Renin-angiotensin system blockers affect cognitive decline and serum adipocytokines in Alzheimer's disease

Alzheimer's and Dementia

Volumn 9, Issue 5, 2013, Pages 512-518

  Furiya, Yoshiko ^a   Ryo, Miwa ^b   Kawahara, Makoto ^a   Kiriyama, Takao ^a   Morikawa, Masami ^a   Ueno, Satoshi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b Osaka Health Support Center   (Japan)

Author keywords

Adiponectin; Alzheimer's disease; Leptin; RAS; Renin angiotensin system; Visceral fat

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALDOSTERONE ANTAGONIST; ANTIHYPERTENSIVE AGENT; IMMUNOREACTIVE INSULIN; LEPTIN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM BLOCKING AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DIZZINESS; DRUG EFFECT; FEMALE; HEADACHE; HOMEOSTASIS; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SCORING SYSTEM;

ADIPONECTIN; ALZHEIMER'S DISEASE; LEPTIN; RAS; RENIN-ANGIOTENSIN SYSTEM; VISCERAL FAT;

ADIPOKINES; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIHYPERTENSIVE AGENTS; FEMALE; HUMANS; HYPERTENSION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PREVALENCE; RENIN-ANGIOTENSIN SYSTEM; RETROSPECTIVE STUDIES;

EID: 84883555275     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2012.06.007     Document Type: Article

References (50)

1. D.A. Evans, H.H. Funkenstein, M.S. Albert, P.A. Scherr, N.R. Cook, and M.J. Chown Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported JAMA 262 1989 2551 2556
2. D.J. Selkoe Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease Cell 58 1989 611 612 (Pubitemid 19210954)
3. S. Craft Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications Alzheimer Dis Assoc Disord 20 2006 298 301 (Pubitemid 44900946)
4. E. Duron, and O. Hanon Vascular risk factors, cognitive decline, and dementia Vasc Health Risk Manage 4 2008 363 381 (Pubitemid 351711965)
5. M. Vanhanen, K. Koivisto, L. Moilanen, E.L. Helkala, T. Hanninen, and H. Soininen Association of metabolic syndrome with Alzheimer disease: a population-based study Neurology 67 2006 843 847 (Pubitemid 44394200)
6. Y. Matsuzawa, I. Shimomura, T. Nakamura, Y. Keno, K. Kotani, and K. Tokunaga Pathophysiology and pathogenesis of visceral fat obesity Obes Res 3 1995 187S 194S
7. J.A. Greenberg, and C.N. Boozer The leptin-fat ratio is constant, and leptin may be part of two feedback mechanisms for maintaining the body fat set point in non-obese male Fischer 344 rats Horm Metab Res 31 1999 525 532 (Pubitemid 29507832)
8. Y.T. Zhou, M. Shimabukuro, K. Koyama, Y. Lee, M.Y. Wang, and F. Trieu Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation Proc Natl Acad Sci U S A 94 1997 6386 6390 (Pubitemid 27270694)
9. N.M. Davies, P.G. Kehoe, Y. Ben-Shlomo, and R.M. Martin Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias J Alzheimers Dis 26 2011 699 708
10. N.C. Li, A. Lee, R.A. Whitmer, M. Kivipelto, E. Lawler, and L.E. Kazis Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis BMJ 340 2010 b5465
11. P.G. Kehoe, and G.K. Wilcock Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease? Lancet Neurol 6 2007 373 378 (Pubitemid 46389616)
12. A.M. Sharma, J. Janke, K. Gorzelniak, S. Engeli, and F.C. Luft Angiotensin blockade prevents type 2 diabetes by formation of fat cells Hypertension 40 2002 609 611 (Pubitemid 35278594)
13. O. von Bohlen und Halbach, and D. Albrecht The CNS renin-angiotensin system Cell Tissue Res 326 2006 599 616 (Pubitemid 44435828)
14. P.G. Kehoe, C. Russ, S. McIlory, H. Williams, P. Holmans, and C. Holmes Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease Nat Genet 21 1999 71 72 (Pubitemid 29036286)
15. E. Savaskan, C. Hock, G. Olivieri, S. Bruttel, C. Rosenberg, and C. Hulette Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia Neurobiol Aging 22 2001 541 546 (Pubitemid 32607737)
16. N. Hirawa, Y. Uehara, Y. Kawabata, A. Numabe, T. Gomi, and T. Ikeda Long-term inhibition of renin-angiotensin system sustains memory function in aged Dahl rats Hypertension 34 1999 496 502 (Pubitemid 29426770)
17. J.S. Miners, Z. van Helmond, P.G. Kehoe, and S. Love Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme Brain Pathol 20 2010 794 802
18. S. Miners, E. Ashby, S. Baig, R. Harrison, H. Tayler, and E. Speedy Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes Am J Transl Res 1 2009 163 177
19. P. Strazzullo, R. Iacone, L. Iacoviello, O. Russo, G. Barba, and P. Russo Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study Ann Intern Med 138 2003 17 23 (Pubitemid 36232090)
20. L.A. Cassis, S.B. Police, F. Yiannikouris, and S.E. Thatcher Local adipose tissue renin-angiotensin system Curr Hypertens Rep 10 2008 93 98
21. T. Ogihara, K. Kikuchi, H. Matsuoka, T. Fujita, J. Higaki, and M. Horiuchi The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009) Hypertens Res 32 2009 3 107
22. American Psychiatric Association Diagnostic and stastical manual of mental disorders DSM-IV 1994 American Psychiatric Assocation Washington, DC
23. K. Tokunaga, Y. Matsuzawa, K. Ishikawa, and S. Tarui A novel technique for the determination of body fat by computed tomography Int J Obes 7 1983 437 445 (Pubitemid 13020976)
24. Y. Matsuzawa Metabolic syndrome: definition and diagnostic criteria in Japan J Atheroscler Thromb 12 2005 301
25. T. Yoshizumi, T. Nakamura, M. Yamane, A.H. Islam, M. Menju, and K. Yamasaki Abdominal fat: standardized technique for measurement at CT Radiology 211 1999 283 286 (Pubitemid 29161765)
26. Y. Matsuzawa New criteria for 'obesity disease' in Japan Circ J 66 2002 987 992 (Pubitemid 35416333)
27. A. Hiuge-Shimizu, K. Kishida, T. Funahashi, Y. Ishizaka, R. Oka, and M. Okada Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study) Ann Med 44 2012 82 92
28. F. Fazekas, R. Kleinert, H. Offenbacher, F. Payer, R. Schmidt, and G. Kleinert The morphologic correlate of incidental punctate white matter hyperintensities on MR images AJNR Am J Neuroradiol 12 1991 915 921
29. J.W. Jeong, K.W. Kim, D.Y. Lee, S.B. Lee, J.H. Park, and E.A. Choi A normative study of the Revised Hasegawa Dementia Scale: comparison of demographic influences between the Revised Hasegawa Dementia Scale and the Mini-Mental Status Examination Dement Geriatr Cogn Disord 24 2007 288 293 (Pubitemid 47482076)
30. F. Anan, N. Takahashi, T. Ooie, M. Hara, H. Yoshimatsu, and T. Saikawa Candesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance Metabolism 53 2004 777 781 (Pubitemid 38880911)
31. R.A. Benndorf, T. Rudolph, D. Appel, E. Schwedhelm, R. Maas, and F. Schulze Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension Metabolism 55 2006 1159 1164 (Pubitemid 44219053)
32. J. Kuusisto, K. Koivisto, L. Mykkanen, E.L. Helkala, M. Vanhanen, and T. Hanninen Essential hypertension and cognitive function: the role of hyperinsulinemia Hypertension 22 1993 771 779 (Pubitemid 23326225)
33. W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, and M.P. Frosch Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proc Natl Acad Sci U S A 100 2003 4162 4167 (Pubitemid 36418174)
34. M. Ryo, T. Nakamura, S. Kihara, M. Kumada, S. Shibazaki, and M. Takahashi Adiponectin as a biomarker of the metabolic syndrome Circ J 68 2004 975 981 (Pubitemid 39540124)
35. B. Chen, W.Q. Liao, N. Xu, H. Xu, J.Y. Wen, and C.A. Yu Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action Brain Res 1273 2009 129 137
36. J. Spranger, S. Verma, I. Gohring, T. Bobbert, J. Seifert, and A.L. Sindler Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells Diabetes 55 2006 141 147 (Pubitemid 43343309)
37. A. Moriuchi, H. Yamasaki, M. Shimamura, A. Kita, H. Kuwahara, and K. Fujishima Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation Biochem Biophys Res Commun 356 2007 1024 1030 (Pubitemid 46529394)
38. T.M. van Himbergen, A.S. Beiser, M. Ai, S. Seshadri, S. Otokozawa, and R. Au Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and Alzheimer disease: results from the Framingham Heart Study Arch Neurol 69 2012 594 600
39. I. Usui, S. Fujisaka, K. Yamazaki, A. Takano, S. Murakami, and Y. Yamazaki Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients Diabetes Res Clin Pract 77 2007 210 214 (Pubitemid 46670421)
40. E. Velkoska, F.J. Warner, T.J. Cole, I. Smith, and M.J. Morris Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat Nutr Metab Cardiovasc Dis 20 2010 49 55
41. S. Zorad, J.T. Dou, J. Benicky, D. Hutanu, K. Tybitanclova, and J. Zhou Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma Eur J Pharmacol 552 2006 112 122 (Pubitemid 44754970)
42. S.J. Greco, A. Hamzelou, J.M. Johnston, M.A. Smith, J.W. Ashford, and N. Tezapsidis Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and beta-amyloid in neurons Biochem Biophys Res Commun 414 2011 170 174
43. A.P. Signore, F. Zhang, Z. Weng, Y. Gao, and J. Chen Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials J Neurochem 106 2008 1977 1990
44. D.A. Power, J. Noel, R. Collins, and D. O'Neill Circulating leptin levels and weight loss in Alzheimer's disease patients Dement Geriatr Cogn Disord 12 2001 167 170 (Pubitemid 32149724)
45. W. Lieb, A.S. Beiser, R.S. Vasan, Z.S. Tan, R. Au, and T.B. Harris Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging JAMA 302 2009 2565 2572
46. C. Sanz, S. Andrieu, A. Sinclair, H. Hanaire, and B. Vellas Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease Neurology 66 2009 1359 1366
47. J.M. Barnes, N.M. Barnes, B. Costall, J. Coughlan, M.E. Kelly, and R.J. Naylor Angiotensin-converting enzyme inhibition, angiotensin, and cognition J Cardiovasc Pharmacol 19 1992 S63 S71
48. K. Wosik, R. Cayrol, A. Dodelet-Devillers, F. Berthelet, M. Bernard, and R. Moumdjian Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis J Neurosci 27 2007 9032 9042 (Pubitemid 47312066)
49. H.K. Hamdi, and R. Castellon A genetic variant of ACE increases cell survival: a new paradigm for biology and disease Biochem Biophys Res Commun 318 2004 187 191 (Pubitemid 38526263)
50. T. Ohrui, T. Matsui, M. Yamaya, H. Arai, S. Ebihara, and M. Maruyama Angiotensin-converting enzyme inhibitors and incidence of Alzheimer's disease in Japan J Am Geriatr Soc 52 2004 649 650 (Pubitemid 38480653)