메뉴 건너뛰기




Volumn 25, Issue 6, 2014, Pages 312-319

Role of interleukins in obesity: Implications for metabolic disease

Author keywords

Beta cell; Inflammasome; Interleukins; Nutrient overload

Indexed keywords

AMYLIN; CARDIOTROPHIN 1; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 33; INTERLEUKIN 36ALPHA; INTERLEUKIN 36BETA; INTERLEUKIN 36GAMMA; INTERLEUKIN 36RA; INTERLEUKIN 37; INTERLEUKIN 38; INTERLEUKIN 4; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; ONCOSTATIN M; STAT3 PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

EID: 84901820722     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.02.004     Document Type: Review
Times cited : (99)

References (99)
  • 1
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson S.E., et al. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116:1793-1801.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1
  • 2
    • 84965094576 scopus 로고
    • Reappraisal of the hypoglycemic action of acetylsalicylate
    • Hecht A., Goldner M.G. Reappraisal of the hypoglycemic action of acetylsalicylate. Metabolism 1959, 8:418-428.
    • (1959) Metabolism , vol.8 , pp. 418-428
    • Hecht, A.1    Goldner, M.G.2
  • 3
    • 0000198118 scopus 로고
    • Aspirin and diabetes mellitus
    • Reid J., et al. Aspirin and diabetes mellitus. Br. Med. J. 1957, 2:1071-1074.
    • (1957) Br. Med. J. , vol.2 , pp. 1071-1074
    • Reid, J.1
  • 4
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., et al. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1
  • 5
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal K.T., et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1
  • 6
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: from innocent bystander to major culprit
    • Karin M., et al. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2:301-310.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1
  • 7
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 8
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005, 11:183-190.
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1
  • 9
    • 0031825424 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase cascades as regulators of stress responses
    • Karin M. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. N. Y. Acad. Sci. 1998, 851:139-146.
    • (1998) Ann. N. Y. Acad. Sci. , vol.851 , pp. 139-146
    • Karin, M.1
  • 10
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1
  • 11
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio G., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322:1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1
  • 12
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    • Gao Z., et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J. Biol. Chem. 2002, 277:48115-48121.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48115-48121
    • Gao, Z.1
  • 13
    • 79952279446 scopus 로고    scopus 로고
    • Evolutionary divergence and functions of the human interleukin (IL) gene family
    • Brocker C., et al. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum. Genomics 2010, 5:30-55.
    • (2010) Hum. Genomics , vol.5 , pp. 30-55
    • Brocker, C.1
  • 14
    • 68549130286 scopus 로고    scopus 로고
    • The role of interleukins in insulin resistance and type 2 diabetes mellitus
    • Feve B., Bastard J.P. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2009, 5:305-311.
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 305-311
    • Feve, B.1    Bastard, J.P.2
  • 15
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
    • (2011) Blood , vol.117 , pp. 3720-3732
    • Dinarello, C.A.1
  • 16
    • 0022364132 scopus 로고
    • Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
    • March C.J., et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 1985, 315:641-647.
    • (1985) Nature , vol.315 , pp. 641-647
    • March, C.J.1
  • 17
    • 0000814155 scopus 로고
    • Nucleotide sequence of human monocyte interleukin 1 precursor cDNA
    • Auron P.E., et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. U.S.A. 1984, 81:7907-7911.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 7907-7911
    • Auron, P.E.1
  • 18
    • 33747598510 scopus 로고    scopus 로고
    • Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes
    • Chaparro R.J., et al. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:12475-12480.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 12475-12480
    • Chaparro, R.J.1
  • 19
    • 0033660085 scopus 로고    scopus 로고
    • Obesity, increased linear growth, and risk of type 1 diabetes in children
    • Hypponen E., et al. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 2000, 23:1755-1760.
    • (2000) Diabetes Care , vol.23 , pp. 1755-1760
    • Hypponen, E.1
  • 20
    • 43549093332 scopus 로고    scopus 로고
    • Cytokines and beta-cell biology: from concept to clinical translation
    • Donath M.Y., et al. Cytokines and beta-cell biology: from concept to clinical translation. Endocr. Rev. 2008, 29:334-350.
    • (2008) Endocr. Rev. , vol.29 , pp. 334-350
    • Donath, M.Y.1
  • 21
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: etiology, immunology, and therapeutic strategies
    • van Belle T.L., et al. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol. Rev. 2011, 91:79-118.
    • (2011) Physiol. Rev. , vol.91 , pp. 79-118
    • van Belle, T.L.1
  • 22
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1
  • 23
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996, 39:1005-1029.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 24
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K., et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. 2002, 110:851-860.
    • (2002) J. Clin. Invest. , vol.110 , pp. 851-860
    • Maedler, K.1
  • 25
    • 34247170807 scopus 로고    scopus 로고
    • Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    • Larsen C.M., et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 2007, 356:1517-1526.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 1517-1526
    • Larsen, C.M.1
  • 26
    • 80053644777 scopus 로고    scopus 로고
    • Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
    • Ridker P.M., et al. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am. Heart J. 2011, 162:597-605.
    • (2011) Am. Heart J. , vol.162 , pp. 597-605
    • Ridker, P.M.1
  • 27
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 28
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes
    • Masters S.L., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol. 2010, 11:897-904.
    • (2010) Nat. Immunol. , vol.11 , pp. 897-904
    • Masters, S.L.1
  • 29
    • 80052650475 scopus 로고    scopus 로고
    • IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
    • Westwell-Roper C., et al. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J. Immunol. 2011, 187:2755-2765.
    • (2011) J. Immunol. , vol.187 , pp. 2755-2765
    • Westwell-Roper, C.1
  • 30
    • 84055182560 scopus 로고    scopus 로고
    • The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
    • Coll R.C., O'Neill L.A. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE 2011, 6:e29539.
    • (2011) PLoS ONE , vol.6
    • Coll, R.C.1    O'Neill, L.A.2
  • 31
    • 84858630049 scopus 로고    scopus 로고
    • A role for the NLRP3 inflammasome in metabolic diseases: did Warburg miss inflammation?
    • Wen H., et al. A role for the NLRP3 inflammasome in metabolic diseases: did Warburg miss inflammation?. Nat. Immunol. 2012, 13:352-357.
    • (2012) Nat. Immunol. , vol.13 , pp. 352-357
    • Wen, H.1
  • 32
    • 79751493607 scopus 로고    scopus 로고
    • Linking the inflammasome to obesity-related disease
    • Horng T., Hotamisligil G.S. Linking the inflammasome to obesity-related disease. Nat. Med. 2011, 17:164-165.
    • (2011) Nat. Med. , vol.17 , pp. 164-165
    • Horng, T.1    Hotamisligil, G.S.2
  • 33
    • 79960920271 scopus 로고    scopus 로고
    • NLRP3 inflammasomes link inflammation and metabolic disease
    • De Nardo D., Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011, 32:373-379.
    • (2011) Trends Immunol. , vol.32 , pp. 373-379
    • De Nardo, D.1    Latz, E.2
  • 34
    • 84878871217 scopus 로고    scopus 로고
    • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
    • Turner N., et al. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 2013, 56:1638-1648.
    • (2013) Diabetologia , vol.56 , pp. 1638-1648
    • Turner, N.1
  • 35
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C., et al. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 1999, 274:24202-24210.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1
  • 36
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
    • Verheij M., et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996, 380:75-79.
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1
  • 37
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland W.L., et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007, 5:167-179.
    • (2007) Cell Metab. , vol.5 , pp. 167-179
    • Holland, W.L.1
  • 38
    • 84870341562 scopus 로고    scopus 로고
    • Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice
    • Bruce C.R., et al. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes 2012, 61:3148-3155.
    • (2012) Diabetes , vol.61 , pp. 3148-3155
    • Bruce, C.R.1
  • 39
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 2011, 17:179-188.
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 40
    • 80053087484 scopus 로고    scopus 로고
    • Inflammasome is a central player in the induction of obesity and insulin resistance
    • Stienstra R., et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:15324-15329.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 15324-15329
    • Stienstra, R.1
  • 41
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra R., et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 2010, 12:593-605.
    • (2010) Cell Metab. , vol.12 , pp. 593-605
    • Stienstra, R.1
  • 42
    • 77649177009 scopus 로고    scopus 로고
    • Interleukin 18 in the CNS
    • Alboni S., et al. Interleukin 18 in the CNS. J. Neuroinflammation 2010, 7:9.
    • (2010) J. Neuroinflammation , vol.7 , pp. 9
    • Alboni, S.1
  • 43
    • 0032514751 scopus 로고    scopus 로고
    • Interleukin 18 stimulates HIV type 1 in monocytic cells
    • Shapiro L., et al. Interleukin 18 stimulates HIV type 1 in monocytic cells. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:12550-12555.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 12550-12555
    • Shapiro, L.1
  • 44
    • 0036348333 scopus 로고    scopus 로고
    • Weight loss reduces interleukin-18 levels in obese women
    • Esposito K., et al. Weight loss reduces interleukin-18 levels in obese women. J. Clin. Endocrinol. Metab. 2002, 87:3864-3866.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3864-3866
    • Esposito, K.1
  • 45
    • 0041322519 scopus 로고    scopus 로고
    • Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
    • Aso Y., et al. Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes. Diabetes Care 2003, 26:2622-2627.
    • (2003) Diabetes Care , vol.26 , pp. 2622-2627
    • Aso, Y.1
  • 46
    • 33745009509 scopus 로고    scopus 로고
    • Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    • Netea M.G., et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat. Med. 2006, 12:650-656.
    • (2006) Nat. Med. , vol.12 , pp. 650-656
    • Netea, M.G.1
  • 47
    • 34547466569 scopus 로고    scopus 로고
    • Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
    • Zorrilla E.P., et al. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:11097-11102.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 11097-11102
    • Zorrilla, E.P.1
  • 48
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 49
    • 11144357516 scopus 로고    scopus 로고
    • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    • Inoue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 2004, 10:168-174.
    • (2004) Nat. Med. , vol.10 , pp. 168-174
    • Inoue, H.1
  • 50
    • 55949119252 scopus 로고    scopus 로고
    • Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    • Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 2008, 88:1379-1406.
    • (2008) Physiol. Rev. , vol.88 , pp. 1379-1406
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 51
    • 84887338975 scopus 로고    scopus 로고
    • Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice
    • Lindegaard B., et al. Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice. Diabetes 2013, 62:3064-3074.
    • (2013) Diabetes , vol.62 , pp. 3064-3074
    • Lindegaard, B.1
  • 52
    • 80052026760 scopus 로고    scopus 로고
    • Role of IL-33 in inflammation and disease
    • Miller A.M. Role of IL-33 in inflammation and disease. J. Inflamm. 2011, 8:22.
    • (2011) J. Inflamm. , vol.8 , pp. 22
    • Miller, A.M.1
  • 53
    • 65549163320 scopus 로고    scopus 로고
    • IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
    • Wood I.S., et al. IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem. Biophys. Res. Commun. 2009, 384:105-109.
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , pp. 105-109
    • Wood, I.S.1
  • 54
    • 77957043879 scopus 로고    scopus 로고
    • Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    • Miller A.M., et al. Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circ. Res. 2010, 107:650-658.
    • (2010) Circ. Res. , vol.107 , pp. 650-658
    • Miller, A.M.1
  • 55
    • 34147159710 scopus 로고    scopus 로고
    • Gp130 receptor ligands as potential therapeutic targets for obesity
    • Febbraio M.A. gp130 receptor ligands as potential therapeutic targets for obesity. J. Clin. Invest. 2007, 117:841-849.
    • (2007) J. Clin. Invest. , vol.117 , pp. 841-849
    • Febbraio, M.A.1
  • 56
  • 57
    • 3142710172 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    • Carey A.L., et al. Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 2004, 47:1029-1037.
    • (2004) Diabetologia , vol.47 , pp. 1029-1037
    • Carey, A.L.1
  • 58
    • 0242299763 scopus 로고    scopus 로고
    • Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
    • Lagathu C., et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem. Biophys. Res. Commun. 2003, 311:372-379.
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 372-379
    • Lagathu, C.1
  • 59
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn J.J., et al. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002, 51:3391-3399.
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1
  • 60
    • 12144290761 scopus 로고    scopus 로고
    • Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
    • Kim H.J., et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004, 53:1060-1067.
    • (2004) Diabetes , vol.53 , pp. 1060-1067
    • Kim, H.J.1
  • 61
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover P.J., et al. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003, 52:2784-2789.
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1
  • 62
    • 33846883060 scopus 로고    scopus 로고
    • Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
    • Pedersen B.K., Febbraio M.A. Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:814-816.
    • (2007) J. Appl. Physiol. , vol.102 , pp. 814-816
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 63
    • 33947518747 scopus 로고    scopus 로고
    • Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
    • discussion 818-819
    • Mooney R.A. Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:816-818. discussion 818-819.
    • (2007) J. Appl. Physiol. , vol.102 , pp. 816-818
    • Mooney, R.A.1
  • 64
    • 0035369080 scopus 로고    scopus 로고
    • Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
    • Starkie R.L., et al. Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. J. Physiol. 2001, 533:585-591.
    • (2001) J. Physiol. , vol.533 , pp. 585-591
    • Starkie, R.L.1
  • 65
    • 0034668926 scopus 로고    scopus 로고
    • Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
    • Steensberg A., et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. 2000, 529:237-242.
    • (2000) J. Physiol. , vol.529 , pp. 237-242
    • Steensberg, A.1
  • 66
    • 4143052910 scopus 로고    scopus 로고
    • Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity
    • Hiscock N., et al. Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J. 2004, 18:992-994.
    • (2004) FASEB J. , vol.18 , pp. 992-994
    • Hiscock, N.1
  • 67
    • 0034006412 scopus 로고    scopus 로고
    • Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
    • Wojtaszewski J.F., et al. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 2000, 49:325-331.
    • (2000) Diabetes , vol.49 , pp. 325-331
    • Wojtaszewski, J.F.1
  • 68
    • 3042721664 scopus 로고    scopus 로고
    • Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
    • Febbraio M.A., et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 2004, 53:1643-1648.
    • (2004) Diabetes , vol.53 , pp. 1643-1648
    • Febbraio, M.A.1
  • 69
    • 0038372035 scopus 로고    scopus 로고
    • Interleukin-6 stimulates lipolysis and fat oxidation in humans
    • van Hall G., et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J. Clin. Endocrinol. Metab. 2003, 88:3005-3010.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3005-3010
    • van Hall, G.1
  • 70
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard H., et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011, 17:1481-1489.
    • (2011) Nat. Med. , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1
  • 71
    • 84885031186 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
    • Shirazi R., et al. Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:16199-16204.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 16199-16204
    • Shirazi, R.1
  • 72
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: skeletal muscle as a secretory organ
    • Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012, 8:457-465.
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 73
    • 0036152683 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop mature-onset obesity
    • Wallenius V., et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 2002, 8:75-79.
    • (2002) Nat. Med. , vol.8 , pp. 75-79
    • Wallenius, V.1
  • 74
    • 3042739678 scopus 로고    scopus 로고
    • Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
    • Di Gregorio G.B., et al. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E182-E187.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287
    • Di Gregorio, G.B.1
  • 75
    • 77957661299 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
    • Matthews V.B., et al. Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 2010, 53:2431-2441.
    • (2010) Diabetologia , vol.53 , pp. 2431-2441
    • Matthews, V.B.1
  • 76
    • 77956335194 scopus 로고    scopus 로고
    • Interleukin-6 signaling in liver parenchymal cells suppresses hepatic inflammation and improves systemic insulin action
    • Wunderlich F.T., et al. Interleukin-6 signaling in liver parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010, 12:237-249.
    • (2010) Cell Metab. , vol.12 , pp. 237-249
    • Wunderlich, F.T.1
  • 77
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    • Carey A.L., et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006, 55:2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1
  • 78
    • 33751501694 scopus 로고    scopus 로고
    • Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle
    • Al-Khalili L., et al. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol. Endocrinol. 2006, 20:3364-3375.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 3364-3375
    • Al-Khalili, L.1
  • 79
    • 33646570554 scopus 로고    scopus 로고
    • CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
    • Watt M.J., et al. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat. Med. 2006, 12:541-548.
    • (2006) Nat. Med. , vol.12 , pp. 541-548
    • Watt, M.J.1
  • 80
    • 77949266016 scopus 로고    scopus 로고
    • Human IL6 enhances leptin action in mice
    • Sadagurski M., et al. Human IL6 enhances leptin action in mice. Diabetologia 2010, 53:525-535.
    • (2010) Diabetologia , vol.53 , pp. 525-535
    • Sadagurski, M.1
  • 81
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • Moore K.W., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 683-765
    • Moore, K.W.1
  • 82
    • 0027959650 scopus 로고
    • Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes
    • Joyce D.A., et al. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur. J. Immunol. 1994, 24:2699-2705.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2699-2705
    • Joyce, D.A.1
  • 83
    • 39849107173 scopus 로고    scopus 로고
    • Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
    • Cintra D.E., et al. Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J. Hepatol. 2008, 48:628-637.
    • (2008) J. Hepatol. , vol.48 , pp. 628-637
    • Cintra, D.E.1
  • 84
    • 84885020680 scopus 로고    scopus 로고
    • Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance
    • Gao M., et al. Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance. Mol. Ther. 2013, 21:1852-1861.
    • (2013) Mol. Ther. , vol.21 , pp. 1852-1861
    • Gao, M.1
  • 85
    • 79953812918 scopus 로고    scopus 로고
    • Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice
    • Kowalski G.M., et al. Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice. Diabetologia 2011, 54:888-899.
    • (2011) Diabetologia , vol.54 , pp. 888-899
    • Kowalski, G.M.1
  • 86
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martinez F.O., et al. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009, 27:451-483.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 451-483
    • Martinez, F.O.1
  • 87
    • 80355133234 scopus 로고    scopus 로고
    • Macrophage-mediated inflammation in metabolic disease
    • Chawla A., et al. Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 2011, 11:738-749.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 738-749
    • Chawla, A.1
  • 88
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K., et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008, 7:485-495.
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1
  • 89
    • 84873804024 scopus 로고    scopus 로고
    • Direct control of hepatic glucose production by interleukin-13 in mice
    • Stanya K.J., et al. Direct control of hepatic glucose production by interleukin-13 in mice. J. Clin. Invest. 2013, 123:261-271.
    • (2013) J. Clin. Invest. , vol.123 , pp. 261-271
    • Stanya, K.J.1
  • 90
    • 84888876129 scopus 로고    scopus 로고
    • Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
    • Jiang L.Q., et al. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am. J. Physiol. Endocrinol. Metab. 2013, 305:E1359-E1366.
    • (2013) Am. J. Physiol. Endocrinol. Metab. , vol.305
    • Jiang, L.Q.1
  • 91
    • 84855804372 scopus 로고    scopus 로고
    • Interleukin-15 biology and its therapeutic implications in cancer
    • Steel J.C., et al. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol. Sci. 2012, 33:35-41.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 35-41
    • Steel, J.C.1
  • 92
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein K.H., et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994, 264:965-968.
    • (1994) Science , vol.264 , pp. 965-968
    • Grabstein, K.H.1
  • 93
    • 0033944108 scopus 로고    scopus 로고
    • Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats
    • Carbo N., et al. Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br. J. Cancer 2000, 83:526-531.
    • (2000) Br. J. Cancer , vol.83 , pp. 526-531
    • Carbo, N.1
  • 94
    • 84896717042 scopus 로고    scopus 로고
    • Endurance training enhances skeletal muscle interleukin-15 in human male subjects
    • Rinnov A., et al. Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine 2013, 45:271-278.
    • (2013) Endocrine , vol.45 , pp. 271-278
    • Rinnov, A.1
  • 95
    • 0035799405 scopus 로고    scopus 로고
    • Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control
    • Carbo N., et al. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim. Biophys. Acta 2001, 1526:17-24.
    • (2001) Biochim. Biophys. Acta , vol.1526 , pp. 17-24
    • Carbo, N.1
  • 96
    • 58249096194 scopus 로고    scopus 로고
    • Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
    • Quinn L.S., et al. Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E191-E202.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Quinn, L.S.1
  • 97
    • 33646039349 scopus 로고    scopus 로고
    • Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load
    • Almendro V., et al. Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load. Biochim. Biophys. Acta 2006, 1761:37-42.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 37-42
    • Almendro, V.1
  • 98
    • 57349146862 scopus 로고    scopus 로고
    • Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
    • Nielsen A.R., et al. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J. Clin. Endocrinol. Metab. 2008, 93:4486-4493.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4486-4493
    • Nielsen, A.R.1
  • 99
    • 84855351190 scopus 로고    scopus 로고
    • Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
    • Barra N.G., et al. Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice. Diabetes Obes. Metab. 2012, 14:190-193.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 190-193
    • Barra, N.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.