Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice

Critical Care Medicine

Volumn 38, Issue 11, 2010, Pages 2190-2198

  Wan, Yanjie ^a,b   Xu, Jing ^a   Meng, Fanzhen ^d   Bao, Yuhua ^d   Ge, Yeying ^d   Lobo, Niyati ^b   Vizcaychipi, Marcela P ^b   Zhang, Denghai ^a   Gentleman, Steve M ^c   Maze, Mervyn ^e   Ma, Daqing ^b  

^a Gongli Hospital   (China)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d XUZHOU MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; astrogliosis; microgliosis; neuroinflammation; Postoperative cognitive dysfunction; amyloid; protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELASTROL; AMYLOID BETA PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; BIOCHEMISTRY; C57BL 6 MOUSE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; GENERAL ANESTHESIA; GLIOSIS; HEPATOLOBECTOMY; HIPPOCAMPUS; LIVER RESECTION; LIVER SURGERY; MALE; MAZE TEST; MICROGLIOSIS; MOUSE; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN PHOSPHORYLATION; SHAM PROCEDURE; AGE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; COGNITIVE DEFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; MEMORY DISORDER; METABOLISM; PHOSPHORYLATION; PSYCHOLOGICAL ASPECT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURGERY; WESTERN BLOTTING;

AGE FACTORS; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; COGNITION DISORDERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLIOSIS; HEPATECTOMY; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURGICAL PROCEDURES, OPERATIVE; TAU PROTEINS;

EID: 78049446331     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181f17bcb     Document Type: Article

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