-
1
-
-
79958273714
-
Nucleophosmin and its complex network: A possible therapeutic target in hematological diseases
-
Colombo E, Alcalay M, Pelicci PG. Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. Oncogene 2011; 30: 2595-2609.
-
(2011)
Oncogene
, vol.30
, pp. 2595-2609
-
-
Colombo, E.1
Alcalay, M.2
Pelicci, P.G.3
-
2
-
-
0036302062
-
Nucleophosmin regulates the stability and transcriptional activity of p53
-
DOI 10.1038/ncb814
-
Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 2002; 4: 529-533. (Pubitemid 34752440)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.7
, pp. 529-533
-
-
Colombo, E.1
Marine, J.-C.2
Danovi, D.3
Falini, B.4
Pelicci, P.G.5
-
3
-
-
27544444006
-
DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF
-
DOI 10.1158/0008-5472.CAN-05-1759
-
Lee C, Smith BA, Bandyopadhyay K, Gjerset RA. DNA damage disrupts the p14ARF-B23 (nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF. Cancer Res 2005; 65: 9834-9842. (Pubitemid 41541462)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9834-9842
-
-
Lee, C.1
Smith, B.A.2
Bandyopadhyay, K.3
Gjerset, R.A.4
-
4
-
-
33846230449
-
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
-
DOI 10.1182/blood-2006-06-001149
-
Mrózek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 2007; 109: 431-448. (Pubitemid 46105936)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 431-448
-
-
Mrozek, K.1
Marcucci, G.2
Paschka, P.3
Whitman, S.P.4
Bloomfield, C.D.5
-
5
-
-
33645802652
-
+ AML
-
DOI 10.1182/blood-2005-11-4745
-
Falini B, Bolli N, Shan J, Martelli MP, Liso A, Pucciarini A et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc AML. Blood 2006; 107: 4514-4523. (Pubitemid 43801380)
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4514-4523
-
-
Falini, B.1
Bolli, N.2
Shan, J.3
Martelli, M.P.4
Liso, A.5
Pucciarini, A.6
Bigerna, B.7
Pasqualucci, L.8
Mannucci, R.9
Rosati, R.10
Gorello, P.11
Diverio, D.12
Roti, G.13
Tiacci, E.14
Cazzaniga, G.15
Biondi, A.16
Schnittger, S.17
Haferlach, T.18
Hiddemann, W.19
Martelli, M.F.20
Gu, W.21
Mecucci, C.22
Nicoletti, I.23
more..
-
6
-
-
77957309010
-
Two novel NPM1 mutations in a therapy-responder AML patient
-
Pianta A, Fabbro D, Damiani D, Tiribelli M, Fanin R, Franzoni A et al. Two novel NPM1 mutations in a therapy-responder AML patient. Hematol Oncol 2010; 28: 151-155.
-
(2010)
Hematol Oncol
, vol.28
, pp. 151-155
-
-
Pianta, A.1
Fabbro, D.2
Damiani, D.3
Tiribelli, M.4
Fanin, R.5
Franzoni, A.6
-
7
-
-
79955469651
-
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
-
Vassiliou GS, Cooper JL, Rad R, Li J, Rice S, Uren A et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 2011; 43: 470-475.
-
(2011)
Nat Genet
, vol.43
, pp. 470-475
-
-
Vassiliou, G.S.1
Cooper, J.L.2
Rad, R.3
Li, J.4
Rice, S.5
Uren, A.6
-
8
-
-
27744440147
-
Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein
-
den Besten W, Kuo ML, Williams RT, Sherr CJ. Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein. Cell Cycle 2005; 4: 1593-1598.
-
(2005)
Cell Cycle
, vol.4
, pp. 1593-1598
-
-
Den Besten, W.1
Kuo, M.L.2
Williams, R.T.3
Sherr, C.J.4
-
9
-
-
33645526300
-
Delocali-zation and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant
-
Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L et al. Delocali-zation and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant. Cancer Res 2006; 66: 3044-3050.
-
(2006)
Cancer Res
, vol.66
, pp. 3044-3050
-
-
Colombo, E.1
Martinelli, P.2
Zamponi, R.3
Shing, D.C.4
Bonetti, P.5
Luzi, L.6
-
10
-
-
47549085556
-
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
-
DOI 10.1083/jcb.200711040
-
Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E. Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J Cell Biol 2008; 182: 19-26. (Pubitemid 352008617)
-
(2008)
Journal of Cell Biology
, vol.182
, Issue.1
, pp. 19-26
-
-
Bonetti, P.1
Davoli, T.2
Sironi, C.3
Amati, B.4
Pelicci, P.G.5
Colombo, E.6
-
11
-
-
45149088440
-
Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-κB in AML carrying NPM1 mutations
-
DOI 10.1038/leu.2008.68, PII LEU200868
-
Cilloni D, Messa F, Rosso V, Arruga F, Defilippi I, Carturan S et al. Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations. Leukemia 2008; 22: 1234-1240. (Pubitemid 351833792)
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1234-1240
-
-
Cilloni, D.1
Messa, F.2
Rosso, V.3
Arruga, F.4
Defilippi, I.5
Carturan, S.6
Catalano, R.7
Pautasso, M.8
Panuzzo, C.9
Nicoli, P.10
Messa, E.11
Morotti, A.12
Iacobucci, I.13
Martinelli, G.14
Bracco, E.15
Saglio, G.16
-
12
-
-
41449083855
-
Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription
-
Gurumurthy M, Tan CH, Ng R, Zeiger L, Lau J, Lee J et al. Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription. J Mol Biol 2008; 378: 302-317.
-
(2008)
J Mol Biol
, vol.378
, pp. 302-317
-
-
Gurumurthy, M.1
Tan, C.H.2
Ng, R.3
Zeiger, L.4
Lau, J.5
Lee, J.6
-
13
-
-
51049097902
-
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
-
Wanzel M, Russ AC, Kleine-Kohlbrecher D, Colombo E, Pelicci PG, Eilers M. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol 2008; 10: 1051-1061.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1051-1061
-
-
Wanzel, M.1
Russ, A.C.2
Kleine-Kohlbrecher, D.3
Colombo, E.4
Pelicci, P.G.5
Eilers, M.6
-
14
-
-
33846876123
-
+ AML): Biologic and clinical features
-
DOI 10.1182/blood-2006-07-012252
-
Falini B, Nicoletti I, Martelli MF, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc AML): biologic and clinical features. Blood 2007; 109: 874-885. (Pubitemid 46220630)
-
(2007)
Blood
, vol.109
, Issue.3
, pp. 874-885
-
-
Falini, B.1
Nicoletti, I.2
Martelli, M.F.3
Mecucci, C.4
-
15
-
-
79251556241
-
Acute myeloid leukemia with mutated nucleophosmin (NPM1): Is it a distinct entity?
-
Falini B, Martelli MP, Bolli N, Sportoletti P, Liso A, Tiacci E et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity? Blood 2011; 117: 1109-1120.
-
(2011)
Blood
, vol.117
, pp. 1109-1120
-
-
Falini, B.1
Martelli, M.P.2
Bolli, N.3
Sportoletti, P.4
Liso, A.5
Tiacci, E.6
-
16
-
-
84901823997
-
-
submitted
-
Londero AP, Orsaria M, Tell G, Marzinotto S, Capodicasa V, Poletto M et al. Expression and prognostic significance of APE1/Ref1 and NPM1 proteins in ovarian serous cancer; submitted.
-
Expression and Prognostic Significance of APE1/Ref1 and NPM1 Proteins in Ovarian Serous Cancer
-
-
Londero, A.P.1
Orsaria, M.2
Tell, G.3
Marzinotto, S.4
Capodicasa, V.5
Poletto, M.6
-
17
-
-
63049121360
-
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
-
Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A et al. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol 2009; 29: 1834-1854.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1834-1854
-
-
Vascotto, C.1
Fantini, D.2
Romanello, M.3
Cesaratto, L.4
Deganuto, M.5
Leonardi, A.6
-
18
-
-
78149471195
-
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
-
Tell G, Fantini D, Quadrifoglio F. Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment. Cell Mol Life Sci 2010; 67: 3589-3608.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 3589-3608
-
-
Tell, G.1
Fantini, D.2
Quadrifoglio, F.3
-
19
-
-
78149466586
-
Small molecule inhibitors of DNA repair nuclease activities of APE1
-
Wilson 3rd DM, Simeonov A. Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol Life Sci 2010; 67: 3621-3631.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 3621-3631
-
-
Wilson III, D.M.1
Simeonov, A.2
-
20
-
-
0026583944
-
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity
-
Xanthoudakis S, Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 1992; 11: 653-665.
-
(1992)
EMBO J
, vol.11
, pp. 653-665
-
-
Xanthoudakis, S.1
Curran, T.2
-
22
-
-
0033544915
-
Thioredoxin-dependent redox regulation of p53-mediated p21 activation
-
Ueno M, Masutani H, Arai RJ, Yamauchi A, Hirota K, Sakai T et al. Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J Biol Chem 1999; 274: 35809-35815. (Pubitemid 129512885)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.50
, pp. 35809-35815
-
-
Ueno, M.1
Masutani, H.2
Arai, R.J.3
Yamauchi, A.4
Hirota, K.5
Sakai, T.6
Inamoto, T.7
Yamaoka, Y.8
Yodoi, J.9
Nikaido, T.10
-
23
-
-
20544433877
-
Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity
-
DOI 10.1038/sj.onc.1208549
-
Seemann S, Hainaut P. Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity. Oncogene 2005; 24: 3853-3863. (Pubitemid 40896397)
-
(2005)
Oncogene
, vol.24
, Issue.24
, pp. 3853-3863
-
-
Seemann, S.1
Hainaut, P.2
-
24
-
-
0030936568
-
Ap-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
-
DOI 10.1073/pnas.94.8.3633
-
Hirota K, Matsui M, Iwata Z, Nishiyama A, Mori K, Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci USA 1997; 94: 3633-3638. (Pubitemid 27180424)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.8
, pp. 3633-3638
-
-
Hirota, K.1
Matsui, M.2
Iwata, S.3
Nishiyama, A.4
Mori, K.5
Yodoi, J.6
-
25
-
-
0034544555
-
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
-
Wei SJ, Botero A, Hirota K, Bradbury CM, Markovina S, Laszlo A et al. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer Res 2000; 60: 6688-6695.
-
(2000)
Cancer Res
, vol.60
, pp. 6688-6695
-
-
Wei, S.J.1
Botero, A.2
Hirota, K.3
Bradbury, C.M.4
Markovina, S.5
Laszlo, A.6
-
26
-
-
6944236323
-
Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene
-
DOI 10.1096/fj.03-1160fje
-
Ziel KA, Campbell CC, Wilson GL, Gillespie MN. Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. FASEB J 2004; 18: 986-988. (Pubitemid 39561500)
-
(2004)
FASEB Journal
, vol.18
, Issue.9
, pp. 986-988
-
-
Ziel, K.A.1
Campbell, C.C.2
Wilson, G.L.3
Gillespie, M.N.4
-
27
-
-
18844444774
-
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
-
DOI 10.1038/sj.onc.1208513
-
Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS et al. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 2005; 24: 3110-3120. (Pubitemid 40695080)
-
(2005)
Oncogene
, vol.24
, Issue.19
, pp. 3110-3120
-
-
Gray, M.J.1
Zhang, J.2
Ellis, L.M.3
Semenza, G.L.4
Evans, D.B.5
Watowich, S.S.6
Gallick, G.E.7
-
28
-
-
14044269479
-
The intracellular localization of APE1/Ref-1: More than a passive phenomenon?
-
DOI 10.1089/ars.2005.7.367
-
Tell G, Damante G, Caldwell D, Kelley MR. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 2005; 7: 367-384. (Pubitemid 40279805)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.3-4
, pp. 367-384
-
-
Tell, G.1
Damante, G.2
Caldwell, D.3
Kelley, M.R.4
-
29
-
-
0347504848
-
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene
-
DOI 10.1093/emboj/cdg595
-
Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S. Role of acetylated human AP-endonuclease (APE1/Ref-1). in regulation of the parathyroid hormone gene. EMBO J 2003; 22: 6299-6309. (Pubitemid 37522587)
-
(2003)
EMBO Journal
, vol.22
, Issue.23
, pp. 6299-6309
-
-
Bhakat, K.K.1
Izumi, T.2
Yang, S.-H.3
Hazra, T.K.4
Mitra, S.5
-
30
-
-
78650501028
-
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
-
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L et al. Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions. Nucleic Acids Res 2010; 38: 8239-8256.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 8239-8256
-
-
Fantini, D.1
Vascotto, C.2
Marasco, D.3
D'Ambrosio, C.4
Romanello, M.5
Vitagliano, L.6
-
31
-
-
73549091674
-
Intrusion of a DNA repair protein in the RNome world: Is this the beginning of a new era?
-
Tell G, Wilson 3rd DM, Lee CH. Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol 2010; 30: 366-371.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 366-371
-
-
Tell, G.1
Wilson III, D.M.2
Lee, C.H.3
-
32
-
-
67651149733
-
Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA
-
Barnes T, Kim WC, Mantha AK, Kim SE, Izumi T, Mitra S et al. Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res 2009; 37: 3946-3958.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 3946-3958
-
-
Barnes, T.1
Kim, W.C.2
Mantha, A.K.3
Kim, S.E.4
Izumi, T.5
Mitra, S.6
-
33
-
-
84878400065
-
Role of the unstructured N-terminal domain of the human apurinic/apyrimidinic endonu-clease 1 (hAPE1) in the modulation of its interaction with nucleic acids and nucleophosmin (NPM1)
-
Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G. Role of the unstructured N-terminal domain of the human apurinic/apyrimidinic endonu-clease 1 (hAPE1) in the modulation of its interaction with nucleic acids and nucleophosmin (NPM1). Biochem J 2013; 452: 545-557.
-
(2013)
Biochem J
, vol.452
, pp. 545-557
-
-
Poletto, M.1
Vascotto, C.2
Scognamiglio, P.L.3
Lirussi, L.4
Marasco, D.5
Tell, G.6
-
34
-
-
0034719372
-
DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination
-
DOI 10.1038/35000249
-
Mol CD, Izumi T, Mitra S, Tainer JA. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination (corrected). Nature 2000; 403: 451-456. (Pubitemid 30073097)
-
(2000)
Nature
, vol.403
, Issue.6768
, pp. 451-456
-
-
Mol, C.D.1
Izumi, T.2
Mitra, S.3
Talner, J.A.4
-
35
-
-
0032515143
-
Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product
-
DOI 10.1074/jbc.273.46.30352
-
Masuda Y, Bennett RA, Demple B. Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product. J Biol Chem 1998; 273: 30352-30359. (Pubitemid 28545505)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.46
, pp. 30352-30359
-
-
Masuda, Y.1
Bennett, R.A.O.2
Demple, B.3
-
36
-
-
26444561851
-
Arf protein stability
-
DOI 10.1128/MCB.25.20.8874-8886.2005
-
Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC et al. Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 2005; 25: 8874-8886. (Pubitemid 41429079)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.20
, pp. 8874-8886
-
-
Colombo, E.1
Bonetti, P.2
Denchi, E.L.3
Martinelli, P.4
Zamponi, R.5
Marine, J.-C.6
Helin, K.7
Falini, B.8
Pelicci, P.G.9
-
37
-
-
84867479746
-
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
-
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M et al. Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells. Mol Biol Cell 2012; 23: 4079-4096.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 4079-4096
-
-
Lirussi, L.1
Antoniali, G.2
Vascotto, C.3
D'Ambrosio, C.4
Poletto, M.5
Romanello, M.6
-
38
-
-
79957456954
-
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage
-
Svilar D, Goellner EM, Almeida KH, Sobol RW. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal 2011; 14: 2491-2507.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 2491-2507
-
-
Svilar, D.1
Goellner, E.M.2
Almeida, K.H.3
Sobol, R.W.4
-
39
-
-
0035231422
-
BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis
-
PII S0079660301680887, Base Excesion Repair
-
Kaina B, Ochs K, Grosch S, Fritz G, Lips J, Tomicic M et al. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Prog Nucleic Acid Res Mol Biol 2001; 68: 41-54. (Pubitemid 33804651)
-
(2001)
Progress in Nucleic Acid Research and Molecular Biology
, vol.68
, pp. 41-54
-
-
Kaina, B.1
Ochs, K.2
Grosch, S.3
Frizz, G.4
Lips, J.5
Tomicic, M.6
Dunkern, T.7
Christmann, M.8
-
40
-
-
70349991252
-
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions
-
Jiang Y, Guo C, Fishel ML, Wang ZY, Vasko MR, Kelley MR. Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. DNA Repair (Amst) 2009; 8: 1273-1282.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1273-1282
-
-
Jiang, Y.1
Guo, C.2
Fishel, M.L.3
Wang, Z.Y.4
Vasko, M.R.5
Kelley, M.R.6
-
41
-
-
33645302335
-
DNA damage by bromate: Mechanism and consequences
-
Ballmair D, Epe B. DNA damage by bromate: mechanism and consequences. Toxicology 2006; 221: 166-171.
-
(2006)
Toxicology
, vol.221
, pp. 166-171
-
-
Ballmair, D.1
Epe, B.2
-
42
-
-
13444257678
-
Bleomycins: Towards better therapeutics
-
DOI 10.1038/nrc1547
-
Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer 2005; 5: 102-112. (Pubitemid 40215859)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.2
, pp. 102-112
-
-
Chen, J.1
Stubbe, J.2
-
43
-
-
79953141978
-
Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin
-
Fung H, Demple B. Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. J Biol Chem 2011; 286: 4968-4977.
-
(2011)
J Biol Chem
, vol.286
, pp. 4968-4977
-
-
Fung, H.1
Demple, B.2
-
44
-
-
84859789451
-
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors
-
Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson 3rd DM et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem 2012; 55: 3101-3112.
-
(2012)
J Med Chem
, vol.55
, pp. 3101-3112
-
-
Rai, G.1
Vyjayanti, V.N.2
Dorjsuren, D.3
Simeonov, A.4
Jadhav, A.5
Wilson III, D.M.6
-
45
-
-
77953578193
-
Proximity ligation assays: A recent addition to the proteomics toolbox
-
Weibrecht I, Leuchowius KJ, Clausson CM, Conze T, Jarvius M, Howell WM et al. Proximity ligation assays: a recent addition to the proteomics toolbox. Expert Rev Proteomics 2010; 7: 401-409.
-
(2010)
Expert Rev Proteomics
, vol.7
, pp. 401-409
-
-
Weibrecht, I.1
Leuchowius, K.J.2
Clausson, C.M.3
Conze, T.4
Jarvius, M.5
Howell, W.M.6
-
46
-
-
19944427850
-
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
-
DOI 10.1056/NEJMoa041974
-
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254-266 (Pubitemid 40110814)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.3
, pp. 254-266
-
-
Falini, B.1
Mecucci, C.2
Tiacci, E.3
Alcalay, M.4
Rosati, R.5
Pasqualucci, L.6
La Starza, R.7
Diverio, D.8
Colombo, E.9
Santucci, A.10
Bigerna, B.11
Pacini, R.12
Pucciarini, A.13
Liso, A.14
Vignetti, M.15
Fazi, P.16
Meani, N.17
Pettirossi, V.18
Saglio, G.19
Mandelli, F.20
Lo-Coco, F.21
Pelicci, P.-G.22
Martelli, M.F.23
more..
-
47
-
-
13744254680
-
Erratum
-
Erratum in: N Engl J Med 2005; 352: 740.
-
(2005)
N Engl J Med
, vol.352
, pp. 740
-
-
-
48
-
-
27144501134
-
Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin
-
DOI 10.1038/sj.leu.2403899, PII 2403899
-
Quentmeier H, Martelli MP, Dirks WG, Bolli N, Liso A, Macleod RA et al. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia 2005; 19: 1760-1767. (Pubitemid 41486153)
-
(2005)
Leukemia
, vol.19
, Issue.10
, pp. 1760-1767
-
-
Quentmeier, H.1
Martelli, M.P.2
Dirks, W.G.3
Bolli, N.4
Liso, A.5
MacLeod, R.A.F.6
Nicoletti, I.7
Mannucci, R.8
Pucciarini, A.9
Bigerna, B.10
Martelli, M.F.11
Mecucci, C.12
Drexler, H.G.13
Falini, B.14
-
49
-
-
0141621094
-
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis
-
DOI 10.1074/jbc.M304914200
-
Yoshida A, Urasaki Y, Waltham M, Bergman AC, Pourquier P, Rothwell DG et al. Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J Biol Chem 2003; 278: 37768-37776. (Pubitemid 37175303)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.39
, pp. 37768-37776
-
-
Yoshida, A.1
Urasaki, Y.2
Waltham, M.3
Bergman, A.-C.4
Pourquier, P.5
Rothwell, D.G.6
Inuzuka, M.7
Weinstein, J.N.8
Ueda, T.9
Appella, E.10
Hickson, I.D.11
Pommier, Y.12
-
50
-
-
0037318731
-
Cleaving the oxidative repair protein Ape I enhances cell death mediated by granzyme A
-
DOI 10.1038/ni885
-
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A et al. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol 2003; 4: 145-153. (Pubitemid 36193016)
-
(2003)
Nature Immunology
, vol.4
, Issue.2
, pp. 145-153
-
-
Fan, Z.1
Beresford, P.J.2
Zhang, D.3
Xu, Z.4
Novina, C.D.5
Yoshida, A.6
Pommier, Y.7
Lieberman, J.8
-
51
-
-
40149091820
-
Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity
-
Guo Y, Chen J, Zhao T, Fan Z. Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. Mol Immunol 2008; 45: 2225-2235.
-
(2008)
Mol Immunol
, vol.45
, pp. 2225-2235
-
-
Guo, Y.1
Chen, J.2
Zhao, T.3
Fan, Z.4
-
52
-
-
80054701610
-
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
-
Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R et al. Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function. Mol Biol Cell 2011; 22: 3887-3901.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 3887-3901
-
-
Vascotto, C.1
Bisetto, E.2
Li, M.3
Zeef, L.A.4
D'Ambrosio, C.5
Domenis, R.6
-
53
-
-
79952833556
-
Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1
-
Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF et al. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxid Redox Signal 2011; 14: 1387-1401.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1387-1401
-
-
Kelley, M.R.1
Luo, M.2
Reed, A.3
Su, D.4
Delaplane, S.5
Borch, R.F.6
-
54
-
-
78651384685
-
BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2
-
Wang HF, Takenaka K, Nakanishi A, Miki Y. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Cancer Res 2011; 71: 68-77.
-
(2011)
Cancer Res
, vol.71
, pp. 68-77
-
-
Wang, H.F.1
Takenaka, K.2
Nakanishi, A.3
Miki, Y.4
-
55
-
-
13244299159
-
A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells
-
DOI 10.1016/j.molcel.2004.12.029, PII S1097276505010397
-
Fung H, Demple B. A vital role for APE1/Ref1 protein in repairing spontaneous DNA damage in human cells. Mol. Cell 2005; 17: 463-470. (Pubitemid 40193316)
-
(2005)
Molecular Cell
, vol.17
, Issue.3
, pp. 463-470
-
-
Fung, H.1
Demple, B.2
-
56
-
-
0038299343
-
1 to S by PDGF in vascular smooth muscle cells
-
He T, Weintraub NL, Goswami PC, Chatterjee P, Flaherty DM, Domann FE et al. Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2003; 285: H804-H812. (Pubitemid 36885914)
-
(2003)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.285
, Issue.2
-
-
He, T.1
Weintraub, N.L.2
Goswami, P.C.3
Chatterjee, P.4
Flaherty, D.M.5
Domann, F.E.6
Oberley, L.W.7
-
57
-
-
17644365775
-
Two essential but distinct functions of the mammalian abasic endonuclease
-
DOI 10.1073/pnas.0500986102
-
Izumi T, Brown DB, Naidu CV, Bhakat KK, Macinnes MA, Saito H et al. Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci USA 2005; 102: 5739-5743. (Pubitemid 40559629)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.16
, pp. 5739-5743
-
-
Izumi, T.1
Brown, D.B.2
Naidu, C.V.3
Bhakat, K.K.4
MacInnes, M.A.5
Saito, H.6
Chen, D.J.7
Mitra, S.8
-
58
-
-
55049124777
-
Long patch base excision repair in mammalian mitochondrial genomes
-
Szczesny B, Tann AW, Longley MJ, Copeland WC, Mitra S. Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem 2008; 283: 26349-26356.
-
(2008)
J Biol Chem
, vol.283
, pp. 26349-26356
-
-
Szczesny, B.1
Tann, A.W.2
Longley, M.J.3
Copeland, W.C.4
Mitra, S.5
-
59
-
-
77953036663
-
Age-and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury
-
Szczesny B, Tann AW, Mitra S. Age-and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev 2010; 131: 330-337.
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 330-337
-
-
Szczesny, B.1
Tann, A.W.2
Mitra, S.3
-
60
-
-
0035820072
-
Mitochondrial localization of APE/Ref-1 in thyroid cells
-
DOI 10.1016/S0921-8777(00)00068-9, PII S0921877700000689
-
Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G et al. Mitochondrial localization of APE/Ref-1 in thyroid cells. Mutat Res 2001; 485: 143-152. (Pubitemid 32157567)
-
(2001)
Mutation Research - DNA Repair
, vol.485
, Issue.2
, pp. 143-152
-
-
Tell, G.1
Crivellato, E.2
Pines, A.3
Paron, I.4
Pucillo, C.5
Manzini, G.6
Bandiera, A.7
Kelley, M.R.8
Di Loreto, C.9
Damante, G.10
-
61
-
-
0035988381
-
Redox factor-1: An extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis
-
DOI 10.1038/sj.cdd.4401025
-
Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, Jeon BH et al. Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ 2002; 9: 717-725. (Pubitemid 34778038)
-
(2002)
Cell Death and Differentiation
, vol.9
, Issue.7
, pp. 717-725
-
-
Angkeow, P.1
Deshpande, S.S.2
Qi, B.3
Liu, Y.-X.4
Park, Y.C.5
Jeon, B.H.6
Ozaki, M.7
Irani, K.8
-
62
-
-
0036618347
-
Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase
-
Ozaki M, Suzuki S, Irani K. Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase. FASEB J 2002; 16: 889-890.
-
(2002)
FASEB J
, vol.16
, pp. 889-890
-
-
Ozaki, M.1
Suzuki, S.2
Irani, K.3
-
63
-
-
79957705984
-
Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function
-
Yu ET, Hadi MZ. Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function. Mutat Res 2011; 722: 140-146.
-
(2011)
Mutat Res
, vol.722
, pp. 140-146
-
-
Yu, E.T.1
Hadi, M.Z.2
-
64
-
-
34250700977
-
A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein [4]
-
DOI 10.1038/sj.leu.2404679, PII 2404679
-
Pitiot AS, Santamaŕia I, García-Suárez O, Centeno I, Astudillo A, Rayón C et al. A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein. Leukemia 2007; 21: 1564-1566. (Pubitemid 46965301)
-
(2007)
Leukemia
, vol.21
, Issue.7
, pp. 1564-1566
-
-
Pitiot, A.S.1
Santamaria, I.2
Garcia-Suarez, O.3
Centeno, I.4
Astudillo, A.5
Rayon, C.6
Balbin, M.7
|