Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3101-3112

  Rai, Ganesha ^a   Vyjayanti, Vaddadi N ^b   Dorjsuren, Dorjbal ^a   Simeonov, Anton ^a   Jadhav, Ajit ^a   Wilson, David M ^b   Maloney, David J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; ESTERASE INHIBITOR; METHYLMETHANE SULFONATE; N [3 (BENZO[D]THIAZOL 2 YL) 6 ISOPROPYL 4,5,6,7 TETRAHYDROTHIENO[2,3 C]PYRIDIN 2 YL]ACETAMIDE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; DRUG SYNTHESIS; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; WHOLE CELL EXTRACT ASSAY;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; BENZOTHIAZOLES; BRAIN; CELL EXTRACTS; DACARBAZINE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG SYNERGISM; HELA CELLS; HUMANS; INJECTIONS, INTRAPERITONEAL; METHYL METHANESULFONATE; MICE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TISSUE DISTRIBUTION;

EID: 84859789451     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201537d     Document Type: Article

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