A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: A study by electron paramagnetic resonance spectroscopy

Brain Research

Volumn 854, Issue 1-2, 2000, Pages 224-229

  Chang, Raymond C C ^a   Rota, Cristina ^a   Glover, Richard E ^a   Mason, Ronald P ^a   Hong, Jau Shyong ^a  

^a Neuropharmacology Section   (United States)

Author keywords

Electron paramagnetic resonance; Microglia; Naloxone; Non heme iron nitrosyl complex; Superoxide

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; BACTERIUM LIPOPOLYSACCHARIDE; CATALASE; HYDROXYL RADICAL; IRON COMPLEX; NALOXONE; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFECT; ELECTRON SPIN RESONANCE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROXYL RADICAL; IRON; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NALOXONE; NARCOTIC ANTAGONISTS; NITRIC OXIDE; NITROGEN OXIDES; REACTIVE OXYGEN SPECIES; RECEPTORS, OPIOID; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 0033978959     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02267-2     Document Type: Article

References (26)

1. Boje K.M., Arora P.K. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587:1992;250-256.
2. Bronstein D.M., Perez-Otano I., Sun V., Mullis Swain S.B., Chan J., Wu G.C., Hudson P.M., Kong L.Y., Hong J.S., McMillian M.K. Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures. Brain Res. 704:1995;112-116.
3. Capdeville C., Pruneau D., Allix M., Plotkine M., Boulu R.G. Naloxone effect on the neurological deficit induced by forebrain ischemia in rats. Life Sci. 38:1985;437-442.
4. Chen W., Chang R.C.C., Hong J.S. Characterization of the inflammatory responses of a murine microglial cell line, BV2. Soc. Neurosci. Abstr. 28:1998;1615. Part 2.
5. 5]enkephalin on interleukin-1β secretion from microglia in mixed brain cell cultures. J. Neuroimmunol. 62:1995;9-17.
6. Duling D.R. Simulation of multiple isotropic spin-trap EPR spectra. J. Magn. Reson. B. 104(2):1994;105-110.
7. Faden A.L., Holaday J.W. Naloxone treatment of endotoxin shock: stereospecificity of physiologic and pharmacologic effects in the rat. J. Pharmacol. Exp. Ther. 212:1980;441-447.
8. Faden A.L., Holaday J.W. Experimental endotoxin shock: the pathophysiologic function of endorphins and treatment with opiate antagonists. J. Infect. Dis. 142:1980;229-238.
9. Faden A.I., Jacobs T.P., Holaday J.W. Opiate antagonist improves neurologic recovery after spinal injury. Science. 211:1981;493-494.
10. Geng Y.-J., Petersson A.-S., Wennmalm A., Hansson G.K. Cytokine-induced expression of nitric oxide synthase results in nitrosylation of heme and non-heme iron proteins in vascular smooth muscle cells. Exp. Cell Res. 214:1994;418-428.
11. Hayes R.L., Galinat B.J., Kulkarne P., Becker D.P. Effects of naloxone on systemic and cerebral responses to experimental concussive brain injury in cats. J. Neurosurg. 58:1983;720-728.
12. Jeohn G.H., Kong L.Y., Wilson B., Hudson P., Hong J.S. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J. Neuroimmunol. 85:1998;1-10.
13. Kong L.Y., Lai C., Wilson B.C., Simpson J.N., Hong J.S. Protein tyrosine kinase inhibitors decrease lipopolysaccharide-induced proinflammatory cytokine production in mixed glia, microglia-enriched or astrocyte-enriched cultures. Neurochem. Int. 30:1997;491-497.
14. Kong L.Y., McMillian M.K., Hudson P.M., Jin L., Hong J.S. Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures. J. Pharmacol. Exp. Ther. 280:1997;61-66.
15. Kong L.Y., McMillian M.K., Maronpot R., Hong J.S. Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures. Brain Res. 729:1996;102-109.
16. Krainev A.G., Williams T.D., Bigelow D.J. Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides. J. Magn. Reson. B. 111(3):1996;272-280.
17. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:1996;312-318.
18. Lancaster J.R. Jr., Langrehr J.M., Bergonia H.A., Murase N., Simmons R.L., Hoffman R.A. EPR detection of heme and non-heme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J. Biol. Chem. 267:1992;10994-10998.
19. Nakashima T., Murakami T., Murai Y., Hori T., Miyata S., Kiyohara T. Naloxone suppress the rising phase of fever induced by interferon-α Brain Res. Bull. 37:1995;61-66.
20. Rose G.M., Freeman B.A. Detection of superoxide generated by endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 23:1984;7269-7273.
21. Sankarapandi S., Zweier J.L., Mukherjee G., Quinn M.T., Huso D.L. Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase dependent pathway. Arch. Biochem. Biophys. 353:1998;312-321.
22. Simpkins C.O., Ives N., Tate E., Johnson M. Naloxone inhibits superoxide release from human neutrophils. Life Sci. 37:1985;1381-1386.
23. Simpkins C.O., Alailima S.T., Tate E.A. Inhibition by naloxone of neutrophil superoxide release: a potentially useful anti-inflammatory effect. Circ. Shock. 20:1986;181-191.
24. Smith M.E., van der Maesen K., Somer F.P. Macrophage and microglial responses to cytokines in vitro: phagocytic activity, proteolytic enzyme release, and free radical production. J. Neurosci. Res. 54:1998;68-78.
25. Tanaka M., Sotomatsu A., Yoshida T., Hirai S., Nishida A. Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death. J. Neurochem. 63:1994;266-270.
26. Yoshida T., Tanaka M., Sotomatsu A., Hirai S. Activated microglia cause superoxide-mediated release of iron from ferritin. Neurosci. Lett. 190:1995;21-24.