Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction

Biochemical and Biophysical Research Communications

Volumn 449, Issue 1, 2014, Pages 74-80

  Li, Zhengqian ^a   Cao, Yiyun ^a   Li, Lunxu ^a   Liang, Yaoxian ^a   Tian, Xiaosheng ^b   Mo, Na ^c   Liu, Yajie ^a   Li, Min ^a   Chui, Dehua ^b   Guo, Xiangyang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c CANCER HOSPITAL   (China)

Author keywords

Angiotensin II receptor type 1; Blood brain barrier; Neuroinflammation; Postoperative cognitive dysfunction; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 1B RECEPTOR; ANGIOTENSIN II; CANDESARTAN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; RENIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD PRESSURE; CONTROLLED STUDY; ENCEPHALITIS; HIPPOCAMPUS; LAPAROTOMY; LONG TERM CARE; LOW DRUG DOSE; MALE; MEMBRANE PERMEABILITY; MEMORY; MICROGLIA; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; POSTOPERATIVE COGNITIVE DYSFUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT MODEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPATIAL LEARNING; SURGICAL STRESS; UPREGULATION;

ANGIOTENSIN II RECEPTOR TYPE 1; BLOOD-BRAIN BARRIER; NEUROINFLAMMATION; POSTOPERATIVE COGNITIVE DYSFUNCTION; RENIN-ANGIOTENSIN SYSTEM;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BLOOD-BRAIN BARRIER; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MALE; NEUROPROTECTIVE AGENTS; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM; TETRAZOLES; TREATMENT OUTCOME;

EID: 84901708659     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.153     Document Type: Article

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