Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer

British Journal of Cancer

Volumn 89, Issue 3, 2003, Pages 552-556

  Edwards, J ^a   Krishna, N S ^a   Grigor, K M ^b   Bartlett, J M S ^a,c  

^a Endocrine Cancer Group   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c University Department of Surgery   (United Kingdom)

Author keywords

Androgen receptor; Gene amplification; Hormone resistant prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; PROSTATE SPECIFIC ANTIGEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HORMONAL THERAPY; HORMONE RESISTANCE; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; X CHROMOSOME; BIOSYNTHESIS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; PROSTATE TUMOR; RETROSPECTIVE STUDY;

ANTINEOPLASTIC AGENTS, HORMONAL; CHROMOSOMES, HUMAN, X; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RETROSPECTIVE STUDIES; SIGNAL TRANSDUCTION;

EID: 0042978480     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601127     Document Type: Article

References (22)

1. Armitage P, Berry G (1995) Statistical Methods in Medical Research, 3 rd ed. Oxford: Blackwell Science
2. Avila DM, Zoppi S, McPhaul (2001) The androgen receptor in syndromes of insensitivity and prostate cancer. J Steroid Biochem Mol Biol 76: 135-142
3. Bubendorf L, Kononen J, Koivisto P, Schraml P, Moch H, Gasser TC, Willi N, Mihatsch, MJ, Sauter G, Kallioniemi O-P (1999) Survey of gene amplifications during prostate cancer progression by high throughput fluorescence in situ hybridization on tissue microarrays. Cancer Res 59: 803-806
4. Culig Z, Hobisch A, Hittmair A, Peterziel H, Cato AC, Bartsch G, Klocker H (1998) Expression, structure, and function of androgen receptor in advanced prostatic carcinoma. Prostate 35: 63-70
5. Edwards J, Krishna NS, Mukherjee R, Watters AD, Underwood MA, Bartlett JMS (2001) Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer. Br J Urol Int 88: 633-637
6. Fraser JA, Reeves JR, Stanton PD, Black DM, Going JJ, Cooke TG, Bartlett JMS (2003) A role for BRCA1 in sporadic breast cancer. Br J Cancer 88: 1263-1270
7. Gnanapragasam VJ, Robson CN, Neal DE, Leung HY (2002) Regulation of FGF8 expression by the androgen receptor in human prostate cancer. Oncogene 21: 5069-5080
8. Goktas S, Ziada A, Crawford ED (1999) Combined androgen blockade for advanced prostatic carcinoma. Prostate Cancer Prostatic Dis 2: 172-179
9. Gregory CW, Hamil KG, Kim D, Hall SH, Pretlow TG, Mohler JL, French FS (1998) Androgen receptor expression in androgen independent prostate cancer is associated with increased expression of androgen regulated genes. Cancer Res 58: 5718-5724
10. Henttu P, Vihko P (1998) The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells. Biochem Biophyls Res Commun 244: 167-171
11. Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, Isola J, Trapman J, Cleutjens K, Noordzij A, Visakorpi T, Kallioniemi O-P (1997) Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res 57: 314-319
12. Koivisto PA, Helin HJ (1999) Androgen receptor gene amplification increases tissue PSA protein expression in hormone-refractory prostate carcinoma. J Pathol 189: 219-223
13. Krishna NS, Edwards J, Underwood MA, Grigor KM, Bartlett JMS (2002) AP-1 as a mediator of androgen refractory prostate cancer. Br J Cancer 86: s34
14. Lin HK, Yeh S, Kang HY, Chang C (2001) Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Nat Acad Sci USA 98: 7200-7205
15. Latil A, Bieche I, Vidaud D, Lidereau R, Berthon P, Cussenot, Vidaud M (2001) Evaluation of androgen, estrogen (ERα and ERβ), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays. Cancer Res 61: 1919-1926
16. Linja MJ, Savinainen KJ, Saramaki OR, Tammela TL, Vessella RL, Visakorpi T (2001) Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res 61: 3550-3555
17. Miyoshi Y, Uemura H, Fujinami K, Mikata K, Harada M, Kitamura H, Koizumi Y, Kubota Y (2000) Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene amplification and chromosomal anomalies in prostate cancer in Japanese patients. Prostate 43: 225-232
18. Newling D, Fossa SD, Anderson L, Abrahamsson PA, Aso Y, Eisenberger MA, Khoury S, Kozlowski JS, Kelly K, Scher H, Hartley-Asp B (1997) Assessment of hormone refractory prostate cancer. Urology 49: 46-53
19. Segawa N, Mori I, Utsunomiya H, Nakamura M, Nakamura Y, Shan L, Kakudo K, Katsuoka Y (2001) Prognostic significance of neuroendocrine differentiation, proliferation activity and androgen receptor expression in prostate cancer. Pathol Int 51: 452-459
20. Trapman J, Cleutjens KBJM (1997) Androgen-regulated gene expression in prostate cancer. Semin Cancer Biol 8: 29-36
21. Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, Palmberg C, Palotie A, Tammela T, Isola J, Kallioniemi OP (1995) In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 9: 401-406
22. Zhu X, Liu JP (1997) Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: a possible role for the MAP kinase signal transduction pathway? Mol Cell Endo 134: 9-14