445 scopus 로고    scopus 로고
    • FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells
    • Sahu, B. et al. FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. Cancer Res. 73, 1570-1580 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 1570-1580
    • Sahu, B.1
  • 155
    • 84860523917 scopus 로고    scopus 로고
    • Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
    • Richards, J. et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 72, 2176-2182 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2176-2182
    • Richards, J.1
  • 156
    • 80052808323 scopus 로고    scopus 로고
    • Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
    • Darshan, M. S. et al. Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Res. 71, 6019-6029 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 6019-6029
    • Darshan, M.S.1
  • 157
    • 78049294167 scopus 로고    scopus 로고
    • Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
    • Zhu, M. L. et al. Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer. Cancer Res. 70, 7992-8002 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7992-8002
    • Zhu, M.L.1
  • 158
    • 84873095322 scopus 로고    scopus 로고
    • Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): A randomised, open-label, phase 3 trial
    • Gravis, G. et al. Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): a randomised, open-label, phase 3 trial. Lancet Oncol. 14, 149-158 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 149-158
    • Gravis, G.1
  • 159
    • 84902120184 scopus 로고    scopus 로고
    • ECOG-ACRIN Cancer Research Group [online]
    • ECOG-ACRIN Cancer Research Group Press Release. ECOG-ACRIN Cancer Research Group [online], http://ecog-acrin.org/wp-content/uploads/PDFs/ Docetaxel-plus-standard-hormone-therapy-extends-life-in-highly-advanced- prostate-cancer.pdf (2013).
    • (2013) ECOG-ACRIN Cancer Research Group Press Release
  • 160
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT00309985 (2014).
    • (2014) US National Library of Medicine
  • 161
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT00268476 (2014).
    • (2014) US National Library of Medicine
  • 162
    • 84883823918 scopus 로고    scopus 로고
    • The mutational landscape of prostate cancer
    • Barbieri, C. E. et al. The mutational landscape of prostate cancer. Eur. Urol. 64, 567-576 (2013).
    • (2013) Eur. Urol. , vol.64 , pp. 567-576
    • Barbieri, C.E.1
  • 163
    • 84894059406 scopus 로고    scopus 로고
    • Molecular alterations and emerging targets in castration resistant prostate cancer
    • Lorente, D. & De Bono, J. S. Molecular alterations and emerging targets in castration resistant prostate cancer. Eur. J. Cancer 50, 753-764 (2014).
    • (2014) Eur. J. Cancer , vol.50 , pp. 753-764
    • Lorente, D.1    De Bono, J.S.2
  • 164
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani, B., Banerji, U. & Workman, P. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol. 30, 679-692 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 165
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01634061 (2014).
    • (2014) US National Library of Medicine
  • 166
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrial.gov/show/NCT01511536 (2014).
    • (2014) US National Library of Medicine
  • 167
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT02043678 (2014).
    • (2014) US National Library of Medicine
  • 168
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01685268 (2014).
    • (2014) US National Library of Medicine
  • 169
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01681433 (2014).
    • (2014) US National Library of Medicine
  • 170
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01193257 (2014).
    • (2014) US National Library of Medicine
  • 171
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01162395 (2014).
    • (2014) US National Library of Medicine
  • 172
    • 84861726854 scopus 로고    scopus 로고
    • ClinicalTrials.gov [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/show/NCT01337518 (2014).
    • (2014) US National Library of Medicine
  • 173
    • 0000855450 scopus 로고
    • Cortisone treatment in advanced carcinoma of the prostate
    • Miller, G. M. & Hinman, F. Jr. Cortisone treatment in advanced carcinoma of the prostate. J. Urol. 72, 485-496 (1954).
    • (1954) J. Urol. , vol.72 , pp. 485-496
    • Miller, G.M.1    Hinman Jr., F.2


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