FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 5, 2014, Pages 1011-1019

  Jung, Dongju ^b,i   York, J Philippe ^a   Wang, Li ^c   Yang, Chaofeng ^d   Zhang, Aijun ^a   Francis, Heather L ^e,f   Webb, Paul ^a   McKeehan, Wallace L ^d   Alpini, Gianfranco ^e,f   LeSage, Gene D ^g   Moore, David D ^b   Xia, Xuefeng ^a,h  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^g East Tennessee State University   (United States)

^h GUANGZHOU MEDICAL UNIVERSITY   (China)

ⁱ UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Cholangiocyte; Cyp27; p38 kinase

Indexed keywords

APOLIPOPROTEIN A1; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 27; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR RECEPTOR 4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIGAND; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; FGFR4 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR 15, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; BILE DUCT; CELL TYPE; CHOLANGIOCYTE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; LASER MICRODISSECTION; LIVER CELL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; GENETICS; HEPG2 CELL LINE; METABOLISM; MOUSE;

ANIMALS; BILE ACIDS AND SALTS; BILE DUCTS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTORS; HEP G2 CELLS; HUMANS; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84901852111     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1364-3     Document Type: Article

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