-
1
-
-
33745861300
-
Inflammation and insulin resistance
-
Shoelson S.E., et al. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116:1793-1801.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1793-1801
-
-
Shoelson, S.E.1
-
2
-
-
84965094576
-
Reappraisal of the hypoglycemic action of acetylsalicylate
-
Hecht A., Goldner M.G. Reappraisal of the hypoglycemic action of acetylsalicylate. Metabolism 1959, 8:418-428.
-
(1959)
Metabolism
, vol.8
, pp. 418-428
-
-
Hecht, A.1
Goldner, M.G.2
-
3
-
-
0000198118
-
Aspirin and diabetes mellitus
-
Reid J., et al. Aspirin and diabetes mellitus. Br. Med. J. 1957, 2:1071-1074.
-
(1957)
Br. Med. J.
, vol.2
, pp. 1071-1074
-
-
Reid, J.1
-
4
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil G.S., et al. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
-
5
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal K.T., et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
-
6
-
-
0036546501
-
NF-kappaB in cancer: from innocent bystander to major culprit
-
Karin M., et al. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2:301-310.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
-
7
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
-
8
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005, 11:183-190.
-
(2005)
Nat. Med.
, vol.11
, pp. 183-190
-
-
Cai, D.1
-
9
-
-
0031825424
-
Mitogen-activated protein kinase cascades as regulators of stress responses
-
Karin M. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. N. Y. Acad. Sci. 1998, 851:139-146.
-
(1998)
Ann. N. Y. Acad. Sci.
, vol.851
, pp. 139-146
-
-
Karin, M.1
-
10
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
11
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322:1539-1543.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
-
12
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao Z., et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J. Biol. Chem. 2002, 277:48115-48121.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
-
13
-
-
79952279446
-
Evolutionary divergence and functions of the human interleukin (IL) gene family
-
Brocker C., et al. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum. Genomics 2010, 5:30-55.
-
(2010)
Hum. Genomics
, vol.5
, pp. 30-55
-
-
Brocker, C.1
-
14
-
-
68549130286
-
The role of interleukins in insulin resistance and type 2 diabetes mellitus
-
Feve B., Bastard J.P. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2009, 5:305-311.
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 305-311
-
-
Feve, B.1
Bastard, J.P.2
-
15
-
-
79953813107
-
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
-
Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
-
(2011)
Blood
, vol.117
, pp. 3720-3732
-
-
Dinarello, C.A.1
-
16
-
-
0022364132
-
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
-
March C.J., et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 1985, 315:641-647.
-
(1985)
Nature
, vol.315
, pp. 641-647
-
-
March, C.J.1
-
17
-
-
0000814155
-
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA
-
Auron P.E., et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. U.S.A. 1984, 81:7907-7911.
-
(1984)
Proc. Natl. Acad. Sci. U.S.A.
, vol.81
, pp. 7907-7911
-
-
Auron, P.E.1
-
18
-
-
33747598510
-
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes
-
Chaparro R.J., et al. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:12475-12480.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 12475-12480
-
-
Chaparro, R.J.1
-
19
-
-
0033660085
-
Obesity, increased linear growth, and risk of type 1 diabetes in children
-
Hypponen E., et al. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 2000, 23:1755-1760.
-
(2000)
Diabetes Care
, vol.23
, pp. 1755-1760
-
-
Hypponen, E.1
-
20
-
-
43549093332
-
Cytokines and beta-cell biology: from concept to clinical translation
-
Donath M.Y., et al. Cytokines and beta-cell biology: from concept to clinical translation. Endocr. Rev. 2008, 29:334-350.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 334-350
-
-
Donath, M.Y.1
-
21
-
-
78751662679
-
Type 1 diabetes: etiology, immunology, and therapeutic strategies
-
van Belle T.L., et al. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol. Rev. 2011, 91:79-118.
-
(2011)
Physiol. Rev.
, vol.91
, pp. 79-118
-
-
van Belle, T.L.1
-
22
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler A.E., et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
-
23
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996, 39:1005-1029.
-
(1996)
Diabetologia
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, T.1
-
24
-
-
0036738398
-
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler K., et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. 2002, 110:851-860.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 851-860
-
-
Maedler, K.1
-
25
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen C.M., et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 2007, 356:1517-1526.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
-
26
-
-
80053644777
-
Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
-
Ridker P.M., et al. Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am. Heart J. 2011, 162:597-605.
-
(2011)
Am. Heart J.
, vol.162
, pp. 597-605
-
-
Ridker, P.M.1
-
27
-
-
77950362382
-
The inflammasomes
-
Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
28
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes
-
Masters S.L., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol. 2010, 11:897-904.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
29
-
-
80052650475
-
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
-
Westwell-Roper C., et al. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J. Immunol. 2011, 187:2755-2765.
-
(2011)
J. Immunol.
, vol.187
, pp. 2755-2765
-
-
Westwell-Roper, C.1
-
30
-
-
84055182560
-
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
-
Coll R.C., O'Neill L.A. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE 2011, 6:e29539.
-
(2011)
PLoS ONE
, vol.6
-
-
Coll, R.C.1
O'Neill, L.A.2
-
31
-
-
84858630049
-
A role for the NLRP3 inflammasome in metabolic diseases: did Warburg miss inflammation?
-
Wen H., et al. A role for the NLRP3 inflammasome in metabolic diseases: did Warburg miss inflammation?. Nat. Immunol. 2012, 13:352-357.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 352-357
-
-
Wen, H.1
-
32
-
-
79751493607
-
Linking the inflammasome to obesity-related disease
-
Horng T., Hotamisligil G.S. Linking the inflammasome to obesity-related disease. Nat. Med. 2011, 17:164-165.
-
(2011)
Nat. Med.
, vol.17
, pp. 164-165
-
-
Horng, T.1
Hotamisligil, G.S.2
-
33
-
-
79960920271
-
NLRP3 inflammasomes link inflammation and metabolic disease
-
De Nardo D., Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011, 32:373-379.
-
(2011)
Trends Immunol.
, vol.32
, pp. 373-379
-
-
De Nardo, D.1
Latz, E.2
-
34
-
-
84878871217
-
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
-
Turner N., et al. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 2013, 56:1638-1648.
-
(2013)
Diabetologia
, vol.56
, pp. 1638-1648
-
-
Turner, N.1
-
35
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer C., et al. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 1999, 274:24202-24210.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
-
36
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij M., et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996, 380:75-79.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
-
37
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland W.L., et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007, 5:167-179.
-
(2007)
Cell Metab.
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
-
38
-
-
84870341562
-
Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice
-
Bruce C.R., et al. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes 2012, 61:3148-3155.
-
(2012)
Diabetes
, vol.61
, pp. 3148-3155
-
-
Bruce, C.R.1
-
39
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 2011, 17:179-188.
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
40
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra R., et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:15324-15329.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
-
41
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R., et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 2010, 12:593-605.
-
(2010)
Cell Metab.
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
-
42
-
-
77649177009
-
Interleukin 18 in the CNS
-
Alboni S., et al. Interleukin 18 in the CNS. J. Neuroinflammation 2010, 7:9.
-
(2010)
J. Neuroinflammation
, vol.7
, pp. 9
-
-
Alboni, S.1
-
43
-
-
0032514751
-
Interleukin 18 stimulates HIV type 1 in monocytic cells
-
Shapiro L., et al. Interleukin 18 stimulates HIV type 1 in monocytic cells. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:12550-12555.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 12550-12555
-
-
Shapiro, L.1
-
44
-
-
0036348333
-
Weight loss reduces interleukin-18 levels in obese women
-
Esposito K., et al. Weight loss reduces interleukin-18 levels in obese women. J. Clin. Endocrinol. Metab. 2002, 87:3864-3866.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 3864-3866
-
-
Esposito, K.1
-
45
-
-
0041322519
-
Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes
-
Aso Y., et al. Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes. Diabetes Care 2003, 26:2622-2627.
-
(2003)
Diabetes Care
, vol.26
, pp. 2622-2627
-
-
Aso, Y.1
-
46
-
-
33745009509
-
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
-
Netea M.G., et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat. Med. 2006, 12:650-656.
-
(2006)
Nat. Med.
, vol.12
, pp. 650-656
-
-
Netea, M.G.1
-
47
-
-
34547466569
-
Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
-
Zorrilla E.P., et al. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:11097-11102.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 11097-11102
-
-
Zorrilla, E.P.1
-
48
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
-
49
-
-
11144357516
-
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
-
Inoue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 2004, 10:168-174.
-
(2004)
Nat. Med.
, vol.10
, pp. 168-174
-
-
Inoue, H.1
-
50
-
-
55949119252
-
Muscle as an endocrine organ: focus on muscle-derived interleukin-6
-
Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 2008, 88:1379-1406.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 1379-1406
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
51
-
-
84887338975
-
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice
-
Lindegaard B., et al. Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice. Diabetes 2013, 62:3064-3074.
-
(2013)
Diabetes
, vol.62
, pp. 3064-3074
-
-
Lindegaard, B.1
-
52
-
-
80052026760
-
Role of IL-33 in inflammation and disease
-
Miller A.M. Role of IL-33 in inflammation and disease. J. Inflamm. 2011, 8:22.
-
(2011)
J. Inflamm.
, vol.8
, pp. 22
-
-
Miller, A.M.1
-
53
-
-
65549163320
-
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
-
Wood I.S., et al. IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem. Biophys. Res. Commun. 2009, 384:105-109.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.384
, pp. 105-109
-
-
Wood, I.S.1
-
54
-
-
77957043879
-
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
-
Miller A.M., et al. Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circ. Res. 2010, 107:650-658.
-
(2010)
Circ. Res.
, vol.107
, pp. 650-658
-
-
Miller, A.M.1
-
55
-
-
34147159710
-
Gp130 receptor ligands as potential therapeutic targets for obesity
-
Febbraio M.A. gp130 receptor ligands as potential therapeutic targets for obesity. J. Clin. Invest. 2007, 117:841-849.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 841-849
-
-
Febbraio, M.A.1
-
56
-
-
18244370762
-
Inflammation, stress, and diabetes
-
Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. J. Clin. Invest. 2005, 115:1111-1119.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1111-1119
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
57
-
-
3142710172
-
Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
-
Carey A.L., et al. Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 2004, 47:1029-1037.
-
(2004)
Diabetologia
, vol.47
, pp. 1029-1037
-
-
Carey, A.L.1
-
58
-
-
0242299763
-
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
-
Lagathu C., et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem. Biophys. Res. Commun. 2003, 311:372-379.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.311
, pp. 372-379
-
-
Lagathu, C.1
-
59
-
-
0036894360
-
Interleukin-6 induces cellular insulin resistance in hepatocytes
-
Senn J.J., et al. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002, 51:3391-3399.
-
(2002)
Diabetes
, vol.51
, pp. 3391-3399
-
-
Senn, J.J.1
-
60
-
-
12144290761
-
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
-
Kim H.J., et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004, 53:1060-1067.
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
-
61
-
-
0242268894
-
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
-
Klover P.J., et al. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003, 52:2784-2789.
-
(2003)
Diabetes
, vol.52
, pp. 2784-2789
-
-
Klover, P.J.1
-
62
-
-
33846883060
-
Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
-
Pedersen B.K., Febbraio M.A. Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:814-816.
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 814-816
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
63
-
-
33947518747
-
Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
-
discussion 818-819
-
Mooney R.A. Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:816-818. discussion 818-819.
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 816-818
-
-
Mooney, R.A.1
-
64
-
-
0035369080
-
Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans
-
Starkie R.L., et al. Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. J. Physiol. 2001, 533:585-591.
-
(2001)
J. Physiol.
, vol.533
, pp. 585-591
-
-
Starkie, R.L.1
-
65
-
-
0034668926
-
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
-
Steensberg A., et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. 2000, 529:237-242.
-
(2000)
J. Physiol.
, vol.529
, pp. 237-242
-
-
Steensberg, A.1
-
66
-
-
4143052910
-
Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity
-
Hiscock N., et al. Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J. 2004, 18:992-994.
-
(2004)
FASEB J.
, vol.18
, pp. 992-994
-
-
Hiscock, N.1
-
67
-
-
0034006412
-
Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
-
Wojtaszewski J.F., et al. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 2000, 49:325-331.
-
(2000)
Diabetes
, vol.49
, pp. 325-331
-
-
Wojtaszewski, J.F.1
-
68
-
-
3042721664
-
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
-
Febbraio M.A., et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 2004, 53:1643-1648.
-
(2004)
Diabetes
, vol.53
, pp. 1643-1648
-
-
Febbraio, M.A.1
-
69
-
-
0038372035
-
Interleukin-6 stimulates lipolysis and fat oxidation in humans
-
van Hall G., et al. Interleukin-6 stimulates lipolysis and fat oxidation in humans. J. Clin. Endocrinol. Metab. 2003, 88:3005-3010.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 3005-3010
-
-
van Hall, G.1
-
70
-
-
81255157471
-
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
-
Ellingsgaard H., et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011, 17:1481-1489.
-
(2011)
Nat. Med.
, vol.17
, pp. 1481-1489
-
-
Ellingsgaard, H.1
-
71
-
-
84885031186
-
Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
-
Shirazi R., et al. Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:16199-16204.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 16199-16204
-
-
Shirazi, R.1
-
72
-
-
84864283300
-
Muscles, exercise and obesity: skeletal muscle as a secretory organ
-
Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012, 8:457-465.
-
(2012)
Nat. Rev. Endocrinol.
, vol.8
, pp. 457-465
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
73
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V., et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 2002, 8:75-79.
-
(2002)
Nat. Med.
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
-
74
-
-
3042739678
-
Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
-
Di Gregorio G.B., et al. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E182-E187.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.287
-
-
Di Gregorio, G.B.1
-
75
-
-
77957661299
-
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
-
Matthews V.B., et al. Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 2010, 53:2431-2441.
-
(2010)
Diabetologia
, vol.53
, pp. 2431-2441
-
-
Matthews, V.B.1
-
76
-
-
77956335194
-
Interleukin-6 signaling in liver parenchymal cells suppresses hepatic inflammation and improves systemic insulin action
-
Wunderlich F.T., et al. Interleukin-6 signaling in liver parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010, 12:237-249.
-
(2010)
Cell Metab.
, vol.12
, pp. 237-249
-
-
Wunderlich, F.T.1
-
77
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
Carey A.L., et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006, 55:2688-2697.
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
-
78
-
-
33751501694
-
Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle
-
Al-Khalili L., et al. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol. Endocrinol. 2006, 20:3364-3375.
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 3364-3375
-
-
Al-Khalili, L.1
-
79
-
-
33646570554
-
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
-
Watt M.J., et al. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat. Med. 2006, 12:541-548.
-
(2006)
Nat. Med.
, vol.12
, pp. 541-548
-
-
Watt, M.J.1
-
80
-
-
77949266016
-
Human IL6 enhances leptin action in mice
-
Sadagurski M., et al. Human IL6 enhances leptin action in mice. Diabetologia 2010, 53:525-535.
-
(2010)
Diabetologia
, vol.53
, pp. 525-535
-
-
Sadagurski, M.1
-
81
-
-
0035062021
-
Interleukin-10 and the interleukin-10 receptor
-
Moore K.W., et al. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 683-765
-
-
Moore, K.W.1
-
82
-
-
0027959650
-
Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes
-
Joyce D.A., et al. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur. J. Immunol. 1994, 24:2699-2705.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2699-2705
-
-
Joyce, D.A.1
-
83
-
-
39849107173
-
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
-
Cintra D.E., et al. Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J. Hepatol. 2008, 48:628-637.
-
(2008)
J. Hepatol.
, vol.48
, pp. 628-637
-
-
Cintra, D.E.1
-
84
-
-
84885020680
-
Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance
-
Gao M., et al. Hydrodynamic delivery of mIL10 gene protects mice from high-fat diet-induced obesity and glucose intolerance. Mol. Ther. 2013, 21:1852-1861.
-
(2013)
Mol. Ther.
, vol.21
, pp. 1852-1861
-
-
Gao, M.1
-
85
-
-
79953812918
-
Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice
-
Kowalski G.M., et al. Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice. Diabetologia 2011, 54:888-899.
-
(2011)
Diabetologia
, vol.54
, pp. 888-899
-
-
Kowalski, G.M.1
-
86
-
-
67650485985
-
Alternative activation of macrophages: an immunologic functional perspective
-
Martinez F.O., et al. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009, 27:451-483.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 451-483
-
-
Martinez, F.O.1
-
87
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla A., et al. Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 2011, 11:738-749.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 738-749
-
-
Chawla, A.1
-
88
-
-
44349112305
-
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
-
Kang K., et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008, 7:485-495.
-
(2008)
Cell Metab.
, vol.7
, pp. 485-495
-
-
Kang, K.1
-
89
-
-
84873804024
-
Direct control of hepatic glucose production by interleukin-13 in mice
-
Stanya K.J., et al. Direct control of hepatic glucose production by interleukin-13 in mice. J. Clin. Invest. 2013, 123:261-271.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 261-271
-
-
Stanya, K.J.1
-
90
-
-
84888876129
-
Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
-
Jiang L.Q., et al. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am. J. Physiol. Endocrinol. Metab. 2013, 305:E1359-E1366.
-
(2013)
Am. J. Physiol. Endocrinol. Metab.
, vol.305
-
-
Jiang, L.Q.1
-
91
-
-
84855804372
-
Interleukin-15 biology and its therapeutic implications in cancer
-
Steel J.C., et al. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol. Sci. 2012, 33:35-41.
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 35-41
-
-
Steel, J.C.1
-
92
-
-
0028179054
-
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
-
Grabstein K.H., et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994, 264:965-968.
-
(1994)
Science
, vol.264
, pp. 965-968
-
-
Grabstein, K.H.1
-
93
-
-
0033944108
-
Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats
-
Carbo N., et al. Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br. J. Cancer 2000, 83:526-531.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 526-531
-
-
Carbo, N.1
-
94
-
-
84896717042
-
Endurance training enhances skeletal muscle interleukin-15 in human male subjects
-
Rinnov A., et al. Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine 2013, 45:271-278.
-
(2013)
Endocrine
, vol.45
, pp. 271-278
-
-
Rinnov, A.1
-
95
-
-
0035799405
-
Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control
-
Carbo N., et al. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim. Biophys. Acta 2001, 1526:17-24.
-
(2001)
Biochim. Biophys. Acta
, vol.1526
, pp. 17-24
-
-
Carbo, N.1
-
96
-
-
58249096194
-
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
-
Quinn L.S., et al. Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E191-E202.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Quinn, L.S.1
-
97
-
-
33646039349
-
Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load
-
Almendro V., et al. Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load. Biochim. Biophys. Acta 2006, 1761:37-42.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 37-42
-
-
Almendro, V.1
-
98
-
-
57349146862
-
Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
-
Nielsen A.R., et al. Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J. Clin. Endocrinol. Metab. 2008, 93:4486-4493.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 4486-4493
-
-
Nielsen, A.R.1
-
99
-
-
84855351190
-
Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
-
Barra N.G., et al. Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice. Diabetes Obes. Metab. 2012, 14:190-193.
-
(2012)
Diabetes Obes. Metab.
, vol.14
, pp. 190-193
-
-
Barra, N.G.1
|