The therapeutic potential of atorvastatin in a mouse model of postoperative cognitive decline

Annals of Surgery

Volumn 259, Issue 6, 2014, Pages 1235-1244

  Vizcaychipi, Marcela P ^a   Watts, Helena R ^a   O'dea, Kieran P ^a   Lloyd, Dafydd G ^a   Penn, Jack W ^a   Wan, Yanjie ^b   Pac Soo, Chen ^a,c   Takata, Masao ^a   Ma, Daqing ^a,d  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b Gongli Hospital   (China)

^c WYCOMBE HOSPITAL   (United Kingdom)

^d HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Atorvastatin; Cognitive; Neuroinflammation; Postoperative; Synapse

Indexed keywords

ATORVASTATIN; CD68 ANTIGEN; CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEAR; HIPPOCAMPUS; INFLAMMATION; MORRIS WATER MAZE TEST; MOUSE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; POSTOPERATIVE COGNITIVE DYSFUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIAL MEMORY; UNINEPHRECTOMY;

ADMINISTRATION, ORAL; ANIMALS; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEMORY; MICE; MICE, INBRED C57BL; NEPHRECTOMY; POSTOPERATIVE COMPLICATIONS; PYRROLES; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 84900866263     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000000257     Document Type: Article

References (46)

1. Moller JT, Cluitmans P, Rasmussen LS, et al. Long-Term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dysfunction. Lancet. 1998;351: 857-861
2. Newman MF, Kirchner JL, Phillips-Bute B, et al. Longitudinal assessment of neurocognitive function after coronary-Artery bypass surgery. N Engl J Med. 2001;344:395-402
3. Vanderweyde T, Bednar MM, Forman SA, et al. Iatrogenic risk factors for Alzheimer's disease: Surgery and anesthesia. J Alzheimers Dis. 2010;22(suppl 3):91-104
4. Monk TG, Price CC. Postoperative cognitive disorders. Curr Opin Crit Care. 2011;17:376-381
5. Bekker A, Lee C, De Santi S, et al. Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction?. Am J Surg. 2010;199:782-788
6. Etzioni DA, Liu JH, Maggard MA, et al. The aging population and its impact on the surgery workforce. Ann Surg. 2003;238:170-177
7. Zhang B, Tian M, Zhen Y, et al. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012;114:410-415
8. Ballard C, Jones E, Gauge N, et al. Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial. PLoS One. 2012;7: E37410
9. Gaudet JG, Yocum GT, Lee SS, et al. MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery. J Clin Neurosci. 2010;17:436-440
10. Ji MH, Yuan HM, Zhang GF, et al. Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery. J Anesth. 2012;27:236-242
11. Wang J, Su T, Liu Y, et al. Postoperative cognitive dysfunction is correlated with urine formaldehyde in elderly noncardiac surgical patients. Neurochem Res. 2012;37:2125-2134
12. Wan Y, Xu J, Ma D, et al. Postoperative impairment of cognitive function in rats: A possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007;106:436-443
13. Cibelli M, Fidalgo AR, Terrando N, et al. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010;68:360-368
14. Terrando N, Rei Fidalgo A,Vizcaychipi M, et al. The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care. 2010;14:R88
15. Wan Y, Xu J, Meng F, et al. Cognitive decline following major surgery is associated with gliosis, beta-Amyloid accumulation, and tau phosphorylation in old mice. Crit Care Med. 2010;38:2190-2198
16. Tang JX, Mardini F, Janik LS, et al. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013;257:439-448
17. Mishra A, Kim HJ, Shin AH, et al. Synapse loss induced by interleukin-1beta requires pre-And post-synaptic mechanisms. JNeuroimmune Pharmacol. 2012;7:571-578
18. Aisen PS, Thal LJ, Ferris SH, et al. Rofecoxib in patients with mild cognitive impairment: Further analyses of data from a randomized, double-blind, trial. Curr Alzheimer Res. 2008;5:73-82
19. Miida T, Takahashi A, Ikeuchi T. Prevention of stroke and dementia by statin therapy: Experimental and clinical evidence of their pleiotropic effects. Pharmacol Ther. 2007;113:378-393
20. Chen J, Zhang ZG, Li Y, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol. 2003;53:743-751
21. Farooqui AA, Ong WY, Horrocks LA, et al. Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans. Brain Res Rev. 2007;56:443-471
22. Clarke RM, Lyons A, O'Connell F, et al. A pivotal role for interleukin-4 in atorvastatin-Associated neuroprotection in rat brain. J Biol Chem. 2008;283:1808-1817
23. Pac-Soo C, Lloyd DG, Vizcaychipi MP, et al. Statins: The role in the treatment and prevention of Alzheimer's neurodegeneration. J Alzheimers Dis. 2011;27:1-10
24. Barone E, Cenini G, Di Domenico F, et al. Long-Term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action. Pharmacol Res. 2011;63:172-180
25. Souza-Costa DC, Sandrim VC, Lopes LF, et al. Anti-inflammatory effects of atorvastatin: Modulation by the T-786C polymorphism in the endothelial nitric oxide synthase gene. Atherosclerosis. 2007;193:438-444
26. Pugh CR, Kumagawa K, Fleshner M, et al. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun. 1998;12:212-229
27. Rosczyk HA, Sparkman NL, Johnson RW. Neuroinflammation and cognitive function in aged mice following minor surgery. Exp Gerontol. 2008;43:840-846
28. Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells. J Leukoc Biol. 2010;87:779-789
29. Hartlage-Rubsamen M, Morawski M, Waniek A, et al. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol. 2011;121:705-719
30. Al Banchaabouchi M, Marescau B, D'Hooge R, et al. Biochemical, histological and behavioral consequences of nephrectomy in young and aged mice. Nephron. 2001;89:90-100
31. Mason RP. Molecular basis of differences among statins and a comparison with antioxidant vitamins. Am J Cardiol. 2006;98:34P-41P.
32. Wood WG, Eckert GP, Igbavboa U, et al. Statins and neuroprotection: A prescription to move the field forward. Ann N Y Acad Sci. 2010;1199:69-76
33. Massaro M, Habib A, Lubrano L, et al. The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. Proc Natl Acad Sci U S A. 2006;103:15184-15189
34. Hilgendorff A, Muth H, Parviz B, et al. Statins differ in their ability to block NF-kappaB activation in human blood monocytes. Int J Clin Pharmacol Ther. 2003;41:397-401
35. Boyle EM, Jr, Pohlman TH, Johnson MC, et al. Endothelial cell injury in cardiovascular surgery: The systemic inflammatory response. Ann Thorac Surg. 1997;63:277-284
36. Bolognin S, Blanchard J,Wang X, et al. An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide. Acta Neuropathol. 2012;123:133-151
37. Cespedes-Rubio A, Jurado FW, Cardona-Gomez GP. p120 catenin/alphaNcatenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia. J Neurosci Res. 2010;88:3621-3634
38. Butterfield DA, Barone E, Di Domenico F, et al. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol. 2012;15:981-987
39. Li X, Jope RS. Is glycogen synthase kinase-3 a central modulator in mood regulation?. Neuropsychopharmacology. 2010;35:2143-2154
40. Cheng G, Chunlei W, Pei W, et al. Simvastatin activates Akt/glycogen synthase kinase-3beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage. Vascul Pharmacol. 2010;52:77-83
41. Derecki NC, Cardani AN, Yang CH, et al. Regulation of learning and memory by meningeal immunity: A key role for IL-4. J Exp Med. 2010;207: 1067-1080
42. Tang JX, Baranov D, Hammond M, et al. Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology. 2011;115:727-732
43. Zhang B, Tian M, Zheng H, et al. Effects of anesthetic isoflurane and desflurane on human cerebrospinal fluid abeta and tau level. Anesthesiology. 2013;119:52-60
44. Kotilinek LA,Westerman MA,WangQ, et al. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 2008;131:651-664
45. Ancelin ML, Carriere I, Barberger-Gateau P, et al. Lipid lowering agents, cognitive decline, and dementia: The three-city study. J Alzheimers Dis. 2012;30:629-637
46. Mathew JP, Grocott HP, McCurdy JR, et al. Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. JCardiothorac Vasc Anesth. 2005;19:294-299.