Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: Potential role of NO/SIRT1/PGC-1α signaling

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 11, 2014, Pages

  Koka, Saisudha ^a   Aluri, Hema S ^a   Xi, Lei ^a   Lesnefsky, Edward J ^a,b   Kukreja, Rakesh C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardioprotection; Nitric oxide; OXPHOS; SIRT1; Tadalafil; Type 2 diabetes

Indexed keywords

DIMETHYL SULFOXIDE; GLUCOSE; GLUTAMIC ACID; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; TADALAFIL; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME SUBSTRATE; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; INSULIN BLOOD LEVEL; MALE; METABOLIC STRESS; MITOCHONDRIAL DNA DISORDER; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

CARDIOPROTECTION; NITRIC OXIDE; OXPHOS; SIRT1; TADALAFIL; TYPE 2 DIABETES;

ANIMALS; CARBOLINES; DIABETES MELLITUS, TYPE 2; HEART; MICE; MITOCHONDRIA; MYOCARDIUM; NITRIC OXIDE; OXIDATIVE PHOSPHORYLATION; PHOSPHODIESTERASE 5 INHIBITORS; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 84901704478     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00865.2013     Document Type: Article

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