P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

Journal of Cell Science

Volumn 127, Issue 11, 2014, Pages 2589-2600

  Damoulakis, George ^a,d   Gambardella, Laure ^a   Rossman, Kent L ^b   Lawson, Campbell D ^a   Anderson, Karen E ^a   Fukui, Yoshinori ^c   Welch, Heidi C ^a   Der, Channing J ^b   Stephens, Len R ^a   Hawkins, Phillip T ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c KYUSHU UNIVERSITY   (Japan)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Cell migration; Cell signalling; NADPH oxidase; Neutrophil; Rho GEF; Small GTPase

Indexed keywords

ACTIN; DOCK2 PROTEIN; F ACTIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR P REX1; INITIATION FACTOR; RAC PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; DOCK2 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PREX1 PROTEIN, MOUSE; PROTEIN KINASE B; RHOG PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL ISOLATION; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REDUCTION; SIGNAL TRANSDUCTION; 129 MOUSE; ANIMAL; BREAST TUMOR; C57BL MOUSE; CARCINOGENESIS; CELL CULTURE; CELL MOTION; GENETICS; KNOCKOUT MOUSE; MELANOMA; METABOLISM; METASTASIS; PHYSIOLOGY;

ACTIN CYTOSKELETON; ANIMALS; BREAST NEOPLASMS; CARCINOGENESIS; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; GTP PHOSPHOHYDROLASES; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MELANOMA; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM METASTASIS; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84901790386     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.153049     Document Type: Article

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