Redox factor-1 mediates NF-κB nuclear translocation for LPS-induced iNOS expression in murine macrophage cell line RAW 264.7

Immunology

Volumn 124, Issue 1, 2008, Pages 58-67

  Song, Ju Dong ^a   Lee, Sang Kwon ^a   Kim, Kang Mi ^a   Kim, Jong Won ^a   Kim, Jong Min ^b   Yoo, Young Hyun ^b   Park, Young Chul ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Dong A University   (South Korea)

Author keywords

Lipopolysaccharide; NADPH oxidase; Nitric oxide; Reactive oxygen species; Redox factor 1

Indexed keywords

ACETYLCYSTEINE; BACTERIUM LIPOPOLYSACCHARIDE; DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN; PROTEIN P47 PHOX; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FUNCTIONAL PROTEOMICS; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; PROTEOMICS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL NUCLEUS; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; NADPH OXIDASE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSLOCATION, GENETIC; UP-REGULATION;

EID: 42149157313     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02736.x     Document Type: Article

References (47)

1. MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997 15 : 323 50.
2. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991 43 : 109 42.
3. Sies H, Mehlhorn R. Mutagenicity of nitroxide-free radicals. Arch Biochem Biophys 1986 251 : 393 6.
4. Ji Y, Akerboom TP, Sies H, Thomas JA. S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch Biochem Biophys 1999 362 : 67 78.
5. Nathan C. Inducible nitric oxide synthase: what difference does it make? J Clin Invest 1997 100 : 2417 23.
6. Brennan FM, Feldmann M. Cytokines in autoimmunity. Curr Opin Immunol 1996 8 : 872 7.
7. Nakamura H, Nakamura K, Yodoi J. Redox regulation of cellular activation. Annu Rev Immunol 1997 15 : 351 69.
8. Xie QW, Kashiwabar Y, Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 1994 269 : 4705 8.
9. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon-γ and lipopolysaccharide. Proc Natl Acad Sci USA 1993 90 : 9730 4.
10. Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J Exp Med 1993 177 : 1779 84.
11. Diaz-Guerra MJ, Velasco MM, Martin-Sanz P, Bosca L. Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes: requirement of NF-κB activation after stimulation with bacterial cell wall products and phorbol esters. J Biol Chem 1996 271 : 30114 20.
12. Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal 1999 11 : 1 14.
13. DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase molecular interactions of oxidase proteins. J Leukoc Biol 1996 60 : 677 91.
14. Demple B, Herman T, Chen DS. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA 1991 88 : 11450 4.
15. Robson CN, Hickson ID. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nucleic Acids Res 1991 19 : 5519 23.
16. Seki S, Akiyama K, Watanabe S, Hatsushika M, Ikeda S, Tsutsui K. cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem 1991 266 : 20797 802.
17. Rothwell DG, Barzilay G, Gorman M, Morera S, Freemont P, Hickson ID. The structure and function of the HAP/Ref-1 protein. Oncol Res 1997 9 : 275 80.
18. Ramana CV, Boldogh I, Izumi T, Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci USA 1998 95 : 5061 6.
19. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996 271 : 32253 9.
20. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 1997 11 : 558 70.
21. Mitomo K, Nakayama K, Fujimoto K, Sun X, Seki S, Yamamoto K. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro. Gene 1994 145 : 197 203.
22. Yao KS, Xanthoudakis S, Curran T, O'Dwyer P. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol 1994 14 : 5997 6003.
23. Grosch S, Fritz G, Kaina B. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Res 1998 58 : 4410 6.
24. Kakolyris S, Kaklamanis L, Giatromanolaki A et al. Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease. Histopathology 1998 33 : 561 9.
25. Duguid JR, Eble JN, Wilson TM, Kelley MR. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res 1995 55 : 6097 102.
26. Kojima H, Sakurai K, Kikuchi K, Kawahara S, Kirino Y, Nagoshi H, Hirata Y, Nagano T. Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore. Chem Pharm Bull (Tokyo) 1998 46 : 373 5.
27. Park YC, Jun CD, Kang HS, Kim HD, Kim HM, Chung HT. Role of intracellular calcium as a priming signal for the induction of nitric oxide synthesis in murine peritoneal macrophages. Immunology 1996 87 : 296 302.
28. Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, Jeon BH, Ozaki M, Irani K. Redox-factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ 2002 9: 717 25.
29. Schreiber E, Matthias P, Muller MM, Schaffner W. Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res 1989 17: 6419.
30. Taylor BS, De Vera ME, Ganster RW, Wang Q, Shapiro RA, Morris SM Jr., Billiar TR, Geller DA. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem 1998 273: 15148 56.
31. Hecker M, Preiss C, Klemm P, Busse R. Inhibition by antioxidants of nitric oxide synthase expression in murine macrophges: role of nuclear factor kappa B and interferon regulatory factor 1. Br J Pharmacol 1996 118: 2178 84.
32. Mercurio F, Zhu H, Murray BW et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 1997 278: 860 6.
33. 2 and antioxidants have opposite effects on activation of NF-kappaB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993 12: 2005 15.
34. 2 and nitric oxide in inducible nitric oxide synthase expression in macrophages. Nitric Oxide 2001 5: 504 13.
35. Liu H, Colavitti R, Rovira II, Finkel T. Redox-dependent transcriptional regulation. Circ Res 2005 97: 967 74.
36. Walker LJ, Robson CN, Black E, Gillespie D, Hickson ID. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol 1993 13: 5370 6.
37. Tell G, Crivellato E, Pines A et al. Mitochondrial localization of APE/Ref-1 in thyroid cells. Mutat Res 2001 485: 143 52.
38. Monick MM, Carter AB, Hunninghake GW. Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. J Biol Chem 1999 274: 18075 80.
39. Suzuki Y, Ono Y, Hirabayashi Y. Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis. FEBS Lett 1998 425: 209 12.
40. Lundqvist-Gustafsson H, Bengtsson T. Activation of the granule pool of the NADPH oxidase accelerates apoptosis in human neutrophils. J Leukoc Biol 1999 65: 196 204.
41. Yoo YH, Lim YJ, Park SE, Kim JM, Park YC. Overexpression of redox factor-1 negatively regulates NO synthesis and apoptosis in LPS-stimulated RAW 264.7 macrophages. FEBS Lett 2004 556: 39 42.
42. Tell G, Pellizzari L, Pucillo C, Puglisi F, Cesselli D, Kelley MR, Di Loreto C, Damante G. TSH controls Ref-1 nuclear translocation in thyroid cells. J Mol Endocrinol 2000 24: 383 90.
43. Gillardon F, Bottiger B, Hossmann KA. Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest. Brain Res Mol Brain Res 1997 52: 194 200.
44. Tell G, Zecca ZA, Pellizzari L, Spessotto P, Colombatti A, Kelley MR, Damante G, Pucillo C. An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation. Nucleic Acids Res 2000 28: 1099 105.
45. Pines A, Perrone L, Bivi N et al. Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. Nucleic Acids Res 2005 33: 4379 94.
46. Guan Z, Basi D, Li Q, Mariash A, Xia YF, Geng JG, Kao E, Hall JL. Loss of redox factor 1 decreases NF-κB activity and increases susceptibility of endothelial cells to apoptosis. Arterioscler Thromb Vas Biol 2005 25: 96 101.
47. Hall JL, Wang X, Adamson V, Zhao Y, Gibbons GH. Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-κB-independent and -dependent pathways. Circ Res 2001 88: 1247 53.